Contrary to the approach in judicial practice,Paragraph 1,Article 153,of the Civil Code of the People’s Republic of China,as a rule of invalidity for violating mandatory provisions,does not adopt a dichotomy towards ...Contrary to the approach in judicial practice,Paragraph 1,Article 153,of the Civil Code of the People’s Republic of China,as a rule of invalidity for violating mandatory provisions,does not adopt a dichotomy towards mandatory provisions with effectiveness and administrative characteristics,yet it maintains the legislative philosophy of differentiation.It leaves unspecified whether mandatory provisions that do not explicitly render a juristic act invalid impact the act’s validity,entrusting this determination to the discretion of judges on a case-by-case basis.When judges,under the authority of Paragraph 1,Article 153 of the Civil Code,explore the normative intent of mandatory provisions to assess their effect on the validity of juristic acts,they should engage in legal policy analysis centered on consequence-based argumentation to overcome the limitations of norm typological analysis.This analysis employs a reasoning model predicated on the normative purpose,utilizing a consequencefocused interpretative approach for formulating and arguing propositions of rules applicable to pending cases,thereby arriving at case-specific conclusions.Since the invalidation of juristic acts serves as an auxiliary regulatory tool for the state economy and society,a consequence-oriented interpretation needs to be based on the idea of mutual instrumentalization of public and private laws.This entails predicting the outcomes of negating the validity of a juristic act in industrial regulatory scenarios and assessing these outcomes within the framework of public and private regulatory instruments.展开更多
The treatment of hepatitis C has undergone a significant boom since the advent of direct acting antivirals (DAA). Indeed, the interferon-ribavirin combination that has been used to treat hepatitis C has a virological ...The treatment of hepatitis C has undergone a significant boom since the advent of direct acting antivirals (DAA). Indeed, the interferon-ribavirin combination that has been used to treat hepatitis C has a virological response in only 45% of cases with significant side effects. The advent of direct-acting antivirals has changed the prognosis of cirrhotic patients with hepatitis C. DAAs have ensured a sustained viral response in the majority of patients. Our work aims to see the evolution of hepatitis C patients at the cirrhosis stage under DAA. We conducted a retrospective study over 15 years (January 2009, January 2024) including all patients with post-viral cirrhosis C, whom we divided into two groups: group A, cirrhotic patients who received ribavirin and interferon, and group B, patients on DAA. From January 2009 to January 2024, we conducted a study of 182 patients with viral hepatitis C, including 102 cirrhotic patients. The mean age was 55 years. 66% of patients were initially treated with the ribavirin interferon combination, while 34% received direct-acting antivirals (DAAs). Since the introduction of DAAs, the most commonly used regimens have been sofosbuvir/daclatasvir with or without ribavirin and sofosbuvir/ledipasvir with or without ribavirin. Group A achieved sustained virological response (SVR) in 60% of cases, with notable side effects. In Group B, SVR was 98.18%, with improved tolerability and fewer side effects than previous treatments. Fifteen patients developed hepatocellular carcinoma (HCC), with a significantly lower mortality rate in those treated with DAAs compared with pegylated dual therapy (p: 0.001).展开更多
According to J.L.Austin and J.R.Searle Speech Act Theory,many actions can actually be performed with words that is to say an important part of the meaning of an utterance is what that utterance does.Language is not on...According to J.L.Austin and J.R.Searle Speech Act Theory,many actions can actually be performed with words that is to say an important part of the meaning of an utterance is what that utterance does.Language is not only used to inform or describe things,it is often used to "do things".The utterances are of three kinds of acts:Locutionary Act,Illocutionary Act,and Perlocutionary Act which are performed simultaneously.Through the study,we see that speech can be far beyond the level of language system.展开更多
The theory of indirect speech acts proposed by John Searle is a problematic issue in speech act theory. The theory is subject to various criticisms.This essay reviews various arguments and the significant problems wit...The theory of indirect speech acts proposed by John Searle is a problematic issue in speech act theory. The theory is subject to various criticisms.This essay reviews various arguments and the significant problems with reference to the indirect speech acts. The review includes some important concepts of speech act theory which are related to indirect speech acts; inference theory and idiom theory which underline indirect speech acts and their major problems in accounting for indirect speech acts.展开更多
随着经济全球化的快速发展,品牌形象成为一个企业利益的重要体现。广告宣传片是解读和阐释品牌形象的直接途径。由于宣传片具备影像制作的众多优势,可以极大地推广某一品牌,因此各大企业都越来越重视广告宣传片的制作和传播。本文以华...随着经济全球化的快速发展,品牌形象成为一个企业利益的重要体现。广告宣传片是解读和阐释品牌形象的直接途径。由于宣传片具备影像制作的众多优势,可以极大地推广某一品牌,因此各大企业都越来越重视广告宣传片的制作和传播。本文以华为海外宣传片Dream It Possible为例,运用视觉表征ACTS模式,对其进行视觉阐释,分析其文本蕴含的深层意义。展开更多
ACTS是英文全称Ability and Competence Test System的首字母缩写,中文名称为＂学业素质与能力评价系统＂。这一科学的评价系统引入学校已近三年,经历了从完全陌生到被动认知再到主动认同和科学使用的过程。学校通过不断学习、培训、研...ACTS是英文全称Ability and Competence Test System的首字母缩写,中文名称为＂学业素质与能力评价系统＂。这一科学的评价系统引入学校已近三年,经历了从完全陌生到被动认知再到主动认同和科学使用的过程。学校通过不断学习、培训、研究、讨论和运用,逐渐探索出基于ACTS的网格化教学管理体系,以评促教,让管理更加科学精细,让教学更为有效针对。三年历程中,展开更多
BACKGROUND Colorectal cancer (CRC) is the third most prevalent malignancy and has the fourth highest global cancer mortality rate. Early diagnosis and prompt medical attention can improve quality of life and the progn...BACKGROUND Colorectal cancer (CRC) is the third most prevalent malignancy and has the fourth highest global cancer mortality rate. Early diagnosis and prompt medical attention can improve quality of life and the prognosis of CRC patients. Accumulating evidence reveals that long non-coding RNAs (lncRNAs) function as oncogenes or anti-oncogenes, as well as biomarkers in various cancers. AIM To investigate the levels and molecular mechanism of the lncRNA maternally expressed gene 3 (MEG3) in CRC. METHODS The levels of lncRNA MEG3 in CRC tissue, serum and cell line samples were explored via qRT-PCR. The relationship between MEG3 levels and clinicopathological features in CRC was investigated. The diagnostic and prognostic values of serum MEG3 levels were analyzed with ROC curves and KaplanMeier survival curves, respectively. RESULTS Significant decreased levels of MEG3 existed in CRC tissue, cell lines and serum. CRC patients with down-regulated serum MEG3 levels had larger tumor sizes, and advanced clinical stages. The sensitivity and specificity of serum MEG3 levels in CRC detection was 0.667 and 0.875, respectively. Tumor size, T stages, and serum MEG3 levels are indie factors that produce an effect on CRC patients' prognosis. KaplanMeier survival curves suggested that CRC patients with high levels of MEG3 had a remarkably better overall survival rate. CONCLUSION LncRNA MEG3 is down-regulated in CRC, and regulates cell functions by targeting adenosine deaminase’s effect on RNA 1 in CRC.展开更多
Pragmatics is a relatively new subject compared with other linguistic studies.In this paper,we will review the definition of pragmatics and its scope.Then a detailed review of speech acts will be shown in the second p...Pragmatics is a relatively new subject compared with other linguistic studies.In this paper,we will review the definition of pragmatics and its scope.Then a detailed review of speech acts will be shown in the second part of the paper.It is mainly about many aspects of speech acts,such as its definition,classification,felicity conditions and so on.The last part of the paper is the prospects of application of pragmatics.展开更多
文摘Contrary to the approach in judicial practice,Paragraph 1,Article 153,of the Civil Code of the People’s Republic of China,as a rule of invalidity for violating mandatory provisions,does not adopt a dichotomy towards mandatory provisions with effectiveness and administrative characteristics,yet it maintains the legislative philosophy of differentiation.It leaves unspecified whether mandatory provisions that do not explicitly render a juristic act invalid impact the act’s validity,entrusting this determination to the discretion of judges on a case-by-case basis.When judges,under the authority of Paragraph 1,Article 153 of the Civil Code,explore the normative intent of mandatory provisions to assess their effect on the validity of juristic acts,they should engage in legal policy analysis centered on consequence-based argumentation to overcome the limitations of norm typological analysis.This analysis employs a reasoning model predicated on the normative purpose,utilizing a consequencefocused interpretative approach for formulating and arguing propositions of rules applicable to pending cases,thereby arriving at case-specific conclusions.Since the invalidation of juristic acts serves as an auxiliary regulatory tool for the state economy and society,a consequence-oriented interpretation needs to be based on the idea of mutual instrumentalization of public and private laws.This entails predicting the outcomes of negating the validity of a juristic act in industrial regulatory scenarios and assessing these outcomes within the framework of public and private regulatory instruments.
文摘The treatment of hepatitis C has undergone a significant boom since the advent of direct acting antivirals (DAA). Indeed, the interferon-ribavirin combination that has been used to treat hepatitis C has a virological response in only 45% of cases with significant side effects. The advent of direct-acting antivirals has changed the prognosis of cirrhotic patients with hepatitis C. DAAs have ensured a sustained viral response in the majority of patients. Our work aims to see the evolution of hepatitis C patients at the cirrhosis stage under DAA. We conducted a retrospective study over 15 years (January 2009, January 2024) including all patients with post-viral cirrhosis C, whom we divided into two groups: group A, cirrhotic patients who received ribavirin and interferon, and group B, patients on DAA. From January 2009 to January 2024, we conducted a study of 182 patients with viral hepatitis C, including 102 cirrhotic patients. The mean age was 55 years. 66% of patients were initially treated with the ribavirin interferon combination, while 34% received direct-acting antivirals (DAAs). Since the introduction of DAAs, the most commonly used regimens have been sofosbuvir/daclatasvir with or without ribavirin and sofosbuvir/ledipasvir with or without ribavirin. Group A achieved sustained virological response (SVR) in 60% of cases, with notable side effects. In Group B, SVR was 98.18%, with improved tolerability and fewer side effects than previous treatments. Fifteen patients developed hepatocellular carcinoma (HCC), with a significantly lower mortality rate in those treated with DAAs compared with pegylated dual therapy (p: 0.001).
文摘According to J.L.Austin and J.R.Searle Speech Act Theory,many actions can actually be performed with words that is to say an important part of the meaning of an utterance is what that utterance does.Language is not only used to inform or describe things,it is often used to "do things".The utterances are of three kinds of acts:Locutionary Act,Illocutionary Act,and Perlocutionary Act which are performed simultaneously.Through the study,we see that speech can be far beyond the level of language system.
文摘The theory of indirect speech acts proposed by John Searle is a problematic issue in speech act theory. The theory is subject to various criticisms.This essay reviews various arguments and the significant problems with reference to the indirect speech acts. The review includes some important concepts of speech act theory which are related to indirect speech acts; inference theory and idiom theory which underline indirect speech acts and their major problems in accounting for indirect speech acts.
文摘随着经济全球化的快速发展,品牌形象成为一个企业利益的重要体现。广告宣传片是解读和阐释品牌形象的直接途径。由于宣传片具备影像制作的众多优势,可以极大地推广某一品牌,因此各大企业都越来越重视广告宣传片的制作和传播。本文以华为海外宣传片Dream It Possible为例,运用视觉表征ACTS模式,对其进行视觉阐释,分析其文本蕴含的深层意义。
文摘ACTS是英文全称Ability and Competence Test System的首字母缩写,中文名称为＂学业素质与能力评价系统＂。这一科学的评价系统引入学校已近三年,经历了从完全陌生到被动认知再到主动认同和科学使用的过程。学校通过不断学习、培训、研究、讨论和运用,逐渐探索出基于ACTS的网格化教学管理体系,以评促教,让管理更加科学精细,让教学更为有效针对。三年历程中,
文摘BACKGROUND Colorectal cancer (CRC) is the third most prevalent malignancy and has the fourth highest global cancer mortality rate. Early diagnosis and prompt medical attention can improve quality of life and the prognosis of CRC patients. Accumulating evidence reveals that long non-coding RNAs (lncRNAs) function as oncogenes or anti-oncogenes, as well as biomarkers in various cancers. AIM To investigate the levels and molecular mechanism of the lncRNA maternally expressed gene 3 (MEG3) in CRC. METHODS The levels of lncRNA MEG3 in CRC tissue, serum and cell line samples were explored via qRT-PCR. The relationship between MEG3 levels and clinicopathological features in CRC was investigated. The diagnostic and prognostic values of serum MEG3 levels were analyzed with ROC curves and KaplanMeier survival curves, respectively. RESULTS Significant decreased levels of MEG3 existed in CRC tissue, cell lines and serum. CRC patients with down-regulated serum MEG3 levels had larger tumor sizes, and advanced clinical stages. The sensitivity and specificity of serum MEG3 levels in CRC detection was 0.667 and 0.875, respectively. Tumor size, T stages, and serum MEG3 levels are indie factors that produce an effect on CRC patients' prognosis. KaplanMeier survival curves suggested that CRC patients with high levels of MEG3 had a remarkably better overall survival rate. CONCLUSION LncRNA MEG3 is down-regulated in CRC, and regulates cell functions by targeting adenosine deaminase’s effect on RNA 1 in CRC.
文摘Pragmatics is a relatively new subject compared with other linguistic studies.In this paper,we will review the definition of pragmatics and its scope.Then a detailed review of speech acts will be shown in the second part of the paper.It is mainly about many aspects of speech acts,such as its definition,classification,felicity conditions and so on.The last part of the paper is the prospects of application of pragmatics.
