Herein, we present a case of gastric adenocarcinoma of fundic gland type(GA-FG) spreading to heterotopic gastric glands(HGG) in the submucosa. A 58-year-old man with epigastric pain was referred to our hospital and un...Herein, we present a case of gastric adenocarcinoma of fundic gland type(GA-FG) spreading to heterotopic gastric glands(HGG) in the submucosa. A 58-year-old man with epigastric pain was referred to our hospital and underwent an esophagogastroduodenoscopy. A Borrmann type II gastric cancer at the antrum and a 10 mm submucosal tumor-like lesion in the lesser curvature of the upper third of the stomach were detected. Histological examination of the biopsy specimens obtained from the submucosal tumorlike lesion suggested a GA-FG. Therefore, endoscopic submucosal dissection was performed as excisional biopsy, and histopathological examination of the resected specimen confirmed a GA-FG and HGG proximal to the GA-FG. Although the GA-FG invaded the submucosal layer slightly, the submucosal lesion of the GA-FG had a poor stromal reaction and was located just above the HGG in the submucosa. Therefore, wefinally diagnosed the lesion as a GA-FG invading the submucosal layer by spreading to HGG.展开更多
A depressed lesion was found at a gastric angle of 76-yearold Japanese woman by esophagogastroduodenoscopy. Four years prior, she was diagnosed with a Helicobacter pylori infection but no eradication was performed. Th...A depressed lesion was found at a gastric angle of 76-yearold Japanese woman by esophagogastroduodenoscopy. Four years prior, she was diagnosed with a Helicobacter pylori infection but no eradication was performed. The pathological diagnosis of biopsy specimens was signet-ring cell carcinoma. Endoscopic submucosal dissection(ESD) was performed. Histopathological examination of the ESD specimen revealed proliferation of well-differentiated tubular adenocarcinoma mimicking fundic gland cells at the deep layer of the lamina propria mucosae. These tumor cells expressed focally pepsinogen-Ⅰ, diffusely MUC6, and scattered H^+/K^+ ATPase according to immunohistochemistry. Therefore, we diagnosed this tumor as gastric adenocarcinoma of fundic gland type(GA-FG). Adjacent to the GA-FG, proliferation of signet-ring cell carcinoma which diffusely expressed MUC 2 and MUC 5AC was observed. Intestinal metaplasia was focally observed in the surrounding mucosa of the signet-ring cell carcinoma. To the best of our knowledge, this is the first case report of GA-FG with a signet-ring cell carcinoma component. The origin of signet-ring cell carcinoma, i.e., whether it accidentally arose from a non-neoplastic mucosa and coexisted with the GA-FG or dedifferentiated from the GA-FG is unclear at present. We expect the accumulation of similar cases and further analysis to clarify this issue.展开更多
Gastric adenocarcinoma of fundic gland type(GA-FG) with chief cell differentiation was recently proposed as an extremely rare type of gastric adenocarcinoma. Here, we report 4 cases of GA-FG with chief cell differenti...Gastric adenocarcinoma of fundic gland type(GA-FG) with chief cell differentiation was recently proposed as an extremely rare type of gastric adenocarcinoma. Here, we report 4 cases of GA-FG with chief cell differentiation. Endoscopic features included a submucosal tumor shape or a flat shape, whitish discoloration and dilated vessels on the surface. The tumors were located in the upper or middle third of the stomach. All cases were preoperatively diagnosed as GA-FG by biopsy, and endoscopic submucosal dissection was performed. Resected specimens revealed well-differentiated adenocarcinomas resembling chief cells. Tumor cells were diffusely positive for pepsinogen-Ⅰ, but partially positive for H+/K+-ATPase in scattered locations around the tumor margin. Despite the presence of minimal invasion of the carcinoma into the submucosal layer, which was observed in two cases, neither lymphatic nor venous invasion was detected in any of the cases. Finally, all cases showed less aggressive clinical behavior with low grade malignancy.展开更多
Recently,a new disease entity termed gastric adenocarcinoma of fundic gland type(GA-FG) was proposed.We treated five cases of GA-FG with endoscopic submucosal dissection.All tumors were small and located in the upper ...Recently,a new disease entity termed gastric adenocarcinoma of fundic gland type(GA-FG) was proposed.We treated five cases of GA-FG with endoscopic submucosal dissection.All tumors were small and located in the upper third of the stomach.Four tumors were macroscopically identified as 0-IIa and one was identified as 0-Ⅱb.Narrow-band imaging with magnifying endoscopy showed an irregular microvascular pattern in 2 cases and a regular microvascular pattern in the remainder.All tumors arose from the deep layer of the lamina propria mucosae and showed submucosal invasion.Lymphatic invasion was seen only in one case,while no venous invasion was recognized.All tumors were positive for pepsinogen-Ⅰ and MUC6 by immunohistochemistry.None showed p53 overexpression,and the labeling index of Ki-67 was low in all cases.All cases have been free from recurrence or metastasis.Herein,we discussed the clinicopathological features of GA-FG in comparison with past reports.展开更多
背景胃底腺型胃癌(gastric adenocarcinoma of the fundic gland type,GA-FG)是近年来新发现的一种胃癌类型,不同于传统的肠癌和弥漫性胃癌,是一种分化良好的肿瘤.预计GA-FG在所有胃癌中的比例将越来越高,但目前内镜医师及临床病理学家...背景胃底腺型胃癌(gastric adenocarcinoma of the fundic gland type,GA-FG)是近年来新发现的一种胃癌类型,不同于传统的肠癌和弥漫性胃癌,是一种分化良好的肿瘤.预计GA-FG在所有胃癌中的比例将越来越高,但目前内镜医师及临床病理学家对该病认识不足容易导致误诊.目的本文通过对该病的内镜、临床及病理特点进行系统回顾,旨在增加该疾病的诊断率并减少漏诊及误诊.方法在Pubmed及中国知网收集2007-01/2022-03期间公开发表的中英文文献中报道的胃底腺型胃癌患者临床、病理及内镜资料,并进行回顾分析.结果共收集67篇文献中320例胃底腺型胃癌患者共322处病变相关资料.病变多位于胃上1/3(81.6%),病变平均大小9.66 mm(1 mm-85 mm),约76.88%病变大体形态为隆起型.窄带成像观察病变表面可见微血管扩张及微腺体结构紊乱或增粗.所有病变中主细胞分化型约占74.84%,显著表达MUC6及胃蛋白酶原,预后良好.结论胃底腺型胃癌发病率低,内镜下完整切除及外科手术可到达治愈性切除的目的,预后较好,但易误诊,诊断时应结合其临床病理学特点,从而减少误诊及漏诊率.展开更多
目的探讨胃底腺癌(gastric adenocarcinoma of the fundic gland type,GA-FG)的临床特点、内镜特征、病理学特点。方法回顾性分析我院2016年3月~2019年3月11例胃底腺癌的临床内镜病理资料。临床特点包括性别、年龄、症状等;内镜特征包...目的探讨胃底腺癌(gastric adenocarcinoma of the fundic gland type,GA-FG)的临床特点、内镜特征、病理学特点。方法回顾性分析我院2016年3月~2019年3月11例胃底腺癌的临床内镜病理资料。临床特点包括性别、年龄、症状等;内镜特征包括部位、内镜下长径、色泽和形态等;病理资料包括长径、浸润深度、幽门螺杆菌(Helicobacter pylori,HP)感染等。结果以60岁以上的老年人(8/11)居多,无特异临床表现。病灶多为位于胃上部(8/11)的隆起型病灶(10/11),长径均≤1 cm。4处病灶浸润黏膜下层。多数(9/11)Ki67≤10%,大部分(10/11)HP阴性。结论胃底腺癌是一种罕见的肿瘤,临床症状不典型,内镜见胃上部隆起型小病灶时需考虑该病可能,确诊需要依靠病理检查。展开更多
文摘Herein, we present a case of gastric adenocarcinoma of fundic gland type(GA-FG) spreading to heterotopic gastric glands(HGG) in the submucosa. A 58-year-old man with epigastric pain was referred to our hospital and underwent an esophagogastroduodenoscopy. A Borrmann type II gastric cancer at the antrum and a 10 mm submucosal tumor-like lesion in the lesser curvature of the upper third of the stomach were detected. Histological examination of the biopsy specimens obtained from the submucosal tumorlike lesion suggested a GA-FG. Therefore, endoscopic submucosal dissection was performed as excisional biopsy, and histopathological examination of the resected specimen confirmed a GA-FG and HGG proximal to the GA-FG. Although the GA-FG invaded the submucosal layer slightly, the submucosal lesion of the GA-FG had a poor stromal reaction and was located just above the HGG in the submucosa. Therefore, wefinally diagnosed the lesion as a GA-FG invading the submucosal layer by spreading to HGG.
文摘A depressed lesion was found at a gastric angle of 76-yearold Japanese woman by esophagogastroduodenoscopy. Four years prior, she was diagnosed with a Helicobacter pylori infection but no eradication was performed. The pathological diagnosis of biopsy specimens was signet-ring cell carcinoma. Endoscopic submucosal dissection(ESD) was performed. Histopathological examination of the ESD specimen revealed proliferation of well-differentiated tubular adenocarcinoma mimicking fundic gland cells at the deep layer of the lamina propria mucosae. These tumor cells expressed focally pepsinogen-Ⅰ, diffusely MUC6, and scattered H^+/K^+ ATPase according to immunohistochemistry. Therefore, we diagnosed this tumor as gastric adenocarcinoma of fundic gland type(GA-FG). Adjacent to the GA-FG, proliferation of signet-ring cell carcinoma which diffusely expressed MUC 2 and MUC 5AC was observed. Intestinal metaplasia was focally observed in the surrounding mucosa of the signet-ring cell carcinoma. To the best of our knowledge, this is the first case report of GA-FG with a signet-ring cell carcinoma component. The origin of signet-ring cell carcinoma, i.e., whether it accidentally arose from a non-neoplastic mucosa and coexisted with the GA-FG or dedifferentiated from the GA-FG is unclear at present. We expect the accumulation of similar cases and further analysis to clarify this issue.
文摘Gastric adenocarcinoma of fundic gland type(GA-FG) with chief cell differentiation was recently proposed as an extremely rare type of gastric adenocarcinoma. Here, we report 4 cases of GA-FG with chief cell differentiation. Endoscopic features included a submucosal tumor shape or a flat shape, whitish discoloration and dilated vessels on the surface. The tumors were located in the upper or middle third of the stomach. All cases were preoperatively diagnosed as GA-FG by biopsy, and endoscopic submucosal dissection was performed. Resected specimens revealed well-differentiated adenocarcinomas resembling chief cells. Tumor cells were diffusely positive for pepsinogen-Ⅰ, but partially positive for H+/K+-ATPase in scattered locations around the tumor margin. Despite the presence of minimal invasion of the carcinoma into the submucosal layer, which was observed in two cases, neither lymphatic nor venous invasion was detected in any of the cases. Finally, all cases showed less aggressive clinical behavior with low grade malignancy.
文摘Recently,a new disease entity termed gastric adenocarcinoma of fundic gland type(GA-FG) was proposed.We treated five cases of GA-FG with endoscopic submucosal dissection.All tumors were small and located in the upper third of the stomach.Four tumors were macroscopically identified as 0-IIa and one was identified as 0-Ⅱb.Narrow-band imaging with magnifying endoscopy showed an irregular microvascular pattern in 2 cases and a regular microvascular pattern in the remainder.All tumors arose from the deep layer of the lamina propria mucosae and showed submucosal invasion.Lymphatic invasion was seen only in one case,while no venous invasion was recognized.All tumors were positive for pepsinogen-Ⅰ and MUC6 by immunohistochemistry.None showed p53 overexpression,and the labeling index of Ki-67 was low in all cases.All cases have been free from recurrence or metastasis.Herein,we discussed the clinicopathological features of GA-FG in comparison with past reports.
文摘背景胃底腺型胃癌(gastric adenocarcinoma of the fundic gland type,GA-FG)是近年来新发现的一种胃癌类型,不同于传统的肠癌和弥漫性胃癌,是一种分化良好的肿瘤.预计GA-FG在所有胃癌中的比例将越来越高,但目前内镜医师及临床病理学家对该病认识不足容易导致误诊.目的本文通过对该病的内镜、临床及病理特点进行系统回顾,旨在增加该疾病的诊断率并减少漏诊及误诊.方法在Pubmed及中国知网收集2007-01/2022-03期间公开发表的中英文文献中报道的胃底腺型胃癌患者临床、病理及内镜资料,并进行回顾分析.结果共收集67篇文献中320例胃底腺型胃癌患者共322处病变相关资料.病变多位于胃上1/3(81.6%),病变平均大小9.66 mm(1 mm-85 mm),约76.88%病变大体形态为隆起型.窄带成像观察病变表面可见微血管扩张及微腺体结构紊乱或增粗.所有病变中主细胞分化型约占74.84%,显著表达MUC6及胃蛋白酶原,预后良好.结论胃底腺型胃癌发病率低,内镜下完整切除及外科手术可到达治愈性切除的目的,预后较好,但易误诊,诊断时应结合其临床病理学特点,从而减少误诊及漏诊率.
文摘目的探讨胃底腺癌(gastric adenocarcinoma of the fundic gland type,GA-FG)的临床特点、内镜特征、病理学特点。方法回顾性分析我院2016年3月~2019年3月11例胃底腺癌的临床内镜病理资料。临床特点包括性别、年龄、症状等;内镜特征包括部位、内镜下长径、色泽和形态等;病理资料包括长径、浸润深度、幽门螺杆菌(Helicobacter pylori,HP)感染等。结果以60岁以上的老年人(8/11)居多,无特异临床表现。病灶多为位于胃上部(8/11)的隆起型病灶(10/11),长径均≤1 cm。4处病灶浸润黏膜下层。多数(9/11)Ki67≤10%,大部分(10/11)HP阴性。结论胃底腺癌是一种罕见的肿瘤,临床症状不典型,内镜见胃上部隆起型小病灶时需考虑该病可能,确诊需要依靠病理检查。
