AIM: To explore whether clinical presentations of gastric small gastrointestinal tumors(GISTs) mimics gastrointestinal dyspepsia symptoms.METHODS: The endosonographic data of 167 patients who underwent endoscopic subm...AIM: To explore whether clinical presentations of gastric small gastrointestinal tumors(GISTs) mimics gastrointestinal dyspepsia symptoms.METHODS: The endosonographic data of 167 patients who underwent endoscopic submucosal dissection at the Tianjin Medical University General Hospital, China between 2009 and 2011 were analyzed. GISTs and leiomyomas had a similar intragastric distribution and similar locations within the gastric wall. Therefore, patients with GISTs were chosen as the study group and those with leiomyomas were chosen as the control group. Dyspepsia symptom questionnaires were used to investigate and compare the gastrointestinal symptoms of patients with GISTs and those with gastric leiomyomas before and after endoscopic submucosal dissection(ESD). The questionnaires evaluated symptoms such as epigastric pain, heartburn, regurgitation, epigastric discomfort, nausea and vomiting, abdominal bloating, and eructation. Symptoms were assessed using a four-point scoring scale.RESULTS: GISTs were the most common gastric submucosal lesion(67 cases, 40.12%), followed by leiomyomas(38 cases, 22.75%). Both groups were similar in terms of gender distribution(P = 0.49), intragastric location(P = 0.525), and originating layer within the gastric wall(P = 0.449), but leiomyomas were more commonly found in the proximal fundus(P < 0.05). Overall, 94.2% of the patients with small GISTs and 93.5% of those with gastric leiomyomas experienced some dyspepsia; however, total symptom scores were significantly lower in the GIST group than in the leiomyoma group(1.34 ± 1.27 vs 2.20 ± 1.70, P < 0.05). Each component of the symptom score demonstrated a statistically significant improvement in the GIST patients after ESD(P < 0.05), including epigastric pain(0.80 ± 0.90 vs 0.13 ± 0.46), heartburn(0.63 ± 1.08 vs 0.13 ± 0.41), regurgitation(0.55 ± 0.87 vs 0.22 ± 0.57), epigastric discomfort(0.70 ± 0.98 vs 0.32 ± 0.47), nausea and vomiting(0.27 ± 0.62 vs 0.05 ± 0.21), abdominal bloating(0.70 ± 0.90 vs 0.27 ± 0.49), and eructation(0.36 ± 0.61 vs 0.21 ± 0.46). For leiomyoma patients, symptoms such as heartburn, nausea, vomiting, and eructation improved after treatment; however, these improvements were not statistically significant(P > 0.05). Thus, the pathophysiology of dyspepsia symptoms may be different between the two groups. CONCLUSION: Symptoms of gastric small GISTs may mimic those of functional dyspepsia. An alternative diagnosis should be considered in patients with functional dyspepsia and treatment failure.展开更多
Objective: To study the tr eatment of postope rative gast ropa resis in pa ti ents with gast ric cancer. Methods: 18 patients with gast ropa resis afte r gast ric cance r sur gery were divided into two gr oups, includ...Objective: To study the tr eatment of postope rative gast ropa resis in pa ti ents with gast ric cancer. Methods: 18 patients with gast ropa resis afte r gast ric cance r sur gery were divided into two gr oups, including 10 pa ti ents in the obse rva tion group and 8 pati ents in the cont rol group. The observation group was treated with traditional Chinese medicine combined with warm acupuncture and moxibustion, and the control group was treated with western medicine. Results: After 7 days tr eatment, the re was significant diffe rence in cure r ate and total effective rate between the two groups (P < 0.01), and the treatment group was obviously superior to the control group. Conclusion: Traditional Chinese medicine combined with warm acupuncture is effective in the treatment of postoperative gastroparesis of gastric cancer.展开更多
目的:建立一种逆转录-实时定量PCR(R T-Q PCR)检测大鼠胃组织中胃泌素(Gast)和胃动素(Mln)m R N A表达的方法。方法:提取大鼠胃组织总RNA,逆转录合成c DNA,利用SYBRGreen荧光染料法实时检测Gast和Mlnm RNA的表达水平。通过溶解曲线分析...目的:建立一种逆转录-实时定量PCR(R T-Q PCR)检测大鼠胃组织中胃泌素(Gast)和胃动素(Mln)m R N A表达的方法。方法:提取大鼠胃组织总RNA,逆转录合成c DNA,利用SYBRGreen荧光染料法实时检测Gast和Mlnm RNA的表达水平。通过溶解曲线分析检测特异性,以管家基因β-actin为内参对Gast和Mln进行定量分析。结果:建立的大鼠Gast和Mlnm RNART-QPCR检测方法具有良好的特异性和敏感性。结论:成功建立RT-QPCR检测Gast和Mlnm RNA基因表达的方法。展开更多
A 4-mo history of both epigastralgia and back pain was presented in a 39-year-old male. Computed tomography showed right lung nodule and abdominal mass attached to the gastric wall, measuring approximately 30 mm and 7...A 4-mo history of both epigastralgia and back pain was presented in a 39-year-old male. Computed tomography showed right lung nodule and abdominal mass attached to the gastric wall, measuring approximately 30 mm and 70 mm in diameter. Since biopsy samples from the lung and abdomen revealed poorly differentiated adenocarcinoma and malignant tumor, clinicians first interpreted the abdominal mass as metastatic carcinoma, and a right lower lobectomy with following resection of the mass was performed. Gross examination of both lesions displayed gray-whitish to yellow-whitish cut surfaces with hemorrhagic and necrotic foci, and the mass attached to the serosa of the lesser curvature on the gastric body. On microscopic examination, the lung tumor was composed of a proliferation of highly atypical epithelial cells having abundant eosinophilic cytoplasm, predominantly arranged in an acinar or solid growth pattern with vessel permeation, while the abdominal tumor consisted of sheets or nests with markedly atypical epithelioid cells having pleomorphic nuclei and abundant eosinophilic to clear cytoplasm focally in a radial perivascular or infiltrative growth pattern. Immunohistochemically, the latter cells were positive for HMB45 or α-smooth muscle actin, but the former ones not. Therefore, we finally made a diagnosis of malignant perivascular epithelioid cell tumor(PEComa) arising in the gastric serosa, combined with primary lung adenocarcinoma. Furthermore, small papillary car-cinoma of the thyroid gland was identified. The current case describes the coincidence of malignant PEComa with other carcinomas, posing a challenge in distinction from metastatic tumor disease.展开更多
突发水污染事故后,高效准确模拟预测是快速采取有效防控措施和制定应急预案的基础。采用基于非均匀网格的图形处理器(graphics processing unit,GPU)加速的水动力及污染物输移数值模型(GPU accelerated surface water flow and associat...突发水污染事故后,高效准确模拟预测是快速采取有效防控措施和制定应急预案的基础。采用基于非均匀网格的图形处理器(graphics processing unit,GPU)加速的水动力及污染物输移数值模型(GPU accelerated surface water flow and associated transport,GAST)对暴雨山洪或溃坝洪水引起的突发水污染事故中污染物输移规律进行了模拟预测。模型采用Godunov格式的有限体积法求解二维浅水方程和污染物输移方程,采用一种基于HLLC(Harten-Lax-Van Leer-contact)的近似黎曼求解器计算单元网格界面通量,采用二阶高精度格式(monotonic upstream-centred scheme for conservation laws,MUSCL)限坡线性重建和龙格-库塔时间积分法实现了二阶精度,同时采用GPU加速计算技术提高模型计算效率。算例结果表明:采用非均匀网格技术局部细化地形复杂区域生成精细网格,地势平坦区域粗化网格,大幅度减少了计算域网格数量,并且在保证模拟精度的同时,提升了模型计算效率。该模型可高效准确地模拟突发水污染事件中污染物输移过程,适用于大规模水污染事故的快速预警和评估。展开更多
本文介绍了GBAS和其进近服务类型,详细介绍了基于GPS单频实现III类运行的GAST D GBAS技术概念框架,研究了地面设备完好性监测框架和播发电文以及机载设备新增算法和监测器设计.针对电离层异常对GBAS运行的影响,根据电离层梯度异常模型,...本文介绍了GBAS和其进近服务类型,详细介绍了基于GPS单频实现III类运行的GAST D GBAS技术概念框架,研究了地面设备完好性监测框架和播发电文以及机载设备新增算法和监测器设计.针对电离层异常对GBAS运行的影响,根据电离层梯度异常模型,模拟了故障场景,设计实现了GAST D地面和机载仿真验证平台,并对模拟的故障场景下GAST D GBAS系统进行验证和分析.展开更多
基金Supported by National Natural Science Foundation of China,No.81070283
文摘AIM: To explore whether clinical presentations of gastric small gastrointestinal tumors(GISTs) mimics gastrointestinal dyspepsia symptoms.METHODS: The endosonographic data of 167 patients who underwent endoscopic submucosal dissection at the Tianjin Medical University General Hospital, China between 2009 and 2011 were analyzed. GISTs and leiomyomas had a similar intragastric distribution and similar locations within the gastric wall. Therefore, patients with GISTs were chosen as the study group and those with leiomyomas were chosen as the control group. Dyspepsia symptom questionnaires were used to investigate and compare the gastrointestinal symptoms of patients with GISTs and those with gastric leiomyomas before and after endoscopic submucosal dissection(ESD). The questionnaires evaluated symptoms such as epigastric pain, heartburn, regurgitation, epigastric discomfort, nausea and vomiting, abdominal bloating, and eructation. Symptoms were assessed using a four-point scoring scale.RESULTS: GISTs were the most common gastric submucosal lesion(67 cases, 40.12%), followed by leiomyomas(38 cases, 22.75%). Both groups were similar in terms of gender distribution(P = 0.49), intragastric location(P = 0.525), and originating layer within the gastric wall(P = 0.449), but leiomyomas were more commonly found in the proximal fundus(P < 0.05). Overall, 94.2% of the patients with small GISTs and 93.5% of those with gastric leiomyomas experienced some dyspepsia; however, total symptom scores were significantly lower in the GIST group than in the leiomyoma group(1.34 ± 1.27 vs 2.20 ± 1.70, P < 0.05). Each component of the symptom score demonstrated a statistically significant improvement in the GIST patients after ESD(P < 0.05), including epigastric pain(0.80 ± 0.90 vs 0.13 ± 0.46), heartburn(0.63 ± 1.08 vs 0.13 ± 0.41), regurgitation(0.55 ± 0.87 vs 0.22 ± 0.57), epigastric discomfort(0.70 ± 0.98 vs 0.32 ± 0.47), nausea and vomiting(0.27 ± 0.62 vs 0.05 ± 0.21), abdominal bloating(0.70 ± 0.90 vs 0.27 ± 0.49), and eructation(0.36 ± 0.61 vs 0.21 ± 0.46). For leiomyoma patients, symptoms such as heartburn, nausea, vomiting, and eructation improved after treatment; however, these improvements were not statistically significant(P > 0.05). Thus, the pathophysiology of dyspepsia symptoms may be different between the two groups. CONCLUSION: Symptoms of gastric small GISTs may mimic those of functional dyspepsia. An alternative diagnosis should be considered in patients with functional dyspepsia and treatment failure.
文摘Objective: To study the tr eatment of postope rative gast ropa resis in pa ti ents with gast ric cancer. Methods: 18 patients with gast ropa resis afte r gast ric cance r sur gery were divided into two gr oups, including 10 pa ti ents in the obse rva tion group and 8 pati ents in the cont rol group. The observation group was treated with traditional Chinese medicine combined with warm acupuncture and moxibustion, and the control group was treated with western medicine. Results: After 7 days tr eatment, the re was significant diffe rence in cure r ate and total effective rate between the two groups (P < 0.01), and the treatment group was obviously superior to the control group. Conclusion: Traditional Chinese medicine combined with warm acupuncture is effective in the treatment of postoperative gastroparesis of gastric cancer.
文摘目的:建立一种逆转录-实时定量PCR(R T-Q PCR)检测大鼠胃组织中胃泌素(Gast)和胃动素(Mln)m R N A表达的方法。方法:提取大鼠胃组织总RNA,逆转录合成c DNA,利用SYBRGreen荧光染料法实时检测Gast和Mlnm RNA的表达水平。通过溶解曲线分析检测特异性,以管家基因β-actin为内参对Gast和Mln进行定量分析。结果:建立的大鼠Gast和Mlnm RNART-QPCR检测方法具有良好的特异性和敏感性。结论:成功建立RT-QPCR检测Gast和Mlnm RNA基因表达的方法。
文摘A 4-mo history of both epigastralgia and back pain was presented in a 39-year-old male. Computed tomography showed right lung nodule and abdominal mass attached to the gastric wall, measuring approximately 30 mm and 70 mm in diameter. Since biopsy samples from the lung and abdomen revealed poorly differentiated adenocarcinoma and malignant tumor, clinicians first interpreted the abdominal mass as metastatic carcinoma, and a right lower lobectomy with following resection of the mass was performed. Gross examination of both lesions displayed gray-whitish to yellow-whitish cut surfaces with hemorrhagic and necrotic foci, and the mass attached to the serosa of the lesser curvature on the gastric body. On microscopic examination, the lung tumor was composed of a proliferation of highly atypical epithelial cells having abundant eosinophilic cytoplasm, predominantly arranged in an acinar or solid growth pattern with vessel permeation, while the abdominal tumor consisted of sheets or nests with markedly atypical epithelioid cells having pleomorphic nuclei and abundant eosinophilic to clear cytoplasm focally in a radial perivascular or infiltrative growth pattern. Immunohistochemically, the latter cells were positive for HMB45 or α-smooth muscle actin, but the former ones not. Therefore, we finally made a diagnosis of malignant perivascular epithelioid cell tumor(PEComa) arising in the gastric serosa, combined with primary lung adenocarcinoma. Furthermore, small papillary car-cinoma of the thyroid gland was identified. The current case describes the coincidence of malignant PEComa with other carcinomas, posing a challenge in distinction from metastatic tumor disease.
文摘本文介绍了GBAS和其进近服务类型,详细介绍了基于GPS单频实现III类运行的GAST D GBAS技术概念框架,研究了地面设备完好性监测框架和播发电文以及机载设备新增算法和监测器设计.针对电离层异常对GBAS运行的影响,根据电离层梯度异常模型,模拟了故障场景,设计实现了GAST D地面和机载仿真验证平台,并对模拟的故障场景下GAST D GBAS系统进行验证和分析.
