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Fufang E’jiao Jiang’s effect on immunity,hematopoiesis,and angiogenesis via a systematic“compound-effect-target”analysis
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作者 Xiang Li Xiao Xu +14 位作者 Ying Dong Shusheng Fan Xueyang Ren Yuan Zheng Jiamu Ma Feng Zhang Qingyue Deng Xianxian Li Yingyu He Mengyu Sun Wei Liu Mengxia Li Qing Xia Yan Zhang Gaimei She 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第5期2813-2832,共20页
Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive im... Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s health.To find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were exhibited.Based on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of FEJ.Transcriptome data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by PCR.The bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and transcriptome.The studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets. 展开更多
关键词 fufang ejiao jiang Zebrafish(Danio rerio) Network pharmacology TRANSCRIPTOMe BIBLIOMeTRICS
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复方阿胶浆药渣替代粗饲料对驴血液参数、脏器指数及肉抗氧化能力的影响 被引量:10
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作者 曲洪磊 刘桂芹 +3 位作者 格日乐其木格 李文强 邢敬亚 董博颖 《饲料工业》 北大核心 2018年第7期24-28,共5页
试验旨在研究复方阿胶浆药渣替代10%粗饲料对育肥驴血液生化参数、脏器指数及抗氧化指标的影响,为其在驴饲料中的开发应用提供依据。试验选取1.5岁左右疆岳驴300头,随机分为2组(试验组和对照组),每组2个重复。对照组饲喂基础饲草,试验... 试验旨在研究复方阿胶浆药渣替代10%粗饲料对育肥驴血液生化参数、脏器指数及抗氧化指标的影响,为其在驴饲料中的开发应用提供依据。试验选取1.5岁左右疆岳驴300头,随机分为2组(试验组和对照组),每组2个重复。对照组饲喂基础饲草,试验组饲喂基础饲草+复方阿胶浆药渣,精料补充料保持一致。试验期90 d。试验结束后各组随机抽取体重相近2公3母屠宰,称取宰前空腹重;静脉采血取全血及血清测定血液指标;屠宰过程中摘取脏器称重,计算脏器指数;取背最长肌置冻存管液氮保存测定抗氧化指标。结果表明:(1)试验组血清甘油三酯(TG)、血清钙(Ca)、血细胞均无显著影响(P>0.05);总胆固醇、总蛋白有升高趋势(0.05<P<0.1);白蛋白(ALB)含量显著升高(P<0.05);总磷(TP)含量极显著下降(P<0.01)。(2)试验组血清谷丙转氨酶(ALT)、肌酸激酶(CK)、乳酸脱氢酶(LDH)均没有显著影响(P>0.05);谷草转氨酶具有明显的升高趋势(0.05<P<0.1);碱性磷酸酶(ALP)含量显著升高(P<0.05)。(3)试验组对驴心脏指数、肺脏指数、肾脏指数、胰脏指数及肠指数均没有显著影响(P>0.05);脾脏指数和肝脏指数均有增加趋势明显(0.05<P<0.1);胃指数显著低于对照组(P<0.05)。(4)肌肉及血液中抗氧化指标均无显著影响(P>0.05)。综上所述,复方阿胶浆药渣可以替代粗饲料饲喂驴;药渣可以通过提高代谢酶、脏器指数等改善机体代谢机能。 展开更多
关键词 复方阿胶浆药渣 血液 生化参数 脏器指数 抗氧化能力
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