BACKGROUND Cervical degenerative disc(CDD)disease is a common type of spondylosis.Although anterior cervical discectomy and fusion(ACDF)is the preferred treatment for CDD disease,internal fixation with a titanium plat...BACKGROUND Cervical degenerative disc(CDD)disease is a common type of spondylosis.Although anterior cervical discectomy and fusion(ACDF)is the preferred treatment for CDD disease,internal fixation with a titanium plate may cause various complications.The invention of the ACDF with a self-locking fusion cage(ROI-C)has effectively decreased the incidence of postoperative complications.AIM To observe the outcomes of CDD disease treated by ACDF with a ROI-C.METHODS Ninety patients with CDD disease treated at our hospital from March 2019 to March 2021 were included.They were divided into two groups(control group and observation group,n=45 in each)using a random number table.Patients in the control group received ACDF plus internal fixation with a titanium plate.Those in the observation group received ACDF+ROI-C placement.The two groups of patients were compared in terms of surgical parameters,pain,cervical spine function,range of motion,and complications.RESULTS The two groups of patients showed no significant differences in surgical time,blood loss,drainage volume,and length of hospital stay(P>0.05).No significant differences in the visual analogue scale(VAS),Japanese Orthopedic Association(JOA),and neck disability index(NDI)scores were observed between the two groups before surgery(P>0.05).The VAS and NDI scores in the observation group were considerably lower than those in the control group after surgery;however,the JOA scores in the observation group were significantly higher than those in the control group(P<0.05).No significant differences were observed in cervical disc height and the range of motion of the superior or inferior adjacent vertebrae between the two groups before surgery(P>0.05).The disc height in the observation group was larger than that in the control group after surgery.The range of motion of both the superior and inferior adjacent vertebrae was significantly smaller in the observation group than in the control group(P<0.05).The incidence of complications was only 2.22% in the observation group compared to 15.56% in the control group,and the difference was statistically significant(P<0.05).CONCLUSION Cervical spine function restoration was better with ROI-C with internal fixation in ACDF than with conventional titanium plates in ACDF for CDD disease.展开更多
Backgrou nd Dense titanium(Ti)fusion cages have been commonly used in transforaminal lumbar interbody fusion.However,the stiffness mismatch between cages and adjacent bone endplates increases the risk of stress shield...Backgrou nd Dense titanium(Ti)fusion cages have been commonly used in transforaminal lumbar interbody fusion.However,the stiffness mismatch between cages and adjacent bone endplates increases the risk of stress shielding and cage subsidence.Methods The current study presents a multiscale optimization approach for porous Ti fusion cage development,including microscale topology optimization based on homogenization theory that obtains a unit cell with prescribed mechanical properties,and macroscale topology optimization that determines the layout of framework structure over the porous cage while maintaining the desired stiffness.The biomechanical performance of the designed porous cage is assessed using numerical simulations of fusion surgery.Selective laser melting is employed to assists with fabricating the designed porous structure and porous cage.Results The simulations demonstrate that the designed porous cage increases the strain energy density of bone grafts and decreases the peak stress on bone endplates.The mechanical and morphological discrepancies between the as-designed and fabricated porous structures are also described.Conclusion From the perspective of biomechanics,it is demonstrated that the designed porous cage contributes to reducing the risk of stress shielding and cage subsidence.The optimization of processing parameters and post-treatments are required to fabricate the designed porous cage.The present multiscale optimization approach can be extended to the development of cages with other shapes or materials and further types of orthopedic implants.展开更多
This work focuses on the influence of elastic modulus on biomechanical properties of lumbar interbody fusion cages by selecting two titanium alloys with different elastic modulus. They were made by a new β type alloy...This work focuses on the influence of elastic modulus on biomechanical properties of lumbar interbody fusion cages by selecting two titanium alloys with different elastic modulus. They were made by a new β type alloy with chemical composition of Ti-24Nb-4Zr-7.6Sn having low Young＇s modulus -50 GPa and by a conventional biomedical alloy Ti-6Al-4V having Young＇s modulus -110 GPa. The results showed that the designed cages with low modulus （LMC） and high modulus （HMC） can keep identical compression load -9.8 kN and endure fatigue cycles higher than 5× 10^6 without functional or mechanical failure under 2.0 kN axial compression. The anti-subsidence ability of both group cages were examined by axial compression of thoracic spine specimens （T9-T10） dissected freshly from the calf with averaged age of 6 months. The results showed that the LMC has better anti-subsidence ability than the HMC （p〈0.05）. The above results suggest that the cage with low elastic modulus has great potential for clinical applications.展开更多
目的:探讨后路寰枢椎侧块关节cage植骨融合内固定术治疗难复性寰枢椎脱位的临床疗效,并与经口咽松解后路复位固定融合术进行疗效对比。方法:回顾性分析2018年1月~2022年8月我科采用后路寰枢椎侧块关节cage植骨融合内固定术(23例,cage组...目的:探讨后路寰枢椎侧块关节cage植骨融合内固定术治疗难复性寰枢椎脱位的临床疗效,并与经口咽松解后路复位固定融合术进行疗效对比。方法:回顾性分析2018年1月~2022年8月我科采用后路寰枢椎侧块关节cage植骨融合内固定术(23例,cage组)与经口咽松解后路复位固定融合术(25例,对照组)治疗的难复性寰枢椎脱位患者的临床资料,cage组男8例,女15例,年龄9~79岁(48.35±14.38岁);对照组男6例,女19例,年龄21~69岁(47.84±13.51岁)。记录两组患者手术时间、术中出血量、住院时间及并发症情况,术前、术后及末次随访时使用JOA评分评估患者神经功能状态,测量术前、术后及末次随访时的寰齿间距(atlantodental interval,ADI)、齿状突顶点距离Chamberlain线的垂直距离(vertical distance from odon to idprocess to Chamberlain′s line,DOCL)、延髓颈髓角(cervicomedullary angle,CMA)、斜坡枢椎角(clivus-axial angle,CAA),评估寰枢椎复位情况。评估侧块关节cage及后方植骨融合情况。结果:所有患者内固定位置良好,减压充分复位满意,症状均明显缓解,未出现椎动脉损伤和脊髓损伤加重。cage组手术时间133.04±34.04min、术中出血量119.13±54.77mL、住院时间14.74±6.10d,均明显短于或少于对照组(253.20±53.98min、181.20±45.40mL、23.96±5.47d)。cage组术前JOA、ADI、DOCL、CMA、CAA分别为6.33±1.13分、7.31±3.05mm、9.47±3.32mm、122.89°±12.58°、122.02°±12.50°,术后分别为13.04±2.17分、2.18±0.67mm、0.89±1.00mm、148.81°±5.43°、146.70°±9.32°,末次随访时分别为14.89±1.17分、2.09±0.69mm、0.83±0.86mm、149.10°±5.11°、146.89°±8.95°;对照组术前JOA、ADI、DOCL、CMA、CAA分别为6.76±1.21分、7.70±0.97mm、10.56±1.99mm、121.53°±4.87°、123.77°±8.95°,术后分别为13.26±1.32分、1.89±0.50mm、1.13±1.08mm、151.40°±6.15°、149.86°±5.58°,末次随访时分别为15.02±0.88分、1.87±0.44mm、0.87±1.39mm、149.48°±4.06°、149.94°±6.61°,两组术后及末次随访JOA、ADI、DOCL、CMA及CAA均较术前明显改善(P<0.05),术后JOA评分与末次随访相比存在统计学差异(P<0.05),但ADI、DOCL、CMA及CAA无统计学差异(P>0.05)。cage组仅1例切口感染;对照组3例切口感染(口咽2例,后路1例),1例脑脊液漏。两组随访期间内固定在位稳定,末次随访植骨均达到骨性融合,cage组关节间隙高度无丢失。结论:难复性寰枢椎脱位采用后路寰枢椎侧块关节cage植骨融合内固定术与经口咽松解后路复位固定融合术相比疗效相当,但增加了植骨融合位点,能更有效融合,避免了经口手术,减少了手术时间、术中出血量、住院时间及并发症的发生。展开更多
目的探讨终板体积骨密度(endplate volumetric bone mineral density,EP-vBMD)对侧方入路腰椎融合(lateral lumbar interbody fusion,LLIF)术后Cage沉降的影响。方法选择2018年1月~2020年12月在本院接受LLIF手术治疗的151例患者进行回...目的探讨终板体积骨密度(endplate volumetric bone mineral density,EP-vBMD)对侧方入路腰椎融合(lateral lumbar interbody fusion,LLIF)术后Cage沉降的影响。方法选择2018年1月~2020年12月在本院接受LLIF手术治疗的151例患者进行回顾性分析,收集患者EP-vBMD、椎体体积骨密度(vertebral body volumetric bone mineral density,VB-vBMD)、年龄、性别、体质量指数(body mass index,BMI)、医学共病(糖尿病等)、吸烟、美国麻醉医师协会(american society of anesthesiologists,ASA)评分、查尔森共病指数(charlson comorbidity index,CCI)、手术节段、手术椎体和是否使用后路螺钉固定等资料。根据术后1年患者是否发生Cage沉降,将患者分为Cage沉降组和非沉降组,比较两组患者临床资料差异,将单因素分析P<0.2的变量进一步采用多因素Logsitic回归分析,观察EP-vBMD对终板沉陷的影响。结果Cage沉降患者的VB-vBMD和EP-vBMD水平均低于非Cage沉降患者,差异均有统计学意义(P<0.05)。Cage沉降组患者年龄高于非Cage沉降组患者,差异有统计学意义(P<0.05);Cage沉降组和非Cage沉降组患者性别、吸烟、糖尿病、后路螺钉固定等资料差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,EP-vBMD和应用后路螺钉固定均是Cage沉降的保护性因素(P<0.05)。结论低EP-vBMD是LLIF术后Cage沉降的风险因素,对患者进行LLIF时,应考虑术前EP-vBMD的测量。展开更多
Anterior Cervical Discectomy and Fusion(ACDF)is the preferred surgical method for the treatment of severe cervical degenerative disc disease with radiculopathy or myelopathy,of which the objectives are to restore the ...Anterior Cervical Discectomy and Fusion(ACDF)is the preferred surgical method for the treatment of severe cervical degenerative disc disease with radiculopathy or myelopathy,of which the objectives are to restore the normal height of intervertebral space and cervical lordosis through the implantation of cervical interbody fusion cage.The biomechanical performance of a cervical interbody fusion cage,which plays a significant role in achieving the goals of ACDF,is influenced by multiple factors.In this paper,various studies focusing on the biomechanical performance of cervical interbody fusion cage are reviewed.Furthermore,the research methods,biomechanical evaluation parameters and data analysis methods of these research are analyzed in order to obtain a comprehensive understanding of the progress and limitations of research in this field.Although great progress has been made to clarify the biomechanical behaviors of cervical interbody fusion cage,there is still controversy regarding the issues such as the relative contribution of multiple factors to the performance of cage,the interactions among these factors,as well as whether the effects of factors change with the process of intervertebral osseointegration and so on.Thus,investigations are still needed to improve the comprehension of cervical interbody fusion cage biomechanically.展开更多
Background: cervical spondylotic myelopathy is a common health problem that neurosurgeons face in Egypt. The aim of this study is to evaluate the efficacy of PEEK cage only in 4 levels anterior cervical discectomy as ...Background: cervical spondylotic myelopathy is a common health problem that neurosurgeons face in Egypt. The aim of this study is to evaluate the efficacy of PEEK cage only in 4 levels anterior cervical discectomy as one of surgical option other than anterior cervical corpectomy, fixation by plat or posterior approach for cervical laminectomy, and assessment of post spinal surgery pain. Methods: this prospective study on 28 patients with cervical spondylotic myelopathy (CSM) over a period of 3 years (between April 2012 and April 2015) with mean period of follow up 30 months. We have done anterior cervical discectomy with fixation by cage only for all cases with perioperative assessment and scoring clinically and radiologically (Japanese Orthopaedic Association [JOA] scores, Visual Analogue Scale [VAS] scores for assessment of neck and arm pain, perioperative parameters (hospital stay, blood loss, operative time), the European Myelopathy Scoring (EMS) and Odom’s criteria, and the incidence of complication,post spinal surgery pain assessment). Results: clinical outcome was excellent (28.55), good (50%) and fair (21.5) according to Odom criteria. The European Myelopathy Scoring (EMS), improved from 10 to 16. The mean JOA score improved from 10.1 ± 2.1 to 14.2 ± 2.3. Fusion failure had been seen in 4 patients in one level for each secondary to anterior displacement of the cage with no other major complications. Conclusion: 4 levels anterior cervical discectomy with PEEK cage only is an effective, save and less costly with less post operative complication and hospital stay and less post spinal surgery pain.展开更多
In this study a lumbar spinal fusion animal model is established to assess the effect of spinal fusion cage,and explore theminimum area ratio of titanium cage section to vertebral section that ensures bone healing and...In this study a lumbar spinal fusion animal model is established to assess the effect of spinal fusion cage,and explore theminimum area ratio of titanium cage section to vertebral section that ensures bone healing and biomechanical property.Lumbarcorpectomy was conducted by posterolateral approach with titanium cage implantation combined with plate fixation.Titaniumcages with the same length but different diameters were used.After implantation of titanium cages,the progress of bone healingwas observed and the bone biomechanical properties were measured,including deformation and displacement in axial compression,flexion,extension,and lateral bending motion.The factors affecting the in vivo growth of spine supporting body wereanalyzed.The results show that the area ratio of titanium cage section to vertebral section should reach 1/2 to ensure the bonehealing,sufficient bone intensity and biomechanical properties.Some bone healing indicators,such as BMP,suggest that there isa relationship between the peak time and the peak value of bone formation and metabolism markers and the bone healing strength.展开更多
目的:通过系统评价的方法分析影响腰椎椎体间融合术后cage后移(cage retropulsion,CR)发生的危险因素。方法:检索PubMed、Embase、Cochrane Library、Web of Science、中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方数据库和维普...目的:通过系统评价的方法分析影响腰椎椎体间融合术后cage后移(cage retropulsion,CR)发生的危险因素。方法:检索PubMed、Embase、Cochrane Library、Web of Science、中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方数据库和维普数据库,收集各数据库建库至2023年4月有关影响腰椎椎体间融合术后CR危险因素的文献,研究类型为队列研究及病例对照研究,采用纽卡斯尔-渥太华质量评估量表(Newcastle-Ottawa scale,NOS)对纳入研究进行质量评价,提取纳入研究的基本信息,包括年龄及性别等以及CR发生相关研究因素,如骨质疏松、终板损伤、螺钉松动、梨形椎间隙、cage形状、cage置入深度及手术时长、出血量等。评价纳入研究的偏倚风险后,使用Stata14.0软件进行Meta分析。结果:共纳入16篇相关文献,其中15篇文献为回顾性病例对照研究,1篇为前瞻性队列研究,均为中等及以上质量研究,NOS评分均≥7分。总样本量12667例,其中发生CR者(CR组)326例,未发生CR者(nCR组)12341例,CR发生率为2.83%。Meta分析结果显示:性别(男性)[比值比(odds ratio,OR)=1.264,95%置信区间(confidence interval,CI)(1.003~1.593),P=0.047]、年龄[效应量标准化平均差(standardized mean difference,SMD)=0.237,95%CI(0.054~0.419),P=0.011]、骨质疏松[OR=3.126,95%CI(1.040~9.401),P=0.042]、骨终板损伤[OR=8.161,95%CI(3.711~17.945),P=0.000]、螺钉松动[OR=7.978,95%CI(3.487~18.255),P=0.000]、梨形椎间隙[OR=6.037,95%CI(2.381~15.305),P=0.000]、cage置入深度不足[OR=5.157,95%CI(1.760~15.111),P=0.003]是腰椎椎体间融合术后发生CR的危险因素。结论:性别(男性)、高龄、骨质疏松、骨终板损伤、螺钉松动、梨形椎间隙、cage置入深度不足与腰椎椎体间融合术后发生CR密切相关,随访期间应对此类患者密切观察,预防发生严重cage移位的并发症。展开更多
文摘BACKGROUND Cervical degenerative disc(CDD)disease is a common type of spondylosis.Although anterior cervical discectomy and fusion(ACDF)is the preferred treatment for CDD disease,internal fixation with a titanium plate may cause various complications.The invention of the ACDF with a self-locking fusion cage(ROI-C)has effectively decreased the incidence of postoperative complications.AIM To observe the outcomes of CDD disease treated by ACDF with a ROI-C.METHODS Ninety patients with CDD disease treated at our hospital from March 2019 to March 2021 were included.They were divided into two groups(control group and observation group,n=45 in each)using a random number table.Patients in the control group received ACDF plus internal fixation with a titanium plate.Those in the observation group received ACDF+ROI-C placement.The two groups of patients were compared in terms of surgical parameters,pain,cervical spine function,range of motion,and complications.RESULTS The two groups of patients showed no significant differences in surgical time,blood loss,drainage volume,and length of hospital stay(P>0.05).No significant differences in the visual analogue scale(VAS),Japanese Orthopedic Association(JOA),and neck disability index(NDI)scores were observed between the two groups before surgery(P>0.05).The VAS and NDI scores in the observation group were considerably lower than those in the control group after surgery;however,the JOA scores in the observation group were significantly higher than those in the control group(P<0.05).No significant differences were observed in cervical disc height and the range of motion of the superior or inferior adjacent vertebrae between the two groups before surgery(P>0.05).The disc height in the observation group was larger than that in the control group after surgery.The range of motion of both the superior and inferior adjacent vertebrae was significantly smaller in the observation group than in the control group(P<0.05).The incidence of complications was only 2.22% in the observation group compared to 15.56% in the control group,and the difference was statistically significant(P<0.05).CONCLUSION Cervical spine function restoration was better with ROI-C with internal fixation in ACDF than with conventional titanium plates in ACDF for CDD disease.
基金financially supported by the National Natural Science Foundation of China(No.51975336)the Key Basic Research Project of Natural Science Foundation of Shandong Province,China(No.ZR2018ZB0106)the Key Research and Development Program of Shandong Province,China(No.2019JZZY010112)。
文摘Backgrou nd Dense titanium(Ti)fusion cages have been commonly used in transforaminal lumbar interbody fusion.However,the stiffness mismatch between cages and adjacent bone endplates increases the risk of stress shielding and cage subsidence.Methods The current study presents a multiscale optimization approach for porous Ti fusion cage development,including microscale topology optimization based on homogenization theory that obtains a unit cell with prescribed mechanical properties,and macroscale topology optimization that determines the layout of framework structure over the porous cage while maintaining the desired stiffness.The biomechanical performance of the designed porous cage is assessed using numerical simulations of fusion surgery.Selective laser melting is employed to assists with fabricating the designed porous structure and porous cage.Results The simulations demonstrate that the designed porous cage increases the strain energy density of bone grafts and decreases the peak stress on bone endplates.The mechanical and morphological discrepancies between the as-designed and fabricated porous structures are also described.Conclusion From the perspective of biomechanics,it is demonstrated that the designed porous cage contributes to reducing the risk of stress shielding and cage subsidence.The optimization of processing parameters and post-treatments are required to fabricate the designed porous cage.The present multiscale optimization approach can be extended to the development of cages with other shapes or materials and further types of orthopedic implants.
文摘This work focuses on the influence of elastic modulus on biomechanical properties of lumbar interbody fusion cages by selecting two titanium alloys with different elastic modulus. They were made by a new β type alloy with chemical composition of Ti-24Nb-4Zr-7.6Sn having low Young＇s modulus -50 GPa and by a conventional biomedical alloy Ti-6Al-4V having Young＇s modulus -110 GPa. The results showed that the designed cages with low modulus （LMC） and high modulus （HMC） can keep identical compression load -9.8 kN and endure fatigue cycles higher than 5× 10^6 without functional or mechanical failure under 2.0 kN axial compression. The anti-subsidence ability of both group cages were examined by axial compression of thoracic spine specimens （T9-T10） dissected freshly from the calf with averaged age of 6 months. The results showed that the LMC has better anti-subsidence ability than the HMC （p〈0.05）. The above results suggest that the cage with low elastic modulus has great potential for clinical applications.
文摘目的:探讨后路寰枢椎侧块关节cage植骨融合内固定术治疗难复性寰枢椎脱位的临床疗效,并与经口咽松解后路复位固定融合术进行疗效对比。方法:回顾性分析2018年1月~2022年8月我科采用后路寰枢椎侧块关节cage植骨融合内固定术(23例,cage组)与经口咽松解后路复位固定融合术(25例,对照组)治疗的难复性寰枢椎脱位患者的临床资料,cage组男8例,女15例,年龄9~79岁(48.35±14.38岁);对照组男6例,女19例,年龄21~69岁(47.84±13.51岁)。记录两组患者手术时间、术中出血量、住院时间及并发症情况,术前、术后及末次随访时使用JOA评分评估患者神经功能状态,测量术前、术后及末次随访时的寰齿间距(atlantodental interval,ADI)、齿状突顶点距离Chamberlain线的垂直距离(vertical distance from odon to idprocess to Chamberlain′s line,DOCL)、延髓颈髓角(cervicomedullary angle,CMA)、斜坡枢椎角(clivus-axial angle,CAA),评估寰枢椎复位情况。评估侧块关节cage及后方植骨融合情况。结果:所有患者内固定位置良好,减压充分复位满意,症状均明显缓解,未出现椎动脉损伤和脊髓损伤加重。cage组手术时间133.04±34.04min、术中出血量119.13±54.77mL、住院时间14.74±6.10d,均明显短于或少于对照组(253.20±53.98min、181.20±45.40mL、23.96±5.47d)。cage组术前JOA、ADI、DOCL、CMA、CAA分别为6.33±1.13分、7.31±3.05mm、9.47±3.32mm、122.89°±12.58°、122.02°±12.50°,术后分别为13.04±2.17分、2.18±0.67mm、0.89±1.00mm、148.81°±5.43°、146.70°±9.32°,末次随访时分别为14.89±1.17分、2.09±0.69mm、0.83±0.86mm、149.10°±5.11°、146.89°±8.95°;对照组术前JOA、ADI、DOCL、CMA、CAA分别为6.76±1.21分、7.70±0.97mm、10.56±1.99mm、121.53°±4.87°、123.77°±8.95°,术后分别为13.26±1.32分、1.89±0.50mm、1.13±1.08mm、151.40°±6.15°、149.86°±5.58°,末次随访时分别为15.02±0.88分、1.87±0.44mm、0.87±1.39mm、149.48°±4.06°、149.94°±6.61°,两组术后及末次随访JOA、ADI、DOCL、CMA及CAA均较术前明显改善(P<0.05),术后JOA评分与末次随访相比存在统计学差异(P<0.05),但ADI、DOCL、CMA及CAA无统计学差异(P>0.05)。cage组仅1例切口感染;对照组3例切口感染(口咽2例,后路1例),1例脑脊液漏。两组随访期间内固定在位稳定,末次随访植骨均达到骨性融合,cage组关节间隙高度无丢失。结论:难复性寰枢椎脱位采用后路寰枢椎侧块关节cage植骨融合内固定术与经口咽松解后路复位固定融合术相比疗效相当,但增加了植骨融合位点,能更有效融合,避免了经口手术,减少了手术时间、术中出血量、住院时间及并发症的发生。
文摘目的探讨终板体积骨密度(endplate volumetric bone mineral density,EP-vBMD)对侧方入路腰椎融合(lateral lumbar interbody fusion,LLIF)术后Cage沉降的影响。方法选择2018年1月~2020年12月在本院接受LLIF手术治疗的151例患者进行回顾性分析,收集患者EP-vBMD、椎体体积骨密度(vertebral body volumetric bone mineral density,VB-vBMD)、年龄、性别、体质量指数(body mass index,BMI)、医学共病(糖尿病等)、吸烟、美国麻醉医师协会(american society of anesthesiologists,ASA)评分、查尔森共病指数(charlson comorbidity index,CCI)、手术节段、手术椎体和是否使用后路螺钉固定等资料。根据术后1年患者是否发生Cage沉降,将患者分为Cage沉降组和非沉降组,比较两组患者临床资料差异,将单因素分析P<0.2的变量进一步采用多因素Logsitic回归分析,观察EP-vBMD对终板沉陷的影响。结果Cage沉降患者的VB-vBMD和EP-vBMD水平均低于非Cage沉降患者,差异均有统计学意义(P<0.05)。Cage沉降组患者年龄高于非Cage沉降组患者,差异有统计学意义(P<0.05);Cage沉降组和非Cage沉降组患者性别、吸烟、糖尿病、后路螺钉固定等资料差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,EP-vBMD和应用后路螺钉固定均是Cage沉降的保护性因素(P<0.05)。结论低EP-vBMD是LLIF术后Cage沉降的风险因素,对患者进行LLIF时,应考虑术前EP-vBMD的测量。
基金This work was supported by the China National Key Research and Development Plan Project(grant number 2016YFB1101100)National Natural Science Foundation of China(grant number 11822201)the 111 Project(grant number B13003).
文摘Anterior Cervical Discectomy and Fusion(ACDF)is the preferred surgical method for the treatment of severe cervical degenerative disc disease with radiculopathy or myelopathy,of which the objectives are to restore the normal height of intervertebral space and cervical lordosis through the implantation of cervical interbody fusion cage.The biomechanical performance of a cervical interbody fusion cage,which plays a significant role in achieving the goals of ACDF,is influenced by multiple factors.In this paper,various studies focusing on the biomechanical performance of cervical interbody fusion cage are reviewed.Furthermore,the research methods,biomechanical evaluation parameters and data analysis methods of these research are analyzed in order to obtain a comprehensive understanding of the progress and limitations of research in this field.Although great progress has been made to clarify the biomechanical behaviors of cervical interbody fusion cage,there is still controversy regarding the issues such as the relative contribution of multiple factors to the performance of cage,the interactions among these factors,as well as whether the effects of factors change with the process of intervertebral osseointegration and so on.Thus,investigations are still needed to improve the comprehension of cervical interbody fusion cage biomechanically.
文摘Background: cervical spondylotic myelopathy is a common health problem that neurosurgeons face in Egypt. The aim of this study is to evaluate the efficacy of PEEK cage only in 4 levels anterior cervical discectomy as one of surgical option other than anterior cervical corpectomy, fixation by plat or posterior approach for cervical laminectomy, and assessment of post spinal surgery pain. Methods: this prospective study on 28 patients with cervical spondylotic myelopathy (CSM) over a period of 3 years (between April 2012 and April 2015) with mean period of follow up 30 months. We have done anterior cervical discectomy with fixation by cage only for all cases with perioperative assessment and scoring clinically and radiologically (Japanese Orthopaedic Association [JOA] scores, Visual Analogue Scale [VAS] scores for assessment of neck and arm pain, perioperative parameters (hospital stay, blood loss, operative time), the European Myelopathy Scoring (EMS) and Odom’s criteria, and the incidence of complication,post spinal surgery pain assessment). Results: clinical outcome was excellent (28.55), good (50%) and fair (21.5) according to Odom criteria. The European Myelopathy Scoring (EMS), improved from 10 to 16. The mean JOA score improved from 10.1 ± 2.1 to 14.2 ± 2.3. Fusion failure had been seen in 4 patients in one level for each secondary to anterior displacement of the cage with no other major complications. Conclusion: 4 levels anterior cervical discectomy with PEEK cage only is an effective, save and less costly with less post operative complication and hospital stay and less post spinal surgery pain.
文摘In this study a lumbar spinal fusion animal model is established to assess the effect of spinal fusion cage,and explore theminimum area ratio of titanium cage section to vertebral section that ensures bone healing and biomechanical property.Lumbarcorpectomy was conducted by posterolateral approach with titanium cage implantation combined with plate fixation.Titaniumcages with the same length but different diameters were used.After implantation of titanium cages,the progress of bone healingwas observed and the bone biomechanical properties were measured,including deformation and displacement in axial compression,flexion,extension,and lateral bending motion.The factors affecting the in vivo growth of spine supporting body wereanalyzed.The results show that the area ratio of titanium cage section to vertebral section should reach 1/2 to ensure the bonehealing,sufficient bone intensity and biomechanical properties.Some bone healing indicators,such as BMP,suggest that there isa relationship between the peak time and the peak value of bone formation and metabolism markers and the bone healing strength.
文摘目的:通过系统评价的方法分析影响腰椎椎体间融合术后cage后移(cage retropulsion,CR)发生的危险因素。方法:检索PubMed、Embase、Cochrane Library、Web of Science、中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方数据库和维普数据库,收集各数据库建库至2023年4月有关影响腰椎椎体间融合术后CR危险因素的文献,研究类型为队列研究及病例对照研究,采用纽卡斯尔-渥太华质量评估量表(Newcastle-Ottawa scale,NOS)对纳入研究进行质量评价,提取纳入研究的基本信息,包括年龄及性别等以及CR发生相关研究因素,如骨质疏松、终板损伤、螺钉松动、梨形椎间隙、cage形状、cage置入深度及手术时长、出血量等。评价纳入研究的偏倚风险后,使用Stata14.0软件进行Meta分析。结果:共纳入16篇相关文献,其中15篇文献为回顾性病例对照研究,1篇为前瞻性队列研究,均为中等及以上质量研究,NOS评分均≥7分。总样本量12667例,其中发生CR者(CR组)326例,未发生CR者(nCR组)12341例,CR发生率为2.83%。Meta分析结果显示:性别(男性)[比值比(odds ratio,OR)=1.264,95%置信区间(confidence interval,CI)(1.003~1.593),P=0.047]、年龄[效应量标准化平均差(standardized mean difference,SMD)=0.237,95%CI(0.054~0.419),P=0.011]、骨质疏松[OR=3.126,95%CI(1.040~9.401),P=0.042]、骨终板损伤[OR=8.161,95%CI(3.711~17.945),P=0.000]、螺钉松动[OR=7.978,95%CI(3.487~18.255),P=0.000]、梨形椎间隙[OR=6.037,95%CI(2.381~15.305),P=0.000]、cage置入深度不足[OR=5.157,95%CI(1.760~15.111),P=0.003]是腰椎椎体间融合术后发生CR的危险因素。结论:性别(男性)、高龄、骨质疏松、骨终板损伤、螺钉松动、梨形椎间隙、cage置入深度不足与腰椎椎体间融合术后发生CR密切相关,随访期间应对此类患者密切观察,预防发生严重cage移位的并发症。
