目的回顾性分析股骨近端骨巨细胞瘤患者的手术方式,验证GTOC临床评分系统的有效性。方法2011年1月至2022年12月,共收集浙江大学医学院附属第二医院股骨近端骨巨细胞瘤患者45例,根据中国骨巨细胞瘤协作组成成员(Member of the Chinese As...目的回顾性分析股骨近端骨巨细胞瘤患者的手术方式,验证GTOC临床评分系统的有效性。方法2011年1月至2022年12月,共收集浙江大学医学院附属第二医院股骨近端骨巨细胞瘤患者45例,根据中国骨巨细胞瘤协作组成成员(Member of the Chinese Association for Giant Cell tumor of Bone,GTOC)临床评分系统进行评分,统计分析GTOC临床评分系统与手术方式、术后并发症、下肢功能的关系,采用MSTS93下肢功能评分系统评估患肢术后功能,分析影响股骨近端骨巨细胞瘤手术方式选择的因素,对扩大刮除术与大段切除术进行对比分析,从而验证GTOC临床评分系统的有效性。结果45例患者随访时间12~86个月,平均25.7个月。共出现13例并发症,总的发生率28.9%,复发2例,总复发率为4.4%。单因素及多因素Cox回归分析显示影响手术方式选择的因素是病理性骨折和病变部位(P<0.05)。统计资料分析显示,高分组与低分组的手术方式差异有统计学意义(χ^(2)=8.557,P<0.05),呈正相关关系(Pearson相关系数R=0.436,P=0.003)。对扩大刮除术与瘤段切除重建术进行对比分析,两种手术方式的术后MSTS功能评分、手术时间有明显差异(P<0.05)。结论GTOC临床评分系统涵盖了手术方式选择的主要影响因素,对于股骨近端骨巨细胞瘤患者在临床治疗手术方案的选择中具有指导价值。展开更多
The 8th edition of the Global Trajectory Optimization Competition(GTOC8)presented a novel concept of a space-based very-long-baseline interferometry(VLBI)telescope in cislunar space for observing selected radio source...The 8th edition of the Global Trajectory Optimization Competition(GTOC8)presented a novel concept of a space-based very-long-baseline interferometry(VLBI)telescope in cislunar space for observing selected radio sources in cosmos.It requires designing a three-spacecraft triangular formation with changeable sizes and orientations such that observation can be scheduled as efficiently as possible.We first review the problem,and then describe the methods employed by representative teams participating in the competition.Subsequently,we present the design techniques employed by the team from the Chinese Academy of Sciences,which are primarily based on orbital-geometry analysis.Two efficient trajectory patterns are summarized:million-kilometer triangular formations with symmetric circular orbits,and consecutive-lunar-flyby trajectories with Moon-to-Moon transfer orbits.These two trajectory patterns enable establishing and reconfiguring the triangular formation with sufficiently different sizes so that a number of radio sources can be observed,thus maximizing the performance index.Finally,we present a solution with the best currently known score of J=158 million km.展开更多
This paper presents the crucial method for obtaining our team's results in the 8th Global Trajectory Optimization Competition(GTOC8).Because the positions and velocities of spacecraft cannot be completely determin...This paper presents the crucial method for obtaining our team's results in the 8th Global Trajectory Optimization Competition(GTOC8).Because the positions and velocities of spacecraft cannot be completely determined by one observation on one radio source,the branch and bound method for sequence optimization of multi-asteroid exploration cannot be directly applied here.To overcome this diculty,an optimization method for searching the observing sequence based on nominal low-thrust trajectories of the symmetric observing con guration is proposed.With the symmetric observing con guration,the normal vector of the triangle plane formed by the three spacecraft rotates in the ecliptic plane periodically and approximately points to the radio sources which are close to the ecliptic plane.All possible observing opportunities are selected and ranked according to the nominal trajectories designed by the symmetric observing con guration.First,the branch and bound method is employed to nd the optimal sequence of the radio source with thrice observations.Second,this method is also used to nd the optimal sequence of the left radio sources.The nominal trajectories are then corrected for accurate observations.The performance index of our result is 128,286,317.0 km which ranks the second place in GTOC8.展开更多
文摘目的回顾性分析股骨近端骨巨细胞瘤患者的手术方式,验证GTOC临床评分系统的有效性。方法2011年1月至2022年12月,共收集浙江大学医学院附属第二医院股骨近端骨巨细胞瘤患者45例,根据中国骨巨细胞瘤协作组成成员(Member of the Chinese Association for Giant Cell tumor of Bone,GTOC)临床评分系统进行评分,统计分析GTOC临床评分系统与手术方式、术后并发症、下肢功能的关系,采用MSTS93下肢功能评分系统评估患肢术后功能,分析影响股骨近端骨巨细胞瘤手术方式选择的因素,对扩大刮除术与大段切除术进行对比分析,从而验证GTOC临床评分系统的有效性。结果45例患者随访时间12~86个月,平均25.7个月。共出现13例并发症,总的发生率28.9%,复发2例,总复发率为4.4%。单因素及多因素Cox回归分析显示影响手术方式选择的因素是病理性骨折和病变部位(P<0.05)。统计资料分析显示,高分组与低分组的手术方式差异有统计学意义(χ^(2)=8.557,P<0.05),呈正相关关系(Pearson相关系数R=0.436,P=0.003)。对扩大刮除术与瘤段切除重建术进行对比分析,两种手术方式的术后MSTS功能评分、手术时间有明显差异(P<0.05)。结论GTOC临床评分系统涵盖了手术方式选择的主要影响因素,对于股骨近端骨巨细胞瘤患者在临床治疗手术方案的选择中具有指导价值。
基金supported by the National Natural Science Foundation of China(No.11372311)the Key Research Program of the Chinese Academy of Sciences(No.ZDRW-KT-2019-1).
文摘The 8th edition of the Global Trajectory Optimization Competition(GTOC8)presented a novel concept of a space-based very-long-baseline interferometry(VLBI)telescope in cislunar space for observing selected radio sources in cosmos.It requires designing a three-spacecraft triangular formation with changeable sizes and orientations such that observation can be scheduled as efficiently as possible.We first review the problem,and then describe the methods employed by representative teams participating in the competition.Subsequently,we present the design techniques employed by the team from the Chinese Academy of Sciences,which are primarily based on orbital-geometry analysis.Two efficient trajectory patterns are summarized:million-kilometer triangular formations with symmetric circular orbits,and consecutive-lunar-flyby trajectories with Moon-to-Moon transfer orbits.These two trajectory patterns enable establishing and reconfiguring the triangular formation with sufficiently different sizes so that a number of radio sources can be observed,thus maximizing the performance index.Finally,we present a solution with the best currently known score of J=158 million km.
基金the National Natural Science Foundation of China(Grant Nos.11672146 and 11432001)The authors thank the organizer of GTOC8.
文摘This paper presents the crucial method for obtaining our team's results in the 8th Global Trajectory Optimization Competition(GTOC8).Because the positions and velocities of spacecraft cannot be completely determined by one observation on one radio source,the branch and bound method for sequence optimization of multi-asteroid exploration cannot be directly applied here.To overcome this diculty,an optimization method for searching the observing sequence based on nominal low-thrust trajectories of the symmetric observing con guration is proposed.With the symmetric observing con guration,the normal vector of the triangle plane formed by the three spacecraft rotates in the ecliptic plane periodically and approximately points to the radio sources which are close to the ecliptic plane.All possible observing opportunities are selected and ranked according to the nominal trajectories designed by the symmetric observing con guration.First,the branch and bound method is employed to nd the optimal sequence of the radio source with thrice observations.Second,this method is also used to nd the optimal sequence of the left radio sources.The nominal trajectories are then corrected for accurate observations.The performance index of our result is 128,286,317.0 km which ranks the second place in GTOC8.
