We first analyzed GPS precipitable water vapor(GPS/PWV) available from a ground-based GPS observation network in Guangdong from 1 August 2009 to 27 August 2012 and then developed a method of quality control before GPS...We first analyzed GPS precipitable water vapor(GPS/PWV) available from a ground-based GPS observation network in Guangdong from 1 August 2009 to 27 August 2012 and then developed a method of quality control before GPS/PWV data is assimilated into the GRAPES 3DVAR system. This method can reject the outliers effectively. After establishing the criterion for quality control, we did three numerical experiments to investigate the impact on the precipitation forecast with and without the quality-controlled GPS/PWV data before they are assimilated into the system.In the numerical experiments, two precipitation cases(on 6 to 7 May, 2010 and 27 to 28 April, 2012 respectively) that occurred in the annually first raining season of Guangdong were selected. The results indicated that after quality control,only the GPS/PWV data that deviates little from the NCEP/PWV data can be assimilated into the system, has reasonable adjustment of the initial water vapor above Guangdong, and eventually improves the intensity and location of 24-h precipitation forecast significantly.展开更多
The quality standards for Fructus Comi have been established based on the effects of the manufacturing processes.Three critical process parameters(CPPs)of extraction,filtration,and concentration to prepare Fructus Com...The quality standards for Fructus Comi have been established based on the effects of the manufacturing processes.Three critical process parameters(CPPs)of extraction,filtration,and concentration to prepare Fructus Comi concentrate were identified by Plackett-Burman design with a single batch of Fructus Corni,which were heating medium temperature,extraction time,and water addition.Morroniside yield,loganin yield,and dry matter yield were process critical quality attributes(CQAs).CPPs arranged with a Box-Behnken design were applied to treat different batches of Fructus Comi After constructing a model that included CPPs,material propertie s,and process CQAs,loganin content was found to be the critical material attribute(CMA).The design space was calculated with a probability method.According to the limits of process CQAs,the minimum content of loganin in Fructus Corni was calculated with an error propagation method,which was 6.92 mg·g^(-1).When the content of loganin in Fructus Corni reaches up to 6.92 mg·g^(-1),the material is considered high-quality and is most suitable for the process.High-quality material can be used for production of Fructus Comi concentrate.This method can also be used to set material quality standards for other Chinese medicines.展开更多
Number and quantities of reference standards (RS) needed for the quality control of drugs are increasing, bringing great pressure to the calibration and using company. This manuscript summarized the four generations f...Number and quantities of reference standards (RS) needed for the quality control of drugs are increasing, bringing great pressure to the calibration and using company. This manuscript summarized the four generations for the development of RS including physical RS, paper atlas, substitute RS and electronic databases. The advantages and disadvantages of each generation were summarized. The concept of digital RS (DRS) was proposed based on this, and summed up the definition, advantages, and technical architecture of DRS. The 10 characteristics of five aspects of the DRS were discussed including digital, multi-dimension, big data, cloud computing, internet, internet of things, sharing, multi-terminal, intelligence, and compliance certification. Then, the necessity of its formation and application in the medicine holistic quality control of internet plus era was discussed in this manuscript.展开更多
基金Natural Science Foundation of Guangdong Province(2016A030313140)Project 973(2015CB452802)+1 种基金Natural Science Foundation of China(41405104)Science and Technology Program of Guangzhou City(201604020012)
文摘We first analyzed GPS precipitable water vapor(GPS/PWV) available from a ground-based GPS observation network in Guangdong from 1 August 2009 to 27 August 2012 and then developed a method of quality control before GPS/PWV data is assimilated into the GRAPES 3DVAR system. This method can reject the outliers effectively. After establishing the criterion for quality control, we did three numerical experiments to investigate the impact on the precipitation forecast with and without the quality-controlled GPS/PWV data before they are assimilated into the system.In the numerical experiments, two precipitation cases(on 6 to 7 May, 2010 and 27 to 28 April, 2012 respectively) that occurred in the annually first raining season of Guangdong were selected. The results indicated that after quality control,only the GPS/PWV data that deviates little from the NCEP/PWV data can be assimilated into the system, has reasonable adjustment of the initial water vapor above Guangdong, and eventually improves the intensity and location of 24-h precipitation forecast significantly.
基金Supported by the Open Fund of Key Laboratory of Modern Chinese Medicine Preparations,Ministry of Education,Jiangxi University of Traditional Chinese Medicine and First-class Discipline Construction Project of Jiangxi Province(JXSYLXK-ZHYAO009,JXSYLXK-ZHYAO010)。
文摘The quality standards for Fructus Comi have been established based on the effects of the manufacturing processes.Three critical process parameters(CPPs)of extraction,filtration,and concentration to prepare Fructus Comi concentrate were identified by Plackett-Burman design with a single batch of Fructus Corni,which were heating medium temperature,extraction time,and water addition.Morroniside yield,loganin yield,and dry matter yield were process critical quality attributes(CQAs).CPPs arranged with a Box-Behnken design were applied to treat different batches of Fructus Comi After constructing a model that included CPPs,material propertie s,and process CQAs,loganin content was found to be the critical material attribute(CMA).The design space was calculated with a probability method.According to the limits of process CQAs,the minimum content of loganin in Fructus Corni was calculated with an error propagation method,which was 6.92 mg·g^(-1).When the content of loganin in Fructus Corni reaches up to 6.92 mg·g^(-1),the material is considered high-quality and is most suitable for the process.High-quality material can be used for production of Fructus Comi concentrate.This method can also be used to set material quality standards for other Chinese medicines.
文摘Number and quantities of reference standards (RS) needed for the quality control of drugs are increasing, bringing great pressure to the calibration and using company. This manuscript summarized the four generations for the development of RS including physical RS, paper atlas, substitute RS and electronic databases. The advantages and disadvantages of each generation were summarized. The concept of digital RS (DRS) was proposed based on this, and summed up the definition, advantages, and technical architecture of DRS. The 10 characteristics of five aspects of the DRS were discussed including digital, multi-dimension, big data, cloud computing, internet, internet of things, sharing, multi-terminal, intelligence, and compliance certification. Then, the necessity of its formation and application in the medicine holistic quality control of internet plus era was discussed in this manuscript.
