Redox nanozymes offer an appealing reactive oxygen species(Ros)-based antibacterial strategy via disrupting intracellular homeostasis,however,they still face many obstacles such as low enzymic activity and irreversibl...Redox nanozymes offer an appealing reactive oxygen species(Ros)-based antibacterial strategy via disrupting intracellular homeostasis,however,they still face many obstacles such as low enzymic activity and irreversible loss of catalytic active center.Meanwhile,the antioxidant glutathione(GSH)overexpressed in infected sites would limit the therapy efficiency.Herein,we develop a multifunctional nanozyme based on copper(l)(Cut)ion doped MoO_(3-x)(Cut-MoO_(3-x))by a simple yet efficient oxygen vacancy-reduced strategy without any pretreatment or additional agents.The resultant Cu^(+)-MoO_(3-x) hybrid possesses enhanced peroxidase-like(POD-like)activity,rapid GSH-depleting function and biodegradable ability.It can achieve highly efficient elimination of Pseudomonas aeruginosa(P.aeruginosa)via disrupting cellular redox balance.展开更多
基金supported by the National Natural Science Foundation of China(Nos.22305134 and 22274084)Natural Science Foundation for Distinguished Young Scholars of Shandong Province(ZR2021JQ04)Taishan Scholars Program of Shandong Province(No.tsqn 201909088).
文摘Redox nanozymes offer an appealing reactive oxygen species(Ros)-based antibacterial strategy via disrupting intracellular homeostasis,however,they still face many obstacles such as low enzymic activity and irreversible loss of catalytic active center.Meanwhile,the antioxidant glutathione(GSH)overexpressed in infected sites would limit the therapy efficiency.Herein,we develop a multifunctional nanozyme based on copper(l)(Cut)ion doped MoO_(3-x)(Cut-MoO_(3-x))by a simple yet efficient oxygen vacancy-reduced strategy without any pretreatment or additional agents.The resultant Cu^(+)-MoO_(3-x) hybrid possesses enhanced peroxidase-like(POD-like)activity,rapid GSH-depleting function and biodegradable ability.It can achieve highly efficient elimination of Pseudomonas aeruginosa(P.aeruginosa)via disrupting cellular redox balance.
