Double-nylon purse-string suture in closing postoperative wounds following endoscopic resection of large(≥3 cm)gastric submucosal tumors

BACKGROUND Endoscopic full-thickness resection(EFTR)of gastric submucosal tumors(SMTs)is safe and effective;however,postoperative wound management is equally important.Literature on suturing following EFTR for large(≥3 cm)SMTs is scarce and limited.AIM To evaluate the efficacy and clinical value of double-nylon purse-string suture in closing postoperative wounds following EFTR of large(≥3 cm)SMTs.METHODS We retrospectively analyzed the data of 85 patients with gastric SMTs in the fundus of the stomach or in the lesser curvature of the gastric body whose wounds were treated with double-nylon purse-string sutures after successful tumor resection at the Endoscopy Center of Renmin Hospital of Wuhan University.The operative,postoperative,and follow-up conditions of the patients were evaluated.RESULTS All tumors were completely resected using EFTR.36(42.35%)patients had tumors located in the fundus of the stomach,and 49(57.65%)had tumors located in the body of the stomach.All patients underwent suturing with double-nylon sutures after EFTR without laparoscopic assistance or further surgical treatment.Postoperative fever and stomach pain were reported in 13(15.29%)and 14(16.47%)patients,respectively.No serious adverse events occurred during the intraoperative or postoperative periods.A postoperative review of all patients revealed no residual or recurrent lesions.CONCLUSION Double-nylon purse-string sutures can be used to successfully close wounds that cannot be completely closed with a single nylon suture,especially for large(≥3 cm)EFTR wounds in SMTs.

Thirty-gauge needle-guided purse-string suture pupilloplasty:a new technique

AIM:To observe the clinical outcomes of 30-gauge(G)needle-guided 10-0 prolene suture purse-string pupilloplasty for atonic pupil management.METHODS:Eight patients with atonic pupils who underwent suture purse-string pupilloplasty were retrospectively analyzed.Preoperative data and at least 6mo of postoperative data were collected from all the patients.RESULTS:The corrected distance visual acuity(CDVA)before and after surgery was 0.58±0.22 and 0.20±0.10 logMAR,respectively(P=0.002).The pre-and postoperative pupil size was 7.38±0.88 and 3.09±0.71 mm(P=0.000),respectively.The corneal endothelial cell count was 2841±176/mm^(2) before and 2692±143/mm^(2) after surgery(P=0.000).No intraoperative or postoperative complications were reported.During the follow-up period of at least 6mo,all treated pupils were centered and generally or nearly round.Furthermore,the patients did not exhibit photophobia,glare,or diplopia.CONCLUSION:This technique is a simple and effective method for pupil reduction.

Feasibility and efficacy of endoscopic purse-string suture-assisted closure for mucosal defects induced by endoscopic manipulations

BACKGROUND Large or transmural defects induced by gastrointestinal endoscopic manipulations are difficult to close,although complete closure is recommended for better recovery.Endoscopic purse-string assisted suturing(EPSS)has been used in clinical practice and has proven to be an effective and safe technique for the closure of large mucosal defects.However,details regarding the efficacy of endoscopic pre-purse-string suture(P-EPSS)are unknown,especially that it offers several advantages over conventional EPSS(C-EPSS).AIM To elucidate the outcomes of EPSS-assisted closure in different clinical situations,and evaluate the efficacy of P-EPSS.METHODS This retrospective observational study included a total of 180 patients who underwent closure assisted by P-EPSS(n=63)or C-EPSS(n=117)between July 2014 and June 2020.The P-EPSS and C-EPSS groups were compared and the intergroup differences in aspects such as the lesion size,location,and morphology,incidence of complete closure,intraoperative perforation,and delayed adverse events were evaluated.Data on the features and clinical course of cases with adverse events were collected for further analysis.RESULTS Patients with lesion size larger than 3 cm,lesions located at the fundus of stomach,or submucosal tumors originating from the deep mucosa were more likely to undergo P-EPSS-assisted closure.The P-EPSS group showed a significantly higher proportion of intraoperative perforation(56%vs 17%)and a much shorter procedure time(9.06±6.14 min vs 14.84±7.25 min).Among adverse events,the incidence of delayed perforation(5%vs 4%;P=0.82)and delayed bleeding(3%vs 4%;P=0.96)did not differ significantly between the groups.Multivariate analysis revealed that lesions with incomplete closure[odds ratio(OR)=21.33;95%confidence interval(CI):5.45-83.45;P<0.01]or size greater than 3 cm(OR=3.14;95%CI:1.08-9.18;P=0.039)showed a statistical tendency to result in an increase in delayed adverse events.CONCLUSION The present study revealed that EPSS could achieve secure complete closure of mucosal defect.PEPSS could shorten the procedure and yield complete closure of mucosal defects.Rather than closure-type selection,incomplete closure or lesion size larger than 3 cm were associated with worse outcomes.

Gastric schwannoma treated by endoscopic full-thickness resection and endoscopic purse-string suture:A case report

BACKGROUND Schwannomas,also known as neurinomas,are tumors that derive from Schwann cells.Gastrointestinal schwannomas are extremely rare,but the stomach is the most common site.Gastric schwannomas are usually asymptomatic.Endoscopy and imaging modalities might offer useful preliminary diagnostic information.However,to diagnose schwannoma,the immunohistochemical positivity for S-100 protein is essential,whereas CD117,CD34,SMA,desmin,and DOG-1 are negative.CASE SUMMARY A 45-year-old female was found to have a gastric mass during a medical examination,which was diagnosed as a gastric schwannoma.We performed endoscopic full-thickness resection and endoscopic purse-string suture.Pathology and immunohistochemical staining confirmed the diagnosis of gastric schwannoma through the positivity of S-100 protein.Furthermore,to exclude the misdiagnosis of gastrointestinal stromal tumor,we performed a mutational detection of the c-Kit and PDGFRA genes.Postoperative follow-up revealed that the patient recovered well.CONCLUSION Immunohistochemical staining is essential for the diagnosis of schwannoma.Endoscopic full-thickness resection is an effective treatment method for gastric schwannoma.

Outpatient hybrid endoscopic submucosal dissection with SOUTEN for early gastric cancer,followed by endoscopic suturing of the mucosal defect:A case report

BACKGROUND Although endoscopic submucosal dissection(ESD)is becoming more common for early gastric cancer,it requires more advanced techniques and a longer treatment duration than endoscopic mucosal resection.Hybrid ESD using a multifunctional snare(SOUTEN)has been reported to be effective for colorectal lesions,as it can reduce treatment duration.Endoscopic suturing of post-ESD mucosal defects has been reported to reduce the incidence of ESD-related complications.CASE SUMMARY This study reports outpatient hybrid ESD for early gastric cancer using SOUTEN,followed by endoscopic suturing of post-ESD mucosal defects in an 86-year-old man.On referral for ESD,a 10-mm flat,depressed lesion was found on the posterior wall of the gastric antrum,the depth of which was expected to be mucosal.Given his history of delirium,we performed outpatient endoscopic treatment.The procedure used was hybrid ESD using SOUTEN to reduce the duration of treatment and endoscopic suturing of post-ESD mucosal ESD defects to reduce complications.The procedure time was 62 min and the lesion was completely resected based on histopathological examination,with no reported postoperative complications.CONCLUSION This safe and useful procedure may be especially important for outpatient endoscopic treatment.

Comparison of a modified anoscope and the purse-string anoscope in stapled haemorrhoidopexy

AIM： To compare the results of the anoscope of the PPH kit and a modified anoscope during stapled haemorrhoidopexy. METHODS： The hospital records of 37 patients who underwent stapled haemorrhoidopexy between 2001 and 2006 were reviewed. The purse-string suture anoscope in the PPH kit was used on 15 patients （Group 1）, and the modified anoscope was used on 22 patients （Group 2）. Demographic characteristics of the patients, operation time, surgeon＇s performance, analgesic requirement, and complications were compared. RESULTS： Operation time was significantly longer in Group 1 （42.0 4- 8.4 min vs 27.7 4- 8.0 min, P = 0.039）. The surgeons reported their operative performance as significantly better in Group 2 （the results of the assessments were poor in ten, medium in four and good in one in Group 1, while good in all patients in Group 2, P 〈 0.001）. The need for haemostatic sutures was significantly higher in Group 1 （six cases） and was needed in two cases in Group 2 （P = 0.034）. CONCLUSION： Operation time decreased and the surgeon＇s satisfaction increased with use of the modified anoscope, and fewer haemostatic sutures were required if the surgeon waited longer before and after firing the stapler.

Transoral outlet reduction:Outcomes of endoscopic Roux-en-Y gastric bypass revision in 284 patients at a community practice

BACKGROUND Transoral outlet reduction(TORe)is a minimally invasive endoscopic revision of Roux-en-Y gastric bypass(RYGB)for weight recurrence;however,little has been published on its clinical implementation in the community setting.AIM To characterize the safety and efficacy of TORe in the community setting for adults with weight recurrence after RYGB.METHODS This is a retrospective cohort study of argon plasma coagulation and purse-string suturing for gastric outlet reduction in consecutive adults with weight recurrence after RYGB at a single community center from September 2020 to September 2022.Patients were provided longitudinal nutritional support via virtual visits.The primary outcome was total body weight loss(TBWL)at twelve months from TORe.Secondary outcomes included TBWL at three months and six months;excess weight loss(EWL)at three,six,and twelve months;twelve-month TBWL by obesity class;predictors of twelve-month TBWL;rates of post-TORe stenosis;and serious adverse events(SAE).Outcomes were reported with descriptive statistics.RESULTS Two hundred eighty-four adults(91.9%female,age 51.3 years,body mass index 39.3 kg/m^(2))underwent TORe an average of 13.3 years after RYGB.Median pre-and post-TORe outlet diameter was 35 mm and 8 mm,respectively.TBWL was 11.7%±4.6%at three months,14.3%±6.3%at six months,and 17.3%±7.9%at twelve months.EWL was 38.4%±28.2%at three months,46.5%±35.4%at six months,and 53.5%±39.2%at twelve months.The number of follow-up visits attended was the strongest predictor of TBWL at twelve months(R^(2)=0.0139,P=0.0005).Outlet stenosis occurred in 11 patients(3.9%)and was successfully managed with endoscopic dilation.There was one instance of post-procedural nausea requiring overnight observation(SAE rate 0.4%).CONCLUSION When performed by an experienced endoscopist and combined with longitudinal nutritional support,purse-string TORe is safe and effective in the community setting for adults with weight recurrence after RYGB.

艾司奥美拉唑在腹腔镜胃溃疡穿孔倒刺线缝合修补术后辅助治疗中的应用价值

目的探讨艾司奥美拉唑在腹腔镜胃溃疡穿孔倒刺线缝合修补术后辅助治疗中的应用价值。方法选取2021年9月至2023年9月抚州市第一人民医院急诊外科收治的68例胃溃疡穿孔患者作为研究对象,随机分为对照组与观察组,各34例。两组均实施腹腔镜胃溃疡穿孔修补术治疗,对照组术后予以其他药物治疗,观察组术后则联合艾司奥美拉唑治疗。比较两组临床疗效、血清转化生长因子α(TGF-α)水平、胃泌素(Gas)水平、血清炎症因子指标[C-反应蛋白(CRP)、白细胞介素-6(IL-6)]、免疫功能指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,两组TGF-α水平均高于治疗前,Gas水平均低于治疗前,且观察组TGF-α水平高于对照组,Gas水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、IL-6水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CD4^(+)水平及CD4^(+)/CD8^(+)均高于治疗前,CD8^(+)水平低于治疗前,且观察组CD4^(+)水平及CD4^(+)/CD8^(+)均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。结论艾司奥美拉唑在腹腔镜胃溃疡穿孔倒刺线缝合修补术后辅助治疗的应用价值较高,不仅可改善患者黏膜环境,促进溃疡恢复,还能避免机体炎症反应加剧,调节机体免疫功能,进一步巩固手术疗效,促进病情康复。

Use of omental patch and endoscopic closure technique as an alternative to surgery after endoscopic full thickness resection of gastric intestinal stromal tumors: A series of cases

BACKGROUND Gastrointestinal stromal tumors(GISTs)originate from interstitial cells of Cajal.GISTs can occur anywhere along the gastrointestinal tract.Large lesions have traditionally been removed surgically.However,with recent innovations in advanced endoscopy,GISTs located within the stomach are now removed endoscopically.We describe a new innovative endoscopic technique to close large and hard to access defects after endoscopic full-thickness resection of gastric GISTs.CASE SUMMARY We present a series of three patients who were diagnosed with a gastric GIST.All patients underwent full-thickness endoscopic resection.In all cases,for closure of the surgical bed,conventional endoscopic techniques including hemoclips,endoloop and suturing were unsuccessful.We performed a new technique in which we pulled omental fat into the gastric lumen and completely closed the defect using endoscopic devices.All patients performed well post-procedure and computed tomography was carried out one day after the procedures which showed no extravasation of contrast.CONCLUSION The omental plug technique may be used as an alternative to surgery in selected cases of gastric perforation.

Application of purse-string suture for management of duodenal stump in radical gastrectomy

Background Gastric cancer （GC） is the second leading cause currently the only possible curative approach. Duodenal stump gastrectomy, and optimal treatment is still lacking. of cancer mortality worldwide, and surgical resection is leakage is the most serious complication after radical Methods We retrospectively reviewed 2034 cases of total or subtotal gastrectomy for GC from January 1995 to December 2009, including 465 cases of duodenal stump closure using purse-string suture （group A）, 835 cases of duodenal stump treated with linear cutting stapler and seromuscular layer suture （group B）, and 734 cases of duodenal stump closure using full-thickness and seromuscular layer suture （group C）. We evaluated the surgical cost, operative time for duodenal stump closure, short-term postoperative complications, perioperative blood loss, and postoperative recovery.

双类荷包加浆肌层间断缝合(徐氏三针法)包埋十二指肠对胃癌根治术患者术后并发症的影响

目的:分析双类荷包加浆肌层间断缝合(徐氏三针法)包埋十二指肠对胃癌根治术患者术后并发症的影响。方法:回顾性选择安徽医科大学第一附属医院2018年1月至2022年3月收治的108例接受胃癌根治术患者,按照其十二指肠包埋方式,将接受浆肌层间断缝合者纳入对照组(n=50),将接受双类荷包加浆肌层间断缝合者纳入观察组(n=58)。对比两组患者手术情况、术后并发症发生情况,分析两种十二指肠包埋方法对手术进程及安全性的影响。结果:观察组与对照组手术总时间、术中出血量比较,未见统计学差异(P>0.05),观察组十二指肠残端处理时间、住院费用较对照组更低(P<0.05)。观察组术后外科并发症发生率较对照组更低(P<0.05);观察组与对照组术后非外科并发症发生率比较,未见统计学差异(P>0.05)。观察组术后并发症Clavien-Dindo分级低于对照组(P<0.05)。结论:与单纯浆肌层间断缝合包埋十二指肠相比,双类荷包缝合能够在不影响手术进程的前提下降低术后外科并发症发生率,从而显著减少患者住院费用。

连续全层加固缝合十二指肠残端方案在胃癌根治术中的应用及生存质量分析

目的:探讨毕Ⅱ式胃癌根治手术中采用连续全层加固缝合十二指肠残端方案的手术效果及对术后生存质量的影响。方法:采取回顾性研究方案,选取我院2017年3月至2021年6月手术治疗的胃癌患者106例进行研究,根据患者手术过程中是否采取连续全层加固缝合十二指肠残端方案分为研究组60例(毕Ⅱ式胃癌根治手术+连续全层加固缝合十二指肠残端方案)、对照组46例(毕Ⅱ式胃癌根治手术+常规荷包加固缝合十二指肠残端或不加固缝合),对比两组患者的手术过程指标、胃肠道Visick分级、术后恢复情况、患者生存质量评分及手术并发症差异。结果:统计分析手术时间、消化道重建时间、手术出血量、术后肛门首次排气时间、术后首次进食时间、住院时间数据并进行对比,研究组和对照组患者之间差异无统计学意义(P>0.05);研究组和对照组患者的Visick分级分布情况比较,差异不具有统计学意义(P>0.05);研究组的手术并发症发生率8.33%低于对照组患者的28.26%,差异具有统计学意义(P<0.05);研究组患者的恶心呕吐症状评分低于对照组,差异具有统计学意义(P<0.05)。结论:毕Ⅱ式胃癌根治手术中采用连续全层加固缝合十二指肠残端方案有利于降低手术并发症率,一定程度上改善患者手术后的生存质量。

两种缝合方式在贲门下及胃底黏膜下肿瘤全层切除术中的比较

目的探讨贲门下及胃底≥1 cm的黏膜下肿瘤(submucosal tumors,SMT)经内镜下全层切除(endoscopic full-thickness resection,EFTR)后创面行两种缝合方式的效能和安全性。方法回顾性分析2021年3月—2023年3月于复旦大学附属中山医院厦门医院住院行EFTR的贲门下及胃底SMT(≥1 cm)的患者,共纳入33例患者,其中16例患者的创面采用尼龙绳联合金属夹行荷包缝合法(尼龙绳组),17例患者采用单纯金属夹缝合法闭合创面(金属夹组)。比较术后创面两种缝合方式的手术时间、创面缝合时间、金属夹使用数量、术后并发症、术后留置胃管时间、抗生素应用时间、住院时间。结果两组缝合方式均有效闭合创面。尼龙绳组的手术时间及缝合时间比金属夹组长,差异有统计学意义(P<0.05)。在金属夹使用数量、术后并发症、术后留置胃管时间、抗生素使用时间、住院时间方面,两组差异无统计学意义(P>0.05)。结论两种缝合方式均能有效缝合胃SMT行EFTR术后的创面,但对于贲门下及胃底这类特殊部位的创面,单纯金属夹缝合更加省时。

食管癌和贲门癌切除食管胃肠线吻合的临床观察

目的 通过食管胃肠线吻合术后内镜观察,证明肠线是食管胃内层缝合的理想材料.方法 随机采用“000”羊肠线(A组)和丝线(B组)施行食管癌和贲门癌切除食管胃吻合各200例.结果 两组术后并发症发生率和手术死亡率无差异,A组进普食顺利者较B组明显增多,而食管胃吻合口瘘的发生率却比B组低.术后食管造影示:逆蠕动、吻合口残留钡剂,残食管扩张和吻合口狭窄的发生率A组较B组明显降低,而且肠线缝合Ⅰ期愈合率较丝线缝合高,说明丝线长期残留是促进纤维组织增生、造成吻合口狭窄的重要原因.结论“000”肠线容易吸收,价格便宜,对组织刺激小,反应轻,吻合口愈合快,能够降低食管胃吻合口狭窄和食管胃吻合口瘘的发生率,是食管癌和贲门癌切除食管胃内层缝合的理想材料.

腹腔镜修补术治疗消化性溃疡急性穿孔40例临床分析

目的探讨腹腔镜胃十二指肠溃疡修补术在消化性溃疡急性穿孔患者的临床应用价值。方法回顾分析我科2010年3月—2011年5月使用腹腔镜行胃十二指肠溃疡修补手术治疗40例消化性溃疡穿孔患者的临床资料。结果 40例患者病理结果均为良性溃疡,手术时间为28～80 min,平均(40.1±17.8)min;术后下床活动时间为14～24 h,平均(16.8±4.7)h;去除胃肠减压时间为14～48 h,平均(19.7±3.5)h;术后镇痛药的使用率为12.5%(5/40);住院时间为4～7 d,平均(5.1±1.4)d;术后均辅以内科抗溃疡药物治疗4～6周,随访6月,无溃疡复发。结论应用腹腔镜胃十二指肠溃疡修补术治疗消化性溃疡穿孔具有安全可靠、疗效好、并发症少、恢复快等优点。

单钳道内镜下荷包缝合术在胃底剥离术并发穿孔中的应用

目的观察使用单钳道内镜下荷包缝合法处理胃底间质瘤剥离时发生穿孔的闭合效果。方法 15例来源胃底固有肌层的间质瘤病例,瘤体长径1.5~3.0 cm,行内镜黏膜下剥离术(ESD)中发生穿孔,单钳道内镜下荷包缝合法闭合创面。结果 15例患者均成功闭合创面,耗时10~15 min,未出现严重并发症。结论单钳道内镜下荷包缝合法处理胃底ESD伴随的穿孔,方法简便有效。

2种改良门奇静脉断流术治疗门静脉高压症上消化道出血效果的比较

目的:对比分析贲门周围血管离断加胃底环行缝扎术与贲门周围血管离断术加应用吻合器食管横断术治疗门静脉高压症上消化道出血的临床疗效。方法:回顾性分析因门静脉高压症上消化道出血行门奇静脉断流术治疗的151例患者,其中行贲门周围血管离断术加胃底环形缝扎术患者122例(胃底环扎组),行贲门周围血管离断术加应用吻合器食管下段横断术患者29例(食管横断组)。对2组患者术前和术后肝功能变化、腹水、肝性脑病、消化道出血、腹腔内出血、消化道瘘发生率等围手术期并发症以及远期再出血发生率进行对比分析。结果:与胃底环扎组比较,行贲门周围血管离断术加胃底环形缝扎术对患者肝脏功能及营养状态影响较为明显,住院时间长、术后消化道瘘发生率高(P<0.05)。在术后远期再出血情况的对比分析中,食管横断组患者其远期再出血(因曲张静脉破裂再出血及因胃黏膜病变再出血)的发生率为30.0%(15.0%,15.0%),高于胃底环扎组患者的8.5%(4.9%,3.6%)。结论:与贲门周围血管离断加应用吻合器食管下段横断术比较,贲门周围血管离断术加胃底环形缝扎术具有对患者肝脏功能打击小,术后并发症少,住院时间短,能有效控制远期再出血的发生率,且操作简单、易于掌握等优点。

内镜下无腹腔镜辅助胃壁全层切除术穿孔修补方法的临床应用

目的探讨内镜下无腹腔镜辅助胃壁全层切除术(endoscopic full-thickness resection,EFTR)穿孔修补方法的临床应用。方法 2012年1月至2014年3月60例通过内镜超声初步诊断并由病理证实的深达浆膜层的胃间质瘤(gastric stromal tumors,GSTs)行EFTR治疗,根据术中穿孔情况,采用不同的修补方法,观察患者术后愈合情况及并发症的严重程度。结果60例患者的包块均顺利完整切除,其中10例采用尼龙圈荷包闭合术,13例采用"大网膜补片法",14例采用"减张固定点缝合法",其余23例采用直接钛夹缝合。60例患者无明显高热及高血象表现,术后(5±1)天好转出院,随访胃镜均无复发迹象。结论 EFTR穿孔应根据切口大小及切口周围张力大小来选择不同缝补方法。

小儿免钉合器腹腔镜胃空肠缝合吻合术

目的探讨腹腔镜下胃空肠缝合吻合手术的方法、安全性和有效性。方法2005年5月～9月，对3例小儿胃流出道梗阻病儿进行腹腔镜下胃空肠缝合吻合术，2例幽门狭窄继发于消化性溃疡同时行高选择性迷走神经切断术。将一段空肠经结肠前上提靠近胃窦部，先浆肌层连续缝合胃空肠固定在一起，超声刀切开胃壁和毗邻空肠，分别连续全层缝合胃空肠侧壁，再间断浆肌层缝合加固。结果3例全部在腹腔镜下完成胃空肠缝合吻合，手术时间分别为135、150、180min，3例术后住院时间均为6d。无并发症发生。各随访8、10和12个月饮食正常，营养状况良好。结论腹腔镜胃空肠缝合吻合术是一种安全可行的技术，创伤小，恢复快且美观。

食管癌术后吻合口狭窄的预防

目的总结预防食管癌、贲门癌术后发生吻合口狭窄的措施。方法2013年1月~2018年1月我院胸外科收治的食管癌、贲门癌病人315例,均采用手术治疗。实验组146例,术前口服庆大霉素生理盐水,术中行胃壁荷包缝合后再进行吻合、减轻吻合口张力,术后及早进食固体食物和口服抑酸药物;对照组169例,仅直接采用吻合器吻合。术后随访2年,比较两组吻合口狭窄发生率。结果对照组术后吻合口狭窄发生率为11.0%,实验组为3.8%,两组比较差异有统计学意义(P<0.05)。结论术前口服庆大霉素盐水,术中行胃壁荷包缝合后再进行吻合、减轻吻合口张力等措施可预防吻合口狭窄。