We examine the relationship between return and volatility of the stock markets and macroeconomic fundamentals for the G-7 countries by using monthly data ranging from July 1985 to June 2015. To meet this end, we apply...We examine the relationship between return and volatility of the stock markets and macroeconomic fundamentals for the G-7 countries by using monthly data ranging from July 1985 to June 2015. To meet this end, we apply the spillover index approach based on the generalized VAR framework developed by Diebold and Yilmaz (2012, 2014). The empirical analysis shows strong interactions between the returns and volatilities of the G-7 stock markets and the considered set of corresponding macroeconomic factors including industrial production, money supply, interest rates, inflation, oil prices and exchange rates. The return and volatility spillover transmission/reception dynamics of the relationships between these stock markets and the macroeconomic fundamentals have changed after the global financial crisis of 2008. Our findings provide useful insights for investors and policy makers concerned with the unprecedented swings in the stock markets of G-7 countries.展开更多
目的观察以壳聚糖(CS)材料为佐剂制备的德国小蠊变应原Bla g 7多肽纳米疫苗对小鼠过敏性气道炎症的疗效,探讨其免疫机制。方法用CS包裹Bla g 7多肽制成纳米疫苗;25只BALB/c小鼠用蟑螂粗提液致敏、激发,随机分为阴性对照组(A组)、模型组(...目的观察以壳聚糖(CS)材料为佐剂制备的德国小蠊变应原Bla g 7多肽纳米疫苗对小鼠过敏性气道炎症的疗效,探讨其免疫机制。方法用CS包裹Bla g 7多肽制成纳米疫苗;25只BALB/c小鼠用蟑螂粗提液致敏、激发,随机分为阴性对照组(A组)、模型组(B组)、Bla g 7多肽治疗组(C组)、Bla g 7多肽+CS治疗组(D组)、CS对照(E组)。通过HE染色观察小鼠肺部炎症;观察支气管肺泡灌洗液(BALF)中细胞总数和细胞分类;气道高反应仪监测治疗前后小鼠气道高反应性的变化。结果成功制备Bla g 7多肽纳米疫苗;D组与A组相比肺部病理改变不明显,BALF中的细胞总数、EOS计数均显著低于模型组(P<0.01),而C组和E组对致敏小鼠无明显疗效。气道高反应数值治疗前后变化差别有统计学意义(P<0.05)。结论Bla g 7多肽壳聚糖纳米疫苗对致敏小鼠具有免疫治疗作用,是一种新型的治疗蟑螂过敏性气道炎症的缓释制剂,为脱敏疫苗的研究提供了理论基础。展开更多
目的探讨m^(7)G相关基因能否作为肝细胞性肝癌预后的生物标志物。方法采用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库筛选肝细胞性肝癌组织和癌旁组织中有表达差异的m^(7)G相关基因组,m^(7)G相关基因和临床数据中的生存时间...目的探讨m^(7)G相关基因能否作为肝细胞性肝癌预后的生物标志物。方法采用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库筛选肝细胞性肝癌组织和癌旁组织中有表达差异的m^(7)G相关基因组,m^(7)G相关基因和临床数据中的生存时间及生存状态按照样本ID号匹配合并后筛选预后基因组,将两组的交集基因纳入lasso回归,对筛选出来的基因进行风险评分,基于风险评分的中位数值将所有肝细胞性肝癌患者分为高、低两个风险组,并对高分险组和低风险组进行单因素和多因素的Cox回归分析,评价风险评分在预后中的差异。结果经lasso回归筛选出4个模型基因(AGO2、NCBP1、NCBP2、WDR4),高风险组的生存率显著低于低风险组(P=0.027),ROC曲线显示风险模型对患者1,2,3年生存预测的曲线下面积(AUC)分别为0.683,0.604,0.602。肿瘤分期、T分期、M分期和风险评分是肝细胞性肝癌预后的相关因素(P<0.05),其中风险评分是影响肝细胞性肝癌患者生存率的独立预后因素(P=0.044,HR=1.637)。结论m^(7)G相关基因可作为肝细胞性肝癌预后的生物标志物。AGO2、NCBP1、NCBP2和WDR4构建的风险模型对肝细胞性肝癌具有重要的预后价值。展开更多
文摘We examine the relationship between return and volatility of the stock markets and macroeconomic fundamentals for the G-7 countries by using monthly data ranging from July 1985 to June 2015. To meet this end, we apply the spillover index approach based on the generalized VAR framework developed by Diebold and Yilmaz (2012, 2014). The empirical analysis shows strong interactions between the returns and volatilities of the G-7 stock markets and the considered set of corresponding macroeconomic factors including industrial production, money supply, interest rates, inflation, oil prices and exchange rates. The return and volatility spillover transmission/reception dynamics of the relationships between these stock markets and the macroeconomic fundamentals have changed after the global financial crisis of 2008. Our findings provide useful insights for investors and policy makers concerned with the unprecedented swings in the stock markets of G-7 countries.
文摘目的观察以壳聚糖(CS)材料为佐剂制备的德国小蠊变应原Bla g 7多肽纳米疫苗对小鼠过敏性气道炎症的疗效,探讨其免疫机制。方法用CS包裹Bla g 7多肽制成纳米疫苗;25只BALB/c小鼠用蟑螂粗提液致敏、激发,随机分为阴性对照组(A组)、模型组(B组)、Bla g 7多肽治疗组(C组)、Bla g 7多肽+CS治疗组(D组)、CS对照(E组)。通过HE染色观察小鼠肺部炎症;观察支气管肺泡灌洗液(BALF)中细胞总数和细胞分类;气道高反应仪监测治疗前后小鼠气道高反应性的变化。结果成功制备Bla g 7多肽纳米疫苗;D组与A组相比肺部病理改变不明显,BALF中的细胞总数、EOS计数均显著低于模型组(P<0.01),而C组和E组对致敏小鼠无明显疗效。气道高反应数值治疗前后变化差别有统计学意义(P<0.05)。结论Bla g 7多肽壳聚糖纳米疫苗对致敏小鼠具有免疫治疗作用,是一种新型的治疗蟑螂过敏性气道炎症的缓释制剂,为脱敏疫苗的研究提供了理论基础。
文摘目的探讨m^(7)G相关基因能否作为肝细胞性肝癌预后的生物标志物。方法采用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库筛选肝细胞性肝癌组织和癌旁组织中有表达差异的m^(7)G相关基因组,m^(7)G相关基因和临床数据中的生存时间及生存状态按照样本ID号匹配合并后筛选预后基因组,将两组的交集基因纳入lasso回归,对筛选出来的基因进行风险评分,基于风险评分的中位数值将所有肝细胞性肝癌患者分为高、低两个风险组,并对高分险组和低风险组进行单因素和多因素的Cox回归分析,评价风险评分在预后中的差异。结果经lasso回归筛选出4个模型基因(AGO2、NCBP1、NCBP2、WDR4),高风险组的生存率显著低于低风险组(P=0.027),ROC曲线显示风险模型对患者1,2,3年生存预测的曲线下面积(AUC)分别为0.683,0.604,0.602。肿瘤分期、T分期、M分期和风险评分是肝细胞性肝癌预后的相关因素(P<0.05),其中风险评分是影响肝细胞性肝癌患者生存率的独立预后因素(P=0.044,HR=1.637)。结论m^(7)G相关基因可作为肝细胞性肝癌预后的生物标志物。AGO2、NCBP1、NCBP2和WDR4构建的风险模型对肝细胞性肝癌具有重要的预后价值。
