A new frog skin peptide, ranamargarin depicted as H-Asp-Asp-Ala-Ser-Asp-Arg-Ala-Lys-Lys-Phe-Tyr-Gly-Leu-Met-NH_(2′), was synthesized by the conventionalmethod. Comparisons of chemical and biological properties of bot...A new frog skin peptide, ranamargarin depicted as H-Asp-Asp-Ala-Ser-Asp-Arg-Ala-Lys-Lys-Phe-Tyr-Gly-Leu-Met-NH_(2′), was synthesized by the conventionalmethod. Comparisons of chemical and biological properties of both the synthetic and natural ranamargarins indicated that they were identical, so the chemical structure of ranamargarin was confirmed. Preliminary pharmacological study showed that ranamargarin was highly selective towards the SP-P subtype receptor.展开更多
The concentrations of seven heavy metals (Pb, Cu, Zn, Cr, Fe, Cd and Mn) were determined in the organs of Rana esculenta (frog) obtained from River Guma, Benue State of Nigeria using Atomic Absorption Spectrophotomete...The concentrations of seven heavy metals (Pb, Cu, Zn, Cr, Fe, Cd and Mn) were determined in the organs of Rana esculenta (frog) obtained from River Guma, Benue State of Nigeria using Atomic Absorption Spectrophotometer. The analysis of the triplicate experiments showed that the intestine contained the lowest concentration (25.9%) of all the heavy metals detected, followed by the skin (30.5%), while the liver contained the highest concentration (43.6%). In all the frog organs, Fe had the highest concentration in the liver, followed by skin and lowest in the intestine. The trend of the heavy metals concentration in the organs can be represented as: Fe > Mn > Pb > Zn > Cu > Cr > Cd. The concentrations of all the metals in the liver, skin and intestine of the frog were found to be statistically significant. Generally, the levels of Pb, Fe, Cr and Mn in all the samples were analyzed above the tolerance limits by the WHO with exception of Cd, Cu and Zn that were below the permissible limits in the samples.展开更多
基金Project supported by the National Natural Science Foundation of China.
文摘A new frog skin peptide, ranamargarin depicted as H-Asp-Asp-Ala-Ser-Asp-Arg-Ala-Lys-Lys-Phe-Tyr-Gly-Leu-Met-NH_(2′), was synthesized by the conventionalmethod. Comparisons of chemical and biological properties of both the synthetic and natural ranamargarins indicated that they were identical, so the chemical structure of ranamargarin was confirmed. Preliminary pharmacological study showed that ranamargarin was highly selective towards the SP-P subtype receptor.
文摘The concentrations of seven heavy metals (Pb, Cu, Zn, Cr, Fe, Cd and Mn) were determined in the organs of Rana esculenta (frog) obtained from River Guma, Benue State of Nigeria using Atomic Absorption Spectrophotometer. The analysis of the triplicate experiments showed that the intestine contained the lowest concentration (25.9%) of all the heavy metals detected, followed by the skin (30.5%), while the liver contained the highest concentration (43.6%). In all the frog organs, Fe had the highest concentration in the liver, followed by skin and lowest in the intestine. The trend of the heavy metals concentration in the organs can be represented as: Fe > Mn > Pb > Zn > Cu > Cr > Cd. The concentrations of all the metals in the liver, skin and intestine of the frog were found to be statistically significant. Generally, the levels of Pb, Fe, Cr and Mn in all the samples were analyzed above the tolerance limits by the WHO with exception of Cd, Cu and Zn that were below the permissible limits in the samples.
