Impact of body mass index in elderly patients treated with laparoscopic liver resection for hepatocellular carcinoma

BACKGROUND The impact of obesity on surgical outcomes in elderly patients candidate for liver surgery is still debated.AIM To evaluate the impact of high body mass index(BMI)on perioperative and oncological outcome in elderly patients(>70 years old)treated with laparoscopic liver resection for hepatocellular carcinoma(HCC).METHODS Retrospective multicenter study including 224 elderly patients(>70 years old)operated by laparoscopy for HCC(196 with a BMI<30 and 28 with BMI≥30),observed from January 2009 to January 2019.RESULTS After propensity score matching,patients in two groups presented comparable results,in terms of operative time(median range:200 min vs 205 min,P=0.7 respectively in non-obese and obese patients),complications rate(22%vs 26%,P=1.0),length of hospital stay(median range:4.5 d vs 6.0 d,P=0.1).There are no significant differences in terms of short-and long-term postoperative results.CONCLUSION The present study showed that BMI did not impact perioperative and oncologic outcomes in elderly patients treated by laparoscopic resection for HCC.

Peri-operative score for elderly patients with resectable hepatocellular carcinoma

BACKGROUND Liver resection is the mainstay for a curative treatment for patients with resectable hepatocellular carcinoma(HCC),also in elderly population.Despite this,the evaluation of patient condition,liver function and extent of disease remains a demanding process with the aim to reduce postoperative morbidity and mortality.AIM To identify new perioperative risk factors that could be associated with higher 90-and 180-d mortality in elderly patients eligible for liver resection for HCC considering traditional perioperative risk scores and to develop a risk score.METHODS A multicentric,retrospective study was performed by reviewing the medical records of patients aged 70 years or older who electively underwent liver resection for HCC;several independent variables correlated with death from all causes at 90 and 180 d were studied.The coefficients of Cox regression proportional-hazards model for sixmonth mortality were rounded to the nearest integer to assign risk factors'weights and derive the scoring algorithm.RESULTS Multivariate analysis found variables(American Society of Anesthesiology score,high rate of comorbidities,Mayo end stage liver disease score and size of biggest lesion)that had independent correlations with increased 90-and 180-d mortality.A clinical risk score was developed with survival profiles.CONCLUSION This score can aid in stratifying this population in order to assess who can benefit from surgical treatment in terms of postoperative mortality.

Characteristics and prognosis of gastric cancer in patients aged ≥ 70 years

AIM:To elucidate the prognostic value of age for gastric cancer and identify the optimal treatment for elderly gastric cancer patients.METHODS:We enrolled 920 patients with gastric cancer who underwent gastrectomy between January 2003and December 2007 in our center.Patients were categorized into three groups:younger group(age<50years),middle-aged group(50-69 years),and elderly group(≥70 years).Clinicopathological features were compared among the three groups and potential prognostic factors were analyzed.The log-rank test was used to assess statistical differences between curves.Independent prognostic factors were identified by the Cox proportional hazards regression model.Stratified analysis was used to investigate the impact of age on survival at each stage.Cancer-specific survival was also compared among the three groups by excluding deaths due to reasons other than gastric cancer.We analyzed the potential prognostic factors for patients aged≥70years.Finally,the impact of extent of lymphadenectomy and postoperative chemotherapy on survival for each age group was evaluated.RESULTS:In the elderly group,there was a male predominance.At the same time,cancers of the upper third of the stomach,differentiated type,and less-invasive surgery were more common than in the younger or middle-aged groups.Elderly patients were more likely to have advanced tumor-node-metastasis(TNM)stage and larger tumors,but less likely to have distant metastasis.Although 5-year overall survival(OS)rate specific to gastric cancer was not significantly different among the three groups,elderly patients demonstrated a significantly lower 5-year OS rate than the younger and middle-aged patients(elderly vs middle-aged vs younger patients=22.0%vs 36.6%vs 38.0%,respectively).In the TNM-stratified analysis,the differences in OS were only observed in patients withⅡandⅢtumors.In multivariate analysis,only surgical margin status,pT4,lymph node metastasis,M1 and sex were independent prognostic factors for elderly patients.The5-year OS rate did not differ between elderly patients undergoing D1 and D2 lymph node resection,and these patients benefited little from chemotherapy.CONCLUSION:Age≥70 years was an independent prognostic factor for gastric cancer after gastrectomy.D1 resection is appropriate and postoperative chemotherapy is possibly unnecessary for elderly patients with gastric cancer.

68例高龄中晚期胃癌姑息性三维适形放疗结果分析

目的:总结3年来我科经病理证实的高龄中晚期胃癌患者接受三维适形放疗的长期随访数据,评价姑息性三维适形放射治疗对中晚期胃癌的价值。方法:回顾性分析我科2010年1月-2012年12月三维适形放疗的68例高龄中晚期胃癌患者的病理分期、放疗的靶区和剂量、放疗后病灶控制的情况、复发转移的情况及生存时间。结果:本组患者男44例,女24例,年龄54-83岁(平均64岁)。病理分期为T2-4N1-3M0-1。全部患者采用直线加速器三维适形放疗。放射靶区为胃癌病灶及胃左动脉淋巴结,放疗总剂量45-55Gy,6MV或15MV-X射线,每次2.0-2.5Gy,18-22次,每周5次。放疗后1-3个月86.4%(19/22)患者进食困难明显减轻或正常进食;91.3%(42/46)患者上腹部疼痛明显减轻。胃镜提示39.7%(27/68)患者胃部病灶缩小甚至消失;72.1%(49/68)患者腹部CT提示胃部病灶及胃左淋巴结缩小。放疗后CR 16.2%(11/68),PR61.7%(42/68)。本组患者生存期为3-18个月,中位生存期为13.5个月。放疗后4.4%(3/68)患者有轻-中度胃痛。结论:对中晚期胃癌三维适形放疗具有与手术类似的控癌作用,又能避免手术引起的创伤等不良反应,尤其是对已有周围脏器浸润的高龄、体质差的中晚期患者姑息性三维适形放射治疗可起到局部肿瘤控制、镇痛、改善生存质量、延长生存期的作用。但姑息性三维适形放疗的靶区确定、治疗剂量的选择以及综合治疗方面尚需进一步研究。

老年人胃癌的围手术期处理(附181例报告)

目的探讨老年胃癌患者的围术期处理经验。方法回顾性分析1996年7月至2007年6月181例60岁以上接受手术治疗的胃癌病例。结果181例患者中合并糖尿病27例,慢性支气管炎37例,阻塞性通气障碍12例,贫血79例,低蛋白血症28例,高血压病63例,冠心病72例。无术前死亡病例,术后出现并发症147例次:胰漏1例,腹水形成13例,伤口裂开1例,伤口感染3例,心衰2例,心绞痛3例,血压升高79例,心律失常57例,血糖升高34例,肺部感染18例,急性胰腺炎1例;死亡3例(1.66%)。结论术前合并症增加了手术的风险性,但术前全面了解病情,加强对其围手术期处理可提高手术的安全性,降低手术死亡率和并发症发生率。

老年胃癌158例临床病理特点及预后的分析

目的通过老年胃癌患者的资料分析,研究老年胃癌的临床病理特点、治疗与预后。方法收集和复习158例患者的临床病理资料,依据WHO(2002)消化系统肿瘤分类标准进行分类。免疫组化采用ElivisionTMPlus方法。结果患者平均年龄66.2岁,临床病理表现与中青年人无明显的差别。主要症状是上腹痛或不适、梗咽感及出血、消瘦、恶心等,部分有慢性胃病史。好发部位依次为贲门,胃窦、胃体、胃底,贲门胃底多发。免疫组化:p53阳性(>10%)为91%,Ki-67阳性(>10%)占81.8%,Her-2阳性定为于胞膜,阳性率15%(>)。结论p53、Ki-67和Her-2阳性预后不良。nm23阳性率为69.7%,在中高分化肿瘤中表达较高。CEA阳性率达94%与血浆CEA升高一致,是比较理想的监测指标。

管状胃在高龄食管癌和贲门癌根治术中的应用

目的总结70岁以上高龄食管癌、贲门癌根治手术中应用管状胃代食管的手术操作方法,分析术后肺部并发症的发生及术后生存的情况。方法回顾分析30例70岁以上高龄食管癌和贲门癌患者临床资料,术中应用管状胃代替食管,统计分析术后发生的肺部并发症和随访资料。结果术中保留胃右动脉及分支的管状胃制作成功,23例术后无明显肺部并发症发生,4例出现明显肺部感染,积极治疗后康复出院;2例术后气管切开,呼吸机辅助呼吸,1周后顺利脱离呼吸机;1例较长时间呼吸机辅助呼吸,出现吻合口瘘,最终死亡。术后随访21例,无明显反流性食管炎发生,术后1月后生活基本自理。1、3年生存率分别为42.8%(9/21)和19.0%(4/21)。结论应用管状胃代食管,对高龄食管癌和贲门癌患者,可以有效预防吻合口瘘,减少胸腔胃对心肺功能的影响,减少反流性食管炎的发生,提高患者术后生存质量。

腹腔镜老年胃癌根治术49例治疗体会

目的探讨腹腔镜老年胃癌根治术的安全性、可行性及围术期处理经验。方法回顾性分析我院2008年6月～2011年6月70岁以上接受腹腔镜胃癌根治术的患者49例。结果 49例均在腹腔镜下完成手术,无中转开腹,平均手术时间273min(180～400min),平均术中出血量158ml(50～450ml),平均清扫淋巴结17.6枚(7～51枚),术后平均排气时间3.5d(2～6d)。术后转入ICU15例(30.6%),平均术后住院天数14天。术后8例(16.3%)伴有不同程度的并发症,无切口感染、切口裂开、吻合口漏,肺部感染6例,心律失常1例,残胃排空障碍1例。术后死亡1例(2.0%),死于肺部感染、急性呼吸功能衰竭。结论腹腔镜老年胃癌根治术安全、可行。加强对其围手术期处理可提高腹腔镜老年胃癌根治术的安全性。

老年胃癌围手术期处理117例分析

老年胃癌病人由于其重要脏器的储备能力下降、病情重、晚期居多、合并症多的特点，其围术期的处理直接影响手术的成败。我科自2007年1月至2008年12月共收治117例老年胃癌病人。现将围术期处理经验总结如下。