Through several years seedling-growing experiments in nursery in Daxing‘anMountains forest region,the author posed that the seedling cultivated for the region mustpossess the characteristics of being suited to thin a...Through several years seedling-growing experiments in nursery in Daxing‘anMountains forest region,the author posed that the seedling cultivated for the region mustpossess the characteristics of being suited to thin and meager soil and having strongresistance to adverse conditions.For this purpose,the cultivation regime ought to bedirectization,standardization and programmatization;seedling growth ought to be promotedby regulating ecological conditions;and the mursery stock quality ought to be tested usingvigor index.展开更多
Suihua City in Heilongjiang Province is located in the heart of the frigid region with black earth and it has created abundant green property resources. However,the environmental issue of this place has caused wide at...Suihua City in Heilongjiang Province is located in the heart of the frigid region with black earth and it has created abundant green property resources. However,the environmental issue of this place has caused wide attention,so the government should make full use of various means to solve the environment problem and protect the ecology in this region. Among the measures taken by the government,the tax means is the most effective economic device to solve the environmental problem. Economic means supplemented by lawful and administrative measures should be adopted to solve the ecological environmental problems in the frigid region with black earth.展开更多
目的:探究当归四逆加吴茱萸生姜汤调节雷诺病的系统药理学机制,筛选先导化合物。方法:基于中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology, TCMSP)和Cytoscape 3.6分析软件,构建当归四逆加吴茱萸...目的:探究当归四逆加吴茱萸生姜汤调节雷诺病的系统药理学机制,筛选先导化合物。方法:基于中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology, TCMSP)和Cytoscape 3.6分析软件,构建当归四逆加吴茱萸生姜汤的“中药-成分-靶点”调控网络,对本方调节靶点进行通路富集分析,综合使用系统药理学和计算机辅助药物设计的方法,筛选本方的潜在活性成分。结果:本方初步筛选出696个化合物成分,获得401个特异性靶点,形成“化合物-靶点”5 446调控对。本方调节靶点基因本体(gene ontology, GO)富集通路包括氨基酸结合、G蛋白偶联受体活性等生物学过程及线粒体基质、线粒体等细胞组分相关,受预激抑制、谷胱甘肽代谢过程、抑制性突触后电位等分子功能影响;京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes, KEGG)富集包括HIF-1信号通路、cAMP信号通路、IL-17信号通路等。分子对接和药效团筛选得出化合物(-)-Medicocarpin具有较好的潜在治疗作用。结论:当归四逆加吴茱萸生姜汤可能通过调节HIF-1信号通路、cAMP信号通路、IL-17信号通路等改善雷诺病;甘草中的(-)-Medicocarpi、Yinyanghuo D与吴茱萸中的Goshuyuamide II等可以作为治疗雷诺病的潜在有效成分。展开更多
文摘Through several years seedling-growing experiments in nursery in Daxing‘anMountains forest region,the author posed that the seedling cultivated for the region mustpossess the characteristics of being suited to thin and meager soil and having strongresistance to adverse conditions.For this purpose,the cultivation regime ought to bedirectization,standardization and programmatization;seedling growth ought to be promotedby regulating ecological conditions;and the mursery stock quality ought to be tested usingvigor index.
基金Supported by the Foundation for Outstanding Youth of Suihua University(SJ09005)
文摘Suihua City in Heilongjiang Province is located in the heart of the frigid region with black earth and it has created abundant green property resources. However,the environmental issue of this place has caused wide attention,so the government should make full use of various means to solve the environment problem and protect the ecology in this region. Among the measures taken by the government,the tax means is the most effective economic device to solve the environmental problem. Economic means supplemented by lawful and administrative measures should be adopted to solve the ecological environmental problems in the frigid region with black earth.
文摘目的:探究当归四逆加吴茱萸生姜汤调节雷诺病的系统药理学机制,筛选先导化合物。方法:基于中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology, TCMSP)和Cytoscape 3.6分析软件,构建当归四逆加吴茱萸生姜汤的“中药-成分-靶点”调控网络,对本方调节靶点进行通路富集分析,综合使用系统药理学和计算机辅助药物设计的方法,筛选本方的潜在活性成分。结果:本方初步筛选出696个化合物成分,获得401个特异性靶点,形成“化合物-靶点”5 446调控对。本方调节靶点基因本体(gene ontology, GO)富集通路包括氨基酸结合、G蛋白偶联受体活性等生物学过程及线粒体基质、线粒体等细胞组分相关,受预激抑制、谷胱甘肽代谢过程、抑制性突触后电位等分子功能影响;京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes, KEGG)富集包括HIF-1信号通路、cAMP信号通路、IL-17信号通路等。分子对接和药效团筛选得出化合物(-)-Medicocarpin具有较好的潜在治疗作用。结论:当归四逆加吴茱萸生姜汤可能通过调节HIF-1信号通路、cAMP信号通路、IL-17信号通路等改善雷诺病;甘草中的(-)-Medicocarpi、Yinyanghuo D与吴茱萸中的Goshuyuamide II等可以作为治疗雷诺病的潜在有效成分。
