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Jim Gallas博士谈褪黑激素产生因子技术 再见,有害光!
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作者 王楠楠 《交通建设与管理》 2015年第22期70-71,共2页
一束蓝光垂直射在一张白纸上,一枚耀眼的光斑即刻呈现在眼前。Jim Gallas博士随手拿起一片黄色的镜片,挡在了光源与白纸之间,光斑瞬间变得柔和。
关键词 褪黑激素 JIM gallas 德克萨斯大学 物理学教授 眩光 颜色视觉 感觉像 搪瓷制品 应用技术 色素上皮细胞
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五倍子在中华倒刺鲃体内的药动学研究(英文) 被引量:3
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作者 郭海燕 张耀光 《淡水渔业》 CSCD 北大核心 2014年第3期68-74,共7页
以五倍子的有效成分没食子酸为目标药物,采用高效液相色谱法检测药物浓度,用房室模型和非房室模型法同时分析药动学数据,获得25.0℃水温条件下20 mg/kg单剂量口灌五倍子(Galla chinensis)后中华倒刺鲃(Spinibarbus sinensis)体内的药物... 以五倍子的有效成分没食子酸为目标药物,采用高效液相色谱法检测药物浓度,用房室模型和非房室模型法同时分析药动学数据,获得25.0℃水温条件下20 mg/kg单剂量口灌五倍子(Galla chinensis)后中华倒刺鲃(Spinibarbus sinensis)体内的药物代谢情况。结果表明:血液中的药动学数据可以用一级吸收二室开放模型描述,一些血液的药动参数和肝脏、肾脏的数据用非房室模型分析,药物在中华倒刺鲃体内的吸收、分布和消除半衰期分别是:0.523 h,1.054 h和10.501 h。在血液、肝脏和肾脏均在1 h时达到最大药物峰,Cmax值分别是9.166μg/mL,76.214μg/mL和85.860μg/mL;药时曲线下面积(AUC)分别是77.396 7μgh/mL,402.106μgh/mL和258.048μgh/mL;平均驻留时间(MRT)分别是19.309 1 h,25.935 h和6.480 h。五倍子在中华倒刺鲃体内有较快和较好的吸收,同时在体内能保持较高浓度足够时间以达到治疗效果。 展开更多
关键词 药动学 五倍子(Galla chinensis) 没食子酸 中华倒刺鲃(Spinibarbus sinensis)
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Chemical composition of Galla chinensis extract and the effect of its main component(s) on the prevention of enamel demineralization in vitro 被引量:11
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作者 Xue-Lian Huang Ming-Dong Liu +2 位作者 Ji-Yao Li Xue-Dong Zhou Jacob M ten Cate 《International Journal of Oral Science》 SCIE CAS CSCD 2012年第3期146-151,共6页
To determine the chemical composition of Galla chinensisextract (GCE) by several analysis techniques and to compare the efficacy of GCE and its main component(s) in inhibition of enamel demineralization, for the d... To determine the chemical composition of Galla chinensisextract (GCE) by several analysis techniques and to compare the efficacy of GCE and its main component(s) in inhibition of enamel demineralization, for the development of future anticaries agents, main organic composition of GCE was qualitatively determined by liquid chromatography-time of flight-mass spectrometry (LC-TOF-MS) and quantified by high-performance liquid chromatography-diode array detector (HPLC-DAD). Inorganic ions were tested by inductively coupled plasma-atomic emission spectroscopy and F was especially measured by ion chromatography. Then, bovine enamel blocks were randomly divided into four treatment groups and were subjected to a pH-cycling regime for 12 times. Each cycle included 5-min applications with one of four treatments: 4g.L-1 GCE solution, 4g.L-1 gallic acid (GA) solution, I g.L-1 NaF solution (positive control), deionized water (DDW, negative control), and then 60-min application in pH 5.0 acidic buffer and 5-min application in neutral buffer. Acidic buffers were retained for calcium analysis. The main organic composition of GCE were GA and its isomer, and, to a lesser extent, small molecule gallotannins. The content of GA in GCE was 71.3%±0.2% (w/w). Inorganic ions were present in various amounts, of which Ca was (136±2.82) μg.g-1, and Zn was (6.8±0.1) μg.g-1. No F was detected in GCE. in pH cycling, GA showed an effect similar to GCE in inhibiting enamel demineralization (P〉0.05). GA was found to be the main effective, demineralization inhibiting component of GCE and could be a promising agent for the development of anticaries agents. 展开更多
关键词 active component Galla chinensis gallic acid COMPOSITION dental caries
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Effect of Galla chinensis on the remineralization of two bovine root lesions morphous in vitro 被引量:5
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作者 Bin Guo Ke-Hua Que +3 位作者 Jing Yang Bo Wang Qian-Qian Liang Hong-Hui Xie 《International Journal of Oral Science》 SCIE CAS CSCD 2012年第3期152-156,共5页
The present study aims to evaluate the effect of Galla chinensis compounds on the remineralization of two artificial root lesions morphous in vitro. Sixty bovine dentine blocks were divided into two groups and individ... The present study aims to evaluate the effect of Galla chinensis compounds on the remineralization of two artificial root lesions morphous in vitro. Sixty bovine dentine blocks were divided into two groups and individually treated with two levels of demineralization solutions to form erosive and subsurface artificial carious lesions in vitro. Each group was then divided into three subgroups, each of which were treated with a remineralization solution (positive control), deionized water (negative control), or 4 000 mg-L-1 aqueous solutions of Galla chinensis extract. The dentine blocks were then subjected to a pH-cycling regime for 7 days. During the first 4 days, the daily cycle included 21-h deal and 3-h demineralization applications. The dentine blocks were dealt with the entire day during the remaining 3 days. Two specimens from each of the treatment groups were selected and observed under a polarized light microscope. Data collected using a laser scanning confocal microscope were computerized and analyzed. Galla chinensis extract clearly enhanced the remineralization of both erosive lesion and subsurface lesion patterns in the specimens (P〈0.05). The level of remineralization of the erosive lesion by Galla chinensis extract was lower than that of the subsurface lesion (P〈0.05). In addition, the remineralization of the subsurface lesion by Galla chinensis extract was higher than that of the remineralization solution (P〈0.05). No significant difference between the remineralization of erosive lesions by Galla chinensis extract and the remineralization solution was observed (P〉0.05). So Galla chinensis extract has the potential to improve the remineralization of artificial root lesions under dynamic pH-cyclic conditions, indicating its potential use as a natural remineralization medicine. 展开更多
关键词 Galla chinensis extract pH-cyclic REMINERALIZATION root lesions
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Effect of Galla chinensis on the In Vitro Remineralization of Advanced Enamel Lesions 被引量:4
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作者 Jacob M.ten Cate 《International Journal of Oral Science》 SCIE CAS CSCD 2010年第1期15-20,共6页
Aim The effect of Galla chinensis on de-/re-mineralization of advanced enamel lesions was investigated by using micro-CT in a prolonged in vitro experiment. Methodology Baseline mineral contents of sound enamels were ... Aim The effect of Galla chinensis on de-/re-mineralization of advanced enamel lesions was investigated by using micro-CT in a prolonged in vitro experiment. Methodology Baseline mineral contents of sound enamels were first analyzed. Then lesions were produced in an acidic buffer solution (2.2 mmol.L-1 Ca(NO3)2, 2.2 mmol-L1 KH2PO4, and pH=4.5) for 21 days, with thrice daily three-minute treatments, divided into four groups: Group A, 4 000 ppm crude aqueous extract of Galla chinensis (GCE); Group B, 4 000 ppm gallic acid; Group C, 1 000 ppm F aq. (as NaF, positive control); Group D, deionized water (negative control). Next, the blocks were immersed in a remineralization solution (1.5 mmol.Lz CaC12, 0.9 mmol.L1 KH2PO4, 0.1 ppm F, and pH=7,0) for 200 days. Mineral loss (ML) in each region of interest (ROI) and integrated mineral loss (IML) of the lesions were calculated (comparing with baseline mineral content of sound enamel) at different time points. Results After 21 days demineralization, fluoride treatment showed a statistically significant demineralization-inhibiting effect among the four groups, and after 200 days of remineralization, mineral content recovery was ordered (lowest to highest) as A=C〈B〈D. Conclusion GCE could slow down the remineralization of enamel in the surface layer and thereby facilitate ion transport into the lesion body. The mechanism of Galla chinensis in enhancing the remineralization of dental caries is different from fluoride. 展开更多
关键词 DEMINERALIZATION REMINERALIZATION advanced enamel lesion Galla chinensis
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Determination of reactive oxygen generated from natural medicines and their antibacterial activity 被引量:8
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作者 Noriko Tajima Makiko Takasaki +3 位作者 Haruka Fukamachi Takeshi Igarashi Yoshijiro Nakajima Hidetoshi Arakawa 《Journal of Pharmaceutical Analysis》 SCIE CAS 2016年第4期214-218,共5页
Extracts of 16 natural medicine powders {Galla chinensis,Malloti cortex,Cassiae semen,Sophorae radix,Myricae cortex,Crataegi fructus,Gambit,Mume fructus,Geranii herba,Phellodendri cortex,Coptidis rhizoma,Swertiae herb... Extracts of 16 natural medicine powders {Galla chinensis,Malloti cortex,Cassiae semen,Sophorae radix,Myricae cortex,Crataegi fructus,Gambit,Mume fructus,Geranii herba,Phellodendri cortex,Coptidis rhizoma,Swertiae herba,and Cinnamomi cortex) were assayed for reactive oxygen concentrations using the peroxyoxalate chemiluminescent detection system.High luminescence intensity was observed in Galla chinensis,Geranii herba,Malloti cortex,Myricae cortex,and Cinnamomi cortex.Additional experiments identified the reactive oxygen species as hydrogen peroxide.Galla chinensis generated 2.4 × 10^(-4) mol/L hydrogen peroxide from a 1 mg/mL solution.In bacterial growth tests,Galla chinensis extract had antibacterial activity against Escherichia coli.Staphylococcus aureus,Bacteroides thetaiotaomicron,Campylobacter sputorum biovar sputorum.Streptococcus salivarius thermophilus,Lactobacillus casei,and Bifidobacterium longum infantis.This antibacterial activity was decreased by the addition of catalase.It revealed that hydrogen peroxide which Galla chinensis produced participated in antibacterial activity. 展开更多
关键词 Galla Chinensis Natural medicines Hydrogen peroxide Antibacterial activity
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EXTERNAL APPLICATION OF DRUGS:ABSORPTION AND MECHANISM
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作者 吴震西 吴自强 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 1993年第1期46-49,共4页
The external use of drugs is a simple,ef-fective,sate and cheap means of treatmentof T.C.M..The following is an introductionto the method.1.Conduction through channels andcollaterals (经络传导):Channels andcollaterals... The external use of drugs is a simple,ef-fective,sate and cheap means of treatmentof T.C.M..The following is an introductionto the method.1.Conduction through channels andcollaterals (经络传导):Channels andcollaterals are important parts of the humanbody.This special system is connected to theskin,muscles and tendons superficially 展开更多
关键词 CONNECTED muscles PAINTING compress cheap absorbed ANGINA PASTE 针灸大成 Galla
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蛮牛出闸
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作者 张为扬 蔡昆成 sens 《科技资讯》 2004年第12X期32-32,共1页
「FERRARI 360请小心!」因为LAMBORGHINI Gallardo 来了!搭载一具 V 型10缸引擎、拥有500hp 最大马力的 Galla rdo,是LAMBORGHINI 的入门车款,家族特征非常明显,很能给人一种跃跃欲试、蓄势待发的感觉,不过,为了与老大哥 Murcielago 做... 「FERRARI 360请小心!」因为LAMBORGHINI Gallardo 来了!搭载一具 V 型10缸引擎、拥有500hp 最大马力的 Galla rdo,是LAMBORGHINI 的入门车款,家族特征非常明显,很能给人一种跃跃欲试、蓄势待发的感觉,不过,为了与老大哥 Murcielago 做更明显的区别,Gallardo 并没有采用 LAMBORGHINI传统的闸刀式车门。至于在座舱氛围的营造上。 展开更多
关键词 Galla 超级跑车 蓄势 四轮驱动 车重
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In Vitro Antibacterial Activity of Galla Chinensis Combined with Different Antibacterial Drugs against Carbapenem-Resistant E.Coli
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作者 Zhizhi Xie Changzhi Xu +2 位作者 Yanhua Yi Donglin Zhu Yun Xi 《Journal of Advances in Medicine Science》 2019年第4期19-23,共5页
Objective:To evaluate the antibacterial effects of meropenem and levofloxacin respectively combined with Galla chinensis on carbapenem-resistant Escherichia coli in vitro.Methods:The protocol was designed with checker... Objective:To evaluate the antibacterial effects of meropenem and levofloxacin respectively combined with Galla chinensis on carbapenem-resistant Escherichia coli in vitro.Methods:The protocol was designed with checkerboard method and the carbapenem-resistant E.coli was isolated in our hospital.The minimum inhibitory concentrations(MICs)of G.chinensis alone and combined with 2 antimicrobial agents against carbapenem-resistant E.coli were determined by broth dilution method and the fractional inhibitory concentration index(FICI)was calculated according to MICs results.Result:the combined use of G.chinensis and meropenem(or levofloxacin)significantly decreased both MIC50 and MIC90;After the combination of G.chinensis and meropenem,the synergistic effect was 86.7%,and the additive effect was 13.3%,no irrelevant and antagonistic effects.After combined use of G.chinensis and levofloxacin,the synergistic effect was 66.7%,and the additive effect was 33.3%.No irrelevant and antagonistic effects.Conclusion:Galla chinensis combined with meropenem or levofloxacin has synergistic and additive antibacterial effect,with certain combined antibacterial activity. 展开更多
关键词 Galla CHINENSIS Carbapenem resistance ESCHERICHIA COLI Combination THERAPY
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基于比较转录组学的盐肤木响应五倍子蚜胁迫的机理探究 被引量:1
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作者 陈彦超 汪启明 +4 位作者 饶力群 彭国平 王旭军 李瑞莲 屠小菊 《分子植物育种》 CAS 北大核心 2024年第6期1861-1869,共9页
五倍子(Galla chinensis)是五倍子蚜寄生在盐肤木上形成的虫瘿,是中国常用的中药材之一。目前,关于五倍子形成过程中盐肤木对五倍子蚜的胁迫响应机制鲜有研究。本研究以成瘿及未成瘿的盐肤木叶片为材料,通过新一代转录组测序技术研究五... 五倍子(Galla chinensis)是五倍子蚜寄生在盐肤木上形成的虫瘿,是中国常用的中药材之一。目前,关于五倍子形成过程中盐肤木对五倍子蚜的胁迫响应机制鲜有研究。本研究以成瘿及未成瘿的盐肤木叶片为材料,通过新一代转录组测序技术研究五倍子形成过程中盐肤木对五倍子蚜的胁迫响应机理。测序共获得成瘿组和未成瘿组间差异表达基因26 117个,其中上调基因21 581个,下调基因4 536个。通过GO和KEGG功能注释发现,差异基因主要富集在物质合成及代谢、遗传物质变化、植物激素及光合作用等途径。本研究共筛选到植物激素合成及信号传导途径差异表达基因292个。其中,乙烯(ET)合成及信号传导途径基因差异最显著,与胁迫响应密切相关,筛选到ET信号转导途径关键基因CTR1、MPK6在两种材料中表达量出现显著差异。此外,对筛选到的差异表达基因进行转录因子注释,共得到差异表达转录因子381个,其中83个与植物响应胁迫密切相关的转录因子家族基因表达量出现明显差异,包括MYB、bHLH、AP2-EREBP、NAC、WRKY、b ZIP。本研究通过二代高通量转录组测序技术研究五倍子蚜侵染下盐肤木胁迫响应相关基因的表达特征,为今后研究盐肤木响应五倍子蚜的胁迫机制及五倍子形成的分子机理奠定了基础。 展开更多
关键词 五倍子(Galla chinensis) 盐肤木 转录组学 胁迫响应机理
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ESR AND FLUORESCENCE POLARIZATION STUDIES OF THE EFFECT OF ANISODAMINE ON THE FLUIDITY OF PHOSPHOLIPID LIPOSOMES
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作者 黄芬 陈建文 +3 位作者 付一工 吴玉薇 王者福 张增佑 《Chinese Science Bulletin》 SCIE EI CAS 1985年第4期539-543,共5页
In the previous paper a study on the effect of anisodamine, scopolamine, anisodine and atropine on the fluidity of DPPC liposomes using DSC technique has been reported. Results showed that anisodamine and atropine can... In the previous paper a study on the effect of anisodamine, scopolamine, anisodine and atropine on the fluidity of DPPC liposomes using DSC technique has been reported. Results showed that anisodamine and atropine can significantly increase thefluidity of lipesomes. This paper further shows that using ESR, fluorescence polarization and freeze-fracture electron microscopic techniques, anisodamine can increase 展开更多
关键词 FLUIDITY liposomes Galla microscopic LIPIDS HEPES TEMPO lamine aniso affects
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Endoscopic Local Spray of Galla Chinensis Compound Solution in Treating Biliary Hemorrhage
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作者 刘金钢 唐丽萍 《Chinese Journal of Integrative Medicine》 SCIE CAS 1997年第4期271-272,共2页
Endoscopic Local Spray of Galla Chinensis Compound Solution in Treating Biliary HemorrhageLIUJin-gangandTANG... Endoscopic Local Spray of Galla Chinensis Compound Solution in Treating Biliary HemorrhageLIUJin-gangandTANGLi-ping(Departmen... 展开更多
关键词 Galla CHINENSIS Compound ENDOSCOPIC BILIARY HEMORRHAGE Local Solution SPRAY TREATING
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