细胞焦亡是一种炎症性程序性死亡方式,是一种有别于传统的坏死、凋亡等的新型细胞死亡方式,主要由成孔蛋白Gasdermin (GSDM)家族介导。活化的半胱氨酸天冬氨酸特异性蛋白酶(caspase)切割Gasdermin家族成员释放N端结构域在胞膜上打孔,从...细胞焦亡是一种炎症性程序性死亡方式,是一种有别于传统的坏死、凋亡等的新型细胞死亡方式,主要由成孔蛋白Gasdermin (GSDM)家族介导。活化的半胱氨酸天冬氨酸特异性蛋白酶(caspase)切割Gasdermin家族成员释放N端结构域在胞膜上打孔,从而导致细胞肿胀破裂死亡。Gasdermin B (GSDMB)属于Gasdermin (GSDM)家族,具有促肿瘤或抗肿瘤作用。在肿瘤细胞的相关研究中发现,GSDMB在乳腺癌、胃癌、肝癌、宫颈癌和结肠癌等癌细胞中高表达。因此,学者们认为GSDMB可能作为癌基因参与了癌症的进展和转移。本文综述了GSDMB在各种恶性肿瘤中的作用,以期为肿瘤的临床诊断、治疗及预后提供新的思路。Pyroptosis is an inflammatory programmed cell death, which is different from traditional necrosis and apoptosis. It is mainly mediated by the poreforming protein Gasdermin (GSDM) family. Activated caspases cleave Gasdermin family members to release N-terminal domains that punch holes in the cell membrane, leading to cell swelling, rupture and death. Gasdermin B (GSDMB) belongs to the Gasdermin (GSDM) family and has pro-or anti-tumor effects. Studies on tumor cells have found that GSDMB is highly expressed in breast cancer, gastric cancer, liver cancer, cervical cancer and colon cancer cells. Therefore, scholars believe that GSDMB may be involved in cancer progression and metastasis as an oncogene. This article reviews the role of GSDMB in various malignant tumors, in order to provide new ideas for the clinical diagnosis, treatment and prognosis of tumors.展开更多
Obiective:To investigate the prognostic value of ORMDL2 in human glioma and its relationship with immune invasion.Methods:The clinical survival data from TCGA-LGG&GBM,CGGA and GEO were used to evaluate the clinica...Obiective:To investigate the prognostic value of ORMDL2 in human glioma and its relationship with immune invasion.Methods:The clinical survival data from TCGA-LGG&GBM,CGGA and GEO were used to evaluate the clinical prognostic value of ORMDL2.The cut off value of ORMDL2 was detected with pROC package to draw ROC curve to prove its value in differential diagnosis of glioma.The first 300 genes with the most significant positive correlation with ORMDL2 were selected to establish PPI network through STRING database and conduct GO and pathway analysis.The relationship between the expression of ORMDL2 mRNA and immune cell infiltration was investigated by using ssGSEA and TIMER2.0 databases.Results:The expression of ORMDL2 mRNA in glioma was significantly higher than that in adjacent normal tissues,and the difference was most significant in high-grade glioma.The expression of ORMDL2 was increased in human glioma,which was related to the clinicopathological characteristics and poor prognosis of glioma patients.In addition,the increased expression of ORMDL2 was associated with a series of immune infiltrating cells,including macrophages.Conclusion:ORMDL2 plays an important role in glioma immune cell infiltration and is a biomarker of prognosis of glioma patients.展开更多
文摘细胞焦亡是一种炎症性程序性死亡方式,是一种有别于传统的坏死、凋亡等的新型细胞死亡方式,主要由成孔蛋白Gasdermin (GSDM)家族介导。活化的半胱氨酸天冬氨酸特异性蛋白酶(caspase)切割Gasdermin家族成员释放N端结构域在胞膜上打孔,从而导致细胞肿胀破裂死亡。Gasdermin B (GSDMB)属于Gasdermin (GSDM)家族,具有促肿瘤或抗肿瘤作用。在肿瘤细胞的相关研究中发现,GSDMB在乳腺癌、胃癌、肝癌、宫颈癌和结肠癌等癌细胞中高表达。因此,学者们认为GSDMB可能作为癌基因参与了癌症的进展和转移。本文综述了GSDMB在各种恶性肿瘤中的作用,以期为肿瘤的临床诊断、治疗及预后提供新的思路。Pyroptosis is an inflammatory programmed cell death, which is different from traditional necrosis and apoptosis. It is mainly mediated by the poreforming protein Gasdermin (GSDM) family. Activated caspases cleave Gasdermin family members to release N-terminal domains that punch holes in the cell membrane, leading to cell swelling, rupture and death. Gasdermin B (GSDMB) belongs to the Gasdermin (GSDM) family and has pro-or anti-tumor effects. Studies on tumor cells have found that GSDMB is highly expressed in breast cancer, gastric cancer, liver cancer, cervical cancer and colon cancer cells. Therefore, scholars believe that GSDMB may be involved in cancer progression and metastasis as an oncogene. This article reviews the role of GSDMB in various malignant tumors, in order to provide new ideas for the clinical diagnosis, treatment and prognosis of tumors.
基金Finance Science and Technology Project of Hainan Province(ZDYF2022SHFZ088),Hainan Medical University Postgraduate Innovative Research Project Category B(HYYS2021B16)。
文摘Obiective:To investigate the prognostic value of ORMDL2 in human glioma and its relationship with immune invasion.Methods:The clinical survival data from TCGA-LGG&GBM,CGGA and GEO were used to evaluate the clinical prognostic value of ORMDL2.The cut off value of ORMDL2 was detected with pROC package to draw ROC curve to prove its value in differential diagnosis of glioma.The first 300 genes with the most significant positive correlation with ORMDL2 were selected to establish PPI network through STRING database and conduct GO and pathway analysis.The relationship between the expression of ORMDL2 mRNA and immune cell infiltration was investigated by using ssGSEA and TIMER2.0 databases.Results:The expression of ORMDL2 mRNA in glioma was significantly higher than that in adjacent normal tissues,and the difference was most significant in high-grade glioma.The expression of ORMDL2 was increased in human glioma,which was related to the clinicopathological characteristics and poor prognosis of glioma patients.In addition,the increased expression of ORMDL2 was associated with a series of immune infiltrating cells,including macrophages.Conclusion:ORMDL2 plays an important role in glioma immune cell infiltration and is a biomarker of prognosis of glioma patients.
