Objective To design and synthesize derivatives of wanpeinine A,the main steroidal alkaloid isolated from the plant Fritillaria shuchengensis,and further study on the structure-activity relationship of the steroidal al...Objective To design and synthesize derivatives of wanpeinine A,the main steroidal alkaloid isolated from the plant Fritillaria shuchengensis,and further study on the structure-activity relationship of the steroidal alkaloid.Methods Acylation and alkylation were used to synthesize the derivatives and their structures were identified via NMR and MS.Results The acylation of wanpeinine A(1) produced 3β,6α-diacetylwanpeinine A(2),3β,6α-dipropionyl-wanpeinine A(3),3β,6α-dichloracetylwanpeinine A(4),3β,6α-dibenzoylwanpeinine A(5),and 3β-methoxy-acylwanpeinine A(6).The alkylation of wanpeinine A formed 3β,6α-dimethoxymethylwanpeinine A(7).Conclusion All compounds are new except for 3β,6α-diacetylwanpeinine A.展开更多
基金supported by The New Century Talents Scheme of the Ministry of Education (NECT-08-0820)National Innovation Experiment Program for University Students (81061320)
文摘Objective To design and synthesize derivatives of wanpeinine A,the main steroidal alkaloid isolated from the plant Fritillaria shuchengensis,and further study on the structure-activity relationship of the steroidal alkaloid.Methods Acylation and alkylation were used to synthesize the derivatives and their structures were identified via NMR and MS.Results The acylation of wanpeinine A(1) produced 3β,6α-diacetylwanpeinine A(2),3β,6α-dipropionyl-wanpeinine A(3),3β,6α-dichloracetylwanpeinine A(4),3β,6α-dibenzoylwanpeinine A(5),and 3β-methoxy-acylwanpeinine A(6).The alkylation of wanpeinine A formed 3β,6α-dimethoxymethylwanpeinine A(7).Conclusion All compounds are new except for 3β,6α-diacetylwanpeinine A.
