Objective:It has been demonstrated that biopterin,an essential cofactor of nitric oxide synthase(NOS),plays an important role in the pathogenesis of endotoxin-induced shock,yet its biological significance ingram-posit...Objective:It has been demonstrated that biopterin,an essential cofactor of nitric oxide synthase(NOS),plays an important role in the pathogenesis of endotoxin-induced shock,yet its biological significance ingram-positive sepsis remains unclear.In this study,we adopted a rat model of postburn Staphylococcus aureus (S.aureus) sepsis to observe the time course and tissue distribution of biopterin in postburn S.aureus infection,and toinvestigate its potential role in the pathogenesis of gram-positive sepsis...展开更多
基金grants from the National Key Program for Fundamental Research and Development(973 Project G1999054203)the National Natural Science Outstanding Youth Foundation of China(Project 30125020).
文摘Objective:It has been demonstrated that biopterin,an essential cofactor of nitric oxide synthase(NOS),plays an important role in the pathogenesis of endotoxin-induced shock,yet its biological significance ingram-positive sepsis remains unclear.In this study,we adopted a rat model of postburn Staphylococcus aureus (S.aureus) sepsis to observe the time course and tissue distribution of biopterin in postburn S.aureus infection,and toinvestigate its potential role in the pathogenesis of gram-positive sepsis...
