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Preparation and analysis of active rat model of rheumatoid arthritis with features of TCM toxic heat-stasis painful obstruction 被引量:4
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作者 Yanan Wang Yan Lu +7 位作者 Jie Wang Zhiming Shen Hui Liu Weiguo Ma Jisheng Zhang Xuehong Ma Kang Wang Fengxian Meng 《Journal of Traditional Chinese Medical Sciences》 2015年第3期166-172,共7页
Objective:To establish a collagen type II-induced rat model of rheumatoid arthritis(RA)presenting characteristics of the human form of the traditional Chinese syndrome pattern of toxic heat-stasis painful obstruction(... Objective:To establish a collagen type II-induced rat model of rheumatoid arthritis(RA)presenting characteristics of the human form of the traditional Chinese syndrome pattern of toxic heat-stasis painful obstruction(bi zheng;arthromyodynia)as well as pathologic features of active RA.The Chinese herbal medicine Tengmei decoction was used to validate the animal model.Methods:Ninety specific pathogen free Sprague-Dawley rats were randomly divided into a normal group of 6 rats and a model group of 84 rats.To establish the rat model of collageninduced arthritis(CIA),bovine type II collagen in complete Freund’s adjuvant was injected into the model group rats as a priming dose(Day 0)and boosting dose(Day 9).Changes in arthritic index(AI)scores,including limb swelling,were monitored.Thereafter,24 successfullyestablished CIA rats were randomly assigned to 4 groups with 6 animals each:model,positive control drug,high-dose traditional Chinese herbal medicine,and traditional Chinese herbal medicine.A blank control group of 6 rats was included.After 12 weeks of intervention with Tengmei decoction,articular synovial tissue and serum specimens were collected to detect interleukin-2(IL-2)and IL-17 transcription and protein expression levels. 展开更多
关键词 Type II collagen Complete freund’s adjuvant Animal model Rheumatoid arthritis Toxic heat-stasis arthromyodynia Bi zheng
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The petroleum ether fraction of Celastrus paniculatus Willd. seeds demonstrates antiarthritic effect in adjuvant-induced arthritis in rats 被引量:2
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作者 Pankaj S.Kothavade Vipin D.Bulani +2 位作者 Padmini S.Deshpande Amrita S.Chowdhury Archana R.Juvekar 《Journal of Traditional Chinese Medical Sciences》 2015年第3期183-193,共11页
Objective:Celastrus paniculatus(CP)Willd.is a plant indigenous to India with medicinal properties.It is used in the ayurvedic treatment of inflammatory ailments such as rheumatoid arthritis.The present study was desig... Objective:Celastrus paniculatus(CP)Willd.is a plant indigenous to India with medicinal properties.It is used in the ayurvedic treatment of inflammatory ailments such as rheumatoid arthritis.The present study was designed to investigate the therapeutic efficacy of the petroleum ether fraction(PCP)obtained from CP seeds on adjuvant-induced arthritis in rats.Methods:Arthritis was induced in SpragueeDawley rats by immunization with Freund’s complete adjuvant(FCA).Arthritis severity was evaluated by arthritis score,paw volume,tibiotarsal joint thickness,body weight,dorsal flexion pain,motility test,stair climbing ability and index of thymus and spleen.Moreover,histopathology of knee joints supported by haematological analysis was used to assess the anti-arthritic action of PCP.The levels of superoxide dismutase(SOD),glutathione(GSH),catalase(CAT),nitric oxide(NO)and malondialdehyde(MDA)in liver were also assessed.Serum samples were collected for estimation of aspartate transaminase(AST),alanine transaminase(ALT)and alkaline phosphatase(ALP).In addition,cytokines such as tumour necrosis factor-alpha(TNF-a)and interleukin-6(IL-6)were estimated in plasma.Results:PCP significantly alleviated arthritic progression with regards to paw swelling,arthritic score,immune organ indices,hyperalgesic effect and body weight.This phenomenon was correlated with significant suppression of overproduction of inflammatory cytokines(TNFa and IL-6),oxidant stress markers(MDA and NO)and cellular enzyme(AST,ALT and ALP)levels versus arthritic rats without treatment.Moreover,PCP restored the decreased levels of SOD,CAT and GSH.Conclusion:Our results suggest that the anti-arthritic properties of PCP may be due to immunosuppressive effects,cytokine regulation,antioxidant effects and bone-protective activities. 展开更多
关键词 Celastrus paniculatus Rheumatoid arthritis freund’s complete adjuvant CYTOKINE
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Analgesic and Anti-Arthritic Effect of <i>Enicostemma littorale</i>Blume 被引量:1
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作者 Mohamed M. Shabi Subashini Uthrapathy +4 位作者 Chellappan David Raj Gayathri Krishnamoorthy Dhevi Ravindhran Jipnomon Joseph Victor G. Rajamanickam 《Advances in Bioscience and Biotechnology》 2014年第13期1018-1024,共7页
Enicostemma littorale (Blume), the folk medicine is used for rheumatic pain and it was selected for scientific validation. The 85% methanolic extract obtained from the whole plant of Enicostemma littorale has been ass... Enicostemma littorale (Blume), the folk medicine is used for rheumatic pain and it was selected for scientific validation. The 85% methanolic extract obtained from the whole plant of Enicostemma littorale has been assessed for analgesic and anti-inflammatory activity. The analgesic activity has been evaluated by hot plate and tail immersion method and the anti-inflammatory and antioxidant activities are evaluated by Complete Freund’s adjuvant induced arthritic model. The results of the evaluation of analgesic activity in hot plate and tail immersion method revealed that the extract exhibits significant activity at 150 mg/kg body weight and the effect is found to increase dose dependently. In Freund’s adjuvant induced arthritis, Enicostemma littorale is found to decrease the paw volume (15.81%). Significant protection is also observed by elevating antioxidant enzymes. In conclusion, the 85% methanolic extract of Enicostemma littorale possesses significant analgesic and anti-inflammatory activities in Freund’s adjuvant induced arthritic model in rats. 展开更多
关键词 Complete freund’s ADJUVANT Hot Plate Oxidative stress TAIL Immersion
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Anti-arthritic effect of Distemonanthus benthamianus extracts against rheumatoid arthritis in rats
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作者 William Yousseu Nana Ernest Allah Hoki Kwenteh +9 位作者 Gilbert Ateufack Eric Gonzal Tsafack Stephanie FloreDjuichou Nguemnang Zenab Linda Fagni Njoya Albert Donatien Atsamo Vanessa Mba Matah Marthe CarineFlore Adjouzem Yacine Karelle Madjo Kouam Elvira Ngoufack Azanze Marius Mbiantcha 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2022年第10期411-420,共10页
Objective:To evaluate the anti-arthritic effect of aqueous and methanolic extracts of Distemonanthus benthamianus.Methods:Monoarthritis was induced by an injection of 0.3 mL zymosan A(0.9%NaCl,v/v)in the right posteri... Objective:To evaluate the anti-arthritic effect of aqueous and methanolic extracts of Distemonanthus benthamianus.Methods:Monoarthritis was induced by an injection of 0.3 mL zymosan A(0.9%NaCl,v/v)in the right posterior knee joints of rats.Then,joint diameter and pain threshold were determined.Polyarthritis was induced by an intracaudal injection of complete Freund’s adjuvant and rats were treated from day 14 post 1st complete Freund’s adjuvant injection until 28 day.The clinical,hematological,biochemical and oxidative stress parameters were evaluated.In addition,histological analysis of the knee joint was perfomed in both tests.Results:The aqueous and methanolic extracts of Distemonanthus benthamianus at a dose of 500 mg/kg ameliorated zymosan A-induced monoarthritis,as evidenced by reduced joint diameter,increased pain threshold,as well as improved joint architecture.In addition,both extracts of Distemonanthus benthamianus markedly increased body weight and pain threshold,while reducing paw edema in polyarthritic rats.They also led to a marked decrease in platelets and white blood cells(P<0.05),as well as a significant increase in red blood cells,hemoglobin and hematocrit(P<0.05).The aqueous and methanolic extracts of Distemonanthus benthamianus significantly reduced alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase activities,while increasing serum protein levels(P<0.05)with no significant variation in creatinine level.Moreover,both extracts increased catalase and glutathione activities(P<0.05),and inhibited malondialdehyde and nitric oxide production(P<0.01 and P<0.001)in the liver and kidneys.Histological analysis of the joints showed that both extracts triggered tissue reparation.Conclusions:Distemonanthus benthamianus could be used as a potential candidate in the treatment of rheumatoid arthritis. 展开更多
关键词 Distemonanthus benthamianus Rheumatoid arthritis Anti-arthritis Complete freund’s adjuvant HYPERALGEsIA Inflammation Oxidative stress
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Biophoton Imaging Evaluation of the Process of Rheumatoid Arthritis in Rats
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作者 Chengming Xia Jinzhong Li +2 位作者 Yi Yue Linhua Chen Jiapei Dai 《Natural Science》 2021年第10期451-456,共6页
Rheumatoid arthritis (RA) is a common form of chronic inflammatory arthritis, and it mainly causes the destruction of small joints. The development of this disease is a relatively secret and repeated process, and ther... Rheumatoid arthritis (RA) is a common form of chronic inflammatory arthritis, and it mainly causes the destruction of small joints. The development of this disease is a relatively secret and repeated process, and therefore early diagnosis and evaluation of the disease is usually difficult. In this study, an arthritis model was successfully induced by injecting complete Freund’s adjuvant (CFA) into the toes of lower limbs of Wistar rats. Seven days after injection of CFA, obvious redness and swelling appeared at the toe joints of lower limbs accompanied by more sensitivity to thermal stimulation. Using the ultraweak bio-photon imaging system (UBIS) established by us, the toe joint area of the lower limbs of rats was imaged 7 days after injection of CFA. It was found that the volar part of lower limbs of arthritis rats showed significantly higher biophoton emissions compared with the control group. The results of this study may provide a basis for further research and devel-opment of early diagnosis and assessment of lesion progression of rheumatoid arthritis. 展开更多
关键词 Rheumatoid Arthritis freund’s Adjuvant BIOPHOTON Biophoton Imaging RAT
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鸡矢藤口服液对大鼠完全佐剂性关节炎的影响及作用机制 被引量:3
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作者 王永昌 高克立 +3 位作者 郭红云 张永东 梁涛 李娟 《中药材》 CAS CSCD 北大核心 2012年第7期1129-1132,共4页
目的:探索鸡矢藤口服液(Paederiae oral liquid,POL)对大鼠Freund's完全佐剂性关节炎原发及继发病变的作用及作用机制。方法:将大鼠随机分为模型组、雷公藤多苷片组(10.5mg/kg)及POL高(0.563g/kg)、中(0.282 g/kg)、低(0.141 g/kg)... 目的:探索鸡矢藤口服液(Paederiae oral liquid,POL)对大鼠Freund's完全佐剂性关节炎原发及继发病变的作用及作用机制。方法:将大鼠随机分为模型组、雷公藤多苷片组(10.5mg/kg)及POL高(0.563g/kg)、中(0.282 g/kg)、低(0.141 g/kg)剂量组。原发病变实验采用灌胃给POL 3次后足跖注射完全佐剂致炎,于3、6、18 h用游标卡尺测量致炎侧踝关节肿胀度。继发病变实验造模后分组同上,于第15天开始灌胃给予POL,连续14 d,用游标卡尺测量致炎与非致炎侧踝关节肿胀度、评分测定疼痛反应、生化方法测定一氧化氮(NO)和前列腺素E2(PGE2)水平。结果:POL高、中、低剂量能有效抑制原发病变踝关节肿胀度,其中3 h抑制效果最好,抑制率分别为44.52%、31.12%、30.81%(均P<0.01)。POL高、中、低剂量对致炎侧继发病变足肿胀无明显作用,而高剂量组在25 d时对非致炎侧踝关节肿胀度抑制率为42.92%,对非致炎侧的红肿、结节有较强抑制作用,抑制率为68.75%(均P<0.01)。POL高、中、低剂量组对致炎侧炎性组织中NO含量分别降低48.93%、54.07%、48.84%(P<0.05或P<0.01),PGE2含量降低23.56%,18.97%,16.67%。结论:鸡矢藤口服液对大鼠完全佐剂性关节炎原发病变有明显抗炎作用,但对继发病变抗炎作用强度不明显,其作用机制与其有效抑制炎性组织中NO、PGE2含量有关。 展开更多
关键词 鸡矢藤口服液 freund’s完全佐剂性关节炎 肿胀度 NO PGE2
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凤尾菇对佐剂诱导的关节炎大鼠的抗风湿活性实验研究(英文)
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作者 Patel Pinal Patel Dharmik Patel Natvarlal 《中国天然药物》 SCIE CAS CSCD 2012年第4期269-274,共6页
Pleurotus sajorcaju(P.sajorcaju),an edible and non-toxic mushroom,was evaluated as antioxidant,antitumor,an-ti-inflammatory and antihypertensive activities.P.sajorcaju is a good source of carbohydrates,dietary fiber,e... Pleurotus sajorcaju(P.sajorcaju),an edible and non-toxic mushroom,was evaluated as antioxidant,antitumor,an-ti-inflammatory and antihypertensive activities.P.sajorcaju is a good source of carbohydrates,dietary fiber,essential amino acids,minerals,vitamin B,folic acid and steroids.Anti-inflammatory,immunomodulatory and analgesic activities of aqueous and methanolic extracts of mycelium of P.sajorcaju were investigated(data is not shown).This finding suggests that extracts of P.sajorcaju can be used against inflammatory and autoimmune disease.So,P.sajorcaju examined for its antiarthritic activity.Plant was collected and separately extracted with water and methanol.For antiarthritic activity 500 and 1 000 mg·kg-1 of both extracts were prepared and ad-ministered by oral route.Body weight,paw edema(inflammation),hematological parameter,spleen weight,radiological and histologi-cal analysis of bone damage were assessed in rats with Freund's adjuvant induced paw inflammation.Both extracts showed significant and dose-dependent anti-inflammatory and anti-arthritic effects compared to control group. 展开更多
关键词 Anti-inflammatory activity Anti-arthritic activity Pleurotus sajorcaju freund’s adjuvant
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