Effect of gastrectomy on G-cell density and functional activity in dogs

INTRODUCTION Billroth gastrectomy has some advantages ofinhibiting acid secretion,low ulcer recurrence andlow mortality. However, postoperativecomplications,such as dumping syndrome andreflux gastritis,often occurred as a result ofpylorectomy.To minimize these complications,pylorus-preserving gastrectomy(PPG)had beenperformed for gastric ulcer with satisfied clinicalresults.Positive correlation was not found betweenulcer recurrence and serum gastrin level.In

实验性狗溃疡病手术后G细胞密度及功能的变化研究

目的 研究实验性狗溃疡病手术后G细胞密度和功能的变化。方法 给成年杂种狗分别施行胃大部切除、胃空肠吻合术(DPG-BⅡ)或保留幽门括约肌胃段切除术(PPSG)或高选择性迷走神经切断术(HSV)。以中和滴定法测定胃酸;以放射免疫法测定血清胃泌素;用免疫组化方法检测G细胞数量和功能。结果 三种手术均能有效抑制胃酸分泌。DPG-BⅡ和PPSG术后血清胃泌素降低,而HSV术后血清胃泌素升高。三种手术后胃窦或残留胃窦、十二指肠和空肠的G细胞数密度增加、功能增强。结论 溃疡病术后G细胞呈代偿性增生和功能增强,胃泌素水平不随胃酸降低而相应降低。