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Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways
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作者 Zhiwen Yang Zongyan Yu Bo Xiao 《Neuroscience Bulletin》 SCIE CAS CSCD 2023年第3期453-465,共13页
Myelin-forming oligodendrocytes in the central nervous system(CNS)and Schwann cells in the peripheral nervous system(PNS)are essential for structural and functional homeostasis of nervous tissue.Albeit with certain si... Myelin-forming oligodendrocytes in the central nervous system(CNS)and Schwann cells in the peripheral nervous system(PNS)are essential for structural and functional homeostasis of nervous tissue.Albeit with certain similarities,the regulation of CNS and PNS myelination is executed differently.Recent advances highlight the coordinated regulation of oligodendrocyte myelination by amino-acid sensing and growth factor signaling pathways.In this review,we discuss novel insights into the understanding of differential regulation of oligodendrocyte and Schwann cell biology in CNS and PNS myelination,with particular focus on the roles of growth factor-stimulated RHEB-mTORC1 and GATOR2-mediated amino-acid sensing/signaling pathways.We also discuss recent progress on the metabolic regulation of oligodendrocytes and Schwann cells and the impact of their dysfunction on neuronal function and disease. 展开更多
关键词 OLIGODENDROCYTE Schwann cell MYELINATION RHEB mTORC1 MIOS gator2 mitochondria LACTATE
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