Three novel gem-dimethyl C-glucosides were designed as sodium-glucose co-transporter 2 （SGLT2） inhibitors, and their syntheses started from D-glucose and three 2-substituted-5-bromobenzoic acids were achieved via a ...Three novel gem-dimethyl C-glucosides were designed as sodium-glucose co-transporter 2 （SGLT2） inhibitors, and their syntheses started from D-glucose and three 2-substituted-5-bromobenzoic acids were achieved via a facile 8-step protocol, with the key step being anhydrous aluminum chloride-catalyzed Friedel-Crafts alkylation of tertiary alcohols and phenetol. These three SGLT2 inhibitors were evaluated in vivo with a mice oral glucose tolerance test （OGTT）, and the anti-hyperglycemic activities of all these three compounds were comparable with that of the positive control Dapagliflozin.展开更多
Seventeen novel gem-difluoromethylene-containing 1,2,3-triazoles were synthesized by the click reaction of ethyl 2-azido-2,2-difluoroacetate and terminal alkynes in the presence of 10 mol% CuI.
为研究气候和土地利用变化情况下岩溶碳汇通量的演变趋势及响应,基于CO_(2)通量全球侵蚀模型(global erosion model for CO_(2)fluxes,GEM-CO_(2))计算2000—2020年恩施州岩溶碳汇通量的时空动态变化,并分析气候和土地利用变化对岩溶碳...为研究气候和土地利用变化情况下岩溶碳汇通量的演变趋势及响应,基于CO_(2)通量全球侵蚀模型(global erosion model for CO_(2)fluxes,GEM-CO_(2))计算2000—2020年恩施州岩溶碳汇通量的时空动态变化,并分析气候和土地利用变化对岩溶碳汇通量的影响。结果表明:2000—2020年恩施州岩溶碳汇通量时空变化差异明显,在时间上呈现稳步上升的趋势,在空间上呈现“南高北低”的分布格局,岩溶碳汇通量多年平均值为3.87×10^(5) t/a;降水量与岩溶碳汇通量的变化为正相关,蒸发量与岩溶碳汇通量的变化为负相关;岩溶碳汇通量对不同时期土地利用变化的响应有所不同。该研究证实了碳酸盐岩风化作用所消耗的CO_(2)参与了全球碳循环,同时可为土地合理利用和固碳增汇措施的实施提供科学依据。展开更多
文摘Three novel gem-dimethyl C-glucosides were designed as sodium-glucose co-transporter 2 （SGLT2） inhibitors, and their syntheses started from D-glucose and three 2-substituted-5-bromobenzoic acids were achieved via a facile 8-step protocol, with the key step being anhydrous aluminum chloride-catalyzed Friedel-Crafts alkylation of tertiary alcohols and phenetol. These three SGLT2 inhibitors were evaluated in vivo with a mice oral glucose tolerance test （OGTT）, and the anti-hyperglycemic activities of all these three compounds were comparable with that of the positive control Dapagliflozin.
基金Project supported by the National Natural Science Foundation of China （No. 21072057）, the Key Project in the National Science ＆ Technology Pillar Program of China in the Twelfth Five-year Plan Period （No. 2011BAE06B05）, and the Shanghai Leading Academic Discipline Project （No. B507）.
文摘Seventeen novel gem-difluoromethylene-containing 1,2,3-triazoles were synthesized by the click reaction of ethyl 2-azido-2,2-difluoroacetate and terminal alkynes in the presence of 10 mol% CuI.
文摘为研究气候和土地利用变化情况下岩溶碳汇通量的演变趋势及响应,基于CO_(2)通量全球侵蚀模型(global erosion model for CO_(2)fluxes,GEM-CO_(2))计算2000—2020年恩施州岩溶碳汇通量的时空动态变化,并分析气候和土地利用变化对岩溶碳汇通量的影响。结果表明:2000—2020年恩施州岩溶碳汇通量时空变化差异明显,在时间上呈现稳步上升的趋势,在空间上呈现“南高北低”的分布格局,岩溶碳汇通量多年平均值为3.87×10^(5) t/a;降水量与岩溶碳汇通量的变化为正相关,蒸发量与岩溶碳汇通量的变化为负相关;岩溶碳汇通量对不同时期土地利用变化的响应有所不同。该研究证实了碳酸盐岩风化作用所消耗的CO_(2)参与了全球碳循环,同时可为土地合理利用和固碳增汇措施的实施提供科学依据。
