Objective:To study the effect of fumigation and washing with Shujin Huoluo Decoction combined with Duhuo Parasitic Decoction on Metalloproteinase inhibitor-1(TIMP-1)and Oxyphosphatase 1,PON1)level.Methods:A total of 1...Objective:To study the effect of fumigation and washing with Shujin Huoluo Decoction combined with Duhuo Parasitic Decoction on Metalloproteinase inhibitor-1(TIMP-1)and Oxyphosphatase 1,PON1)level.Methods:A total of 100 KOA patients,59 males and 41 females,were selected for diagnosis and treatment in our hospital from November 2018 to November 2019.The patients were divided into the control group and the combined group with 50 patients each according to a completely random method.The control group was treated with Duhuo Parasitic Decoction and the combined group was treated with Duhuo Parasitic Decoction and Shujinhuoluo decoction.Detection of TIMP-1,PON1,Matrix metalloproteinase-3(MMP-3),C-reactive protease(CRP),Tumor necrosis factor-alpha(TNF-α)and Superoxide dismutase(SOD)levels.WOMAC score,Lysholm score,and VAS score were evaluated.Results:The levels of TIMP-1 and PON1 in the combined group were higher than those in the control group after treatment,and the levels of MMP-3 were lower than those in control group(P<0.05).The WOMAC score and VAS score of the combined group were lower than those of the control group,and the Lysholm score was higher than that of control group(P<0.05).The levels of CRP and TNF-αin the combined group were lower than those in the control group,and the SOD levels were higher than those in control group(P<0.05).The total effective rate of the combined group was higher than the total effective rate of control group(P<0.05).Conclusion:The combination of fumigation and washing with Shujin Huoluo Decoction and Duhuo Parasitic Decoction has a significant effect on the treatment of KOA patients.It improves the levels of TIMP-1 and PON1,improves the knee function of patients and pain.展开更多
目的:观察苦参汤加减熏洗对混合痔外剥内扎术后创面愈合、疼痛及肛门功能的影响。方法:将86例混合痔患者按照随机数字表法分为对照组和观察组,每组各43例。对照组术后第2天给予高锰酸钾坐浴,观察组术后第2天给予苦参汤加减熏洗。比较两...目的:观察苦参汤加减熏洗对混合痔外剥内扎术后创面愈合、疼痛及肛门功能的影响。方法:将86例混合痔患者按照随机数字表法分为对照组和观察组,每组各43例。对照组术后第2天给予高锰酸钾坐浴,观察组术后第2天给予苦参汤加减熏洗。比较两组患者的临床疗效、并发症发生情况、创面愈合时间、疼痛及治疗前后视觉模拟评分(visual analog score, VAS)、肛门功能变化情况。结果:对照组有效率为79.07%,观察组有效率为95.35%,两组有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后VAS评分低于本组治疗前,且治疗后观察组低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后肛管高压带长度短于本组治疗前,且治疗后观察组短于对照组,两组患者治疗后肛管舒张压、肛管最大收缩压及肛管静息压高于治疗前,且治疗后观察组高于对照组,差异均有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。观察组创面愈合时间短于对照组,差异有统计学意义(P<0.05)。结论:苦参汤加减熏洗可减轻混合痔外剥内扎术后疼痛程度,改善肛门功能,减少并发症的发生,促进创面愈合。展开更多
基金Health and Planning Commission of Guangxi Zhuang Autonomous Region(No.Z20170705)
文摘Objective:To study the effect of fumigation and washing with Shujin Huoluo Decoction combined with Duhuo Parasitic Decoction on Metalloproteinase inhibitor-1(TIMP-1)and Oxyphosphatase 1,PON1)level.Methods:A total of 100 KOA patients,59 males and 41 females,were selected for diagnosis and treatment in our hospital from November 2018 to November 2019.The patients were divided into the control group and the combined group with 50 patients each according to a completely random method.The control group was treated with Duhuo Parasitic Decoction and the combined group was treated with Duhuo Parasitic Decoction and Shujinhuoluo decoction.Detection of TIMP-1,PON1,Matrix metalloproteinase-3(MMP-3),C-reactive protease(CRP),Tumor necrosis factor-alpha(TNF-α)and Superoxide dismutase(SOD)levels.WOMAC score,Lysholm score,and VAS score were evaluated.Results:The levels of TIMP-1 and PON1 in the combined group were higher than those in the control group after treatment,and the levels of MMP-3 were lower than those in control group(P<0.05).The WOMAC score and VAS score of the combined group were lower than those of the control group,and the Lysholm score was higher than that of control group(P<0.05).The levels of CRP and TNF-αin the combined group were lower than those in the control group,and the SOD levels were higher than those in control group(P<0.05).The total effective rate of the combined group was higher than the total effective rate of control group(P<0.05).Conclusion:The combination of fumigation and washing with Shujin Huoluo Decoction and Duhuo Parasitic Decoction has a significant effect on the treatment of KOA patients.It improves the levels of TIMP-1 and PON1,improves the knee function of patients and pain.
文摘目的:观察苦参汤加减熏洗对混合痔外剥内扎术后创面愈合、疼痛及肛门功能的影响。方法:将86例混合痔患者按照随机数字表法分为对照组和观察组,每组各43例。对照组术后第2天给予高锰酸钾坐浴,观察组术后第2天给予苦参汤加减熏洗。比较两组患者的临床疗效、并发症发生情况、创面愈合时间、疼痛及治疗前后视觉模拟评分(visual analog score, VAS)、肛门功能变化情况。结果:对照组有效率为79.07%,观察组有效率为95.35%,两组有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后VAS评分低于本组治疗前,且治疗后观察组低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后肛管高压带长度短于本组治疗前,且治疗后观察组短于对照组,两组患者治疗后肛管舒张压、肛管最大收缩压及肛管静息压高于治疗前,且治疗后观察组高于对照组,差异均有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。观察组创面愈合时间短于对照组,差异有统计学意义(P<0.05)。结论:苦参汤加减熏洗可减轻混合痔外剥内扎术后疼痛程度,改善肛门功能,减少并发症的发生,促进创面愈合。