BACKGROUND Multinucleated giant cells(MGCs)in bladder carcinomas are poorly studied.AIM To describe the function,morphogenesis,and origin of mononuclear and MGCs in urothelial carcinoma(UC)of the bladder in Bulgarian ...BACKGROUND Multinucleated giant cells(MGCs)in bladder carcinomas are poorly studied.AIM To describe the function,morphogenesis,and origin of mononuclear and MGCs in urothelial carcinoma(UC)of the bladder in Bulgarian and French patients.METHODS Urothelial bladder carcinomas(n=104)from 2016-2020 were analyzed retrospectively using immunohistochemical(IHC)and histochemical stain examination.Giant cells in the bladder stroma were found in 35.6%of cases,more often in highgrades.RESULTS We confirm that MGCs in the mucosa in UC of the bladder were positive for both mesenchymal and myofibroblast markers(vimentin,smooth muscle actin,Desmin,and CD34)and the macrophage marker CD68.Furthermore,IHC studies revealed the following profile of these cells:Positive for p16;negative for epithelial(CK AE1/AE3 and GATA-3),vascular(CD31),neural(PS100 and CKIT),cambial,blastic(CD34-blasts and C-KIT),and immune markers(IG G,immunoglobulin G4,and PD-L1);no proliferative activity,possess no specific immune function,and cannot be used to calculate the Combined Positive Score scale.CONCLUSION In conclusion,the giant stromal cells in non-tumor and tumor bladder can be used as a characteristic and relatively constant,although nonspecific,histological marker for chronic bladder damage,reflecting the chronic irritation or inflammation.Likewise,according to the morphological and IHC of the mono-and multinucleated giant cells in the bladder,they are most likely represent telocytes capable of adapting their morphology to the pathology of the organ.展开更多
The thermal infrared channel (IRS4) of HJ-1B satellite obtains view zenith angles (VZA) up to ±33°. The view angle should be taken into account when retrieving land surface temperature (LST) from IRS4 data. ...The thermal infrared channel (IRS4) of HJ-1B satellite obtains view zenith angles (VZA) up to ±33°. The view angle should be taken into account when retrieving land surface temperature (LST) from IRS4 data. This study aims at improving the mono-window algorithm for retrieving LST from IRS4 data. Based on atmospheric radiative transfer simulations,a model for correcting the VZA effects on atmospheric transmittance is proposed. In addition,a generalized model for calculating the effective mean atmospheric temperature is developed. Validation with the simulated dataset based on standard atmospheric profiles reveals that the improved mono-window algorithm for IRS4 obtains high accuracy for LST retrieval,with the mean absolute error (MAE) and root mean square error (RMSE) being 1.0 K and 1.1 K,respectively. Numerical experiment with the radiosonde profile acquired in Beijing in winter demonstrates that the improved mono-window algorithm exhibits excellent ability for LST retrieval,with MAE and RMSE being 0.6 K and 0.6 K,respectively. Further application in Qinghai Lake and comparison with the Moderate-Resolution Imaging Spectroradiometer (MODIS) LST product suggest that the improved mono-window algorithm is applicable and feasible in actual conditions.展开更多
In this paper, a new trust region algorithm for unconstrained LC1 optimization problems is given. Compare with those existing trust regiion methods, this algorithm has a different feature: it obtains a stepsize at eac...In this paper, a new trust region algorithm for unconstrained LC1 optimization problems is given. Compare with those existing trust regiion methods, this algorithm has a different feature: it obtains a stepsize at each iteration not by soloving a quadratic subproblem with a trust region bound, but by solving a system of linear equations. Thus it reduces computational complexity and improves computation efficiency. It is proven that this algorithm is globally convergent and locally superlinear under some conditions.展开更多
Urban water consumption has some characteristics of grey because it is influenced by economy, population, standard of living and so on. The multi-variable grey model (MGM(1,n)), as the expansion and complement of GM(1...Urban water consumption has some characteristics of grey because it is influenced by economy, population, standard of living and so on. The multi-variable grey model (MGM(1,n)), as the expansion and complement of GM(1,1) model, reveals the relationship between restriction and stimulation among variables, and the genetic algorithm has the whole optimal and parallel characteristics. In this paper, the parameter q of MGM(1,n) model was optimized, and a multi-variable grey model (MGM(1,n,q)) was built by using the genetic algorithm. The model was validated by examining the urban water consumption from 1990 to 2003 in Dalian City. The result indicated that the multi-variable grey model (MGM(1,n,q)) based on genetic algorithm was better than MGM(1,n) model, and the MGM(1,n) model was better than MGM(1,1) model.展开更多
In this paper a hybrid parallel multi-objective genetic algorithm is proposed for solving 0/1 knapsack problem. Multi-objective problems with non-convex and discrete Pareto front can take enormous computation time to ...In this paper a hybrid parallel multi-objective genetic algorithm is proposed for solving 0/1 knapsack problem. Multi-objective problems with non-convex and discrete Pareto front can take enormous computation time to converge to the true Pareto front. Hence, the classical multi-objective genetic algorithms (MOGAs) (i.e., non- Parallel MOGAs) may fail to solve such intractable problem in a reasonable amount of time. The proposed hybrid model will combine the best attribute of island and Jakobovic master slave models. We conduct an extensive experimental study in a multi-core system by varying the different size of processors and the result is compared with basic parallel model i.e., master-slave model which is used to parallelize NSGA-II. The experimental results confirm that the hybrid model is showing a clear edge over master-slave model in terms of processing time and approximation to the true Pareto front.展开更多
We implemented a 3-3-1 algorithm in order to provide safe and simple self-titration in patients who newly initiated BOT as well as who were already on BOT and evaluated its utility in clinical setting. A total of 46 p...We implemented a 3-3-1 algorithm in order to provide safe and simple self-titration in patients who newly initiated BOT as well as who were already on BOT and evaluated its utility in clinical setting. A total of 46 patients, 21 patients in the newly-initiated group and 25 patients in the existing BOT group performed dose adjustment using 3-3-1 algorithm. HbA1c was significantly improved 4 weeks after the initiation from 8.5% ± 1.2% at baseline to 7.3% ± 0.7% at the final evaluation (p 0.01, vs. Baseline). The average daily insulin units increased throughout the study period from 10.1 ± 6.7 at baseline to 14.6 ± 8.9 units at the final evaluation. Weight didn’t significantly change throughout the study (p = 0.12). The incidents of hypoglycemia were 0.8/month during the insulin dose self-adjustment period and 0.4/month during the follow-up period. The 3-3-1 algorithm using insulin glargine provided a safe and simple dose adjustment and demonstrated its utility in patients who were newly introduced to insulin treatment as well as who were already on BOT.展开更多
For indoor location estimation based on received signal strength( RSS) in wireless local area networks( WLAN),in order to reduce the influence of noise on the positioning accuracy,a large number of RSS should be colle...For indoor location estimation based on received signal strength( RSS) in wireless local area networks( WLAN),in order to reduce the influence of noise on the positioning accuracy,a large number of RSS should be collected in offline phase. Therefore,collecting training data with positioning information is time consuming which becomes the bottleneck of WLAN indoor localization. In this paper,the traditional semisupervised learning method based on k-NN and ε-NN graph for reducing collection workload of offline phase are analyzed,and the result shows that the k-NN or ε-NN graph are sensitive to data noise,which limit the performance of semi-supervised learning WLAN indoor localization system. Aiming at the above problem,it proposes a l1-graph-algorithm-based semi-supervised learning( LG-SSL) indoor localization method in which the graph is built by l1-norm algorithm. In our system,it firstly labels the unlabeled data using LG-SSL and labeled data to build the Radio Map in offline training phase,and then uses LG-SSL to estimate user's location in online phase. Extensive experimental results show that,benefit from the robustness to noise and sparsity ofl1-graph,LG-SSL exhibits superior performance by effectively reducing the collection workload in offline phase and improving localization accuracy in online phase.展开更多
In order to optimize the knapsack problem further, this paper proposes an innovative model based on dynamic expectation efficiency, and establishes a new optimization algorithm of 0-1 knapsack problem after analysis a...In order to optimize the knapsack problem further, this paper proposes an innovative model based on dynamic expectation efficiency, and establishes a new optimization algorithm of 0-1 knapsack problem after analysis and research. Through analyzing the study of 30 groups of 0-1 knapsack problem from discrete coefficient of the data, we can find that dynamic expectation model can solve the following two types of knapsack problem. Compared to artificial glowworm swam algorithm, the convergence speed of this algorithm is ten times as fast as that of artificial glowworm swam algorithm, and the storage space of this algorithm is one quarter that of artificial glowworm swam algorithm. To sum up, it can be widely used in practical problems.展开更多
A fast algorithm is proposed for recursively computing the DFTs of prime length. Only (N-1) / 2 real multiplications are required to compute all N frequency components in terms of permuting the input data. The multipl...A fast algorithm is proposed for recursively computing the DFTs of prime length. Only (N-1) / 2 real multiplications are required to compute all N frequency components in terms of permuting the input data. The multiplication in recursive computation is replaced by shifting. Complexity of the algorithm is studied. A factor η is introduced and presented. When the ratio of multiplier's period Tm to adder's period Ta is greater than the factor η (i.e.Tm / Ta >η), the new algorithm is faster than FFT. The necessary condition and error of the algorithm are studied. The signal-to-noise ratio for different length N is presented. A high accuracy scheme is proposed for improving the SNR about 20 -30dB.展开更多
The generalized l1 greedy algorithm was recently introduced and used to reconstruct medical images in computerized tomography in the compressed sensing framework via total variation minimization. Experimental results ...The generalized l1 greedy algorithm was recently introduced and used to reconstruct medical images in computerized tomography in the compressed sensing framework via total variation minimization. Experimental results showed that this algorithm is superior to the reweighted l1-minimization and l1 greedy algorithms in reconstructing these medical images. In this paper the effectiveness of the generalized l1 greedy algorithm in finding random sparse signals from underdetermined linear systems is investigated. A series of numerical experiments demonstrate that the generalized l1 greedy algorithm is superior to the reweighted l1-minimization and l1 greedy algorithms in the successful recovery of randomly generated Gaussian sparse signals from data generated by Gaussian random matrices. In particular, the generalized l1 greedy algorithm performs extraordinarily well in recovering random sparse signals with nonzero small entries. The stability of the generalized l1 greedy algorithm with respect to its parameters and the impact of noise on the recovery of Gaussian sparse signals are also studied.展开更多
This paper present a simulation study of an evolutionary algorithms, Particle Swarm Optimization PSO algorithm to optimize likelihood function of ARMA(1, 1) model, where maximizing likelihood function is equivalent ...This paper present a simulation study of an evolutionary algorithms, Particle Swarm Optimization PSO algorithm to optimize likelihood function of ARMA(1, 1) model, where maximizing likelihood function is equivalent to maximizing its logarithm, so the objective function 'obj.fun' is maximizing log-likelihood function. Monte Carlo method adapted for implementing and designing the experiments of this simulation. This study including a comparison among three versions of PSO algorithm “Constriction coefficient CCPSO, Inertia weight IWPSO, and Fully Informed FIPSO”, the experiments designed by setting different values of model parameters al, bs sample size n, moreover the parameters of PSO algorithms. MSE used as test statistic to measure the efficiency PSO to estimate model. The results show the ability of PSO to estimate ARMA' s parameters, and the minimum values of MSE getting for COPSO.展开更多
煤炭是我国能源资源安全的压舱石,“双碳”背景下实现煤炭清洁加工与高效利用意义重大,而灰分检测对煤炭清洁化和智能化发展尤为重要。针对现有灰分检测存在的检测精度有待提高的突出问题,以两淮矿区典型煤样为研究对象,通过慢灰和X射...煤炭是我国能源资源安全的压舱石,“双碳”背景下实现煤炭清洁加工与高效利用意义重大,而灰分检测对煤炭清洁化和智能化发展尤为重要。针对现有灰分检测存在的检测精度有待提高的突出问题,以两淮矿区典型煤样为研究对象,通过慢灰和X射线荧光(X ray fluorescence,XRF)测试系统地探究了煤样的灰分和元素组成分布规律,并结合机器学习理论构建了灰分-元素特征数据集;结合灰色系统理论和新陈代谢算法,构建了自适应的GM(1,N)动态网络灰分拟合优化模型,并详细设计了动态网络算法流程;提出了GM(1,N)动态模型的关键超参数,并通过与常规拟合方法对比,全面地评价了模型拟合性能。结果表明:两淮矿区煤可视为由可燃元素和成灰元素共同构成,且成灰元素中质量分数占比最高为Si和Al,次之为S、Fe和Ca等,最少为P和Cl等,并且煤中成灰元素总含量与灰分呈正相关,而可燃元素与之相反;以灰分为标签值、以组成元素为特征值,形成了煤的灰分-元素特征数据集;以样本数据划分→动态网络灰分拟合→模型评价机制→动态拟合模型自适应优化→鲁棒性提升→多轮迭代优化为主线设计了GM(1,N)动态网络灰分拟合模型及其算法流程,有效提升了数据集稳定性和新鲜度,并且迭代收敛速度快,灰分误差阈值5%时其准确率达100%;对比经典GM(1,N)模型和常规多元线性回归模型,证明了新模型的灰分拟合性能得到显著提升,其相对误差为0.16%~4.96%、误差均值仅2.29%。展开更多
基金the European Union-NextGenerationEU,through the National Recovery and Resilience Plan of the Republic of Bulgaria,No.BG-RRP-2.004-0008.
文摘BACKGROUND Multinucleated giant cells(MGCs)in bladder carcinomas are poorly studied.AIM To describe the function,morphogenesis,and origin of mononuclear and MGCs in urothelial carcinoma(UC)of the bladder in Bulgarian and French patients.METHODS Urothelial bladder carcinomas(n=104)from 2016-2020 were analyzed retrospectively using immunohistochemical(IHC)and histochemical stain examination.Giant cells in the bladder stroma were found in 35.6%of cases,more often in highgrades.RESULTS We confirm that MGCs in the mucosa in UC of the bladder were positive for both mesenchymal and myofibroblast markers(vimentin,smooth muscle actin,Desmin,and CD34)and the macrophage marker CD68.Furthermore,IHC studies revealed the following profile of these cells:Positive for p16;negative for epithelial(CK AE1/AE3 and GATA-3),vascular(CD31),neural(PS100 and CKIT),cambial,blastic(CD34-blasts and C-KIT),and immune markers(IG G,immunoglobulin G4,and PD-L1);no proliferative activity,possess no specific immune function,and cannot be used to calculate the Combined Positive Score scale.CONCLUSION In conclusion,the giant stromal cells in non-tumor and tumor bladder can be used as a characteristic and relatively constant,although nonspecific,histological marker for chronic bladder damage,reflecting the chronic irritation or inflammation.Likewise,according to the morphological and IHC of the mono-and multinucleated giant cells in the bladder,they are most likely represent telocytes capable of adapting their morphology to the pathology of the organ.
基金Under the auspices of Opening Funding of State Key Laboratory for Remote Sensing ScienceNational High-tech Research and Development Program (863 Program) (No. 2007AA120205, 2007AA120306)
文摘The thermal infrared channel (IRS4) of HJ-1B satellite obtains view zenith angles (VZA) up to ±33°. The view angle should be taken into account when retrieving land surface temperature (LST) from IRS4 data. This study aims at improving the mono-window algorithm for retrieving LST from IRS4 data. Based on atmospheric radiative transfer simulations,a model for correcting the VZA effects on atmospheric transmittance is proposed. In addition,a generalized model for calculating the effective mean atmospheric temperature is developed. Validation with the simulated dataset based on standard atmospheric profiles reveals that the improved mono-window algorithm for IRS4 obtains high accuracy for LST retrieval,with the mean absolute error (MAE) and root mean square error (RMSE) being 1.0 K and 1.1 K,respectively. Numerical experiment with the radiosonde profile acquired in Beijing in winter demonstrates that the improved mono-window algorithm exhibits excellent ability for LST retrieval,with MAE and RMSE being 0.6 K and 0.6 K,respectively. Further application in Qinghai Lake and comparison with the Moderate-Resolution Imaging Spectroradiometer (MODIS) LST product suggest that the improved mono-window algorithm is applicable and feasible in actual conditions.
文摘In this paper, a new trust region algorithm for unconstrained LC1 optimization problems is given. Compare with those existing trust regiion methods, this algorithm has a different feature: it obtains a stepsize at each iteration not by soloving a quadratic subproblem with a trust region bound, but by solving a system of linear equations. Thus it reduces computational complexity and improves computation efficiency. It is proven that this algorithm is globally convergent and locally superlinear under some conditions.
文摘Urban water consumption has some characteristics of grey because it is influenced by economy, population, standard of living and so on. The multi-variable grey model (MGM(1,n)), as the expansion and complement of GM(1,1) model, reveals the relationship between restriction and stimulation among variables, and the genetic algorithm has the whole optimal and parallel characteristics. In this paper, the parameter q of MGM(1,n) model was optimized, and a multi-variable grey model (MGM(1,n,q)) was built by using the genetic algorithm. The model was validated by examining the urban water consumption from 1990 to 2003 in Dalian City. The result indicated that the multi-variable grey model (MGM(1,n,q)) based on genetic algorithm was better than MGM(1,n) model, and the MGM(1,n) model was better than MGM(1,1) model.
文摘In this paper a hybrid parallel multi-objective genetic algorithm is proposed for solving 0/1 knapsack problem. Multi-objective problems with non-convex and discrete Pareto front can take enormous computation time to converge to the true Pareto front. Hence, the classical multi-objective genetic algorithms (MOGAs) (i.e., non- Parallel MOGAs) may fail to solve such intractable problem in a reasonable amount of time. The proposed hybrid model will combine the best attribute of island and Jakobovic master slave models. We conduct an extensive experimental study in a multi-core system by varying the different size of processors and the result is compared with basic parallel model i.e., master-slave model which is used to parallelize NSGA-II. The experimental results confirm that the hybrid model is showing a clear edge over master-slave model in terms of processing time and approximation to the true Pareto front.
文摘We implemented a 3-3-1 algorithm in order to provide safe and simple self-titration in patients who newly initiated BOT as well as who were already on BOT and evaluated its utility in clinical setting. A total of 46 patients, 21 patients in the newly-initiated group and 25 patients in the existing BOT group performed dose adjustment using 3-3-1 algorithm. HbA1c was significantly improved 4 weeks after the initiation from 8.5% ± 1.2% at baseline to 7.3% ± 0.7% at the final evaluation (p 0.01, vs. Baseline). The average daily insulin units increased throughout the study period from 10.1 ± 6.7 at baseline to 14.6 ± 8.9 units at the final evaluation. Weight didn’t significantly change throughout the study (p = 0.12). The incidents of hypoglycemia were 0.8/month during the insulin dose self-adjustment period and 0.4/month during the follow-up period. The 3-3-1 algorithm using insulin glargine provided a safe and simple dose adjustment and demonstrated its utility in patients who were newly introduced to insulin treatment as well as who were already on BOT.
基金Sponsored by the National Natural Science Foundation of China(Grant No.61101122)the National High Technology Research and Development Program of China(Grant No.2012AA120802)the National Science and Technology Major Project of the Ministry of Science and Technology of China(Grant No.2012ZX03004-003)
文摘For indoor location estimation based on received signal strength( RSS) in wireless local area networks( WLAN),in order to reduce the influence of noise on the positioning accuracy,a large number of RSS should be collected in offline phase. Therefore,collecting training data with positioning information is time consuming which becomes the bottleneck of WLAN indoor localization. In this paper,the traditional semisupervised learning method based on k-NN and ε-NN graph for reducing collection workload of offline phase are analyzed,and the result shows that the k-NN or ε-NN graph are sensitive to data noise,which limit the performance of semi-supervised learning WLAN indoor localization system. Aiming at the above problem,it proposes a l1-graph-algorithm-based semi-supervised learning( LG-SSL) indoor localization method in which the graph is built by l1-norm algorithm. In our system,it firstly labels the unlabeled data using LG-SSL and labeled data to build the Radio Map in offline training phase,and then uses LG-SSL to estimate user's location in online phase. Extensive experimental results show that,benefit from the robustness to noise and sparsity ofl1-graph,LG-SSL exhibits superior performance by effectively reducing the collection workload in offline phase and improving localization accuracy in online phase.
文摘In order to optimize the knapsack problem further, this paper proposes an innovative model based on dynamic expectation efficiency, and establishes a new optimization algorithm of 0-1 knapsack problem after analysis and research. Through analyzing the study of 30 groups of 0-1 knapsack problem from discrete coefficient of the data, we can find that dynamic expectation model can solve the following two types of knapsack problem. Compared to artificial glowworm swam algorithm, the convergence speed of this algorithm is ten times as fast as that of artificial glowworm swam algorithm, and the storage space of this algorithm is one quarter that of artificial glowworm swam algorithm. To sum up, it can be widely used in practical problems.
文摘A fast algorithm is proposed for recursively computing the DFTs of prime length. Only (N-1) / 2 real multiplications are required to compute all N frequency components in terms of permuting the input data. The multiplication in recursive computation is replaced by shifting. Complexity of the algorithm is studied. A factor η is introduced and presented. When the ratio of multiplier's period Tm to adder's period Ta is greater than the factor η (i.e.Tm / Ta >η), the new algorithm is faster than FFT. The necessary condition and error of the algorithm are studied. The signal-to-noise ratio for different length N is presented. A high accuracy scheme is proposed for improving the SNR about 20 -30dB.
文摘The generalized l1 greedy algorithm was recently introduced and used to reconstruct medical images in computerized tomography in the compressed sensing framework via total variation minimization. Experimental results showed that this algorithm is superior to the reweighted l1-minimization and l1 greedy algorithms in reconstructing these medical images. In this paper the effectiveness of the generalized l1 greedy algorithm in finding random sparse signals from underdetermined linear systems is investigated. A series of numerical experiments demonstrate that the generalized l1 greedy algorithm is superior to the reweighted l1-minimization and l1 greedy algorithms in the successful recovery of randomly generated Gaussian sparse signals from data generated by Gaussian random matrices. In particular, the generalized l1 greedy algorithm performs extraordinarily well in recovering random sparse signals with nonzero small entries. The stability of the generalized l1 greedy algorithm with respect to its parameters and the impact of noise on the recovery of Gaussian sparse signals are also studied.
文摘This paper present a simulation study of an evolutionary algorithms, Particle Swarm Optimization PSO algorithm to optimize likelihood function of ARMA(1, 1) model, where maximizing likelihood function is equivalent to maximizing its logarithm, so the objective function 'obj.fun' is maximizing log-likelihood function. Monte Carlo method adapted for implementing and designing the experiments of this simulation. This study including a comparison among three versions of PSO algorithm “Constriction coefficient CCPSO, Inertia weight IWPSO, and Fully Informed FIPSO”, the experiments designed by setting different values of model parameters al, bs sample size n, moreover the parameters of PSO algorithms. MSE used as test statistic to measure the efficiency PSO to estimate model. The results show the ability of PSO to estimate ARMA' s parameters, and the minimum values of MSE getting for COPSO.
文摘煤炭是我国能源资源安全的压舱石,“双碳”背景下实现煤炭清洁加工与高效利用意义重大,而灰分检测对煤炭清洁化和智能化发展尤为重要。针对现有灰分检测存在的检测精度有待提高的突出问题,以两淮矿区典型煤样为研究对象,通过慢灰和X射线荧光(X ray fluorescence,XRF)测试系统地探究了煤样的灰分和元素组成分布规律,并结合机器学习理论构建了灰分-元素特征数据集;结合灰色系统理论和新陈代谢算法,构建了自适应的GM(1,N)动态网络灰分拟合优化模型,并详细设计了动态网络算法流程;提出了GM(1,N)动态模型的关键超参数,并通过与常规拟合方法对比,全面地评价了模型拟合性能。结果表明:两淮矿区煤可视为由可燃元素和成灰元素共同构成,且成灰元素中质量分数占比最高为Si和Al,次之为S、Fe和Ca等,最少为P和Cl等,并且煤中成灰元素总含量与灰分呈正相关,而可燃元素与之相反;以灰分为标签值、以组成元素为特征值,形成了煤的灰分-元素特征数据集;以样本数据划分→动态网络灰分拟合→模型评价机制→动态拟合模型自适应优化→鲁棒性提升→多轮迭代优化为主线设计了GM(1,N)动态网络灰分拟合模型及其算法流程,有效提升了数据集稳定性和新鲜度,并且迭代收敛速度快,灰分误差阈值5%时其准确率达100%;对比经典GM(1,N)模型和常规多元线性回归模型,证明了新模型的灰分拟合性能得到显著提升,其相对误差为0.16%~4.96%、误差均值仅2.29%。