The influence of the G‐quartet structural integrity on the catalytic activity of the G‐quadruplex(G4)was investigated by comparing the G4‐DNAzyme performances of a series of G4s with a G‐vacancy site and a G‐trip...The influence of the G‐quartet structural integrity on the catalytic activity of the G‐quadruplex(G4)was investigated by comparing the G4‐DNAzyme performances of a series of G4s with a G‐vacancy site and a G‐triplex(G‐tri).The results presented herein not only confirm that the structural integrity of the 3'‐end G‐quartet is necessary for G4s to be catalytically competent but also show how to remediate G‐vacancy‐mediated catalytic activity losses via the addition of guanine surrogates in an approach referred to as G‐vacancy complementation strategy that is applicable to parallel G4s only.Furthermore,this study demonstrates that the terminal G‐quartet could act as a proximal coordinating group and cooperate with the flanking nucleotide to activate the hemin cofactor.展开更多
Using the sea surface temperature （SST） predicted for the equatorial Pacific Ocean by the Flexible Global Ocean-Atmosphere-Land System Model-gamil （FGOALS-g）, an analysis of the prediction errors was performed for...Using the sea surface temperature （SST） predicted for the equatorial Pacific Ocean by the Flexible Global Ocean-Atmosphere-Land System Model-gamil （FGOALS-g）, an analysis of the prediction errors was performed for the seasonally dependent predictability of SST anomalies both for neutral years and for the growth/decay phase of El Nino/La Nina events. The study results indicated that for the SST predictions relating to the growth phase and the decay phase of El Nino events, the prediction errors have a seasonally dependent evolution. The largest increase in errors occurred in the spring season, which indicates that a prominent spring predictability barrier （SPB） occurs during an El Nino-Southern Oscillation （ENSO） warming episode. Furthermore, the SPB associated with the growth-phase prediction is more prominent than that associated with the decay-phase prediction. However, for the neutral years and for the growth and decay phases of La Nifia events, the SPB phenomenon was less prominent. These results indicate that the SPB phenomenon depends extensively on the ENSO events themselves. In particular, the SPB depends on the phases of the ENSO events. These results may provide useful knowledge for improving ENSO forecasting.展开更多
We consider a Lotka-Volterra prey-predator model with cross-diffusion and Holling type-II functional response.The main concern is the existence of positive solutions under the combined effect of cross-diffusion and Ho...We consider a Lotka-Volterra prey-predator model with cross-diffusion and Holling type-II functional response.The main concern is the existence of positive solutions under the combined effect of cross-diffusion and Holling type-II functional response.Here,a positive solution corresponds to a coexistence state of the model.Firstly,we study the sufficient conditions to ensure the existence of positive solutions by using degree theory and analyze the coexistence region in parameter plane.In addition,we present the uniqueness of positive solutions in one dimension case.Secondly,we study the stability of the trivial and semi-trivial solutions by analyzing the principal eigenvalue of the corresponding linearized system,and then we characterize the stable/unstable regions of semi-trivial solutions in parameter plane.展开更多
文摘The influence of the G‐quartet structural integrity on the catalytic activity of the G‐quadruplex(G4)was investigated by comparing the G4‐DNAzyme performances of a series of G4s with a G‐vacancy site and a G‐triplex(G‐tri).The results presented herein not only confirm that the structural integrity of the 3'‐end G‐quartet is necessary for G4s to be catalytically competent but also show how to remediate G‐vacancy‐mediated catalytic activity losses via the addition of guanine surrogates in an approach referred to as G‐vacancy complementation strategy that is applicable to parallel G4s only.Furthermore,this study demonstrates that the terminal G‐quartet could act as a proximal coordinating group and cooperate with the flanking nucleotide to activate the hemin cofactor.
基金sponsored by the Knowledge Innovation Programof the Chinese Academy of Sciences (Grant No. KZCX2-YW-QN203)the National Basic Research Program of China (GrantNos. 2010CB950400 and 2007CB411800)
文摘Using the sea surface temperature （SST） predicted for the equatorial Pacific Ocean by the Flexible Global Ocean-Atmosphere-Land System Model-gamil （FGOALS-g）, an analysis of the prediction errors was performed for the seasonally dependent predictability of SST anomalies both for neutral years and for the growth/decay phase of El Nino/La Nina events. The study results indicated that for the SST predictions relating to the growth phase and the decay phase of El Nino events, the prediction errors have a seasonally dependent evolution. The largest increase in errors occurred in the spring season, which indicates that a prominent spring predictability barrier （SPB） occurs during an El Nino-Southern Oscillation （ENSO） warming episode. Furthermore, the SPB associated with the growth-phase prediction is more prominent than that associated with the decay-phase prediction. However, for the neutral years and for the growth and decay phases of La Nifia events, the SPB phenomenon was less prominent. These results indicate that the SPB phenomenon depends extensively on the ENSO events themselves. In particular, the SPB depends on the phases of the ENSO events. These results may provide useful knowledge for improving ENSO forecasting.
基金supported by National Natural Science Foundation of China(Grant No.11201380)the Fundamental Research Funds for the Central Universities(Grant No.XDJK2012B007)+2 种基金Doctor Fund of Southwest University(Grant No.SWU111021)Educational Fund of Southwest University(Grant No.2010JY053)National Research Foundation of Korea Grant funded by the Korean Government(Ministry of Education,Science and Technology)(Grant No.NRF-2011-357-C00006)
文摘We consider a Lotka-Volterra prey-predator model with cross-diffusion and Holling type-II functional response.The main concern is the existence of positive solutions under the combined effect of cross-diffusion and Holling type-II functional response.Here,a positive solution corresponds to a coexistence state of the model.Firstly,we study the sufficient conditions to ensure the existence of positive solutions by using degree theory and analyze the coexistence region in parameter plane.In addition,we present the uniqueness of positive solutions in one dimension case.Secondly,we study the stability of the trivial and semi-trivial solutions by analyzing the principal eigenvalue of the corresponding linearized system,and then we characterize the stable/unstable regions of semi-trivial solutions in parameter plane.
