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Comprehensive treatment and a rare presentation of Cronkhite–Canada syndrome: Two case reports and review of literature
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作者 Yan-Qing Lv Mei-Lan Wang +1 位作者 Tong-Yu Tang Yu-Qin Li 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第11期2646-2656,共11页
BACKGROUND Cronkhite–Canada syndrome(CCS)is a rare sporadic polyposis syndrome that presents with gastrointestinal and ectodermal symptoms in addition to nutritional deficiencies.CCS combined with hypothyroidism is a... BACKGROUND Cronkhite–Canada syndrome(CCS)is a rare sporadic polyposis syndrome that presents with gastrointestinal and ectodermal symptoms in addition to nutritional deficiencies.CCS combined with hypothyroidism is an even rarer condition,with no standard treatment guidelines.CASE SUMMARY The present study described 2 patients with CCS:A 67-year-old woman with concomitant hypothyroidism and 68-year-old man treated with endoscopic mucosal resection(EMR).Both patients had multiple gastrointestinal symptoms and ectodermal changes,along with multiple gastrointestinal polyps.Microscopic examination showed that the mucosa in both patients was hyperemic and edematous,with pathologic examination showing distorted,atrophic,and dilated glands.Patient 1 had concomitant hypothyroidism and was treated with levothyroxine.Due to her self-reduction of hormone dose,her disease relapsed.Patient 2 underwent EMR,but refused further hormonal or biological treatments.Subsequently,he was treated with an oral Chinese medical preparation.CONCLUSION Pharmacotherapy can induce and maintain remission in CCS patients,with adjuvant EMR,long-term follow-up,and endoscopic surveillance being necessary.Case 1:Based on the aforementioned findings,Patient 1 was diagnosed with CCS and hypothyroidism.Case 2:Based on the aforementioned findings,Patient 2 was diagnosed with CCS. 展开更多
关键词 Cronkhite–Canada syndrome Clinical features gastrointestinal polyps HYPOTHYROIDISM Case report
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Laparoscopic restorative proctocolectomy with ileal pouch-anal anastomosis for Peutz-Jeghers syndrome with synchronous rectal cancer 被引量:2
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作者 Min-Er Zhong Bei-Zhan Niu +1 位作者 Wu-Yang Ji Bin Wu 《World Journal of Gastroenterology》 SCIE CAS 2016年第22期5293-5296,共4页
We report on a patient diagnosed with PeutzJeghers syndrome(PJS) with synchronous rectal cancer who was treated with laparoscopic restorative proctocolectomy with ileal pouch-anal anastomosis(IPAA). PJS is an autosoma... We report on a patient diagnosed with PeutzJeghers syndrome(PJS) with synchronous rectal cancer who was treated with laparoscopic restorative proctocolectomy with ileal pouch-anal anastomosis(IPAA). PJS is an autosomal dominant syndrome characterized by multiple hamartomatous polyps in the gastrointestinal tract, mucocutaneous pigmentation, and increased risks of gastrointestinal and nongastrointestinal cancer. This report presents a patient with a 20-year history of intermittent bloody stool, mucocutaneous pigmentation and a family history of PJS, which together led to a diagnosis of PJS. Moreover, colonoscopy and biopsy revealed the presence of multiple serried giant pedunculated polyps and rectal adenocarcinoma. Currently, few options exist for the therapeutic management of PJS with synchronous rectal cancer. For this case, we adopted an unconventional surgical strategy and ultimately performed laparoscopic restorative proctocolectomy with IPAA. This procedure is widely considered to be the first-line treatment option for patients with ulcerative colitis or familial adenomatous polyposis. However, there are no previous reports of treating PJS patients with laparoscopic IPAA. Since the operation, the patient has experienced no further episodes of gastrointestinal bleeding and has demonstrated satisfactory bowel control. Laparoscopic restorative proctocolectomy with IPAA may be a safe and effective treatment for patients with PJS with synchronous rectal cancer. 展开更多
关键词 Peutz-Jeghers syndrome LAPAROSCOPY Ileal pouch-anal anastomosis Restorative proctocolectomy Multiple polyps in gastrointestinal tract
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Cronkhite-Canada syndrome:from clinical features to treatment 被引量:6
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作者 Ze-Yu Wu Li-Xuan Sang Bing Chang 《Gastroenterology Report》 SCIE EI 2020年第5期333-342,I0001,共11页
Cronkhite-Canada syndrome(CCS)is a rare acquired polyposis with unknown etiology.To date,>500 cases have been reported worldwide.CCS is typically characterized by gastrointestinal symptoms,such as diarrhea and skin... Cronkhite-Canada syndrome(CCS)is a rare acquired polyposis with unknown etiology.To date,>500 cases have been reported worldwide.CCS is typically characterized by gastrointestinal symptoms,such as diarrhea and skin changes(e.g.alopecia,pigmentation,and nail atrophy).Endoscopic features include diffuse polyps throughout the entire gastrointestinal tract,except for the esophagus.Pathological types of polyps in CCS mainly include inflammatory,hyperplastic,hamartomatous,and adenomatous polyps.CCS can be complicated by many diseases and has a canceration tendency with a high mortality rate.Moreover,there is no uniform standard treatment for CCS.A review of the reported cases of CCS is presented herein,with the goal of improving our understanding of this disease. 展开更多
关键词 Cronkhite-Canada syndrome clinical characteristics gastrointestinal polyps malignant transformation
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