Analysis of demographic characteristics in 3242 young age gastric cancer patients in Korea

AIM:To evaluate the epidemiologic features of young age gastric cancer(GC). METHODS:Retrospectively,a total of 3242 patients with GC between 18 and 45 years of age and 3000 sex-and age-matched controls were reviewed.All subjects were stratified into 3 groups based on age (A,18-30 years;B,31-40 years;C,41-45 years). Epidemiologic characteristics and risk factors were investigated with reference to their age and gender. RESULTS:Compared to controls,more frequent intake of high risk diet(P=0.00075),history of heavy smoking(P=0.00087),intake of heavy alcohol(P= 0.00091),lower social economic status(P=0.00083), body mass index>30(P=0.00097),urban residence(P=0.00065),and more frequent exposure to harmful occupational environments(P=0.00072)were observed in all age groups and both genders in young age GC.These relationships were weaker in females compared to males of the same age,and were stronger as the age of patients increased.However,in group C of young age GC patients,environmental factors played important roles in females and males with a similar body weight.In females,older age at first delivery(> 35 years),lack of lactation history,nulliparity,and poor nutritional status during pregnancy were significantly associated with an increased risk of GC(P=0.00034). In this study,252 patients(7.8%)had a family history of GC with high odds ratio(OR)(3.22-4.21).In particular, family history was more closely associated with GC in males(OR,4.21 in male vs 3.46 in female)and more advanced cases(P=0.00051). CONCLUSION:Hormonal associated factors were more commonly associated with females whereas environmental factors were more commonly associated with males in young age GC patients.

Age,gender and type 2 diabetes contribute to the risk of gastric cancer:a retrospective single institution analysis

Diabetes is involved in the development of several cancers. However, whether type 2 diabetes mellitus （T2DM） as well as other potential risk factors are related to gastric cancer （GC） remains unclear. In this study, 1320 patients with gastric cancer （gastric cancer group） and 1252 thyroid nodule patients （control group）, who were admitted in our hospital from Jan 2010 to Dec 2012, were analyzed in a case-control study. Logistic regression analysis was applied to evaluate the risk of diabetes condition, gender, age, body-mass index （BMI） level and other factors for GC. There were 416 patients with DM in the gastric cancer group （31.5%） and 120 patients with DM in the control group （9.6%）. The differences between the two groups were significant （P = 0.000）. Compared with the control group, the logistic regression analyses suggested that male patients had a higher risk of GC. Moreover, older individuals （especially over 65 years） were more susceptible to GC, and as for T2DM, it was found to be associated with GC, that is, the incidence in the gastric cancer group was significantly higher than in the control group. The OR values of age, T2DM, gender and BMI were 16.951, 15.130, 2.658 and 0.224, respectively. In conclusion, age, gender and T2DM are the risk factors of gastric cancer. Furthermore, male patient over 65 years with T2DM is susceptible to GC, and T2DM is the risk factor only second to age, and there might be synergistic effects among these factors.

1554例胃癌的临床分析

目的:研究探讨年龄、性别因素与胃癌的发病和临床病理学之间的关系。方法:收集1993年1月至2000年12月在本院接受外科手术治疗的1554例胃癌患者的术后病理学资料,比较分析不同性别、年龄段胃癌患者的分布状况及临床病理学差异。结果:胃癌的发病率男女均随年龄增长而升高,51～70岁为高峰年龄段(49%～61%);40岁以下女性发病多于男性,40岁以上则相反。40岁以下男女胃癌患者的组织学类型大多为分化较差的低、未分化腺癌或印戒细胞癌(85%～93%),40岁以上患者中中分化腺癌的比例逐渐增高,尤以男性明显;低分化腺癌和印戒细胞癌是各年龄段女性胃癌的主要组织学类型(61%～89%)。不同性别、年龄段胃癌患者的淋巴结转移状况相同。结论:不同性别、年龄段胃癌患者具有不同的发病状况和组织学类型,提示可能存在不同的发病机制和预后。

324例不同年龄段胃癌患者临床病理资料分析

目的：了解该院近5年胃癌手术患者临床病理资料特点，探讨不同年龄段胃癌患者的临床病理特点差异。方法将2009年1月-2013年12月期间于该院进行手术治疗的324例胃癌患者作为研究对象，对一般资料、肿瘤病理分型、发病部位、临床分期等进行回顾性分析。结果324例胃癌患者中，男性232例（71．6％），女性92例（28．4％），高发年龄组为50～70岁；组织类型以腺癌居多，占64．2％，分化程度以低分化为主，占53．1％；发生部位以胃窦和贲门胃底居多，分别占40．8％和35．8％；TNM临床分期中以Ⅲ期为主，占59．2％。结论（1）年轻胃癌患者中女性所占比例较高，病理以低分化腺癌较多见，晚期肿瘤较其他年龄组多见；（2）中老年患者中男性所占比例较高，发生部位以胃窦及贲门胃底部多见，TNM分期相对较早。

不同性别青年胃癌患者的临床病理特点分析

目的探讨不同性别青年胃癌患者的临床病理特点。方法回顾性分析78例不同性别住院青年胃癌患者的临床病理特点。结果不同性别青年胃癌患者临床表现、肿瘤部位、分型、TNM分期、生存率差异无统计学意义(P均>0.05),组织学类型中高中分化腺癌和低分化腺癌差异有统计学意义(P<0.05)。结论不同性别青年胃癌患者共同特点为临床表现缺乏特异性,多发生于胃体和胃窦部,分型以浸润溃疡型和弥漫浸润型为主,TNM分期以Ⅲ～Ⅳ期多见,长期生存率低;不同点为青年胃癌患者女性更多见,平均发病年龄偏小,病理类型男性以高中分化腺癌和低分化腺癌多见,女性以低分化腺癌为主。

586例胃癌的临床分析

目的:研究讨论年龄、性别因素与胃癌的发病和临床病理学之间的关系。方法:收集1998年1月至2008年1月在本院接受外科手术治疗的586例胃癌患者的手术后病理学资料,比较分析不同胃癌患者的性别、年龄分布情况及临床病理学差异。结果:胃癌的发病率随着年龄的增长而升高,51～60岁为高峰年龄段,40岁以下女性发病多于男性,40岁以上则相反。40岁以下胃癌患者的组织学类型大多为分化较差的低分化腺癌或者印戒细胞癌(63%～89%),40岁以上的患者中分化腺癌的比例逐渐增高,男性尤其明显;低分化腺癌和印戒细胞癌是各年龄段女性胃癌的主要组织学类型。结论:不同性别、年龄组胃癌患者具有不同的发病状况和组织学类型。

958例胃癌临床病理资料分析

目的了解近6年来就诊于我院的胃癌患者流行病学及临床病理资料的特点,为疾病的诊断与评估提供帮助。方法将2004年1月至2009年12月期间于我院进行手术治疗的958例胃癌患者作为研究对象,对其一般资料、肿瘤病理类型、发生部位、临床分期等进行回顾性分析。结果 958例胃癌患者中,男697例（72.8%）,女261例（27.2%）。年龄26~91岁,平均62.6岁;高发年龄为46~65岁组,占49.4%（473/958）,其后依次为≥66岁组及≤45岁组,分别为42.3%（405/958）和8.3%（80/958）。病理的大体分型上,BorrmannⅡ型占大多数（70.1%）;病理类型以腺癌居多,占82.3%,印戒细胞癌占7.8%;分化程度以低分化为主,占46.9%。发生部位以贲门居多,占53.0%。TNM临床分期中以Ⅲ期为主,占47.4%。结论①胃癌多见于中老年男性患者,以贲门部低分化腺癌多见,贲门癌发病率明显高于胃窦癌;②在胃癌患者中,恶性程度较高的低分化、印戒细胞癌中所占比例最高者为相对较年轻的患者（≤45岁组）;③行手术治疗的大部分为中晚期患者,胃癌的早期诊断有待进一步提高。