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Surveillance Imaging and GAAD/GALAD Scores for Detection of Hepatocellular Carcinoma in Patients with Chronic Hepatitis
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作者 Chung-Feng Huang Konstantin Kroeniger +13 位作者 Chih-Wen Wang Tyng-Yuan Jang Ming-Lun Yeh Po-Cheng Liang Yu-Ju Wei Po-Yao Hsu Ching-I Huang Ming-Yen Hsieh Yi-Hung Lin Jee-Fu Huang Chia-Yen Dai Wan-Long Chuang Ashish Sharma Ming-Lung Yu 《Journal of Clinical and Translational Hepatology》 SCIE 2024年第11期907-916,共10页
Background and Aims:Early detection of hepatocellular carcinoma(HCC)is crucial for improving survival in patients with chronic hepatitis.The GALAD algorithm combines gen-der(biological sex),age,α-fetoprotein(AFP),Len... Background and Aims:Early detection of hepatocellular carcinoma(HCC)is crucial for improving survival in patients with chronic hepatitis.The GALAD algorithm combines gen-der(biological sex),age,α-fetoprotein(AFP),Lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),and protein in-duced by vitamin K absence or antagonist-II(PIVKA-II)for HCC detection.Similarly,the GAAD algorithm incorporates gender(biological sex),age,AFP,and PIVKA-II.This study aimed to assess the clinical utility of AFP-L3 in the GALAD algorithm and its potential synergies with ultrasound.We compared the clinical performance of GALAD with GAAD;AFP;AFP-L3;and PIVKA-II,with or without ultrasound,in Taiwan residents adults.Methods:A total of 439 serum samples were analyzed using a Cobas®e 601 analyzer(healthy con-trols,n=200;chronic liver disease controls,n=177;HCC cases,n=62).Performance was assessed through receiver operating characteristic curve analyses to calculate the area under the curve.Results:The area under the curve for dif-ferentiating early-stage HCC from patients with chronic liver disease was optimal for PIVKA-II(84.9%),GAAD(79.8%),and GALAD(79.4%),with slightly improved performance for detecting all-stage HCC.Clinical performance was unaffected by disease stage or etiology.Sensitivity for early-stage HCC was highest for GAAD(57.6%)and GALAD(57.6%).Sen-sitivity for each strategy was further enhanced when com-bined with ultrasound,regardless of disease stage or etiology(P<0.01).Conclusions:These findings indicate that the role of AFP-L3 in the GALAD algorithm is minimal,supporting the use of GAAD for HCC detection.A combination of GAAD,GALAD,or PIVKA-II with ultrasound may improve diagnostic efficiency compared with recommended strategies. 展开更多
关键词 Algorithm Biomarkers CIRRHOSIS Diagnosis DETECTION gaad GALAD Hepatocellular carcinoma Liver cancer SURVEILLANCE Ultrasound
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甘草酸对H_2O_2诱导小肠上皮细胞DNA损伤的保护作用 被引量:5
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作者 张娴 黄羽 曾星 《中药新药与临床药理》 CAS CSCD 北大核心 2012年第3期239-242,共4页
目的初步研究甘草酸(Glycyrrhizic acid,GA)对氧化损伤小肠上皮细胞IEC-6的保护作用及可能机制。方法实验设空白对照组,H2O2模型组,GA低、中、高剂量组(50,100,200μg/mL)。GA各组加入相应浓度的药物作用48 h后,与模型组一起加入200μmo... 目的初步研究甘草酸(Glycyrrhizic acid,GA)对氧化损伤小肠上皮细胞IEC-6的保护作用及可能机制。方法实验设空白对照组,H2O2模型组,GA低、中、高剂量组(50,100,200μg/mL)。GA各组加入相应浓度的药物作用48 h后,与模型组一起加入200μmol/L的H2O2作用2 h,空白对照组正常培养。用单细胞凝胶电泳检测DNA损伤,RT-PCR检测p53,Gadd45α mRNA表达,Western blot检测p53,Gadd45α蛋白表达。结果与空白对照组比较,模型组DNA损伤严重,Gadd45α mRNA和蛋白表达增高;与H2O2模型组比较,GA各组DNA损伤明显减轻,GA100μg/mL和200μg/mL组p53 mRNA及其蛋白表达明显升高,同时Gadd45α mRNA及其蛋白表达明显升高。结论 GA在100~200μg/mL可以保护H2O2诱导的小肠上皮细胞DNA损伤,其机制可能与p53和Gaad45α的表达增高相关。 展开更多
关键词 甘草酸 DNA损伤 小肠上皮细胞 p53 gaad45α
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