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卫360-平1井C_1+GAMMA地质导向钻井技术 被引量:4
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作者 曹泽甫 张敏 +1 位作者 刘明国 徐长伟 《石油钻采工艺》 CAS CSCD 北大核心 2009年第3期18-20,25,共4页
为降低成本,达到对地质靶精确控制的目的,中原油田结合老油区已有的地质资料,采用MWD随钻GAMMA测量技术,配合气测录井的甲烷C1监测数据,通过计算调整井眼轨迹控制,综合判定油层着陆,走向倾角变化,提高了水平井眼的油层穿透率,有效地达... 为降低成本,达到对地质靶精确控制的目的,中原油田结合老油区已有的地质资料,采用MWD随钻GAMMA测量技术,配合气测录井的甲烷C1监测数据,通过计算调整井眼轨迹控制,综合判定油层着陆,走向倾角变化,提高了水平井眼的油层穿透率,有效地达到了利用地质导向施工水平井的目的。结合卫360-平1井的具体施工过程,介绍了C1+GAMMA地质导向技术在中原油田薄油层水平井施工中的应用经验,为今后油田水平井开发提供了技术参考。 展开更多
关键词 水平井 剖面优化技术 钻具组合 轨迹控制 C1+gamma动态找油 地质测量 卫360-平1井
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大鼠大脑局部脑缺血周围区海马及大脑皮质CLIC4及14-3-3gamma蛋白的表达及其意义
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作者 孙绍骞 于春艳 刘玉和 《中国老年学杂志》 CAS CSCD 北大核心 2012年第1期106-108,共3页
目的探讨局灶性脑缺血模型中,海马和大脑皮质14-3-3gamma和线粒体氯通道(CLIC4)蛋白的表达。方法通过大脑中动脉阻塞(MCAO)法,应用病理形态学染色发现海马和大脑皮质表现出局灶性脑缺血。应用TTC染色显示大脑缺血区面积。通过Western印... 目的探讨局灶性脑缺血模型中,海马和大脑皮质14-3-3gamma和线粒体氯通道(CLIC4)蛋白的表达。方法通过大脑中动脉阻塞(MCAO)法,应用病理形态学染色发现海马和大脑皮质表现出局灶性脑缺血。应用TTC染色显示大脑缺血区面积。通过Western印迹检测Bax蛋白表达。结果脑缺血周围区海马及大脑皮质组织14-3-3gamma蛋白在神经元细胞质及细胞核呈阳性表达。对照组可见海马及大脑皮质组织CLIC4蛋白在细胞核阳性表达,缺血组可见脑缺血周围区海马及大脑皮质CLIC4蛋白在神经元细胞质呈阳性表达,Bax蛋白表达上调。结论 14-3-3gamma和CLIC4蛋白在脑缺血周围区发挥保护神经元作用。 展开更多
关键词 线粒体氯通道(CLIC4) 14-3-3gamma 局灶性脑缺血
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On the intrinsic shape of the gamma-ray spectrum for Fermi blazars 被引量:1
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作者 Shi-Ju Kang Qingwen Wu +8 位作者 Yong-Gang Zheng Yue Yin Jia-Li Song Hang Zou Jian-Chao Feng Ai-Jun Dong Zhong-Zu Wu Zhi-Bin Zhang Lin-Hui Wu 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2018年第5期93-98,共6页
The curvature of the γ-ray spectrum in blazars may reflect the intrinsic distribution of emitting electrons, which will further give some information on the possible acceleration and cooling processes in the emitting... The curvature of the γ-ray spectrum in blazars may reflect the intrinsic distribution of emitting electrons, which will further give some information on the possible acceleration and cooling processes in the emitting region. The γ-ray spectra of Fermi blazars are normally fitted either by a single power-law(PL) or a log-normal(call Logarithmic Parabola, LP) form. The possible reason for this difference is not clear. We statistically explore this issue based on the different observational properties of 1419 Fermi blazars in the 3 LAC Clean Sample. We find that the γ-ray flux(100 Me V–100 Ge V) and variability index follow bimodal distributions for PL and LP blazars, where the γ-ray flux and variability index show a positive correlation. However, the distributions of γ-ray luminosity and redshift follow a unimodal distribution. Our results suggest that the bimodal distribution of γ-ray fluxes for LP and PL blazars may not be intrinsic and all blazars may have an intrinsically curved γ-ray spectrum, and the PL spectrum is just caused by the fitting effect due to less photons. 展开更多
关键词 GALAXIES active - galaxies jets - gamma rays galaxies - galaxies STATISTICS
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基于非对称漂移双gamma跳-扩散过程的创新幂型期权定价模型
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作者 石泽龙 唐志毅 《经济数学》 2015年第1期31-36,共6页
针对假设股价的对数收益率布朗运动在期权定价时产生的无法解释股价对数收益率的尖峰厚尾和序列相关性的缺陷,采用了Zhang提出的非对称漂移双gamma跳-扩散过程来描述资产(股价)的对数收益率运动形态(该过程是kou提出的双指数跳-扩散过... 针对假设股价的对数收益率布朗运动在期权定价时产生的无法解释股价对数收益率的尖峰厚尾和序列相关性的缺陷,采用了Zhang提出的非对称漂移双gamma跳-扩散过程来描述资产(股价)的对数收益率运动形态(该过程是kou提出的双指数跳-扩散过程的推广),并利用Esscher风险中性变换,研究了幂型期权的定价公式.还设计了两种创新的幂型期权,在非对称漂移双gamma跳-扩散过程下给出了相应的定价公式. 展开更多
关键词 非对称漂移双gamma-扩散过程 创新幂型期权 ESSCHER变换
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A statistical classification of the unassociated gamma-ray sources in the second Fermi Large Area Telescope Catalog 被引量:1
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作者 Zhu Mao Yun-Wei Yu 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2013年第8期952-960,共9页
With the assistance of the identified/associated sources in the second Fermi Large Area Telescope (LAT) catalog, we analyze and resolve the spatial distribution and the distributions of the gamma-ray spectral and va... With the assistance of the identified/associated sources in the second Fermi Large Area Telescope (LAT) catalog, we analyze and resolve the spatial distribution and the distributions of the gamma-ray spectral and variability indices of the remaining 575 unassociated Fermi LAT sources. Consequently, it is suggested that the unassociated sources could statistically consist of Galactic supernova remnants/pulsar wind nebulae, BL Lacertae objects, fiat spectrum radio quasars and other types of active galaxies with fractions of 25%, 29%, 41% and 5%, respectively. 展开更多
关键词 gamma rays: general - catalogs - methods: statistical
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Ring-Shaped Jets in Gamma-Ray Bursts
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作者 Ming Xu Yong-Feng Huang Si-Wei Kong 《Chinese Journal of Astronomy and Astrophysics》 CSCD 2008年第4期411-420,共10页
When the axis of a gamma-ray burst (GRB) does not coincide with the spin axis of its source, there may result a ring-shaped jet. Using some refined jet dynamics, we calculate multi-wavelength afterglow light curves ... When the axis of a gamma-ray burst (GRB) does not coincide with the spin axis of its source, there may result a ring-shaped jet. Using some refined jet dynamics, we calculate multi-wavelength afterglow light curves for such ring-shaped jets. In the R-band we find an obvious break in the afterglow light curve due to the beaming effect and the break is affected by many parameters, such as the electron energy fraction ζe, the magnetic energy fraction ζB^2, the width of ring △θ and the medium number density n. The overall light curve can be divided into three power-law stages, i.e., an ultra-relativistic stage, an after-break stage and a deep Newtonian stage. For each stage the power-law index is larger in the ring-shaped jet than in the corresponding conical jet. 展开更多
关键词 gamma rays bursts - ISM jets and outflows
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Gamma-ray Bursts: a Probe of Black Holes
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作者 Wei Wang and Yong-Heng Zhao National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 《Chinese Journal of Astronomy and Astrophysics》 CSCD 北大核心 2001年第6期487-493,共7页
There is strong evidence for the existence of black holes (BHs) in some X-ray binaries and in most galactic nuclei based on different types of measurement, but black holes have not been definitely identified for the l... There is strong evidence for the existence of black holes (BHs) in some X-ray binaries and in most galactic nuclei based on different types of measurement, but black holes have not been definitely identified for the lack of very firm observational evidence up to now. Because direct evidence for BHs should come from determination of strong gravitational redshift, we expect an object can fall into the region near the BH horizon where radiation can be detected. Therefore the object must be a compact star such as a neutron star (NS), and intense astrophysical processes will release highly energetic radiation that is transient and fast-varying. These characteristics may point to the observed gamma-ray bursts (GRBs). Recent observations of iron lines suggest that afterglows of GRBs show properties similar to those observed in active galactic nuclei (AGNs), implying that the GRBs may originate from intense events related to black holes. A model for GRBs and after-glows is proposed here to obtain the range of gravitational redshifts (zg) of GRBs with known cosmological redshifts. Here, we provide a new method that, with a search for high-energy emission lines (X- or -γ-rays) in GRBs, one can determine the gravitational redshift. We expect zg to be 0.5 or even larger, so we can rule out the possibility of other compact objects such as NSs, and identify the central progenitors of GRBs as black holes. 展开更多
关键词 black hole physics - accretion accretion disks - gamma rays: burst
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Time-resolved spectral analysis of prompt emission from long gamma-ray bursts with GeV emission
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作者 Arikkala Raghurama Rao Rupal Basak +4 位作者 Jishnu Bhattacharya Sarthak Chandra Nikunj Maheshwari Manojendu Choudhury Ranjeev Misra 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2014年第1期35-46,共12页
We performed detailed time-resolved spectroscopy of bright tong gamma- ray bursts (GRBs) which show significant GeV emissions (GRB 080916C, GRB 090902B and GRB 090926A). In addition to the standard Band model, we ... We performed detailed time-resolved spectroscopy of bright tong gamma- ray bursts (GRBs) which show significant GeV emissions (GRB 080916C, GRB 090902B and GRB 090926A). In addition to the standard Band model, we also use a model consisting of a black body and a power law to fit the spectra. We find that for the latter model there are indications of an additional soft component in the spectra. While previous studies have shown that such models are required for GRB 090902B, here we find that a composite spectral model consisting of two blackbodies and a power law adequately fits the data of all the three bright GRBs. We investigate the evolution of the spectral parameters and find several interesting features that appear in all three GRBs, like (a) temperatures of the blackbodies are strongly correlated with each other, (b) fluxes in the black body components are strongly correlated with each other, (c) the temperatures of the black body trace the profile of the individual pulses of the GRBs, and (d) the characteristics of power law components like the spectral index and the delayed onset bear a close similarity to the emission characteristics in the GeV regions. We discuss the implications of these results and the possibility of identifying the radiation mechanisms during the prompt emission of GRBs. 展开更多
关键词 gamma rays: bursts - gamma rays: observations - methods: data analysis
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Gamma-ray Emission from the γ-ray-loud BL Lac Objects
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作者 Guang-ZhongXie Ben-ZhongDai +1 位作者 En-WeiLiang Zhao-HuaXie 《Chinese Journal of Astronomy and Astrophysics》 CSCD 北大核心 2001年第6期494-500,共7页
Using the HST observation data of BL Lac objects by Urry et al. and γ-ray observation data, we find that there is a correlation between Fγ and Fonuclei forγ-ray-loud BL Lac objects (correlation coefficients: 7γ=0.... Using the HST observation data of BL Lac objects by Urry et al. and γ-ray observation data, we find that there is a correlation between Fγ and Fonuclei forγ-ray-loud BL Lac objects (correlation coefficients: 7γ=0.63,p = 4.0 × 10-2), but no correlation between Fγ and Fohost, where Fonuclei and Fohost are the fluxes of nuclei and host galaxy in V-band. For 19γ-ray-loud BL Lac objects with observed spectral index in multi-wavebands, the spectral index correlations between any two bands are as follow: (1) there is a strong correlation between aγ and aK for 15 BL Lac objects(γ = 0.84,p = 3.11 × 10-4); (2) the correlation between aγ and ao for 12 BL Lac objects isγ = 0.82, p = 1.5 × 10-3; (3) there is no correlation between a7 and ax for 16 BL Lac objects. The results, together with characteristic double-humped shape of their SEDs, show that the synchrotron self-Compton mechanism might be a main mechanism for theγ-ray emission of the BL Lac objects. The electrons emitting JR and optical radiation via synchrotron are also responsible for upscattering these photons toγ-rays, and a variability in IR-optical regime should be accompanied by a change in theγ-rays. 展开更多
关键词 gamma rays - BL Lacertae objects: general
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On the Evolution of the Apparent Size of Gamma-Ray Burst Remnants
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作者 Ting-Ting Gao Yong-Feng Huang 《Chinese Journal of Astronomy and Astrophysics》 CSCD 2006年第3期305-311,共7页
The remnants of two gamma-ray bursts, GRB 030329 and GRB 041227, have been resolved by Very Long Baseline Interferometry observations. The radio counterparts were observed to expand with time. These observations provi... The remnants of two gamma-ray bursts, GRB 030329 and GRB 041227, have been resolved by Very Long Baseline Interferometry observations. The radio counterparts were observed to expand with time. These observations provide an important way to test the dynamics of the standard fireball model. We show that the observed size evolution of these two events cannot be explained by a simple jet model, rather, it can be satisfactorily explained by the two-component jet model. It strongly hints that gamma-ray burst ejecta may have complicated structures. 展开更多
关键词 gamma rays: bursts - ISM: jets and outflows
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NCS-382对丙泊酚、氯胺酮和依托咪酯催眠镇痛作用的影响 被引量:6
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作者 宋苏沛 王雷 +6 位作者 廖艺聪 刘晶晶 张明阳 周美艳 周慧轩 唐然 戴体俊 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2011年第4期344-348,共5页
目的探讨γ-羟基丁酸受体拮抗剂NCS-382对丙泊酚、氯胺酮和依托咪酯催眠及镇痛作用的影响。方法①催醒实验:120只小鼠分别ip给予丙泊酚200 mg.kg-1、氯胺酮150 mg.kg-1和依托咪酯40mg.kg-1制备催眠模型后,再按分组分别icv给予人工脑脊液... 目的探讨γ-羟基丁酸受体拮抗剂NCS-382对丙泊酚、氯胺酮和依托咪酯催眠及镇痛作用的影响。方法①催醒实验:120只小鼠分别ip给予丙泊酚200 mg.kg-1、氯胺酮150 mg.kg-1和依托咪酯40mg.kg-1制备催眠模型后,再按分组分别icv给予人工脑脊液(aCSF),NCS-382 1,5和25μg.kg-1,记录睡眠时间。②热板实验:80只小鼠分别ip给予生理盐水10 ml.kg-1和氯胺酮40 mg.kg-1后,再按分组分别ith给予aCSF和NCS-382 1,5和25μg.kg-1,记录热板法痛阈。③扭体实验:80只小鼠分别ip给予生理盐水10 ml.kg-1和氯胺酮40 mg.kg-1后,再按分组分别ith给予aCSF和NCS-382 1,5和25μg.kg-1,1 min后ip给予1.0%冰醋酸溶液10 ml.kg-1,记录15 min内小鼠扭体次数。结果①催醒实验:NS-382 1,5和25μg.kg-1组小鼠的睡眠时间明显缩短,从丙泊酚组的(81±30)min缩短到44±23,40±21,(40±17)min;从氯胺酮组的(19±4)min缩短到8±4,12±3,(15±4)min;从依托咪酯组的(31±11)min缩短到21±9,22±6,(23±10)min;②热板实验:小鼠在给予氯胺酮麻醉后10~30 min痛阈明显长于基础痛阈(P<0.05),NCS-382对氯胺酮所致痛阈延长无改善作用。单用NCS-382对正常小鼠的痛阈无影响;③扭体实验:单用NCS-382对正常小鼠的扭体次数无明显差异;氯胺酮组小鼠扭体次数明显少于正常对照组(P<0.05),给予NCS-382对此无改善作用。结论γ-羟基丁酸受体可能介导了静脉麻醉药丙泊酚、氯胺酮和依托咪酯的催眠作用,但可能与氯胺酮镇痛作用关系不大。 展开更多
关键词 受体 Γ-羟基丁酸 NCS-382 丙泊酚 氯胺酮 依托咪酯 催眠 镇痛
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γ-羟基丁酸受体在大鼠局灶性脑缺血再灌注损伤中的作用 被引量:10
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作者 靳榕 蒋新颖 +2 位作者 马行 谷淑玲 戴体俊 《药学学报》 CAS CSCD 北大核心 2007年第8期838-842,共5页
研究γ-羟基丁酸(gamma-hydroxybutyric acid,GHB)受体在大鼠局灶性脑缺血再灌注损伤中的作用及其机制。选用GHB受体选择性激动剂NCS-356和特异性拮抗剂NCS-382作为工具药,采用改良的Longa法制备大鼠大脑中动脉栓塞(MCAO)模型。缺血2 h... 研究γ-羟基丁酸(gamma-hydroxybutyric acid,GHB)受体在大鼠局灶性脑缺血再灌注损伤中的作用及其机制。选用GHB受体选择性激动剂NCS-356和特异性拮抗剂NCS-382作为工具药,采用改良的Longa法制备大鼠大脑中动脉栓塞(MCAO)模型。缺血2 h再灌注2 h后,动物进行Longa法行为功能评分;再灌注24 h后,部分动物用TTC染色法测定大鼠脑梗死体积;部分动物应用流式细胞仪测定神经细胞内游离钙离子浓度;分光光度法测定缺血侧大脑皮质中总一氧化氮合酶(tNOS)、诱导型一氧化氮合酶(iNOS)活性和一氧化氮(NO)含量;放射免疫法测定大鼠缺血侧大脑皮层环磷酸鸟苷(cGMP)含量。Isc/R组大鼠行为功能评分、脑梗死体积、神经细胞内游离Ca2+浓度、cGMP和NO含量、tNOS及iNOS活性均显著高于假手术组;NCS-356 160μg.kg-1(N1)、NCS-356 320μg.kg-1(N2)、NCS-356 640μg.kg-1(N3)和尼莫地平600μg.kg-1(Nim)组的上述各指标均不同程度地低于Isc/R组,而NCS-382 640μg.kg-1+NCS-356 640μg.kg-1(NCS-382+N3)组则能显著对抗N3组的作用。激动GHB受体对大鼠局灶性脑缺血再灌注损伤具有一定的保护作用,其作用机制可能与降低神经细胞内游离Ca2+浓度,减少NO及cGMP含量有关。 展开更多
关键词 Γ-羟基丁酸受体 脑缺血 再灌注损伤 一氧化氮 环磷酸鸟苷
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γ-羟基丁酸在急性中毒大鼠体液和组织中的检测及分布 被引量:7
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作者 刘伟 沈敏 +2 位作者 刘晓茜 沈保华 向平 《法医学杂志》 CAS CSCD 2006年第1期55-57,共3页
目的建立生物检材中γ-羟基丁酸(GHB)的检测方法,研究GHB急性中毒大鼠体内GHB的分布,为GHB中毒的鉴定提供方法和评价依据。方法用GC/MS法检测生物检材中的GHB;以1000mg/kg剂量给大鼠灌胃使其染毒,分别于1h和3h处死,测定体液和组织中GHB... 目的建立生物检材中γ-羟基丁酸(GHB)的检测方法,研究GHB急性中毒大鼠体内GHB的分布,为GHB中毒的鉴定提供方法和评价依据。方法用GC/MS法检测生物检材中的GHB;以1000mg/kg剂量给大鼠灌胃使其染毒,分别于1h和3h处死,测定体液和组织中GHB的含量。结果测组织中内源性GHB的线性范围是1~20μg/g,R2=0.9974;测组织中外源性GHB的线性范围为100~1500μg/g,R2=0.9958。相对回收率为98%~103%。体内内源性GHB的含量均≤10μg/mL或10μg/g。尿液中GHB含量为最高,其他依次为:胃、血液、肠、肾、肺、脾、心、肝和脑。结论所建方法准确、便捷,适用于GHB中毒的鉴定;尿液是体内检测GHB的最佳检材。 展开更多
关键词 γ-羟基丁酸(GHB) 气/质联用法 体内分布 急性中毒
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尿液、血液中γ-羟丁酸的气质联用法分析 被引量:8
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作者 刘晓茜 沈敏 +2 位作者 刘伟 沈保华 向平 《中国法医学杂志》 CSCD 2005年第1期17-21,共5页
目的为尿液、血液中γ-羟丁酸(gamma-hydroxybutyricacid,GHB),γ-羟丁酸内酯(gamma-butyrolactone,GBL)和1,4-丁二醇(1,4-butanediol,1,4-BD)的鉴定提供方法和依据。方法100μl尿液或血液以GHBd6为内标,经乙酸乙酯提取、BSTFA衍生化后,... 目的为尿液、血液中γ-羟丁酸(gamma-hydroxybutyricacid,GHB),γ-羟丁酸内酯(gamma-butyrolactone,GBL)和1,4-丁二醇(1,4-butanediol,1,4-BD)的鉴定提供方法和依据。方法100μl尿液或血液以GHBd6为内标,经乙酸乙酯提取、BSTFA衍生化后,用GC/MS法分析。结果测尿液中内源性GHB的线性范围是20-800ng/ml,R2=0.9995,最低检出限为10ng/ml(S/N≥3);测尿液、血液中外源性GHB的线性范围为5-60μg/ml,R2分别为0.9999和0.9928。相对回收率为99%-104%。以所建方法测定了健康志愿者尿液中内源性GHB含量,并考察了健康受试者外源性GHB的代谢情况。结论所建方法准确、便捷、省时、选择性好,适用于法医毒物学鉴定。 展开更多
关键词 GHB 尿液 血液 丁酸 外源性 内源性 气质联用法 法医 适用 依据
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激动γ-羟基丁酸受体对大鼠局灶性脑缺血/再灌注神经细胞凋亡的影响 被引量:3
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作者 靳榕 马行 +2 位作者 蒋新颖 谷淑玲 戴体俊 《中国药理学通报》 CAS CSCD 北大核心 2007年第7期874-877,共4页
目的研究γ-羟基丁酸受体(gamma-hydroxybutyrate receptor,GHBR)对大鼠局灶性脑缺血/再灌注神经细胞凋亡的影响。方法成年♂SD大鼠,分为假手术组(Sham),缺血/再灌注(Isc/R),NCS-356160、320、640μg.kg-1组(N1、N2、N3),NCS-382640+NCS... 目的研究γ-羟基丁酸受体(gamma-hydroxybutyrate receptor,GHBR)对大鼠局灶性脑缺血/再灌注神经细胞凋亡的影响。方法成年♂SD大鼠,分为假手术组(Sham),缺血/再灌注(Isc/R),NCS-356160、320、640μg.kg-1组(N1、N2、N3),NCS-382640+NCS-356640μg.kg-1组(NCS-382+N3),尼莫地平600μg.kg-1组(Nim)。采用改良的Longa法制备大鼠大脑中动脉栓塞(MCAO)模型。再灌24h后,一部分动物应用免疫组织化学染色法测定大鼠缺血侧大脑皮质Bax,Bcl-2,Caspase-3蛋白的表达,另一部分动物应用流式细胞仪测定神经细胞凋亡率。结果NCS-356160、320、640μg.kg-1及Nim增加缺血神经细胞的Bcl-2表达和Bcl-2/Bax比值,降低Bax、Caspase-3阳性细胞数和细胞凋亡百分率,上述作用可被NCS-382拮抗。结论激动GHBR可抑制大鼠局灶性脑缺血/再灌注损伤引起的细胞凋亡。 展开更多
关键词 Γ-羟基丁酸受体 大鼠 脑缺血 再灌注损伤 细胞凋亡
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化学显色法快速筛选饮料及尿液中γ-羟基丁酸和γ-丁内酯 被引量:8
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作者 张绍雨 黄增萍 《法医学杂志》 CAS CSCD 2006年第6期424-427,F0004,共5页
目的建立化学显色法快速筛选饮料及尿液中γ-羟基丁酸(GHB)及其前体γ-丁内酯(GBL)的方法。方法在酸性条件下GHB转化为GBL,GBL和盐酸羟胺在碱性条件下生成γ-羟基丁酰羟胺,γ-羟基丁酰羟胺在酸性条件下和三氯化铁反应,生成紫红色的络合... 目的建立化学显色法快速筛选饮料及尿液中γ-羟基丁酸(GHB)及其前体γ-丁内酯(GBL)的方法。方法在酸性条件下GHB转化为GBL,GBL和盐酸羟胺在碱性条件下生成γ-羟基丁酰羟胺,γ-羟基丁酰羟胺在酸性条件下和三氯化铁反应,生成紫红色的络合物。结果饮料中GHB最低检出浓度为0.5~2mg/mL,低于常见滥用质量浓度。该方法也可以用于尿液分析,最低检出质量浓度为0.5mg/mL。考察了常见有机溶剂和麻醉镇静药物的干扰。结论该方法简单、安全、快速,为临床和法庭科学实验室快速筛选GHB和GBL提供了便利。 展开更多
关键词 γ-羟基丁酸(GHB) γ-丁内酯(GBL) 化学显色法 筛选试验
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超高效液相色谱-串联质谱法测定4种饮料中γ-羟基丁酸及其2种相关物质 被引量:3
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作者 金绍明 宁霄 曹进 《食品安全质量检测学报》 CAS 2018年第19期5202-5207,共6页
目的建立超高效液相色谱-串联质谱法测定4种不同饮料基质中γ-羟基丁酸及其相关物质的方法。方法采用乙腈沉淀蛋白、稀释、过滤、超声等简单的样本前处理方法,选取Agilent SB-C_(18)(150 mm×3.0 mm,1.8μm)色谱柱,流动相为0.02%甲... 目的建立超高效液相色谱-串联质谱法测定4种不同饮料基质中γ-羟基丁酸及其相关物质的方法。方法采用乙腈沉淀蛋白、稀释、过滤、超声等简单的样本前处理方法,选取Agilent SB-C_(18)(150 mm×3.0 mm,1.8μm)色谱柱,流动相为0.02%甲酸水溶液(A)和甲醇(B),梯度洗脱流速为400μL/min,柱温:40℃,选取电喷雾离子源(electrospray ion source, ESI),正离子模式下多反应监测模式(multiple reaction monitoring, MRM)进行分析。结果 4种化合物在50~1000ng/mL的浓度范围内线性关系良好,相关系数(r2)均不小于0.99,低中高3个浓度下的平均加标回收率为88.9%~105.7%,平均相对标准偏差为1.16%~9.83%(n=5)。采用所建立的方法对2批次的问题饮料进行分析,均准确测定样品中4种化合物的量。结论该方法样品处理简单,分析时间短,重复性和稳定性良好,适合做饮料中γ-羟基丁酸及其相关物质的测定。 展开更多
关键词 Γ-羟基丁酸 Γ-丁内酯 1 4-丁二醇 饮料
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γ-羟丁酸诱发的大鼠失神性癫痫持续发作诱导丘脑Fos癌蛋白表达 被引量:4
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作者 张遐 鞠躬 +1 位作者 刘惠玲 G.LeGalLaSalle 《解剖学报》 CAS CSCD 北大核心 1993年第1期30-33,T004,共5页
用Fos抗体免疫组织化学法在γ-羟丁酸诱发的大鼠失神性癫痫持续发作模型上,对丘脑Fos癌蛋白表达的分布进行了研究。失神性癫痫发作后30min,双侧丘脑室旁核内可见到少量Fos免疫阳性细胞核;1h时,Fos的大量双侧标记分布于外侧缰核、室旁核... 用Fos抗体免疫组织化学法在γ-羟丁酸诱发的大鼠失神性癫痫持续发作模型上,对丘脑Fos癌蛋白表达的分布进行了研究。失神性癫痫发作后30min,双侧丘脑室旁核内可见到少量Fos免疫阳性细胞核;1h时,Fos的大量双侧标记分布于外侧缰核、室旁核、菱形核和丘脑板内核群。提示外侧缰核及丘脑中线和板内核群极可能涉及失神性癫痫发作的病理生理机制。 展开更多
关键词 癫痫 羟丁酸 丘脑 癌基因
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股票价格服从跳-扩散过程的期权定价模型 被引量:27
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作者 宁丽娟 刘新平 《陕西师范大学学报(自然科学版)》 CAS CSCD 北大核心 2003年第4期16-19,共4页
研究了股票价格的行为模型问题.假定股票价格的跳过程为一类特殊的更新过程,建立了股票价格服从跳 扩散过程的行为模型.在风险中性的假设下,推导出了基于股票的欧式期权定价公式.
关键词 股票价格 -扩散过程 期权定价模型 更新过程 gamma分布 Possion过程
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γ-羟基丁酸对脑出血的保护作用的研究 被引量:3
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作者 郜旭 赵庆杰 吴秀萍 《中国急救医学》 CAS CSCD 北大核心 2006年第10期644-646,共3页
目的评价γ-羟基丁酸治疗脑出血的临床疗效及其对脑出血后脑水肿的影响。方法60例脑出血病例随机分为γ-羟基丁酸组及对照组,两组均接受神经内科脑出血常规治疗。γ-羟基丁酸组采用γ-羟基丁酸静脉滴注,每日1次,共2周。应用欧洲卒中评... 目的评价γ-羟基丁酸治疗脑出血的临床疗效及其对脑出血后脑水肿的影响。方法60例脑出血病例随机分为γ-羟基丁酸组及对照组,两组均接受神经内科脑出血常规治疗。γ-羟基丁酸组采用γ-羟基丁酸静脉滴注,每日1次,共2周。应用欧洲卒中评分评价临床神经功能情况,利用CT测卒中灶体积。结果γ-羟基丁酸组临床疗效明显优于对照组,治疗后与对照组相比出血灶周围脑水肿体积明显减小。结论γ-羟基丁酸治疗脑出血有效,而且安全。 展开更多
关键词 Γ-羟基丁酸 脑出血 脑水肿
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