Soil erosion has been recognized as a critical environmental issue worldwide.While previous studies have primarily focused on watershed-scale soil erosion vulnerability from a natural factor perspective,there is a not...Soil erosion has been recognized as a critical environmental issue worldwide.While previous studies have primarily focused on watershed-scale soil erosion vulnerability from a natural factor perspective,there is a notable gap in understanding the intricate interplay between natural and socio-economic factors,especially in the context of spatial heterogeneity and nonlinear impacts of human-land interactions.To address this,our study evaluates the soil erosion vulnerability at a provincial scale,taking Hubei Province as a case study to explore the combined effects of natural and socio-economic factors.We developed an evaluation index system based on 15 indicators of soil erosion vulnerability:exposure,sensitivity,and adaptability.In addition,the combination weighting method was applied to determine index weights,and the spatial interaction was analyzed using spatial autocorrelation,geographical temporally weighted regression and geographical detector.The results showed an overall decreasing soil erosion intensity in Hubei Province during 2000 and 2020.The soil erosion vulnerability increased before 2000 and then.The areas with high soil erosion vulnerability were mainly confined in the central and southern regions of Hubei Province(Xiantao,Tianmen,Qianjiang and Ezhou)with obvious spatial aggregation that intensified over time.Natural factors(habitat quality index)had negative impacts on soil erosion vulnerability,whereas socio-economic factors(population density)showed substantial spatial variability in their influences.There was a positive correlation between soil erosion vulnerability and erosion intensity,with the correlation coefficients ranging from-0.41 and 0.93.The increase of slope was found to enhance the positive correlation between soil erosion vulnerability and intensity.展开更多
To improve the accuracy and speed in cycle-accurate power estimation, this paper uses multiple dimensional coefficients to build a Bayesian inference dynamic power model. By analyzing the power distribution and intern...To improve the accuracy and speed in cycle-accurate power estimation, this paper uses multiple dimensional coefficients to build a Bayesian inference dynamic power model. By analyzing the power distribution and internal node state, we find the deficiency of only using port information. Then, we define the gate level number computing method and the concept of slice, and propose using slice analysis to distill switching density as coefficients in a special circuit stage and participate in Bayesian inference with port information. Experiments show that this method can reduce the power-per-cycle estimation error by 21.9% and the root mean square error by 25.0% compared with the original model, and maintain a 700 + speedup compared with the existing gate-level power analysis technique.展开更多
This study proposes a combined hybrid energy storage system(HESS) and transmission grid(TG) model, and a corresponding time series operation simulation(TSOS) model is established to relieve the peak-shaving pressure o...This study proposes a combined hybrid energy storage system(HESS) and transmission grid(TG) model, and a corresponding time series operation simulation(TSOS) model is established to relieve the peak-shaving pressure of power systems under the integration of renewable energy. First, a linear model for the optimal operation of the HESS is established, which considers the different power-efficiency characteristics of the pumped storage system, electrochemical storage system, and a new type of liquid compressed air energy storage. Second, a TSOS simulation model for peak shaving is built to maximize the power entering the grid from the wind farms and HESS. Based on the proposed model, this study considers the transmission capacity of a TG. By adding the power-flow constraints of the TG, a TSOS-based HESS and TG combination model for peak shaving is established. Finally, the improved IEEE-39 and IEEE-118 bus systems were considered as examples to verify the effectiveness and feasibility of the proposed model.展开更多
Ensuring a sufficient energy supply is essential to a country. Natural gas constitutes a vital part in energy supply and therefore forecasting natural gas consumption reliably and accurately is an essential part of a ...Ensuring a sufficient energy supply is essential to a country. Natural gas constitutes a vital part in energy supply and therefore forecasting natural gas consumption reliably and accurately is an essential part of a country's energy policy. Over the years, studies have shown that a combinative model gives better projected results compared to a single model. In this study, we used Polynomial Curve and Moving Average Combination Projection (PCMACP) model to estimate the future natural gas consumption in China from 2009 to 2015. The new proposed PCMACP model shows more reliable and accurate results: its Mean Absolute Percentage Error (MAPE) is less than those of any previous models within the investigated range. According to the PCMACP model, the average annual growth rate will increase for the next 7 years and the amount of natural gas consumption will reach 171600 million cubic meters in 2015 in China.展开更多
In this paper, a new spatial coherence model of seismic ground motions is proposed by a fitting procedure. The analytical expressions of modal combination (correlation) coefficients of structural response are develo...In this paper, a new spatial coherence model of seismic ground motions is proposed by a fitting procedure. The analytical expressions of modal combination (correlation) coefficients of structural response are developed for multi-support seismic excitations. The coefficients from both the numerical integration and analytical solutions are compared to verify the accuracy of the solutions. It is shown that the analytical expressions of numerical modal combination coefficients are of high accuracy. The results of random responses of an example bridge show that the analytical modal combination coefficients developed in this paper are accurate enough to meet the requirements needed in practice. In addition, the computational efficiency of the analytical solutions of the modal combination coefficients is demonstrated by the response computation of the example bridge. It is found that the time required for the structural response analysis by using the analytical modal combination coefficients is less than 1/20 of that using numerical integral methods.展开更多
Post-construction settlement has gained increasing attention because it frequently causes engineering problems. A combined model is a commonly used prediction model that overcomes the difficulty of a single model( i. ...Post-construction settlement has gained increasing attention because it frequently causes engineering problems. A combined model is a commonly used prediction model that overcomes the difficulty of a single model( i. e., cannot reflect various regulations of settlement at some stages or the entire process). In this study,the correlation coefficient,maximum error values,and other values were obtained according to the fitting and predicted results of a single model. The coefficient of variation was then introduced to determine the weight of each model forming the combination. The proposed model was used to fit and predict for settlement and overcome the issue of utilizing a single model while determining the weight. The fitting predictive effect was also analyzed using the settlement fitting precision results. The fitting precision of optimizing the combination model is high. The predicted data of the post-construction settlement are closer to the calculated value of the settlement monitoring data. Moreover,the proposed model has good practicability,does not require the interval data of settlement,and restricts the model number. Thus,this model can be applied in the engineering field.展开更多
As an important factor in evaluating service,QoS(Quality of Service) has drawn more and more concerns with the rapid increasing of Web services. However,due to the great volatility of services in Mobile Internet envir...As an important factor in evaluating service,QoS(Quality of Service) has drawn more and more concerns with the rapid increasing of Web services. However,due to the great volatility of services in Mobile Internet environments,such as internet of vehicles,Web services often do not work as announced and thus cause unacceptable problems. QoS prediction can avoid failure before it takes place,which is considered a more effective way to assure quality. However,Current QoS prediction approaches neither consider the highly dynamic of Web services,nor maintain good prediction performance all the time. Consequently we propose a novel Bayesian combinational model to predict QoS by continuously adjusting credit values of the basic models so as to keep good prediction accuracy. QoS attributes such as response time,throughput and reliability are used to validate the proposed model. Experimental results show that the model can provide stable prediction results in Mobile Internet environments.展开更多
Existing“evaluation indicators”are selected and combined to build a model to support the optimization of shale gas horizontal wells.Towards this end,different“weighting methods”,including AHP and the so-called ent...Existing“evaluation indicators”are selected and combined to build a model to support the optimization of shale gas horizontal wells.Towards this end,different“weighting methods”,including AHP and the so-called entropy method,are combined in the frame of the game theory.Using a relevant test case for the implementation of the model,it is shown that the horizontal section of the considered well is in the middle sweet spot area with good physical properties and fracturing ability.In comparison with the FSI(flow scanner Image)gas production profile,the new model seems to display better abilities for the optimization of horizontal wells.展开更多
BACKGROUND Acetaminophen overdose is the most frequent cause of drug-induced liver failure in developed countries.Substantial progress has been made in understanding the mechanism of hepatocellular injury,but N-acetyl...BACKGROUND Acetaminophen overdose is the most frequent cause of drug-induced liver failure in developed countries.Substantial progress has been made in understanding the mechanism of hepatocellular injury,but N-acetylcysteine remains the only effective treatment despite its short therapeutic window.Thus,other hepatoprotective drugs are needed for the delayed treatment of acetaminopheninduced hepatotoxicity.Our interest focused on glycyrrhizin for its role as an inhibitor of high mobility group box 1(HMGB1)protein,a member of the family of damage-associated molecular pattern,known to play an important pathological role in various diseases.AIM To investigate the efficacy of the N-acetylcysteine/glycyrrhizin combination compared to N-acetylcysteine alone in the prevention of liver toxicity.METHODS Eight-week-old C57BL/6J wild-type female mice were used for all our experiments.Mice fasted for 15 h were treated with acetaminophen(500 mg/kg)or vehicle(phosphate-buffered saline)by intraperitoneal injection and separated into the following groups:Glycyrrhizin(200 mg/kg);N-acetylcysteine(150 mg/kg);and N-acetylcysteine/glycyrrhizin.In all groups,mice were sacrificed 12 h following acetaminophen administration.The assessment of hepatotoxicity was performed by measuring plasma levels of alanine aminotransferase,aspartate aminotransferase and lactate dehydrogenase.Hepatotoxicity was also evaluated by histological examination of hematoxylin and eosin-stained tissues sections.Survival rates were compared between various groups using Kaplan-Meier curves.RESULTS Consistent with data published in the literature,we confirmed that intraperitoneal administration of acetaminophen(500 mg/kg)in mice induced severe liver injury as evidenced by increases in alanine aminotransferase,aspartate aminotransferase and lactate dehydrogenase but also by liver necrosis score.Glycyrrhizin administration was shown to reduce the release of HMGB1 and significantly decreased the severity of liver injury.Thus,the co-administration of glycyrrhizin and N-acetylcysteine was investigated.Administered concomitantly with acetaminophen,the combination significantly reduced the severity of liver injury.Delayed administration of the combination of drugs,2 h or 6 h after acetaminophen,also induced a significant decrease in hepatocyte necrosis compared to mice treated with N-acetylcysteine alone.In addition,administration of N-acetylcysteine/glycyrrhizin combination was associated with an improved survival rate compared to mice treated with only N-acetylcysteine.CONCLUSION We demonstrate that,compared to N-acetylcysteine alone,co-administration of glycyrrhizin decreases the liver necrosis score and improves survival in a murine model of acetaminophen-induced liver injury.Our study opens a potential new therapeutic pathway in the prevention of acetaminophen hepatotoxicity.展开更多
Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in undergroun...Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in underground engineering.To reveal the effect of this way,the uniaxial compression experiments with PSC monitoring were conducted on three types of coal-rock combination samples with different strength combinations.The mechanism explanation of PSCs are investigated by resistivity test,atomic force microscopy(AFM)and computed tomography(CT)methods,and a PSC flow model based on progressive failure process is proposed.The influence of strength combinations on PSCs in the progressive failure process are emphasized.The results show the PSC responses between rock part,coal part and the two components are different,which are affected by multi-scale fracture characteristics and electrical properties.As the rock strength decreases,the progressive failure process changes obviously with the influence range of interface constraint effect decreasing,resulting in the different responses of PSC strength and direction in different parts to fracture behaviors.The PSC flow model is initially validated by the relationship between the accumulated charges of different parts.The results are expected to provide a new reference and method for mining design and roadway quality assessment.展开更多
This study focused on the mechanical behavior of a deep-buried tunnel constructed in horizontally layered limestone,and investigated the effect of a new combined rockboltecable support system on the tunnel response.Th...This study focused on the mechanical behavior of a deep-buried tunnel constructed in horizontally layered limestone,and investigated the effect of a new combined rockboltecable support system on the tunnel response.The Yujingshan Tunnel,excavated through a giant karst cave,was used as a case study.Firstly,a multi-objective optimization model for the rockboltecable support was proposed by using fuzzy mathematics and multi-objective comprehensive decision-making principles.Subsequently,the parameters of the surrounding rock were calibrated by comparing the simulation results obtained by the discrete element method(DEM)with the field monitoring data to obtain an optimized support scheme based on the optimization model.Finally,the optimization scheme was applied to the karst cave section,which was divided into the B-and C-shaped sections.The distribution range of the rockboltecable support in the C-shaped section was larger than that in the B-shaped section.The field monitoring results,including tunnel crown settlement,horizontal convergence,and axial force of the rockboltecable system,were analyzed to assess the effectiveness of the optimization scheme.The maximum crown settlement and horizontal convergence were measured to be 25.9 mm and 35 mm,accounting for 0.1%and 0.2%of the tunnel height and span,respectively.Although the C-shaped section had poorer rock properties than the B-shaped section,the crown settlement and horizontal convergence in the C-shaped section ranged from 46%to 97%of those observed in the B-shaped section.The cable axial force in the Bshaped section was approximately 60%of that in the C-shaped section.The axial force in the crown rockbolt was much smaller than that in the sidewall rockbolt.Field monitoring results demonstrated that the optimized scheme effectively controlled the deformation of the layered surrounding rock,ensuring that it remained within a safe range.These results provide valuable references for the design of support systems in deep-buried tunnels situated in layered rock masses.展开更多
BACKGROUND: In localized brain proton magnetic resonance spectroscopy (^1H-MRS), metabolite levels are often expressed as ratios, rather than absolute concentrations. Frequently, the denominator is creatine, which ...BACKGROUND: In localized brain proton magnetic resonance spectroscopy (^1H-MRS), metabolite levels are often expressed as ratios, rather than absolute concentrations. Frequently, the denominator is creatine, which is assumed to be stable in normal, as well as many pathological, states. However, in vivo creatine levels do not remain constant. Therefore, absolute metabolite measurements, which provide the precise concentrations of certain chemical compounds, are superior to metabolite ratios for determining pathological and evolutional changes. OBJECTIVE: To investigate the feasibility of quantification analysis of brain metabolite changes caused by central analgesics nasal spray using the ^1H-MRS and linear combination model (LCModel) methods. DESIGN, TIME AND SETTING: This neuroimaging, observational, animal study was performed at the Laboratory of the Department of Medical Imaging, Second Affiliated Hospital, Medical College, Shantou University, China from July to December 2007. MATERIALS: Butorphanol tartrate nasal spray, as a mixed agonist-antagonist opioid analgesic, was purchased from Shanghai Hengrui Pharmacy, China. A General Electric Signa 1.5T System (General Electric Medical Systems, Milwaukee, WI, USA) and LCModel software (Stephen Provencher, Oakville, Ontario, Canada) were used in this study. METHODS: MRS images were acquired in ten healthy swine aged 2 weeks using single-voxel point-resolved spectroscopic sequence. A region of interest (2 cm × 2 cm × 2 cm) was placed in the image centers of maximum brain parenchyma. Repeated MRS scanning was performed 15-20 minutes after intranasal administration of 1 mg of butorphanol tartrate. Three settings of repetition time/echo time were selected before and after nasal spray administration 3 000 ms/30 ms,1 500 ms/30 ms, and 3 000 ms/50 ms. Metabolite concentrations were estimated by LCModel software. MAIN OUTCOME MEASURES: ^1H-MRS spectra was obtained using various repetition time/echo time settings. Concentrations of glutamate compounds (glutamate + glutamine), N-acetyl aspartate, and choline were detected in swine brain prior to and following nasal spray treatment. RESULTS: The glutamate compounds curve was consistent with original spectra, when a repetition time/echo time of 3 000 ms/30 ms was adopted. Concentrations of glutamate compounds, N-acetyl aspartate, and choline decreased following administration. The most significant reduction was observed in glutamate compound concentrations from (9.28 ± 0.54) mmol/kg to (7.28 ± 0.54) mmol/kg (P 〈 0.05). CONCLUSION: ^1H-MRS and LCModel software were effectively utilized to quantitatively analyze and measure brain metabolites. Glutamate compounds might be an important neurotransmitter in central analgesia.展开更多
Resources are the base and core of education information, but current web education resources have no structure and it is still difficult to reuse them and make them can be self assembled and developed continually. Ac...Resources are the base and core of education information, but current web education resources have no structure and it is still difficult to reuse them and make them can be self assembled and developed continually. According to the knowledge structure of course and text, the relation among knowledge points, knowledge units from three levels of media material, we can build education resource components, and build TKCM (Teaching Knowledge Combination Model) based on resource components. Builders can build and assemble knowledge system structure and make knowledge units can be self assembled, thus we can develop and consummate them continually. Users can make knowledge units can be self assembled and renewed, and build education knowledge system to satisfy users' demand under the form of education knowledge system.展开更多
As the acceleration of aged population tendency, building models to forecast Alzheimer’s Disease (AD) is essential. In this article, we surveyed 1157 interviewees. By analyzing the results using three machine learnin...As the acceleration of aged population tendency, building models to forecast Alzheimer’s Disease (AD) is essential. In this article, we surveyed 1157 interviewees. By analyzing the results using three machine learning methods—BP neural network, SVM and random forest, we can derive the accuracy of them in forecasting AD, so that we can compare the methods in solving AD prediction. Among them, random forest is the most accurate method. Moreover, to combine the advantages of the methods, we build a new combination forecasting model based on the three machine learning models, which is proved more accurate than the models singly. At last, we give the conclusion of the connection between life style and AD, and provide several suggestions for elderly people to help them prevent AD.展开更多
The mixed model of improved exponential and power function and unequal interval gray GM(1,1)model have poor accuracy in predicting the maximum pull-out load of anchor bolts.An optimal combination model was derived usi...The mixed model of improved exponential and power function and unequal interval gray GM(1,1)model have poor accuracy in predicting the maximum pull-out load of anchor bolts.An optimal combination model was derived using the optimally weighted combination theory and the minimum sum of logarithmic squared errors as the objective function.Two typical anchor bolt pull-out engineering cases were selected to compare the performance of the proposed model with those of existing ones.Results showed that the optimal combination model was suitable not only for the slow P-s curve but also for the steep P-s curve.Its accuracy and stable reliability,as well as its prediction capability classification,were better than those of the other prediction models.Therefore,the optimal combination model is an effective processing method for predicting the maximum pull-out load of anchor bolts according to measured data.展开更多
To solve the medium and long term power load forecasting problem,the combination forecasting method is further expanded and a weighted combination forecasting model for power load is put forward.This model is divided ...To solve the medium and long term power load forecasting problem,the combination forecasting method is further expanded and a weighted combination forecasting model for power load is put forward.This model is divided into two stages which are forecasting model selection and weighted combination forecasting.Based on Markov chain conversion and cloud model,the forecasting model selection is implanted and several outstanding models are selected for the combination forecasting.For the weighted combination forecasting,a fuzzy scale joint evaluation method is proposed to determine the weight of selected forecasting model.The percentage error and mean absolute percentage error of weighted combination forecasting result of the power consumption in a certain area of China are 0.7439%and 0.3198%,respectively,while the maximum values of these two indexes of single forecasting models are 5.2278%and 1.9497%.It shows that the forecasting indexes of proposed model are improved significantly compared with the single forecasting models.展开更多
[Objective] Analysis of combining ability of starch content variation in hybrid sorghum with the assistant of AMMI model. [Method] Based on the analyses of GCA using incomplete diallel cross(NCII), the SCA of hybrid s...[Objective] Analysis of combining ability of starch content variation in hybrid sorghum with the assistant of AMMI model. [Method] Based on the analyses of GCA using incomplete diallel cross(NCII), the SCA of hybrid sorghum was analyzed by AMMI model. [Result] For the starch content change of F1 hybrid sorghum, the effects of GCA and SCA accounted for 81.06% and 17.97%, respectively. In the present study, CMS lines 45A, 29A and restorer lines Hui 1, 44R were proved to be the excellent parent materials for preparing high starch hybrid sorghum cultivars. [Conclusion] The improvement of starch content in parents should be mainly concerned in breeding high starch content hybrid sorghum.展开更多
This paper analyzes the characteristics of the destination distribution of trips and proposes a stratified sampling strategy for travel mode choice.The stratified sampling strategy can reduce the size of the alternati...This paper analyzes the characteristics of the destination distribution of trips and proposes a stratified sampling strategy for travel mode choice.The stratified sampling strategy can reduce the size of the alternative set;thus,the computation burden of simulation is decreased.Using the stratified sampling strategy,a combined choice model of the trip mode and destination is developed based on the Bayesian theory.Simulations are carried out to verify the proposed model.The results show that the combined choice model of the trip mode and destination can efficiently simulate travelers' choice behaviors.Furthermore,the forecasting accuracy of the combined choice model is higher than the one of the gravity model.Therefore,the proposed model is a powerful tool with which to analyze travelers' behaviors in selecting the trip mode.展开更多
This paper briefs the configuration and performance of large size gas turbines and their composed combined cycle power plants designed and produced by four large renown gas turbine manufacturing firms in the world, pr...This paper briefs the configuration and performance of large size gas turbines and their composed combined cycle power plants designed and produced by four large renown gas turbine manufacturing firms in the world, providing reference for the relevant sectors and enterprises in importing advanced gas turbines and technologies.展开更多
基金supported by the National Natural Science Foundation of China(42377354)the Natural Science Foundation of Hubei province(2024AFB951)the Chunhui Plan Cooperation Research Project of the Chinese Ministry of Education(202200199).
文摘Soil erosion has been recognized as a critical environmental issue worldwide.While previous studies have primarily focused on watershed-scale soil erosion vulnerability from a natural factor perspective,there is a notable gap in understanding the intricate interplay between natural and socio-economic factors,especially in the context of spatial heterogeneity and nonlinear impacts of human-land interactions.To address this,our study evaluates the soil erosion vulnerability at a provincial scale,taking Hubei Province as a case study to explore the combined effects of natural and socio-economic factors.We developed an evaluation index system based on 15 indicators of soil erosion vulnerability:exposure,sensitivity,and adaptability.In addition,the combination weighting method was applied to determine index weights,and the spatial interaction was analyzed using spatial autocorrelation,geographical temporally weighted regression and geographical detector.The results showed an overall decreasing soil erosion intensity in Hubei Province during 2000 and 2020.The soil erosion vulnerability increased before 2000 and then.The areas with high soil erosion vulnerability were mainly confined in the central and southern regions of Hubei Province(Xiantao,Tianmen,Qianjiang and Ezhou)with obvious spatial aggregation that intensified over time.Natural factors(habitat quality index)had negative impacts on soil erosion vulnerability,whereas socio-economic factors(population density)showed substantial spatial variability in their influences.There was a positive correlation between soil erosion vulnerability and erosion intensity,with the correlation coefficients ranging from-0.41 and 0.93.The increase of slope was found to enhance the positive correlation between soil erosion vulnerability and intensity.
文摘To improve the accuracy and speed in cycle-accurate power estimation, this paper uses multiple dimensional coefficients to build a Bayesian inference dynamic power model. By analyzing the power distribution and internal node state, we find the deficiency of only using port information. Then, we define the gate level number computing method and the concept of slice, and propose using slice analysis to distill switching density as coefficients in a special circuit stage and participate in Bayesian inference with port information. Experiments show that this method can reduce the power-per-cycle estimation error by 21.9% and the root mean square error by 25.0% compared with the original model, and maintain a 700 + speedup compared with the existing gate-level power analysis technique.
基金supported by the State Grid Science and Technology Project (No.52999821N004)。
文摘This study proposes a combined hybrid energy storage system(HESS) and transmission grid(TG) model, and a corresponding time series operation simulation(TSOS) model is established to relieve the peak-shaving pressure of power systems under the integration of renewable energy. First, a linear model for the optimal operation of the HESS is established, which considers the different power-efficiency characteristics of the pumped storage system, electrochemical storage system, and a new type of liquid compressed air energy storage. Second, a TSOS simulation model for peak shaving is built to maximize the power entering the grid from the wind farms and HESS. Based on the proposed model, this study considers the transmission capacity of a TG. By adding the power-flow constraints of the TG, a TSOS-based HESS and TG combination model for peak shaving is established. Finally, the improved IEEE-39 and IEEE-118 bus systems were considered as examples to verify the effectiveness and feasibility of the proposed model.
基金supported by the Youth Fund of Chinese Academy of Sciences Knowledge Innovation Program area frontier projects (No. S200603)the Innovation Team Project of Education Department of Liaoning Province (No. 2007T050)
文摘Ensuring a sufficient energy supply is essential to a country. Natural gas constitutes a vital part in energy supply and therefore forecasting natural gas consumption reliably and accurately is an essential part of a country's energy policy. Over the years, studies have shown that a combinative model gives better projected results compared to a single model. In this study, we used Polynomial Curve and Moving Average Combination Projection (PCMACP) model to estimate the future natural gas consumption in China from 2009 to 2015. The new proposed PCMACP model shows more reliable and accurate results: its Mean Absolute Percentage Error (MAPE) is less than those of any previous models within the investigated range. According to the PCMACP model, the average annual growth rate will increase for the next 7 years and the amount of natural gas consumption will reach 171600 million cubic meters in 2015 in China.
基金National Natural Science Foundation of China Under Grant No. 50478112
文摘In this paper, a new spatial coherence model of seismic ground motions is proposed by a fitting procedure. The analytical expressions of modal combination (correlation) coefficients of structural response are developed for multi-support seismic excitations. The coefficients from both the numerical integration and analytical solutions are compared to verify the accuracy of the solutions. It is shown that the analytical expressions of numerical modal combination coefficients are of high accuracy. The results of random responses of an example bridge show that the analytical modal combination coefficients developed in this paper are accurate enough to meet the requirements needed in practice. In addition, the computational efficiency of the analytical solutions of the modal combination coefficients is demonstrated by the response computation of the example bridge. It is found that the time required for the structural response analysis by using the analytical modal combination coefficients is less than 1/20 of that using numerical integral methods.
基金National Natural Science Foundations of China(Nos.41172236,41402243,and 40911120044)Basic Research Project of Jilin University,China(No.450060491448)
文摘Post-construction settlement has gained increasing attention because it frequently causes engineering problems. A combined model is a commonly used prediction model that overcomes the difficulty of a single model( i. e., cannot reflect various regulations of settlement at some stages or the entire process). In this study,the correlation coefficient,maximum error values,and other values were obtained according to the fitting and predicted results of a single model. The coefficient of variation was then introduced to determine the weight of each model forming the combination. The proposed model was used to fit and predict for settlement and overcome the issue of utilizing a single model while determining the weight. The fitting predictive effect was also analyzed using the settlement fitting precision results. The fitting precision of optimizing the combination model is high. The predicted data of the post-construction settlement are closer to the calculated value of the settlement monitoring data. Moreover,the proposed model has good practicability,does not require the interval data of settlement,and restricts the model number. Thus,this model can be applied in the engineering field.
基金supported by National Natural Science Foundation of China (61572171,61202097,61202136)Research Fund for the Doctoral Program of Higher Education of China (20120094120009)+2 种基金Fundamental Research Funds for the Central Universities of China (B15020191)the national college students innovation training program (No.201511460012)by Jiangsu Province,and key special funds of efficient utilization of water resources (No.2016YFC0402710)
文摘As an important factor in evaluating service,QoS(Quality of Service) has drawn more and more concerns with the rapid increasing of Web services. However,due to the great volatility of services in Mobile Internet environments,such as internet of vehicles,Web services often do not work as announced and thus cause unacceptable problems. QoS prediction can avoid failure before it takes place,which is considered a more effective way to assure quality. However,Current QoS prediction approaches neither consider the highly dynamic of Web services,nor maintain good prediction performance all the time. Consequently we propose a novel Bayesian combinational model to predict QoS by continuously adjusting credit values of the basic models so as to keep good prediction accuracy. QoS attributes such as response time,throughput and reliability are used to validate the proposed model. Experimental results show that the model can provide stable prediction results in Mobile Internet environments.
基金supported by the National Science and Technology Major Project during the 13th Five-Year Plan under grant(2016ZX05060-019)the National Science and Technology Major Project during the 13th Five-Year Plan under grant(2016ZX05060004).
文摘Existing“evaluation indicators”are selected and combined to build a model to support the optimization of shale gas horizontal wells.Towards this end,different“weighting methods”,including AHP and the so-called entropy method,are combined in the frame of the game theory.Using a relevant test case for the implementation of the model,it is shown that the horizontal section of the considered well is in the middle sweet spot area with good physical properties and fracturing ability.In comparison with the FSI(flow scanner Image)gas production profile,the new model seems to display better abilities for the optimization of horizontal wells.
基金Supported by the Bourse du Conseil Médical de l’hôpital Erasme,Fonds E.et S.Jacobs and Novartis GrantThe CMMI is supported by the European Regional Development Fund and Wallonia
文摘BACKGROUND Acetaminophen overdose is the most frequent cause of drug-induced liver failure in developed countries.Substantial progress has been made in understanding the mechanism of hepatocellular injury,but N-acetylcysteine remains the only effective treatment despite its short therapeutic window.Thus,other hepatoprotective drugs are needed for the delayed treatment of acetaminopheninduced hepatotoxicity.Our interest focused on glycyrrhizin for its role as an inhibitor of high mobility group box 1(HMGB1)protein,a member of the family of damage-associated molecular pattern,known to play an important pathological role in various diseases.AIM To investigate the efficacy of the N-acetylcysteine/glycyrrhizin combination compared to N-acetylcysteine alone in the prevention of liver toxicity.METHODS Eight-week-old C57BL/6J wild-type female mice were used for all our experiments.Mice fasted for 15 h were treated with acetaminophen(500 mg/kg)or vehicle(phosphate-buffered saline)by intraperitoneal injection and separated into the following groups:Glycyrrhizin(200 mg/kg);N-acetylcysteine(150 mg/kg);and N-acetylcysteine/glycyrrhizin.In all groups,mice were sacrificed 12 h following acetaminophen administration.The assessment of hepatotoxicity was performed by measuring plasma levels of alanine aminotransferase,aspartate aminotransferase and lactate dehydrogenase.Hepatotoxicity was also evaluated by histological examination of hematoxylin and eosin-stained tissues sections.Survival rates were compared between various groups using Kaplan-Meier curves.RESULTS Consistent with data published in the literature,we confirmed that intraperitoneal administration of acetaminophen(500 mg/kg)in mice induced severe liver injury as evidenced by increases in alanine aminotransferase,aspartate aminotransferase and lactate dehydrogenase but also by liver necrosis score.Glycyrrhizin administration was shown to reduce the release of HMGB1 and significantly decreased the severity of liver injury.Thus,the co-administration of glycyrrhizin and N-acetylcysteine was investigated.Administered concomitantly with acetaminophen,the combination significantly reduced the severity of liver injury.Delayed administration of the combination of drugs,2 h or 6 h after acetaminophen,also induced a significant decrease in hepatocyte necrosis compared to mice treated with N-acetylcysteine alone.In addition,administration of N-acetylcysteine/glycyrrhizin combination was associated with an improved survival rate compared to mice treated with only N-acetylcysteine.CONCLUSION We demonstrate that,compared to N-acetylcysteine alone,co-administration of glycyrrhizin decreases the liver necrosis score and improves survival in a murine model of acetaminophen-induced liver injury.Our study opens a potential new therapeutic pathway in the prevention of acetaminophen hepatotoxicity.
基金supported by National Key R&D Program of China(No.2022YFC3004705)the National Natural Science Foundation of China(Nos.52074280,52227901 and 52204249)National Natural Science Foundation of China Youth Fund(No.52104230).
文摘Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in underground engineering.To reveal the effect of this way,the uniaxial compression experiments with PSC monitoring were conducted on three types of coal-rock combination samples with different strength combinations.The mechanism explanation of PSCs are investigated by resistivity test,atomic force microscopy(AFM)and computed tomography(CT)methods,and a PSC flow model based on progressive failure process is proposed.The influence of strength combinations on PSCs in the progressive failure process are emphasized.The results show the PSC responses between rock part,coal part and the two components are different,which are affected by multi-scale fracture characteristics and electrical properties.As the rock strength decreases,the progressive failure process changes obviously with the influence range of interface constraint effect decreasing,resulting in the different responses of PSC strength and direction in different parts to fracture behaviors.The PSC flow model is initially validated by the relationship between the accumulated charges of different parts.The results are expected to provide a new reference and method for mining design and roadway quality assessment.
基金supported by the Fundamental Research Funds for the Central Universities (Grant No.2023JBZY024)Beijing Natural Science Foundation (Grant No.9244040)opening Fund of State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology (Grant No.SKLGP2023K015).
文摘This study focused on the mechanical behavior of a deep-buried tunnel constructed in horizontally layered limestone,and investigated the effect of a new combined rockboltecable support system on the tunnel response.The Yujingshan Tunnel,excavated through a giant karst cave,was used as a case study.Firstly,a multi-objective optimization model for the rockboltecable support was proposed by using fuzzy mathematics and multi-objective comprehensive decision-making principles.Subsequently,the parameters of the surrounding rock were calibrated by comparing the simulation results obtained by the discrete element method(DEM)with the field monitoring data to obtain an optimized support scheme based on the optimization model.Finally,the optimization scheme was applied to the karst cave section,which was divided into the B-and C-shaped sections.The distribution range of the rockboltecable support in the C-shaped section was larger than that in the B-shaped section.The field monitoring results,including tunnel crown settlement,horizontal convergence,and axial force of the rockboltecable system,were analyzed to assess the effectiveness of the optimization scheme.The maximum crown settlement and horizontal convergence were measured to be 25.9 mm and 35 mm,accounting for 0.1%and 0.2%of the tunnel height and span,respectively.Although the C-shaped section had poorer rock properties than the B-shaped section,the crown settlement and horizontal convergence in the C-shaped section ranged from 46%to 97%of those observed in the B-shaped section.The cable axial force in the Bshaped section was approximately 60%of that in the C-shaped section.The axial force in the crown rockbolt was much smaller than that in the sidewall rockbolt.Field monitoring results demonstrated that the optimized scheme effectively controlled the deformation of the layered surrounding rock,ensuring that it remained within a safe range.These results provide valuable references for the design of support systems in deep-buried tunnels situated in layered rock masses.
基金the National Natural Science Foundation of China,No. 3047051530570480
文摘BACKGROUND: In localized brain proton magnetic resonance spectroscopy (^1H-MRS), metabolite levels are often expressed as ratios, rather than absolute concentrations. Frequently, the denominator is creatine, which is assumed to be stable in normal, as well as many pathological, states. However, in vivo creatine levels do not remain constant. Therefore, absolute metabolite measurements, which provide the precise concentrations of certain chemical compounds, are superior to metabolite ratios for determining pathological and evolutional changes. OBJECTIVE: To investigate the feasibility of quantification analysis of brain metabolite changes caused by central analgesics nasal spray using the ^1H-MRS and linear combination model (LCModel) methods. DESIGN, TIME AND SETTING: This neuroimaging, observational, animal study was performed at the Laboratory of the Department of Medical Imaging, Second Affiliated Hospital, Medical College, Shantou University, China from July to December 2007. MATERIALS: Butorphanol tartrate nasal spray, as a mixed agonist-antagonist opioid analgesic, was purchased from Shanghai Hengrui Pharmacy, China. A General Electric Signa 1.5T System (General Electric Medical Systems, Milwaukee, WI, USA) and LCModel software (Stephen Provencher, Oakville, Ontario, Canada) were used in this study. METHODS: MRS images were acquired in ten healthy swine aged 2 weeks using single-voxel point-resolved spectroscopic sequence. A region of interest (2 cm × 2 cm × 2 cm) was placed in the image centers of maximum brain parenchyma. Repeated MRS scanning was performed 15-20 minutes after intranasal administration of 1 mg of butorphanol tartrate. Three settings of repetition time/echo time were selected before and after nasal spray administration 3 000 ms/30 ms,1 500 ms/30 ms, and 3 000 ms/50 ms. Metabolite concentrations were estimated by LCModel software. MAIN OUTCOME MEASURES: ^1H-MRS spectra was obtained using various repetition time/echo time settings. Concentrations of glutamate compounds (glutamate + glutamine), N-acetyl aspartate, and choline were detected in swine brain prior to and following nasal spray treatment. RESULTS: The glutamate compounds curve was consistent with original spectra, when a repetition time/echo time of 3 000 ms/30 ms was adopted. Concentrations of glutamate compounds, N-acetyl aspartate, and choline decreased following administration. The most significant reduction was observed in glutamate compound concentrations from (9.28 ± 0.54) mmol/kg to (7.28 ± 0.54) mmol/kg (P 〈 0.05). CONCLUSION: ^1H-MRS and LCModel software were effectively utilized to quantitatively analyze and measure brain metabolites. Glutamate compounds might be an important neurotransmitter in central analgesia.
基金Supported by the National High Technology Research and Development Program of China (863 Program) (2002AA111010 2003AA001032)
文摘Resources are the base and core of education information, but current web education resources have no structure and it is still difficult to reuse them and make them can be self assembled and developed continually. According to the knowledge structure of course and text, the relation among knowledge points, knowledge units from three levels of media material, we can build education resource components, and build TKCM (Teaching Knowledge Combination Model) based on resource components. Builders can build and assemble knowledge system structure and make knowledge units can be self assembled, thus we can develop and consummate them continually. Users can make knowledge units can be self assembled and renewed, and build education knowledge system to satisfy users' demand under the form of education knowledge system.
文摘As the acceleration of aged population tendency, building models to forecast Alzheimer’s Disease (AD) is essential. In this article, we surveyed 1157 interviewees. By analyzing the results using three machine learning methods—BP neural network, SVM and random forest, we can derive the accuracy of them in forecasting AD, so that we can compare the methods in solving AD prediction. Among them, random forest is the most accurate method. Moreover, to combine the advantages of the methods, we build a new combination forecasting model based on the three machine learning models, which is proved more accurate than the models singly. At last, we give the conclusion of the connection between life style and AD, and provide several suggestions for elderly people to help them prevent AD.
基金The National Natural Science Foundation of China(No.51778485).
文摘The mixed model of improved exponential and power function and unequal interval gray GM(1,1)model have poor accuracy in predicting the maximum pull-out load of anchor bolts.An optimal combination model was derived using the optimally weighted combination theory and the minimum sum of logarithmic squared errors as the objective function.Two typical anchor bolt pull-out engineering cases were selected to compare the performance of the proposed model with those of existing ones.Results showed that the optimal combination model was suitable not only for the slow P-s curve but also for the steep P-s curve.Its accuracy and stable reliability,as well as its prediction capability classification,were better than those of the other prediction models.Therefore,the optimal combination model is an effective processing method for predicting the maximum pull-out load of anchor bolts according to measured data.
文摘To solve the medium and long term power load forecasting problem,the combination forecasting method is further expanded and a weighted combination forecasting model for power load is put forward.This model is divided into two stages which are forecasting model selection and weighted combination forecasting.Based on Markov chain conversion and cloud model,the forecasting model selection is implanted and several outstanding models are selected for the combination forecasting.For the weighted combination forecasting,a fuzzy scale joint evaluation method is proposed to determine the weight of selected forecasting model.The percentage error and mean absolute percentage error of weighted combination forecasting result of the power consumption in a certain area of China are 0.7439%and 0.3198%,respectively,while the maximum values of these two indexes of single forecasting models are 5.2278%and 1.9497%.It shows that the forecasting indexes of proposed model are improved significantly compared with the single forecasting models.
基金This paper is supported by National Natural Science Foundation of China (No. 61074078) and Fundamental Research Funds for the Central Universities (No. 12MS121).
文摘[Objective] Analysis of combining ability of starch content variation in hybrid sorghum with the assistant of AMMI model. [Method] Based on the analyses of GCA using incomplete diallel cross(NCII), the SCA of hybrid sorghum was analyzed by AMMI model. [Result] For the starch content change of F1 hybrid sorghum, the effects of GCA and SCA accounted for 81.06% and 17.97%, respectively. In the present study, CMS lines 45A, 29A and restorer lines Hui 1, 44R were proved to be the excellent parent materials for preparing high starch hybrid sorghum cultivars. [Conclusion] The improvement of starch content in parents should be mainly concerned in breeding high starch content hybrid sorghum.
文摘This paper analyzes the characteristics of the destination distribution of trips and proposes a stratified sampling strategy for travel mode choice.The stratified sampling strategy can reduce the size of the alternative set;thus,the computation burden of simulation is decreased.Using the stratified sampling strategy,a combined choice model of the trip mode and destination is developed based on the Bayesian theory.Simulations are carried out to verify the proposed model.The results show that the combined choice model of the trip mode and destination can efficiently simulate travelers' choice behaviors.Furthermore,the forecasting accuracy of the combined choice model is higher than the one of the gravity model.Therefore,the proposed model is a powerful tool with which to analyze travelers' behaviors in selecting the trip mode.
文摘This paper briefs the configuration and performance of large size gas turbines and their composed combined cycle power plants designed and produced by four large renown gas turbine manufacturing firms in the world, providing reference for the relevant sectors and enterprises in importing advanced gas turbines and technologies.