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Game-Based Learning for Competency Abilities in Blended Museum Contexts for Diverse Learners
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作者 Hsin-Yi Liang Tien-Yu Hsu 《Psychology Research》 2020年第9期338-348,共11页
Museums offer a lifelong edutainment environment with flexible choices for the public and provide fruitful interdisciplinary learning resources to support competency-based education.However,the lack of proper scaffold... Museums offer a lifelong edutainment environment with flexible choices for the public and provide fruitful interdisciplinary learning resources to support competency-based education.However,the lack of proper scaffolding and supports in museums negatively affect learner learning.Further,the individual differences need to be considered to effectively support the diverse learners learning in museums.In this study,an innovative learning model to support competency education for lifelong learning in museums is proposed.A game-based learning service named CoboFun that offers various types of problem-solving activities was developed to facilitate learners’interaction with exhibits and their peers in the museum.To examine the service design of CoboFun,learners’perceptions were evaluated and the differences in their cognitive styles were examined(Field Independent(FI)and Field Dependent(FD)).The results showed that both FI and FD learners enjoyed learning with CoboFun but that flexible learning tools needed to be provided to satisfy the different needs for the learners with different cognitive styles. 展开更多
关键词 competency-based learning museum learning game-based learning virtual and physical lifelong learning
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Play by Design:Developing Artificial Intelligence Literacy through Game-based Learning
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作者 Xiaoxue Du Xi Wang 《Journal of Computer Science Research》 2023年第4期1-12,共12页
The paper proposes an innovative approach aimed at fostering AI literacy through interactive gaming experiences.This paper designs a game-based prototype for preparing pre-service teachers to innovate teaching practic... The paper proposes an innovative approach aimed at fostering AI literacy through interactive gaming experiences.This paper designs a game-based prototype for preparing pre-service teachers to innovate teaching practices across disciplines.The simulation,Color Conquest,serves as a strategic game to encourage educators to reconsider their pedagogical practices.It allows teachers to use and develop various scenarios by customizing maps,giving students agency to engage in the complex decision-making process.Additionally,this engagement process provides teachers with an opportunity to develop students’skills in artificial intelligence literacy as students actively develop strategic thinking,problem-solving,and critical reasoning skills. 展开更多
关键词 game-based learning game-based assessment Artificial intelligence literacy Design thinking Computational thinking Teacher education
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Comprehensive Review and Analysis on Facial Emotion Recognition:Performance Insights into Deep and Traditional Learning with Current Updates and Challenges
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作者 Amjad Rehman Muhammad Mujahid +2 位作者 Alex Elyassih Bayan AlGhofaily Saeed Ali Omer Bahaj 《Computers, Materials & Continua》 SCIE EI 2025年第1期41-72,共32页
In computer vision and artificial intelligence,automatic facial expression-based emotion identification of humans has become a popular research and industry problem.Recent demonstrations and applications in several fi... In computer vision and artificial intelligence,automatic facial expression-based emotion identification of humans has become a popular research and industry problem.Recent demonstrations and applications in several fields,including computer games,smart homes,expression analysis,gesture recognition,surveillance films,depression therapy,patientmonitoring,anxiety,and others,have brought attention to its significant academic and commercial importance.This study emphasizes research that has only employed facial images for face expression recognition(FER),because facial expressions are a basic way that people communicate meaning to each other.The immense achievement of deep learning has resulted in a growing use of its much architecture to enhance efficiency.This review is on machine learning,deep learning,and hybrid methods’use of preprocessing,augmentation techniques,and feature extraction for temporal properties of successive frames of data.The following section gives a brief summary of assessment criteria that are accessible to the public and then compares them with benchmark results the most trustworthy way to assess FER-related research topics statistically.In this review,a brief synopsis of the subject matter may be beneficial for novices in the field of FER as well as seasoned scholars seeking fruitful avenues for further investigation.The information conveys fundamental knowledge and provides a comprehensive understanding of the most recent state-of-the-art research. 展开更多
关键词 Face emotion recognition deep learning hybrid learning CK+ facial images machine learning technological development
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The Internet of Things under Federated Learning:A Review of the Latest Advances and Applications
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作者 Jinlong Wang Zhenyu Liu +2 位作者 Xingtao Yang Min Li Zhihan Lyu 《Computers, Materials & Continua》 SCIE EI 2025年第1期1-39,共39页
With the rapid development of artificial intelligence,the Internet of Things(IoT)can deploy various machine learning algorithms for network and application management.In the IoT environment,many sensors and devices ge... With the rapid development of artificial intelligence,the Internet of Things(IoT)can deploy various machine learning algorithms for network and application management.In the IoT environment,many sensors and devices generatemassive data,but data security and privacy protection have become a serious challenge.Federated learning(FL)can achieve many intelligent IoT applications by training models on local devices and allowing AI training on distributed IoT devices without data sharing.This review aims to deeply explore the combination of FL and the IoT,and analyze the application of federated learning in the IoT from the aspects of security and privacy protection.In this paper,we first describe the potential advantages of FL and the challenges faced by current IoT systems in the fields of network burden and privacy security.Next,we focus on exploring and analyzing the advantages of the combination of FL on the Internet,including privacy security,attack detection,efficient communication of the IoT,and enhanced learning quality.We also list various application scenarios of FL on the IoT.Finally,we propose several open research challenges and possible solutions. 展开更多
关键词 Federated learning Internet of Things SENSORS machine learning privacy security
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Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning
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作者 Zhenghua Xu Miao Yu Yuhang Song 《Neural Regeneration Research》 SCIE CAS 2025年第11期3215-3216,共2页
Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human brain.To enable learning by brain and machine,it is essential to accurately identify and correct the pr... Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human brain.To enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience. 展开更多
关键词 ASSIGNMENT learning enable
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Federated Learning’s Role in Next-Gen TV Ad Optimization
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作者 Gabriela Dobrita Simona-Vasilica Oprea Adela Bâra 《Computers, Materials & Continua》 SCIE EI 2025年第1期675-712,共38页
In the rapidly evolving landscape of television advertising,optimizing ad schedules to maximize viewer engagement and revenue has become significant.Traditional methods often operate in silos,limiting the potential in... In the rapidly evolving landscape of television advertising,optimizing ad schedules to maximize viewer engagement and revenue has become significant.Traditional methods often operate in silos,limiting the potential insights gained from broader data analysis due to concerns over privacy and data sharing.This article introduces a novel approach that leverages Federated Learning(FL)to enhance TV ad schedule optimization,combining the strengths of local optimization techniques with the power of global Machine Learning(ML)models to uncover actionable insights without compromising data privacy.It combines linear programming for initial ads scheduling optimization with ML—specifically,a K-Nearest Neighbors(KNN)model—for predicting ad spot positions.Taking into account the diversity and the difficulty of the ad-scheduling problem,we propose a prescriptivepredictive approach in which first the position of the ads is optimized(using Google’s OR-Tools CP-SAT)and then the scheduled position of all ads will be the result of the optimization problem.Second,this output becomes the target of a predictive task that predicts the position of new entries based on their characteristics ensuring the implementation of the scheduling at large scale(using KNN,Light Gradient Boosting Machine and Random Forest).Furthermore,we explore the integration of FL to enhance predictive accuracy and strategic insight across different broadcasting networks while preserving data privacy.The FL approach resulted in 8750 ads being precisely matched to their optimal category placements,showcasing an alignment with the intended diversity objectives.Additionally,there was a minimal deviation observed,with 1133 ads positioned within a one-category variance from their ideal placement in the original dataset. 展开更多
关键词 Ad scheduling prescriptive-predictive approach federated learning KNN
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Early identification of stroke through deep learning with multi-modal human speech and movement data
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作者 Zijun Ou Haitao Wang +9 位作者 Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li 《Neural Regeneration Research》 SCIE CAS 2025年第1期234-241,共8页
Early identification and treatment of stroke can greatly improve patient outcomes and quality of life.Although clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are... Early identification and treatment of stroke can greatly improve patient outcomes and quality of life.Although clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized training.In this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute settings.We collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the FAST.We compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and MViT.We found that the findings of our deep learning model had a higher clinical value compared with the other approaches.Moreover,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech audio.These results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting. 展开更多
关键词 artificial intelligence deep learning DIAGNOSIS early detection FAST SCREENING STROKE
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A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning
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作者 Yunjian Guo Kunpeng Li +4 位作者 Wei Yue Nam‑Young Kim Yang Li Guozhen Shen Jong‑Chul Lee 《Nano-Micro Letters》 SCIE EI CAS 2025年第2期417-431,共15页
Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily activities.Unlike existing approaches that often focus on static gestures and require extensive labeled data,the pro... Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily activities.Unlike existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple scenarios.It features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance output.Through wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist movements.Remarkably,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various tasks.The system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and letters.The proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific training.Its utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication. 展开更多
关键词 Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction
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Industrial Control Anomaly Detection Based on Distributed Linear Deep Learning
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作者 Shijie Tang Yong Ding Huiyong Wang 《Computers, Materials & Continua》 SCIE EI 2025年第1期1129-1150,共22页
As more and more devices in Cyber-Physical Systems(CPS)are connected to the Internet,physical components such as programmable logic controller(PLC),sensors,and actuators are facing greater risks of network attacks,and... As more and more devices in Cyber-Physical Systems(CPS)are connected to the Internet,physical components such as programmable logic controller(PLC),sensors,and actuators are facing greater risks of network attacks,and fast and accurate attack detection techniques are crucial.The key problem in distinguishing between normal and abnormal sequences is to model sequential changes in a large and diverse field of time series.To address this issue,we propose an anomaly detection method based on distributed deep learning.Our method uses a bilateral filtering algorithm for sequential sequences to remove noise in the time series,which can maintain the edge of discrete features.We use a distributed linear deep learning model to establish a sequential prediction model and adjust the threshold for anomaly detection based on the prediction error of the validation set.Our method can not only detect abnormal attacks but also locate the sensors that cause anomalies.We conducted experiments on the Secure Water Treatment(SWAT)and Water Distribution(WADI)public datasets.The experimental results show that our method is superior to the baseline method in identifying the types of attacks and detecting efficiency. 展开更多
关键词 Anomaly detection CPS deep learning MLP(multi-layer perceptron)
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Hybrid Deep Learning Approach for Automating App Review Classification:Advancing Usability Metrics Classification with an Aspect-Based Sentiment Analysis Framework
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作者 Nahed Alsaleh Reem Alnanih Nahed Alowidi 《Computers, Materials & Continua》 SCIE EI 2025年第1期949-976,共28页
App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While t... App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While traditional machine learning(ML)models rely on basic word-based feature extraction,deep learning(DL)methods,enhanced with advanced word embeddings,have shown superior performance.This research introduces a novel aspectbased sentiment analysis(ABSA)framework to classify app reviews based on key non-functional requirements,focusing on usability factors:effectiveness,efficiency,and satisfaction.We propose a hybrid DL model,combining BERT(Bidirectional Encoder Representations from Transformers)with BiLSTM(Bidirectional Long Short-Term Memory)and CNN(Convolutional Neural Networks)layers,to enhance classification accuracy.Comparative analysis against state-of-the-art models demonstrates that our BERT-BiLSTM-CNN model achieves exceptional performance,with precision,recall,F1-score,and accuracy of 96%,87%,91%,and 94%,respectively.Thesignificant contributions of this work include a refined ABSA-based relabeling framework,the development of a highperformance classifier,and the comprehensive relabeling of the Instagram App Reviews dataset.These advancements provide valuable insights for software developers to enhance usability and drive user-centric application development. 展开更多
关键词 Requirements Engineering(RE) app review analysis usabilitymetrics hybrid deep learning BERT-BiLSTM-CNN
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Interpretable Machine Learning Method for Compressive Strength Prediction and Analysis of Pure Fly Ash-based Geopolymer Concrete
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作者 SHI Yuqiong LI Jingyi +1 位作者 ZHANG Yang LI Li 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2025年第1期65-78,共14页
In order to study the characteristics of pure fly ash-based geopolymer concrete(PFGC)conveniently,we used a machine learning method that can quantify the perception of characteristics to predict its compressive streng... In order to study the characteristics of pure fly ash-based geopolymer concrete(PFGC)conveniently,we used a machine learning method that can quantify the perception of characteristics to predict its compressive strength.In this study,505 groups of data were collected,and a new database of compressive strength of PFGC was constructed.In order to establish an accurate prediction model of compressive strength,five different types of machine learning networks were used for comparative analysis.The five machine learning models all showed good compressive strength prediction performance on PFGC.Among them,R2,MSE,RMSE and MAE of decision tree model(DT)are 0.99,1.58,1.25,and 0.25,respectively.While R2,MSE,RMSE and MAE of random forest model(RF)are 0.97,5.17,2.27 and 1.38,respectively.The two models have high prediction accuracy and outstanding generalization ability.In order to enhance the interpretability of model decision-making,we used importance ranking to obtain the perception of machine learning model to 13 variables.These 13 variables include chemical composition of fly ash(SiO_(2)/Al_(2)O_(3),Si/Al),the ratio of alkaline liquid to the binder,curing temperature,curing durations inside oven,fly ash dosage,fine aggregate dosage,coarse aggregate dosage,extra water dosage and sodium hydroxide dosage.Curing temperature,specimen ages and curing durations inside oven have the greatest influence on the prediction results,indicating that curing conditions have more prominent influence on the compressive strength of PFGC than ordinary Portland cement concrete.The importance of curing conditions of PFGC even exceeds that of the concrete mix proportion,due to the low reactivity of pure fly ash. 展开更多
关键词 machine learning pure fly ash geopolymer compressive strength feature perception
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Game Selection Method for Game-Based History Learning
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作者 Woo-Hyun Lee Won-Hyung Lee 《Journal of Contemporary Educational Research》 2021年第10期67-81,共15页
Games that are used in research on game-based learning and serious games that are used for education are usually exclusive,making it difficult for teachers to attempt new methods in education.According to the data pub... Games that are used in research on game-based learning and serious games that are used for education are usually exclusive,making it difficult for teachers to attempt new methods in education.According to the data published in 2009 by the European Schoolnet(EUN),a network of European Ministries of Education,most of the problems that teachers face when using games in class are related to game selection.Based on the aforementioned data,this study presents a set of criteria for selecting games in order to solve the inconvenience experienced by teachers.The games,which are used as teaching materials for game-based learning,have been replaced with commercial games that are easily purchased,rather than serious games that are difficult to obtain the licensing.Based on the criteria,two games were selected in this study and the classes were conducted at the educational site.Compared to the group trained with textbooks,it has been confirmed that the effect of game-based learning was sufficient.In addition,five out of ten problems that teachers face were resolved. 展开更多
关键词 game-based learning History education Commercial game Reenactment of history learning
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An Iterated Greedy Algorithm with Memory and Learning Mechanisms for the Distributed Permutation Flow Shop Scheduling Problem
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作者 Binhui Wang Hongfeng Wang 《Computers, Materials & Continua》 SCIE EI 2025年第1期371-388,共18页
The distributed permutation flow shop scheduling problem(DPFSP)has received increasing attention in recent years.The iterated greedy algorithm(IGA)serves as a powerful optimizer for addressing such a problem because o... The distributed permutation flow shop scheduling problem(DPFSP)has received increasing attention in recent years.The iterated greedy algorithm(IGA)serves as a powerful optimizer for addressing such a problem because of its straightforward,single-solution evolution framework.However,a potential draw-back of IGA is the lack of utilization of historical information,which could lead to an imbalance between exploration and exploitation,especially in large-scale DPFSPs.As a consequence,this paper develops an IGA with memory and learning mechanisms(MLIGA)to efficiently solve the DPFSP targeted at the mini-malmakespan.InMLIGA,we incorporate a memory mechanism to make a more informed selection of the initial solution at each stage of the search,by extending,reconstructing,and reinforcing the information from previous solutions.In addition,we design a twolayer cooperative reinforcement learning approach to intelligently determine the key parameters of IGA and the operations of the memory mechanism.Meanwhile,to ensure that the experience generated by each perturbation operator is fully learned and to reduce the prior parameters of MLIGA,a probability curve-based acceptance criterion is proposed by combining a cube root function with custom rules.At last,a discrete adaptive learning rate is employed to enhance the stability of the memory and learningmechanisms.Complete ablation experiments are utilized to verify the effectiveness of the memory mechanism,and the results show that this mechanism is capable of improving the performance of IGA to a large extent.Furthermore,through comparative experiments involving MLIGA and five state-of-the-art algorithms on 720 benchmarks,we have discovered that MLI-GA demonstrates significant potential for solving large-scale DPFSPs.This indicates that MLIGA is well-suited for real-world distributed flow shop scheduling. 展开更多
关键词 Distributed permutation flow shop scheduling MAKESPAN iterated greedy algorithm memory mechanism cooperative reinforcement learning
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Text-Image Feature Fine-Grained Learning for Joint Multimodal Aspect-Based Sentiment Analysis
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作者 Tianzhi Zhang Gang Zhou +4 位作者 Shuang Zhang Shunhang Li Yepeng Sun Qiankun Pi Shuo Liu 《Computers, Materials & Continua》 SCIE EI 2025年第1期279-305,共27页
Joint Multimodal Aspect-based Sentiment Analysis(JMASA)is a significant task in the research of multimodal fine-grained sentiment analysis,which combines two subtasks:Multimodal Aspect Term Extraction(MATE)and Multimo... Joint Multimodal Aspect-based Sentiment Analysis(JMASA)is a significant task in the research of multimodal fine-grained sentiment analysis,which combines two subtasks:Multimodal Aspect Term Extraction(MATE)and Multimodal Aspect-oriented Sentiment Classification(MASC).Currently,most existing models for JMASA only perform text and image feature encoding from a basic level,but often neglect the in-depth analysis of unimodal intrinsic features,which may lead to the low accuracy of aspect term extraction and the poor ability of sentiment prediction due to the insufficient learning of intra-modal features.Given this problem,we propose a Text-Image Feature Fine-grained Learning(TIFFL)model for JMASA.First,we construct an enhanced adjacency matrix of word dependencies and adopt graph convolutional network to learn the syntactic structure features for text,which addresses the context interference problem of identifying different aspect terms.Then,the adjective-noun pairs extracted from image are introduced to enable the semantic representation of visual features more intuitive,which addresses the ambiguous semantic extraction problem during image feature learning.Thereby,the model performance of aspect term extraction and sentiment polarity prediction can be further optimized and enhanced.Experiments on two Twitter benchmark datasets demonstrate that TIFFL achieves competitive results for JMASA,MATE and MASC,thus validating the effectiveness of our proposed methods. 展开更多
关键词 Multimodal sentiment analysis aspect-based sentiment analysis feature fine-grained learning graph convolutional network adjective-noun pairs
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Comparative analysis of empirical and deep learning models for ionospheric sporadic E layer prediction
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作者 BingKun Yu PengHao Tian +6 位作者 XiangHui Xue Christopher JScott HaiLun Ye JianFei Wu Wen Yi TingDi Chen XianKang Dou 《Earth and Planetary Physics》 EI CAS 2025年第1期10-19,共10页
Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 km.Because they can significantly influence radio communications and navigation systems,... Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 km.Because they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite systems.In this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde observations.The deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular. 展开更多
关键词 ionospheric sporadic E layer radio occultation ionosondes numerical model deep learning model artificial intelligence
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Machine learning applications in healthcare clinical practice and research
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作者 Nikolaos-Achilleas Arkoudis Stavros P Papadakos 《World Journal of Clinical Cases》 SCIE 2025年第1期16-21,共6页
Machine learning(ML)is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis,thus creating machines that can complete tasks otherwise requiring human intelligen... Machine learning(ML)is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis,thus creating machines that can complete tasks otherwise requiring human intelligence.Among its various applications,it has proven groundbreaking in healthcare as well,both in clinical practice and research.In this editorial,we succinctly introduce ML applications and present a study,featured in the latest issue of the World Journal of Clinical Cases.The authors of this study conducted an analysis using both multiple linear regression(MLR)and ML methods to investigate the significant factors that may impact the estimated glomerular filtration rate in healthy women with and without non-alcoholic fatty liver disease(NAFLD).Their results implicated age as the most important determining factor in both groups,followed by lactic dehydrogenase,uric acid,forced expiratory volume in one second,and albumin.In addition,for the NAFLD-group,the 5th and 6th most important impact factors were thyroid-stimulating hormone and systolic blood pressure,as compared to plasma calcium and body fat for the NAFLD+group.However,the study's distinctive contribution lies in its adoption of ML methodologies,showcasing their superiority over traditional statistical approaches(herein MLR),thereby highlighting the potential of ML to represent an invaluable advanced adjunct tool in clinical practice and research. 展开更多
关键词 Machine learning Artificial INTELLIGENCE CLINICAL Practice RESEARCH Glomerular filtration rate Non-alcoholic fatty liver disease MEDICINE
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DEEP NEURAL NETWORKS COMBINING MULTI-TASK LEARNING FOR SOLVING DELAY INTEGRO-DIFFERENTIAL EQUATIONS
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作者 WANG Chen-yao SHI Feng 《数学杂志》 2025年第1期13-38,共26页
Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay di... Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay differential equations(DDEs)and delay integrodifferential equations(DIDEs)with constant delays,primarily due to their low regularity at delayinduced breaking points.In this paper,a DNN method that combines multi-task learning(MTL)which is proposed to solve both the forward and inverse problems of DIDEs.The core idea of this approach is to divide the original equation into multiple tasks based on the delay,using auxiliary outputs to represent the integral terms,followed by the use of MTL to seamlessly incorporate the properties at the breaking points into the loss function.Furthermore,given the increased training dificulty associated with multiple tasks and outputs,we employ a sequential training scheme to reduce training complexity and provide reference solutions for subsequent tasks.This approach significantly enhances the approximation accuracy of solving DIDEs with DNNs,as demonstrated by comparisons with traditional DNN methods.We validate the effectiveness of this method through several numerical experiments,test various parameter sharing structures in MTL and compare the testing results of these structures.Finally,this method is implemented to solve the inverse problem of nonlinear DIDE and the results show that the unknown parameters of DIDE can be discovered with sparse or noisy data. 展开更多
关键词 Delay integro-differential equation Multi-task learning parameter sharing structure deep neural network sequential training scheme
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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice
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作者 Yujia Liu Xue Han +6 位作者 Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia 《Neural Regeneration Research》 SCIE CAS 2025年第9期2727-2736,共10页
Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life ... Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction. 展开更多
关键词 Chil1 hippocampus learning and memory M2 microglia NEUROINFLAMMATION postoperative cognitive dysfunction(POCD) recombinant CHI3L1
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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease
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作者 Mackenzie M.Spicer Jianqi Yang +5 位作者 Daniel Fu Alison N.DeVore Marisol Lauffer Nilufer S.Atasoy Deniz Atasoy Rory A.Fisher 《Neural Regeneration Research》 SCIE CAS 2025年第10期2969-2981,共13页
Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rode... Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease. 展开更多
关键词 adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus EXERCISE learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)
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改进Q-Learning的路径规划算法研究 被引量:1
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作者 宋丽君 周紫瑜 +2 位作者 李云龙 侯佳杰 何星 《小型微型计算机系统》 CSCD 北大核心 2024年第4期823-829,共7页
针对Q-Learning算法学习效率低、收敛速度慢且在动态障碍物的环境下路径规划效果不佳的问题,本文提出一种改进Q-Learning的移动机器人路径规划算法.针对该问题,算法根据概率的突变性引入探索因子来平衡探索和利用以加快学习效率;通过在... 针对Q-Learning算法学习效率低、收敛速度慢且在动态障碍物的环境下路径规划效果不佳的问题,本文提出一种改进Q-Learning的移动机器人路径规划算法.针对该问题,算法根据概率的突变性引入探索因子来平衡探索和利用以加快学习效率;通过在更新函数中设计深度学习因子以保证算法探索概率;融合遗传算法,避免陷入局部路径最优同时按阶段探索最优迭代步长次数,以减少动态地图探索重复率;最后提取输出的最优路径关键节点采用贝塞尔曲线进行平滑处理,进一步保证路径平滑度和可行性.实验通过栅格法构建地图,对比实验结果表明,改进后的算法效率相较于传统算法在迭代次数和路径上均有较大优化,且能够较好的实现动态地图下的路径规划,进一步验证所提方法的有效性和实用性. 展开更多
关键词 移动机器人 路径规划 Q-learning算法 平滑处理 动态避障
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