Objectives Phenotypic switching of smooth muscle cells(SMCs) plays a critical role in the pathogenesis of atherosclerotic lesions such as coronary artery disease (CAD).Accumulating evidence demonstrates(hat a cellular...Objectives Phenotypic switching of smooth muscle cells(SMCs) plays a critical role in the pathogenesis of atherosclerotic lesions such as coronary artery disease (CAD).Accumulating evidence demonstrates(hat a cellular repressor of E1A-stimulated genes(CREG) plays a role in the maintenance of the mature phenotype of vascular SMCs. The purpose of the present study was to assess the possible association between CREG and CAD in the Han population of North China.Methods The promoter region of CREG by direct sequencing was conducted in 48 subjects.Then SNP rs2995073 and another 4 tagSNPs(rs4657669,rs3767443, rsl6859185,rs3753921) were selected for the association study.All five selected SNPs were determined in 1161 patients with angiographically proven CAD and 960 controls with normal coronary angiograms to investigate the possible involvement of CREG in CAD.Results Genotype frequencies of the five examined polymorphisms were similarly distributed between CAD group and controls(P】0.05).Further haplotype analysis also found no significant differences in the distributions between CAD group and controls(P】0.05). Conclusions This study did not show an association between common variants of CREG and CAD in the northern Chinese Han population.展开更多
介绍一个温情的歌手,要尽量没有噱头和刺激性言语,还要避免让它被轻易划入花草派的嫌疑里,这中间的权衡拿捏都要对得起他们的音乐,实在不是一件易事。Greg Laswell就是这个重新让我陷入胶着的歌手。3月份才出EP《How the Day Sounds》,...介绍一个温情的歌手,要尽量没有噱头和刺激性言语,还要避免让它被轻易划入花草派的嫌疑里,这中间的权衡拿捏都要对得起他们的音乐,实在不是一件易事。Greg Laswell就是这个重新让我陷入胶着的歌手。3月份才出EP《How the Day Sounds》,其中的"High And Low"和"Embrace Me"至今还让我百般回昧,转眼到夏天,才思泉涌的Greg Laswell又在MySpace放出他出道十年的第三张个人唱片《Three Flights From Alto Nido》。"alto nido"在西班牙语中为"荫蔽处",按照他自己的解释,专辑意思是"走在寻找安乐窝的路上"。展开更多
文摘Objectives Phenotypic switching of smooth muscle cells(SMCs) plays a critical role in the pathogenesis of atherosclerotic lesions such as coronary artery disease (CAD).Accumulating evidence demonstrates(hat a cellular repressor of E1A-stimulated genes(CREG) plays a role in the maintenance of the mature phenotype of vascular SMCs. The purpose of the present study was to assess the possible association between CREG and CAD in the Han population of North China.Methods The promoter region of CREG by direct sequencing was conducted in 48 subjects.Then SNP rs2995073 and another 4 tagSNPs(rs4657669,rs3767443, rsl6859185,rs3753921) were selected for the association study.All five selected SNPs were determined in 1161 patients with angiographically proven CAD and 960 controls with normal coronary angiograms to investigate the possible involvement of CREG in CAD.Results Genotype frequencies of the five examined polymorphisms were similarly distributed between CAD group and controls(P】0.05).Further haplotype analysis also found no significant differences in the distributions between CAD group and controls(P】0.05). Conclusions This study did not show an association between common variants of CREG and CAD in the northern Chinese Han population.
文摘介绍一个温情的歌手,要尽量没有噱头和刺激性言语,还要避免让它被轻易划入花草派的嫌疑里,这中间的权衡拿捏都要对得起他们的音乐,实在不是一件易事。Greg Laswell就是这个重新让我陷入胶着的歌手。3月份才出EP《How the Day Sounds》,其中的"High And Low"和"Embrace Me"至今还让我百般回昧,转眼到夏天,才思泉涌的Greg Laswell又在MySpace放出他出道十年的第三张个人唱片《Three Flights From Alto Nido》。"alto nido"在西班牙语中为"荫蔽处",按照他自己的解释,专辑意思是"走在寻找安乐窝的路上"。
