[Objectives]The purpose was to analyze and predict the mechanism of Fuxin decoction in the treatment of heart failure based on network pharmacology.[Methods]Relevant tools and methods of network pharmacology were used...[Objectives]The purpose was to analyze and predict the mechanism of Fuxin decoction in the treatment of heart failure based on network pharmacology.[Methods]Relevant tools and methods of network pharmacology were used to obtain the active ingredients and action targets of Fuxin decoction and action targets of heart failure,find out the key targets and core clusters of Fuxin decoction on heart failure,and analyze related signal pathways,to explore possible molecular mechanisms.[Results]A total of 53 active ingredients and 224 action targets of Fuxin decoction,1010 heart failure-related target genes,and 94 drug-disease directly acting targets were obtained.From the PPI network constructed,225 key targets and a core cluster composed of 56 nodes and 297 interactions were screened out.Association with tumors,glutamate synapse and other related pathways and related genes such as adenylate cyclase and MAPK were known.[Conclusions]The mechanism of Fuxin decoction in the treatment of heart failure is related toβARs-G protein-adenylate cyclase,PI3K-Akt signaling pathway and HSP90,MAPK and other proteins.展开更多
OBJECTIVE:To observe the effects of Fuxin decoction in rats with heart failure induced by doxorubicin injections.METHODS:We employed a doxorubicin-induced heart failure model to investigate the effect of Fuxin decocti...OBJECTIVE:To observe the effects of Fuxin decoction in rats with heart failure induced by doxorubicin injections.METHODS:We employed a doxorubicin-induced heart failure model to investigate the effect of Fuxin decoction.Rats were orally administered with Fuxin decoction from 10 to 40 mg/kg.Organization structure changes were assessed by histology,circulating levels of oxidative stress-related biomarkers and inflammatory cytokines were detected via enzyme-linked immunosorbent assay.RESULTS:Administration of Fuxin decoction improved the growth retardation in doxorubicin hydrochloride injection rats.Cardiac involvement was alleviated by Fuxin decoction,as well as changes of congestion systemic circulation in this rat models.Furthermore,Fuxin decoction regulates immune responses and suppresses oxidation reaction in doxorubicin hydrochloride-induced rats.CONCLUSION:Fuxin decoction might be an interesting candidate for congestive heart failure.展开更多
基金Supported by National Natural Science Foundation of China(81774247).
文摘[Objectives]The purpose was to analyze and predict the mechanism of Fuxin decoction in the treatment of heart failure based on network pharmacology.[Methods]Relevant tools and methods of network pharmacology were used to obtain the active ingredients and action targets of Fuxin decoction and action targets of heart failure,find out the key targets and core clusters of Fuxin decoction on heart failure,and analyze related signal pathways,to explore possible molecular mechanisms.[Results]A total of 53 active ingredients and 224 action targets of Fuxin decoction,1010 heart failure-related target genes,and 94 drug-disease directly acting targets were obtained.From the PPI network constructed,225 key targets and a core cluster composed of 56 nodes and 297 interactions were screened out.Association with tumors,glutamate synapse and other related pathways and related genes such as adenylate cyclase and MAPK were known.[Conclusions]The mechanism of Fuxin decoction in the treatment of heart failure is related toβARs-G protein-adenylate cyclase,PI3K-Akt signaling pathway and HSP90,MAPK and other proteins.
基金grants from clinical-scientific research program of Capital Medical University(No.16JL74)Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(No.ZYLX201611)
文摘OBJECTIVE:To observe the effects of Fuxin decoction in rats with heart failure induced by doxorubicin injections.METHODS:We employed a doxorubicin-induced heart failure model to investigate the effect of Fuxin decoction.Rats were orally administered with Fuxin decoction from 10 to 40 mg/kg.Organization structure changes were assessed by histology,circulating levels of oxidative stress-related biomarkers and inflammatory cytokines were detected via enzyme-linked immunosorbent assay.RESULTS:Administration of Fuxin decoction improved the growth retardation in doxorubicin hydrochloride injection rats.Cardiac involvement was alleviated by Fuxin decoction,as well as changes of congestion systemic circulation in this rat models.Furthermore,Fuxin decoction regulates immune responses and suppresses oxidation reaction in doxorubicin hydrochloride-induced rats.CONCLUSION:Fuxin decoction might be an interesting candidate for congestive heart failure.
