目的探讨乳腺Paget病(m emm ary paget’s d isease,MPD)和乳腺外Paget病(extram amm ary paget’s d isease,EMPD)的临床病理特征及其诊断。方法对61例Paget病(Paget’s d isease,PD)进行形态学观察、AB/PAS组化染色及免疫组化检测。...目的探讨乳腺Paget病(m emm ary paget’s d isease,MPD)和乳腺外Paget病(extram amm ary paget’s d isease,EMPD)的临床病理特征及其诊断。方法对61例Paget病(Paget’s d isease,PD)进行形态学观察、AB/PAS组化染色及免疫组化检测。结果①EMPD细胞具有独特的排列方式和细胞形态,MPD细胞形态与伴发的BC细胞类似。②GCDFP-15、Muc-1及CK8在MPD中的阳性表达率分别为2%(1/50)、92%(46/50)及88%(44/50),在EMPD中的阳性表达率分别为18%(2/11)、36%(4/11)及81%(9/11)。结论PD是表皮内的腺癌,可分为原发与继发两类,原发性PD细胞可分为大汗腺样、皮脂腺样、黏液型及混合细胞型,诊断应排除病变周围原发性腺癌的存在;继发性PD大多来自深部相关肿瘤。展开更多
Breast cancer with stomach metastasis rare with an incidence of 1% or less among metastatic breast cancer patients. We experienced a case of breast cancer metastasizing to the stomach in 65-year-old female patient. Sh...Breast cancer with stomach metastasis rare with an incidence of 1% or less among metastatic breast cancer patients. We experienced a case of breast cancer metastasizing to the stomach in 65-year-old female patient. She experienced dyspepsia and poor oral intake before visiting the clinic. Diffuse infiltration with nodular mucosal thickening of the stomach wall was observed, suggesting advanced gastric cancer based on gross endoscopic finding. Spread of poorly cohesive tumor cells in the gastric mucosa observed upon hematoxylin and eosin stain resembled signet ring cell carcinoma, but diffuse positive staining for GATA3 in immunohistochemical stain allowed for a conclusive diagnosis of breast cancer metastasizing to the stomach. Based on the final diagnosis, systemic chemotherapy was administered instead of primary surgical resection. After 2 cycles of docetaxel administration, she showed a partial response based on abdominal computed tomography scan. This case is an unusual presentation of breast cancer metastasizing to the gastrointestinal tract.展开更多
文摘目的探讨乳腺Paget病(m emm ary paget’s d isease,MPD)和乳腺外Paget病(extram amm ary paget’s d isease,EMPD)的临床病理特征及其诊断。方法对61例Paget病(Paget’s d isease,PD)进行形态学观察、AB/PAS组化染色及免疫组化检测。结果①EMPD细胞具有独特的排列方式和细胞形态,MPD细胞形态与伴发的BC细胞类似。②GCDFP-15、Muc-1及CK8在MPD中的阳性表达率分别为2%(1/50)、92%(46/50)及88%(44/50),在EMPD中的阳性表达率分别为18%(2/11)、36%(4/11)及81%(9/11)。结论PD是表皮内的腺癌,可分为原发与继发两类,原发性PD细胞可分为大汗腺样、皮脂腺样、黏液型及混合细胞型,诊断应排除病变周围原发性腺癌的存在;继发性PD大多来自深部相关肿瘤。
文摘Breast cancer with stomach metastasis rare with an incidence of 1% or less among metastatic breast cancer patients. We experienced a case of breast cancer metastasizing to the stomach in 65-year-old female patient. She experienced dyspepsia and poor oral intake before visiting the clinic. Diffuse infiltration with nodular mucosal thickening of the stomach wall was observed, suggesting advanced gastric cancer based on gross endoscopic finding. Spread of poorly cohesive tumor cells in the gastric mucosa observed upon hematoxylin and eosin stain resembled signet ring cell carcinoma, but diffuse positive staining for GATA3 in immunohistochemical stain allowed for a conclusive diagnosis of breast cancer metastasizing to the stomach. Based on the final diagnosis, systemic chemotherapy was administered instead of primary surgical resection. After 2 cycles of docetaxel administration, she showed a partial response based on abdominal computed tomography scan. This case is an unusual presentation of breast cancer metastasizing to the gastrointestinal tract.
