Global transplantation:Lessons from organ transplantation organizations worldwide

Although national transplant organizations share common visions and goals,the creation of a unified global organization remains impractical.Differences in ethnicity,culture,religion,and education shape local practices and infrastructure,making the establishment of a single global entity unfeasible.Even with these social disparities aside,logistical factors such as time and distance between organ procurement and transplantation sites pose significant challenges.While technological advancements have extended organ preservation times,they have yet to support the demands of transcontinental transplantations effectively.This review presents a comparative analysis of the structures,operational frameworks,policies,and legislation governing various transplant organizations around the world.Key differences pertain to the administration of these organizations,trends in organ donation,and organ allocation policies,which reflect the financial,cultural,and religious diversity across different regions.While a global transplant organization may be out of reach,agreeing on best practices for the benefit of patients is essential.

Oruxmaps软件结合Global Mapper软件在矿产资源行业并购中的应用

纸质地质图结合手持GPS,采用手工方式野外记录的传统地质调查工作方式已不能适应数字化和信息化的要求,在矿产资源并购项目中,运用Oruxmaps、Global Mapper等软件,可以制作适应地质调查工作所特需的离线地质图,实现地质图、GPS定位、路线轨迹记录、文字记录、影像记录等的有机结合,形成了一套行之有效的工作流程,极大地提高了路线地质调查工作的质量和效率。

Global Mapper在水库库容计算及淤积分析中的应用研究

基于快捷精准计算水库库容,并与原始库容对比分析库容淤积的目的,使用Global Mapper软件的库容计算和DEM叠加分析功能,通过水库库容复核工程实例进行应用试验,结果表明使用Global Mapper计算库容的结果精度与等高线法的库容结果相当,计算高效、结果可靠,DEM叠加分析成果可以直观展示库容淤积分布,有助于为管理单位冲淤冲沙提供决策。

Correlation Analysis of Persistent Heavy Rainfall Events in the Vicinity of the Yangtze River Valley and Global Outgoing Longwave Radiation in the Preceding Month

Based on the National Oceanic and Atmospheric Administration （NOAA） daily satellite dataset of global outgoing longwave radiation （OLR） for the period of 1974-2004 and the NCEP-NCAR reanalysis for 1971- 2004, the linkage between persistent heavy rainfall （PHR） events in the vicinity of the Yangtze River valley and global OLR leading up to those events （with 1- to 3O-day lag） was investigated. The results reveal that there is a significant connection between the initiation of PHR events over the study area and anomalous convective activity over the tropical Indian Ocean, maritime continent, and tropical western Pacific Ocean. During the 30-day period prior to the onset of PHR events, the major significantly anomalous convective centers have an apparent dipole structure, always with enhanced convection in the west and suppressed convection in the east. This dipole structure continuously shifts eastward with time during the 30-day lead period. The influence of the anomalous convective activity over the tropical oceans on the initiation of PHR events over the study area is achieved via an interaction between tropical and extratropical latitudes. More specifically, anomalous convective activity weakens the Walker circulation cell over the tropical Indian Ocean first. This is followed by a weakening of the Indian summer monsoon background state and the excitation and dispersion of Rossby wave activity over Eurasia. Finally, a major modulation of the large scale background circulation occurs. As a result, the condition of a phase-lock among major large scale circulation features favoring PHR events is established over the study area.

小麦胚芽鞘长度QTL定位和GWAS分析

在干旱条件下,小麦(Triticum aestivum L.)适当深播可提高出苗率,胚芽鞘长度决定了小麦播种的最大深度,因此培育长胚芽鞘小麦品种至关重要。为了挖掘控制小麦胚芽鞘长度相关的数量性状位点(quantitative trait loci,QTL),本研究以275份豆麦/石4185重组自交系(recombinant inbred lines,RIL)群体和186份自然群体为材料,根据90K SNP芯片的分型结果,利用3个环境下小麦胚芽鞘长度表型数据进行QTL鉴定。采用完备区间作图法(inclusive composite interval mapping,ICIM)在RIL群体中鉴定到2个稳定的QTL位点,分别位于4BS(30.17~40.59 Mb)和6BL(700.08~703.53 Mb)染色体上,解释表型变异率(PVE)分别为26.29%~28.46%和4.16%~4.36%;全基因组关联分析(GWAS)采用混合线性模型(Mixed linear model,MLM)方法,共鉴定到36个稳定的QTL位点,分别位于1A(3)、1B(3)、1D(2)、2A(1)、3A(2)、3B(2)、4B(11)、5A(1)、5B(3)、6B(4)、7A(2)、7B(2)染色体上,在3个环境中重复检测到的显著关联位点有7个,其中3个位点与已报道的位点重叠或邻近,其他4个位点推测为新位点,分别位于1A(499.03 Mb)、3A(73.06 Mb)、4B(648.74~648.87 Mb)、7A(36.31 Mb)染色体上,预测了5个候选基因(TraesCS1A03G0748300、Rht1、TraesCS4B03G0110000、TraesCS4B03G0112200和TraesCS7A03G0146600)。在两个群体中均鉴定到位于4BS(30.17~40.59 Mb)染色体上的主效QTL位点,该位点的候选基因Rht1已被证实能降低小麦胚芽鞘长度。该研究结果为挖掘控制小麦胚芽鞘长度的基因以及胚芽鞘长度相关性状分子标记辅助选择育种奠定了基础。

基于GWAS模型的邯郸市水资源优化配置研究

近年来邯郸市上游河流入境水量减少,地下水开采总量愈加限制,难以满足不同行业大幅度上升的用水需求,加之南水北调、引黄和引卫工程建设后对一部分行业供水水源的置换,邯郸市水资源短缺问题和供需矛盾越发尖锐复杂。通过分析邯郸市的水资源特点及水利工程分布特征,并对各区县进行水量供需预测,基于GWAS构建了邯郸市多水源、多用户和多目标的水资源优化配置模型。结果显示:邯郸市2025年P=50%保证率的总需水量为3013.01×10^(6)m^(3),总分配水量为2473.97×10^(6)m^(3),缺水率为17.89%;P=75%保证率的总需水量为3434.90×10^(6)m^(3),总分配水量为2498.22×10^(6)m^(3),缺水率为27.27%。缺水主要集中在第一产业。配置结果符合邯郸市的实际用水情况,研究成果可为邯郸市水资源管理提供技术参考。

El Niño and the AMO Sparked the Astonishingly Large Margin of Warming in the Global Mean Surface Temperature in 2023

In 2023,the majority of the Earth witnessed its warmest boreal summer and autumn since 1850.Whether 2023 will indeed turn out to be the warmest year on record and what caused the astonishingly large margin of warming has become one of the hottest topics in the scientific community and is closely connected to the future development of human society.We analyzed the monthly varying global mean surface temperature(GMST)in 2023 and found that the globe,the land,and the oceans in 2023 all exhibit extraordinary warming,which is distinct from any previous year in recorded history.Based on the GMST statistical ensemble prediction model developed at the Institute of Atmospheric Physics,the GMST in 2023 is predicted to be 1.41℃±0.07℃,which will certainly surpass that in 2016 as the warmest year since 1850,and is approaching the 1.5℃ global warming threshold.Compared to 2022,the GMST in 2023 will increase by 0.24℃,with 88%of the increment contributed by the annual variability as mostly affected by El Niño.Moreover,the multidecadal variability related to the Atlantic Multidecadal Oscillation(AMO)in 2023 also provided an important warming background for sparking the GMST rise.As a result,the GMST in 2023 is projected to be 1.15℃±0.07℃,with only a 0.02℃ increment,if the effects of natural variability—including El Niño and the AMO—are eliminated and only the global warming trend is considered.

Identification of an Aux/IAA regulator for flesh firmness using combined GWAS and bulked segregant RNA-Seq analysis in watermelon

Watermelon is a highly cultivated fruit crop renowned for its quality properties of fruit flesh.Among various quality factors,fruit flesh firmness is a crucial quality parameter influencing the fruit texture,shelf life and its commercial value.The auxin/indole-3-acetic acid(Aux/IAA)plays a significant role in fruit development and ripening of non-climacteric fruits.However,the regulatory mechanism of Aux/IAA in controlling fruit flesh firmness and ripening in watermelon remains unknown.In this study,we employed an integrative approach combining genome-wide association study(GWAS)and bulked segregant RNA-Seq analysis(BSR-Seq)to identify an overlapping candidate region between 12776310 and 12968331 bp on chromosome 6,underlying an auxin-responsive gene(Aux/IAA)associated with flesh firmness in watermelon.Transcriptome analysis,followed by real-time quantitative reverse transcription PCR(qRT-PCR),confirmed that the expression of Aux/IAA was consistently higher in fruits with high flesh firmness.The sequence alignment revealed a single base mutation in the coding region of Aux/IAA.Furthermore,the concomitant Kompetitive/Competitive allele-specific PCR(KASP)genotyping data sets for F2 population and germplasm accessions identified Aux/IAA as a strong candidate gene associated with flesh firmness.Aux/IAA was enriched in the plant hormone signal transduction pathway,involving cell enlargement and leading to low flesh firmness.We determined the higher accumulation of abscisic acid(ABA)in fruits with low flesh firmness than hard flesh.Moreover,overexpression of Aux/IAA induced higher flesh firmness with an increased number of fruit flesh cells while reducing ABA content and flesh cell sizes.Additionally,the allelic variation in Aux/IAA for soft flesh firmness was found to exist in Citrullus mucosospermus and gradually fixed into Citrullus lanatus during domestication,indicating that soft flesh firmness was a domesticated trait.These findings significantly enhanced our understanding of watermelon fruit flesh firmness and consequently the watermelon fruit quality.

‘Partly'globalized networks and driving mechanism in resource-based state-owned enterprises:A case study of J Group

In the context of economic globalization,while multinational enterprises from developed countries occupy a high-end position in the global value chain,enterprises from developing countries are often marginalized in the world market.In China,resource-based state-owned enterprises(SOEs)are tasked with the mission of safeguarding resource security,and their internationalization development ideas and strategic deployment are significantly and fundamentally different from those of other non-state-owned enterprises and large multinational corporations.This study provides ideas for the globalization policies of enterprises in developing countries.We consider J Group in western China as a case and discuss its productive investment and global production network development from 2010 to 2019.We found that J Group was‘Partly'globalized,and there are multiple core nodes with the characteristics of centralized and decentralized coexistence in the production network;in addition,the overall layout centre shifted to Southeast Asia and China;however,its global production was restricted by the enterprise's investment security considerations,support and restrictions of the home country,political security risk of the host country,and sanctions from the West.These findings provide insights for future research:under the wave of anti-globalization and'internal circulation as the main body',resource SOEs should consider the potential risk of investment,especially keeping the middle and downstream industrial chain in China as much as possible.

Record-breaking High-temperature Outlook for 2023: An Assessment Based on the China Global Merged Temperature(CMST) Dataset

According to the latest version(version 2.0) of the China global Merged Surface Temperature(CMST2.0) dataset, the global mean surface temperature(GMST) in the first half of 2023 reached its third warmest value since the period of instrumental observation began, being only slightly lower than the values recorded in 2016 and 2020, and historically record-breaking GMST emerged from May to July 2023. Further analysis also indicates that if the surface temperature in the last five months of 2023 approaches the average level of the past five years, the annual average surface temperature anomaly in 2023 of approximately 1.26°C will break the previous highest surface temperature, which was recorded in 2016of approximately 1.25°C(both values relative to the global pre-industrialization period, i.e., the average value from 1850 to1900). With El Ni?o triggering a record-breaking hottest July, record-breaking average annual temperatures will most likely become a reality in 2023.

Global hybrid simulations of soft X-ray emissions in the Earth’s magnetosheath

Earth’s magnetopause is a thin boundary separating the shocked solar wind plasma from the magnetospheric plasmas,and it is also the boundary of the solar wind energy transport to the magnetosphere.Soft X-ray imaging allows investigation of the large-scale magnetopause by providing a two-dimensional(2-D)global view from a satellite.By performing 3-D global hybrid-particle-in-cell(hybrid-PIC)simulations,we obtain soft X-ray images of Earth’s magnetopause under different solar wind conditions,such as different plasma densities and directions of the southward interplanetary magnetic field.In all cases,magnetic reconnection occurs at low latitude magnetopause.The soft X-ray images observed by a hypothetical satellite are shown,with all of the following identified:the boundary of the magnetopause,the cusps,and the magnetosheath.Local X-ray emissivity in the magnetosheath is characterized by large amplitude fluctuations(up to 160%);however,the maximum line-of-sight-integrated X-ray intensity matches the tangent directions of the magnetopause well,indicating that these fluctuations have limited impact on identifying the magnetopause boundary in the X-ray images.Moreover,the magnetopause boundary can be identified using multiple viewing geometries.We also find that solar wind conditions have little effect on the magnetopause identification.The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will provide X-ray images of the magnetopause for the first time,and our global hybrid-PIC simulation results can help better understand the 2-D X-ray images of the magnetopause from a 3-D perspective,with particle kinetic effects considered.

A Universally Beneficial and Inclusive Economic Globalization:Connotations,Logical Basis and Contemporary Relevance

The world is undergoing seismic upheavals unseen in a century.Globalization faces complex challenges and attacks from the political forces advocating reverse globalization and deglobalization.Pessimistic arguments such as“the end of globalization”1 and“global trade fragmentation”2 keep rising.The open world economy is at a crossroads.

GLOBAL SOLUTIONS TO 1D COMPRESSIBLE NAVIER-STOKES/ALLEN-CAHN SYSTEM WITH DENSITY-DEPENDENT VISCOSITY AND FREE-BOUNDARY

This paper is concerned with the Navier-Stokes/Allen-Cahn system,which is used to model the dynamics of immiscible two-phase flows.We consider a 1D free boundary problem and assume that the viscosity coefficient depends on the density in the form ofη(ρ)=ρ^(α).The existence of unique global H^(2m)-solutions(m∈N)to the free boundary problem is proven for when 0<α<1/4.Furthermore,we obtain the global C^(∞)-solutions if the initial data is smooth.

Emerging global interest:Unraveling the link between diabetes mellitus and depression

BACKGROUND Studies have shown a strong bidirectional association between diabetes and depression,with diabetes increasing the risk of developing depression and vice versa.Depression among patients with diabetes is associated with poor glycemic control,complications,and poor self-care.AIM To explore the present state of research globally concerning diabetes and depression,to aid understanding the current research landscape and identify potential future areas of research.METHODS A bibliometric approach was used,utilizing the Scopus database to gather pertinent research articles released from 2004 to 2023.Analyses encompassed publication patterns,significant contributors,research focal points,prevalent themes,and the most influential articles,aimed at discerning emerging research subjects.RESULTS A total of 3229 publications that met the search criteria were identified.A significant increase in the number of publications related to diabetes and depression has been observed in the past two decades.The most productive nation was the USA(n=1015;31.43%),followed by China(n=325;10.07%),the UK(n=236;7.31%),and Germany(n=218;6.75%).Three principal themes in research on depression and diabetes were delineated by the analysis.First,the exploration of the elevated prevalence and etiology of this comorbidity;second,the focus on interventions,particularly randomized controlled trials,aimed at enhancing diabetes management among individuals with depression;and finally,the investigation of the involved risk factors and biological mechanisms under-lying this bidirectional relationship.CONCLUSION There has been a recent surge of interest in the relationship between diabetes and depression.This could aid researchers to identify areas lacking in the literature and shape future research.

Research on a Monte Carlo global variance reduction method based on an automatic importance sampling method

Global variance reduction is a bottleneck in Monte Carlo shielding calculations.The global variance reduction problem requires that the statistical error of the entire space is uniform.This study proposed a grid-AIS method for the global variance reduction problem based on the AIS method,which was implemented in the Monte Carlo program MCShield.The proposed method was validated using the VENUS-Ⅲ international benchmark problem and a self-shielding calculation example.The results from the VENUS-Ⅲ benchmark problem showed that the grid-AIS method achieved a significant reduction in the variance of the statistical errors of the MESH grids,decreasing from 1.08×10^(-2) to 3.84×10^(-3),representing a 64.00% reduction.This demonstrates that the grid-AIS method is effective in addressing global issues.The results of the selfshielding calculation demonstrate that the grid-AIS method produced accurate computational results.Moreover,the grid-AIS method exhibited a computational efficiency approximately one order of magnitude higher than that of the AIS method and approximately two orders of magnitude higher than that of the conventional Monte Carlo method.

Background removal from global auroral images:Data-driven dayglow modeling

Global images of auroras obtained by cameras on spacecraft are a key tool for studying the near-Earth environment.However,the cameras are sensitive not only to auroral emissions produced by precipitating particles,but also to dayglow emissions produced by photoelectrons induced by sunlight.Nightglow emissions and scattered sunlight can contribute to the background signal.To fully utilize such images in space science,background contamination must be removed to isolate the auroral signal.Here we outline a data-driven approach to modeling the background intensity in multiple images by formulating linear inverse problems based on B-splines and spherical harmonics.The approach is robust,flexible,and iteratively deselects outliers,such as auroral emissions.The final model is smooth across the terminator and accounts for slow temporal variations and large-scale asymmetries in the dayglow.We demonstrate the model by using the three far ultraviolet cameras on the Imager for Magnetopause-to-Aurora Global Exploration(IMAGE)mission.The method can be applied to historical missions and is relevant for upcoming missions,such as the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission.

Integrated multi-scale approach combining global homogenization and local refinement for multi-field analysis of high-temperature superconducting composite magnets

Second-generation high-temperature superconducting(HTS)conductors,specifically rare earth-barium-copper-oxide(REBCO)coated conductor(CC)tapes,are promising candidates for high-energy and high-field superconducting applications.With respect to epoxy-impregnated REBCO composite magnets that comprise multilayer components,the thermomechanical characteristics of each component differ considerably under extremely low temperatures and strong electromagnetic fields.Traditional numerical models include homogenized orthotropic models,which simplify overall field calculation but miss detailed multi-physics aspects,and full refinement(FR)ones that are thorough but computationally demanding.Herein,we propose an extended multi-scale approach for analyzing the multi-field characteristics of an epoxy-impregnated composite magnet assembled by HTS pancake coils.This approach combines a global homogenization(GH)scheme based on the homogenized electromagnetic T-A model,a method for solving Maxwell's equations for superconducting materials based on the current vector potential T and the magnetic field vector potential A,and a homogenized orthotropic thermoelastic model to assess the electromagnetic and thermoelastic properties at the macroscopic scale.We then identify“dangerous regions”at the macroscopic scale and obtain finer details using a local refinement(LR)scheme to capture the responses of each component material in the HTS composite tapes at the mesoscopic scale.The results of the present GH-LR multi-scale approach agree well with those of the FR scheme and the experimental data in the literature,indicating that the present approach is accurate and efficient.The proposed GH-LR multi-scale approach can serve as a valuable tool for evaluating the risk of failure in large-scale HTS composite magnets.

基于Ka波段的海事卫星Global Xpress系统

文章主要介绍了基于Ka波段的海事卫星Global Xpress系统的技术特点,着重与传统Vsat业务进行了对比,简单介绍了GX的海事业务。

Combined ATAC-seq,RNA-seq,and GWAS analysis reveals glycogen metabolism regulatory network in Jinjiang oyster(Crassostrea ariakensis)

Glycogen serves as the principal energy reserve for metabolic processes in aquatic shellfish and substantially contributes to the flavor and quality of oysters.The Jinjiang oyster(Crassostrea ariakensis)is an economically and ecologically important species in China.In the present study,RNA sequencing(RNA-seq)and assay for transposase-accessible chromatin using sequencing(ATAC-seq)were performed to investigate gene expression and chromatin accessibility variations in oysters with different glycogen contents.Analysis identified 9483 differentially expressed genes(DEGs)and 7215 genes with significantly differential chromatin accessibility(DCAGs)were obtained,with an overlap of 2600 genes between them.Notably,a significant proportion of these genes were enriched in pathways related to glycogen metabolism,including“Glycogen metabolic process”and“Starch and sucrose metabolism”.In addition,genome-wide association study(GWAS)identified 526 single nucleotide polymorphism(SNP)loci associated with glycogen content.These loci corresponded to 241 genes,63 of which were categorized as both DEGs and DCAGs.This study enriches basic research data and provides insights into the molecular mechanisms underlying the regulation of glycogen metabolism in C.ariakensis.

QTL mapping by GWAS and functional analysis of OsbZIP72 for cold tolerance at rice seedling stage

Rice is a major crop susceptible to chilling stress.The identification of quantitative trait loci and genes for cold tolerance is crucial for the rice breeding.Of 30 quantitative-trait loci affecting seedling cold tolerance identified in a genome-wide association study of 540 rice accessions,OsbZIP72 was assigned as the causative gene for one,qCTS9.1.A single-nucleotide polymorphism in its promoter accounted for variation in expression between indica and japonica subspecies.The favorable haplotype of OsbZIP72 originated in wild rice and contributed to the expansion of japonica rice to colder habitats.OsbZIP72 positively regulates genes coding reactive oxygen species(ROS)-scavenging proteins and maintains intracellular ROS homeostasis.These findings not only enhanced our understanding of environmental adaptation but also provide novel genetic resources and potential targets for molecular design breeding for cold tolerance in rice.