To explore the mechanism of Fuyang Jiebiao granules against viral pneumonia based on network pharmacology and pharmacodynamics

Objective:To investigate the mechanism of Fuyang Jiebiao granule(FYJBKL)in the treatment of viral pneumonia.Methods:Firstly,a network model was constructed using network pharmacology to study the target expression sites of FYJBKL viral pneumonia,so as to determine the main targets and important signal transduction pathways for the treatment of viral pneumonia.Secondly,the main components of the drug and the main target are docked.Then,the fever,sweating and inflammation rat models were established to explore the antipyretic,sweating and anti-inflammatory mechanisms of FYJBKL.Finally,the contents of IL-17,IL-1β,TNF-αand IL-6 in blood samples of rats were analyzed by ELISA method,and the morphological changes of lung tissue were observed by HE staining.Results:Quercetin,luteolin,kaempferol,etc.,and the main mechanism targets are IL-17,IL-1β,TNF-α,IL-6 and so on.Thirty signal pathways were identified by KEGG enrichment analysis,including interleukin-17 signaling pathway(IL-17 signaling pathway),human cytomegalovirus infection pathway(human cytomegalovirus infection),Kaposi's sarcoma associated herpesvirus infection pathway(Kaposi's sarcoma-as-sociated herpesvirus infection)and so on.After the study of molecular docking,we found that the contact efficiency between active substances and possible key targets is good.The high and middle concentration groups of FYJBKL significantly decreased the expression of IL-17,IL-1β,TNF-αand IL-6 in the blood of rats with inflammation(P<0.05).FYJBKL significantly reduced the foot swelling induced by egg white and inhibited the increase of body temperature induced by yeast in rats(P<0.05).HE staining showed that FYJBKL improved pulmonary fibrosis and inflammatory exudation to varying degrees.Conclusion:The effects of FuyangJiebiao granules on the related signal pathways of anti-virus,anti-immune and anti-inflammation as well as biological and cellular processes may be caused by the binding of quercetin,luteolin,kaempferol and other active ingredients to their shared targets.Fuyang Jiebiao granules can improve the related symptoms caused by viral pneumonia,and its mechanism may be related to the activities of TNF,IL-17,IL-6 and other related channels,which are multiple targets of inflammation regulation.

Application of Fuyang Paper Cutting Art in Cultural and Creative Design from the Perspective of Rural Revitalization

The application significance of Fuyang paper cutting art in cultural and creative design from the perspective of rural revitalization was discussed,and the implementation principles and specific practices of applying the elements and techniques of Fuyang traditional paper cutting art in cultural and creative products with local features were analyzed to provide reference for rural revitalization and development of cultural industry.

Quality Standard of Fuyang Wenshen Granules

[Objectives]To establish the quality standard of Fuyang Wenshen Granules and carry out the routine examination of granule type.[Methods]The particle size,water content,solubility,loading difference and microbial limit of Fuyang Wenshen Granules were examined,and TLC was used for qualitative identification of Astmgali Radix and Notoginseng Radix Et Rhizoma.[Results]The particle size,water content,solubility,loading difference,and microbial limit of Fuyang Wenshen Granules complied with the relevant provisions of the Pharmacopoeia of the People's Republic of China(2020).The TLC spots of Astmgali Radix and Notoginseng Radix Et Rhizoma were clearly colored,and negative had no interference.[Conclusions]The method was simple,accurate,reliable,specific and reproducible,and can effectively control the quality of Fuyang Wenshen Granules.

Application of Multi-agent Models to Urban Expansion in Medium and Small Cities: A Case Study in Fuyang City,Zhejiang Province,China

In this study, three-phase satellite images were used to define rules for the allocation of time and space in construction land resources based on a complex adaptive system and game theory. The decision behavior and rules of government agent, enterprise agent and resident agent in construction land growth were explored. A distinctive and dynamic simulation model of construction land growth was built, which integrated multi-agent, GIS technology and RS data and described the interaction among influencing agents, Taking Fuyang City in the Changjiang River Delta as an example, an assessment process for the remote sensing data in construction land and scenario planning was constructed. Repast and ArcGIS were used as simulation platforms. A simulation of the spatial pattern in land-use planning and the setting of scenario planning were conducted by using the incomplete active game, which was based on different natural, social and economic levels. Through this model, a simulation of urban planning space and decision-making for Fuyang City was created. Relevant non-structured problems arising from urban planning management could be identified, and the process and logic of urban planning spatial decision-making could thus be improved. Cell-by-cell comparison showed that the simulation accuracy was over 72%. This model has great potential for use by government and town planners in decision support and technique support in the policy-making process.

Seismic identification of channel sandbodies in the Fuyang oil layer in North Songliao Basin, China

The Fuyang oil-layer in North Songliao Basin is characterized by thin interbedded sands and shales, strong lateral variation, strong reservoir heterogeniety, and so on. The thickness of individual sand layers is generally 3 - 5 m. Identifying the channel sand-bodies of the Fuyang oil layer using seismic techniques is very difficult due to the low seismic resolution. Taking the GTZ area as an example, we discuss the genetic characteristics of the channel sand-bodies and point out the real difficulty in using seismic techniques to predict the channel sand-bodies. Two methods for the identification of channels are presented： frequency spectrum imaging and pre-stack azimuthal anisotropy. Identifying the channel sand-bodies in Fuyu oil-layer using the two seismic methods results in a success rate up to 80% compared with well data.

Inheritance and Development of Fuyang Folk Paper-cut Art: A Case Study of “Cheng’s Paper-cut” Art

Intangible cultural heritage plays a prominent role in local cultural construction and tourism brand building. This paper took Fuyang as an example to expound the origin and development of Fuyang folk paper-cut art, analyzed its characteristics, and put forward some countermeasures and ways of inheritance and development, so as to promote the inheritance, protection and development of intangible cultural heritage.

Mechanism and Research Progress of Fuyang Huoxue Jiedu Formula against Recurrence of Ulcerative Colitis

By introducing the composition and modern pharmacology of Fuyang Huoxue Jiedu Formula,the paper further explored the mechanism and research progress of Fuyang Huoxue Jiedu Formula against recurrence of ulcerative colitis(UC).The formula can effectively improve the TCM syndromes of UC patients,reduce the recurrence rate,and improve clinical efficacy and patients’quality of life.

Clinical Effect of Fuyang Prescription in Treatment of Ischemic Stroke during the Convalescent Stage:An Analysis of 25 Cases

[Objectives]The paper was to investigate the clinical effect of Fuyang prescription in the treatment of yang deficiency syndrome in the convalescent stage of ischemic stroke(IS)and its mechanism of action.[Methods]A total of 50 patients with yang deficiency syndrome in the convalescent stage of IS were randomly divided into treatment group and control group,with 25 patients in each group.The patients in the treatment group were given basic treatment combined with Fuyang prescription,and those in the control group were given basic treatment combined with Buyang Huanwu decoction;the course of treatment was 28 d for both groups.The activities of daily living(ADL)score,National Institutes of Health Stroke Scale(NIHSS)score,quality of life score,TCM syndrome score,and safety in both groups were observed before treatment and at 14 and 28 d post treatment,and their clinical outcome was evaluated.[Results]There was a significant difference in overall response rate between the treatment group and the control group[92.00%(23/25)vs 76.00%(19/25),P<0.05].After treatment,both groups had significant changes in ADL score,NIHSS score,quality of life score,and TCM syndrome score,and there were significant differences in these indices between the two groups at the same time point after treatment(P<0.05 or P<0.01).There were no significant changes in routine blood,routine stool,routine urine,and liver/renal function in either group after treatment.[Conclusions]Fuyang prescription has a marked clinical effect in the treatment of yang deficiency syndrome in the convalescent stage of IS,with significantly better clinical effect than Buyang Huanwu decoction,and it provides clinical evidence for the traditional Chinese medicine theory of yang supporting in the treatment of IS in the convalescent stage.

Fuyang Welcomes Investors From Abroad

Fuyang is located in the northwesternpart of Anhui Province,bordering theHuai River to the south and adjoiningCentral China to the north.With a populationof 13.33 million,the city covers and area of18,169 square km and has jurisdiction overseven counties and three districts.It is one ofthe largest cities in the country,with itspopulation,area of farmland and output ofgrains all accounting for one percent of thenation’s total respectively. The Beijing-Kowloon railway runsfor 192 km long through the city’s area.Oneof the country’s six largest hubs of rail traffic,the Fuyang railway hub boasts an array of244 parallel tracks laid in its marshallingyard with a daily handling capacity of morethan 10,000 trains and cars.Its

Anhui Fuyang Pharmaceutical Works

Established in 1970,the Fuyang PharmaceuticalWorks is a large pharmaceutical and chemicalenterprise with complete category of products,including citric acid,infusion fluid,tablets,capsules,lotion and health products;it is also one of China’s top100 pharmaceutical enterprises,one of Anhui’s top100 best enterprises,Anhui’s new high-tech enterpriseand Anhui’s important export enterprise withautonomous import and export rights. The factory has a staff of 1168,including

Anhui Fuyang Economic and Technological Development Area

The Fuyang Economic and TechnologicalDevelopment area(FETDA) is aprovincial development area approvedby the Anhui provincial government.Situatedin the south of the city,the area is close to theold town in the north and bordering to thesouth the outer ring road,and the Beijing-Kowloon railway in the east.To the southeastis the large freight terminal of the railway.And the Xiqinghe River runs along its westernborder.It is four km away from Fuyangairport and national highway 105 and theFuyang-Yingzhou highway run through thearea,which covers a total area of eight sqkm. With all kinds of public facilities,thearea will be operated in line with

Development Characteristics,Problems and Recommendations of Sweet Potato Industry in Fuyang City

The development of sweet potato industry in Fuyang City takes on following characteristics:increase in planting area of specialized households and professional cooperatives;increase in production input and yield;constant optimization of planting varieties;diversified planting modes.Sweet potato industry has made significant contribution to Fuyang City:(1)enriching types of agricultural products and promoting healthy diet;(2)driving development of agricultural product processing industry and increasing the employment rate of rural labor;(3)increasing financial revenue and rate of export-making foreign exchange of agricultural products;(4)increasing farmers'income and promoting new socialist countryside construction.In line with comparative advantages and existing problems of sweet potato industry in Fuyang City,it presents corresponding industrial development recommendations.

Difference analysis of Doppler ultrasound blood flow of Cunkou(radial artery)pulse,Renying(carotid artery)pulse,and Fuyang(anterior tibial artery)pulse

OBJECTIVE:To analyze the Doppler ultrasound blood flow of Renying(carotid artery)pulse,Cunkou(radial artery)pulse,and Fuyang(anterior tibial artery)pulse in the normal group and the functional constipation with gastrointestinal heat(FCGH)group,and to compare and explore the differences of Renying,Cunkou and Fuyang pulses.METHODS:Sixty normal subjects and 60 patients with gastrointestinal heat constipation were collected in the department of ultrasound,Beijing Anzhen Hospital,Capital Medical University.Doppler ultrasound was used to observe the blood flow indexes including maximum systolic velocity(Vp),maximum diastolic velocity(Vd),mean velocity(Vm),pulse index(PI),resistance index(RI),vascular diameter(D),and circulation blood flow cycle(ET)of Renying pulse,Cunkou pulse and Fuyang pulse in the normal group and patients with gastrointestinal heat constipation.The differences of these three pulses were compared between the normal group and the FCGH group.RESULTS:The PI,Vp,Vm,RI,and D of the three pulses in the normal group were statistically significant different(P<0.01).In the comparison of Doppler flow diagram of three pulses in the FCGH group,there were significant differences in PI,Vd,Vp,Vm,RI,and D(P<0.01).CONCLUSION:Under normal conditions,the indexes of Renying pulse Doppler flow diagram,Cunkou pulse Doppler flow diagram,and Fuyang pulse Doppler flow diagram are significantly different.In the FCGH group,most of the indexes of Renying pulse Doppler flow diagram,Cunkou pulse Doppler flow diagram,and Fuyang pulse Doppler flow diagram are different.This result verified the necessity of simultaneous examinations of all Renying,Cunkou,and Fuyang pulses in modern Chinese medicine.

中晚熟甜樱桃新品种福阳的选育

福阳是由黑珍珠×(萨米脱+先锋)杂交选育出的中晚熟甜樱桃新品种。果实心脏形,果皮紫黑色、有光泽,果顶稍凹陷,果肉、果汁深红色;果肉脆硬,味甜。平均单果质量9.7 g,最大单果质量14.1 g;果柄中短,柄长3.45 cm;核小,果实可食率94.6%。果肉可溶性固形物含量(w,后同)18.7%,总糖含量11.62%,总酸含量0.61%;鲜食品质上。果实在鲜红至紫红色时,口感即好,挂果时间长。果实生育期55 d左右,烟台地区6月上中旬成熟;树势健壮,萌芽率高(98.2%),成枝力强,成花易。福阳耐贮运,早实、丰产、稳产,4年生树每666.7 m^(2)产量268 kg,综合性状优良。适宜在山东省甜樱桃适栽区推广种植。

阜阳市幸福河湖评价及障碍因子识别

从水资源供给、水资源利用、水环境治理、水生态环境、水经济发展5个方面出发,选取15个指标建立了幸福河湖评价指标体系。基于熵权法和TOPSIS模型对阜阳市2012—2021年的幸福河湖情况进行了综合评价,采用障碍度模型识别了影响阜阳市幸福河湖的障碍因子。结果表明:阜阳市的幸福河湖建设情况在2012—2021年呈逐步增长趋势,影响幸福河湖的主要因素是水资源量、水资源利用及水生态环境情况。据此,结合阜阳市的水资源对经济发展的承载能力等方面,提出了优化阜阳市幸福河湖建设的建议。

基于SWAT模型的滏阳河流域断流河道复流研究

针对滏阳河流域断流河道生态修复的问题,为了实现断流河道尽可能恢复有水时间并且恢复基本生态功能的目标,基于节水措施和调水工程现状,通过建立滏阳河流域SWAT(soil and water assessment tool)水文模型,在模型中设置不同补水水量、补水方式的生态补水情景,分析不同情景下断流河道断面的径流量变化和恢复有水天数,并结合生态流量评价标准评价不同情景的河流生态恢复效果。结果表明:滏阳河流域邯郸断面在节水情景和调水情景中恢复河流生态效果较好,在通过上游节水措施和补充年调水1.00×10^(8)m^(3)/a的情景下,可以达到5—10月恢复有水184 d、恢复径流量3486.7×10^(4)m^(3)/a的目标;年内恢复径流峰值在8月中旬,并且河道年均径流量可以恢复到“好”等级的生态流量标准。滏阳河下游邢台断面在节水情景和调水情景下恢复径流量较少,河道有水天数不达标,需要在上游节水条件下补充外来调水水量1.50×10^(8)m^(3)/a来达到恢复年有水天数304 d、恢复径流量1906.5×10^(4)m^(3)/a的目标,年内恢复径流峰值分别在3月中旬和8月中旬;并且在达到恢复有水目标的情景下邢台断面仅达到“一般”等级的生态流量标准,需要考虑增加调水水量进行分时段单点位补水的补水方案。

扶阳学派运用附子之经验

基于“阳主阴从”观,扶阳学派集百年之经验,将大剂量附子灵活应用于各类急危重症和疑难杂症,取得了显著的临床疗效。文章通过阐述四川江油道地药材附子的辨证运用要点、配伍方法、剂量把握等方面的内容,并结合临床医案,对扶阳学派运用附子的用药经验进行了回顾性总结,旨在为其临床推广和应用提供可借鉴的依据。