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Vascularization ability of glioma stem cells in different three-dimensional microenvironments 被引量:1
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作者 Xuanzhi Wang Tao Xu Chaoshi Niu 《Regenerative Biomaterials》 SCIE EI CSCD 2024年第1期34-43,共10页
Glioblastoma(GBM)is among the most common and aggressive adult central nervous system tumors.One prominent charac-teristic of GBM is the presence of abnormal microvessels.A significant correlation between angiogenesis... Glioblastoma(GBM)is among the most common and aggressive adult central nervous system tumors.One prominent charac-teristic of GBM is the presence of abnormal microvessels.A significant correlation between angiogenesis and prognosis has been observed.Accurately reconstructing this neovascula-rization and tumor microenvironment through personalized in vitro disease models presents a significant challenge.However,it is crucial to develop new anti-angiogenic therapies for GBM.In this study,3D bioprinted glioma stem cell(GSC)-laden hydrogel scaffolds,hybrid Gsc hydrogels and ceil-free hydrogel scaffolds were manufactured to investigate the vas-cularization ability of GsCs in varying 3D microenvironments. 展开更多
关键词 3D bioprinting xenograft tumors gsc-laden hydrogel scaffold GLIOBLASTOMA angiogenesis
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