Objective: To study the inhibitory effect of Gantai capsules (肝泰胶囊, GTC) on replication and expression of HBsAg and HBeAg. Methods: The 2.2.15 cell line was chosen as a in vitro cell culture system, and by means o...Objective: To study the inhibitory effect of Gantai capsules (肝泰胶囊, GTC) on replication and expression of HBsAg and HBeAg. Methods: The 2.2.15 cell line was chosen as a in vitro cell culture system, and by means of radioimmunoassay, the hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) in cell cultured medium were examined. Results: HBsAg, HBeAg values of 2.2.15 cells treated by GTC (200 μg/ml-1200 μg/ml) were lower than those of the control. And this inhibitory effect was in a dose dependent manner under experimental condition, GTC had no cytotoxicity. Conclusion: GTC could inhibit HBV replication and expression.展开更多
文摘Objective: To study the inhibitory effect of Gantai capsules (肝泰胶囊, GTC) on replication and expression of HBsAg and HBeAg. Methods: The 2.2.15 cell line was chosen as a in vitro cell culture system, and by means of radioimmunoassay, the hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) in cell cultured medium were examined. Results: HBsAg, HBeAg values of 2.2.15 cells treated by GTC (200 μg/ml-1200 μg/ml) were lower than those of the control. And this inhibitory effect was in a dose dependent manner under experimental condition, GTC had no cytotoxicity. Conclusion: GTC could inhibit HBV replication and expression.
