While cellular networks have continuously evolved in re- cent years, the industry has clearly seen unprecedented chal- lenges to meet the exponentially growing expectations in the near future. The 5G system is facing ...While cellular networks have continuously evolved in re- cent years, the industry has clearly seen unprecedented chal- lenges to meet the exponentially growing expectations in the near future. The 5G system is facing grand challenges such as the ever-increasing traffic volumes and remarkably diver- sified services connecting humans and machines alike. As a result, the future network has to deliver massively increased capacity, greater flexibility, incorporated computing capabili- ty, support of significantly extended battery lifetime, and ac- commodation of varying payloads with fast setup and low latency, etc. In particular, as 5G requires more spectrum resource, higher frequency bands are desirable. Nowadays, millimeter wave has been widely accepted as one of the main communication bands for 5G.展开更多
While cellular networks have continuously evolved in recent years, the industry has clearly seen unprecedented challenges to meet the exponentially growing expectations in the near future.
Objectives To investigate the effect of Gαq/11 signaling pathway and ATP-sensitive potassium channel ( KATP channel ) on ischemic preconditioning (IPC) protection in rat hearts. Methods Two series of experiments were...Objectives To investigate the effect of Gαq/11 signaling pathway and ATP-sensitive potassium channel ( KATP channel ) on ischemic preconditioning (IPC) protection in rat hearts. Methods Two series of experiments were performed in Wistar rat hearts. In the first series of experiment, ischemic preconditioning was induced by left anterior descending occlusion (three, 5 min episodes separated by 5 min of reperfusion), ischemia-reperfusion injury was induced by 30 min coronary artery occlusion followed by 90 min reperfusion. Hemodynamics, infarct size and scores of ventricular arrhythmias were measured. The expression of Gαq/11 protein in the heart was measured by Western blot analysis in the second series. Results Ischemic preconditioning rats showed decreased infarct size and scores of ventricular arrhythmia vs non-IP control rats. The effect of IPC was significantly attenuated by glibenclamide (1 mg/kg, ip), a nonselective KATP channel inhibitor. IPC caused a significant increase in the expression of Gαq/11 protein. Conclusions Activations of Gαq/11 signal pathway and KATP channel played significant roles in the classical cardioprotection of ischemic precon-ditioning rat heart and might be an important mechanism of signal transduction pathway during the ischemic preconditioning.展开更多
文摘While cellular networks have continuously evolved in re- cent years, the industry has clearly seen unprecedented chal- lenges to meet the exponentially growing expectations in the near future. The 5G system is facing grand challenges such as the ever-increasing traffic volumes and remarkably diver- sified services connecting humans and machines alike. As a result, the future network has to deliver massively increased capacity, greater flexibility, incorporated computing capabili- ty, support of significantly extended battery lifetime, and ac- commodation of varying payloads with fast setup and low latency, etc. In particular, as 5G requires more spectrum resource, higher frequency bands are desirable. Nowadays, millimeter wave has been widely accepted as one of the main communication bands for 5G.
文摘While cellular networks have continuously evolved in recent years, the industry has clearly seen unprecedented challenges to meet the exponentially growing expectations in the near future.
文摘Objectives To investigate the effect of Gαq/11 signaling pathway and ATP-sensitive potassium channel ( KATP channel ) on ischemic preconditioning (IPC) protection in rat hearts. Methods Two series of experiments were performed in Wistar rat hearts. In the first series of experiment, ischemic preconditioning was induced by left anterior descending occlusion (three, 5 min episodes separated by 5 min of reperfusion), ischemia-reperfusion injury was induced by 30 min coronary artery occlusion followed by 90 min reperfusion. Hemodynamics, infarct size and scores of ventricular arrhythmias were measured. The expression of Gαq/11 protein in the heart was measured by Western blot analysis in the second series. Results Ischemic preconditioning rats showed decreased infarct size and scores of ventricular arrhythmia vs non-IP control rats. The effect of IPC was significantly attenuated by glibenclamide (1 mg/kg, ip), a nonselective KATP channel inhibitor. IPC caused a significant increase in the expression of Gαq/11 protein. Conclusions Activations of Gαq/11 signal pathway and KATP channel played significant roles in the classical cardioprotection of ischemic precon-ditioning rat heart and might be an important mechanism of signal transduction pathway during the ischemic preconditioning.
