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The Aging Study on Polyethylene Terephthalate with Surface Modification by Water Vapor Plasma 被引量:1
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作者 敖玲 钮金真 +2 位作者 刘裕明 胡建芳 陈慧英 《Plasma Science and Technology》 SCIE EI CAS CSCD 2001年第3期761-764,共4页
The aging effects of the contact angle and surface energy on polyethylene terephthalate (PET) have been investigated with surface modification by water vapor plasma. The experimental results show that the contact ang... The aging effects of the contact angle and surface energy on polyethylene terephthalate (PET) have been investigated with surface modification by water vapor plasma. The experimental results show that the contact angle of water and PET decreases obviously and surface energy increases. However, with the increase of the aging time, the contact angle and surface energy change back gradually to original state. 展开更多
关键词 The Aging study on Polyethylene Terephthalate with Surface modification by Water Vapor Plasma PET
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Experimental study on discharge coefficient of a gear-shaped weir 被引量:1
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作者 Jing Zhang Qian Chang +1 位作者 Qing-hua Zhang Shu-ning Li 《Water Science and Engineering》 EI CAS CSCD 2018年第3期258-264,共7页
This study focused on hydraulic characteristics around a gear-shaped weir in a straight channel. Systematic experiments were carried out for weirs with two different gear heights and eight groups of geometrical parame... This study focused on hydraulic characteristics around a gear-shaped weir in a straight channel. Systematic experiments were carried out for weirs with two different gear heights and eight groups of geometrical parameters. The impacts of various geometrical parameters of gear-shaped weirs on the discharge capacity were investigated. The following conclusions are drawn from the experimental study:(1) The discharge coefficient(m_c) was influenced by the size of the gear: at a constant discharge, the weir with larger values of a/b(a is the width of the gear, and b is the width between the two neighboring gears) and a/c(c is the height of the gear) had a smaller value of m_c. The discharge capacity of the gear-shaped weir was influenced by the water depth in the weir.(2) For type C1 with a gear height of 0.01 m, when the discharge was less than 60m^3/h and H_1=P < 1.0(H_1 is the water depth at the low weir crest, and P is the weir height), m_c significantly increased with the discharge and H_1=P; with further increases of the discharge and H_1=P, m_cshowed insignificant decreases and fluctuated within small ranges. For type C2 with a gear height of 0.02 m, when the discharge was less than 60m^3/h and H_1=P < 1.0, m_csignificantly increased with the discharge and H_1=P; when the discharge was larger than 60m^3/h and H_1=P > 1.0, m_c slowly decreased with the increases of the discharge and H_1=P for a=b 1.0 and a=c 1.0, and slowly increased with the discharge and H_1=P for a=b > 1.0 and a=c > 1.0.(3) A formula of m_cfor gear-shaped weirs was established based on the principle of weir flow, with consideration of the water depth in the weir, the weir height and width, and the height of the gear. 展开更多
关键词 Experimental study DISCHARGE COEFFICIENT DISCHARGE capacity gear-shaped WEIR GEOMETRICAL parameter
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Experimental Study on Material Surface Modification of Tool Steel
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作者 沈丽如 童洪辉 +2 位作者 王珂 铁军 孙爱萍 《Plasma Science and Technology》 SCIE EI CAS CSCD 2002年第1期1141-1146,共6页
This paper presents the surface temperature behavior of M42 high-speed tool steel samples during N+ implantation in an industrialized GLZ-100 metal-ion implantation machine. A detail study has been made on the paramet... This paper presents the surface temperature behavior of M42 high-speed tool steel samples during N+ implantation in an industrialized GLZ-100 metal-ion implantation machine. A detail study has been made on the parameters of N+ implantation. Optimized technical parameters have been presented. The microhardness of the sample surface implanted under these parameters has been increased by a factor of 2.3, and the wear-resistance has been improved by about 5.4 times. The research on the mechanism of surface modification of M42 steel by nitrogen ion implantation has also been made. 展开更多
关键词 Experimental study on Material Surface modification of Tool Steel HIGH
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Study on different surface modification treatments on poly(D,L-lactic acid)with silk Fibroin and their effects on the culture of osteoblast in vitro
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《Chinese Journal of Biomedical Engineering(English Edition)》 2001年第3期106-107,共2页
关键词 PDLLA acid D L-lactic acid)with silk Fibroin and their effects on the culture of osteoblast in vitro study on different surface modification treatments on poly
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Study of a New Drafting System of Rubbed Roving Frame
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作者 杨建成 蒋秀明 刘敦平 《Journal of Donghua University(English Edition)》 EI CAS 2006年第3期93-96,共4页
This paper puts forward a new drafting system of the rubbed roving frame, which consists of a nine-link gear, two slipping gears. It has brought forward a new design method of the nine-link gear and the slipping gears... This paper puts forward a new drafting system of the rubbed roving frame, which consists of a nine-link gear, two slipping gears. It has brought forward a new design method of the nine-link gear and the slipping gears, and set up approximate formulas for modification coefficients of gears for the first time. And the principles of transmitting rate designing for the system are given. The calculating results demonstrate that the new design method satisfies the demands of processing technology. This mechanism has been used successfully in the kind of rubbed roving frame. 展开更多
关键词 rubbed roving frame a new drafting system design of nine-link gear modification coefficient.
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Modification Design Method for an Enveloping Hourglass Worm Gear with Consideration of Machining and Misalignment Errors 被引量:16
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作者 DENG Xingqiao WANG Jinge HORSTEMEYER Mark F 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2013年第5期948-956,共9页
The influences of machining and misalignment errors play a very critical role in the performance of the anti-backlash double-roller enveloping hourglass worm gear(ADEHWG).However,a corresponding efficient method for e... The influences of machining and misalignment errors play a very critical role in the performance of the anti-backlash double-roller enveloping hourglass worm gear(ADEHWG).However,a corresponding efficient method for eliminating or reducing these errors on the tooth profile of the ADEHWG is seldom reported.The gear engagement equation and tooth profile equation for considering six different errors that could arise from the machining and gear misalignment are derived from the theories of differential geometry and gear meshing.Also,the tooth contact analysis(TCA) is used to systematically investigate the influence of the machining and misalignment errors on the contact curves and the tooth profile by means of numerical analysis and three-dimensional solid modeling.The research results show that vertical angular misalignment of the worm wheel(Δβ) has the strongest influences while the tooth angle error(Δα) has the weakest influences on the contact curves and the tooth profile.A novel efficient approach is proposed and used to minimize the effect of the errors in manufacturing by changing the radius of the grinding wheel and the approaching point of contact.The results from the TCA and the experiment demonstrate that this tooth profile design modification method can indeed reduce the machining and misalignment errors.This modification design method is helpful in understanding the manufacturing technology of the ADEHWG. 展开更多
关键词 worm gears tooth contact analysis machining and misalignment errors tooth profile errors modification method
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Statistical Modification Analysis of Helical Planetary Gears based on Response Surface Method and Monte Carlo Simulation 被引量:15
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作者 ZHANG Jun GUO Fan 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2015年第6期1194-1203,共10页
Tooth modification technique is widely used in gear industry to improve the meshing performance of gearings. However, few of the present studies on tooth modification considers the influence of inevitable random error... Tooth modification technique is widely used in gear industry to improve the meshing performance of gearings. However, few of the present studies on tooth modification considers the influence of inevitable random errors on gear modification effects. In order to investigate the uncertainties of tooth modification amount variations on system's dynamic behaviors of a helical planetary gears, an analytical dynamic model including tooth modification parameters is proposed to carry out a deterministic analysis on the dynamics of a helical planetary gear. The dynamic meshing forces as well as the dynamic transmission errors of the sun-planet 1 gear pair with and without tooth modifications are computed and compared to show the effectiveness of tooth modifications on gear dynamics enhancement. By using response surface method, a fitted regression model for the dynamic transmission error(DTE) fluctuations is established to quantify the relationship between modification amounts and DTE fluctuations. By shifting the inevitable random errors arousing from manufacturing and installing process to tooth modification amount variations, a statistical tooth modification model is developed and a methodology combining Monte Carlo simulation and response surface method is presented for uncertainty analysis of tooth modifications. The uncertainly analysis reveals that the system's dynamic behaviors do not obey the normal distribution rule even though the design variables are normally distributed. In addition, a deterministic modification amount will not definitely achieve an optimal result for both static and dynamic transmission error fluctuation reduction simultaneously. 展开更多
关键词 tooth modification helical planetary gears response surface method Monte Carlo simulation
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Planetary Gear Profile Modification Design Based on Load Sharing Modelling 被引量:9
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作者 IGLESIAS Miguel FERNáNDEZ DEL RINCóN Alfonso +3 位作者 DE-JUAN Ana Magdalena GARCIA Pablo DIEZ Alberto VIADERO Fernando 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2015年第4期810-820,共11页
In order to satisfy the increasing demand on high performance planetary transmissions, an important line of research is focused on the understanding of some of the underlying phenomena involved in this mechanical syst... In order to satisfy the increasing demand on high performance planetary transmissions, an important line of research is focused on the understanding of some of the underlying phenomena involved in this mechanical system. Through the development of models capable of reproduce the system behavior, research in this area contributes to improve gear transmission insight, helping developing better maintenance practices and more efficient design processes. A planetary gear model used for the design of profile modifications ratio based on the levelling of the load sharing ratio is presented. The gear profile geometry definition, following a vectorial approach that mimics the real cutting process of gears, is thoroughly described. Teeth undercutting and hypotrochoid definition are implicitly considered, and a procedure for the incorporation of a rounding arc at the tooth tip in order to deal with corner contacts is described. A procedure for the modeling of profile deviations is presented, which can be used for the introduction of both manufacturing errors and designed profile modifications. An easy and flexible implementation of the profile deviation within the planetary model is accomplished based on the geometric overlapping. The contact force calculation and dynamic implementation used in the model are also introduced, and parameters from a real transmission for agricultural applications are presented for the application example. A set of reliefs is designed based on the levelling of the load sharing ratio for the example transmission, and finally some other important dynamic factors of the transmission are analyzed to assess the changes in the dynamic behavior with respect to the non-modified case. Thus, the main innovative aspect of the proposed planetary transmission model is the capacity of providing a simulated load sharing ratio which serves as design variable for the calculation of the tooth profile modifications. 展开更多
关键词 TRANSMISSION planetary gear load sharing RELIEF profile modification
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Characteristic of involute slope modification of asymmetric spur gear 被引量:3
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作者 邓小禾 华林 韩星会 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第5期1676-1684,共9页
The meshing characteristic of asymmetric involute spur gear was studied, the equations of the geometric shape of the asymmetric gear for both sides were deduced, and the equations of contact ratio and the key points o... The meshing characteristic of asymmetric involute spur gear was studied, the equations of the geometric shape of the asymmetric gear for both sides were deduced, and the equations of contact ratio and the key points of contact were also obtained.Meanwhile, an involute slope modification method considering the effects of static transmission errors was proposed based on the meshing properties. The characteristic of the involute slope modification was analyzed by changing different modification parameters.The mesh stiffness and synthetic mesh stiffness of unmodified and modified asymmetric spur gears were investigated. Furthermore,the spectrums of synthetic mesh stiffness under different modification parameters were compared. Research results showed that the modification parameters influence the meshing performance of gear pairs, and the proposed modification method was feasible to improve the transmission performance of gear pairs with appropriate modification parameters. 展开更多
关键词 asymmetric gears involute slope modification synthetic mesh stiffness
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Investigation of a Design Modification for Double Helical Gears Reducing Vibration and Noise 被引量:6
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作者 王成 方宗德 贾海涛 《Journal of Marine Science and Application》 2010年第1期81-86,共6页
To reduce vibration and noise and increase transmission efficiency, a three segment method for modifying the pinion profile was proposed. Cutter surface equations were deduced by changing the shape of the cutter-edge,... To reduce vibration and noise and increase transmission efficiency, a three segment method for modifying the pinion profile was proposed. Cutter surface equations were deduced by changing the shape of the cutter-edge, substituting three segment parabolas for the line. The influence of longitudinal tooth modifications on tooth surface load distributions was discussed. Transmission error minimization and uniformity of tooth surface load distribution were chosen as optimization goals and the modified parameters were obtained by applying the complex method. Finally, an experiment comparing the loaded transmission error, vibration, and noise both before and after modifications was carried out. The results indicate that the modified design is reliable. 展开更多
关键词 tooth profile modification tooth longitudinal modification double helical gears loaded transmission error
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Effect of Tooth Profile Modification on Vibration of Power Split Gear Transmission System 被引量:2
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作者 Jincheng Dong Sanmin Wang +1 位作者 Jiashun Guo He Lin 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2016年第3期61-68,共8页
Based on Newton ' s second law,the bend-torsion-shaft coupling nonlinear dynamic model and equations of power split gear transmission system are established.According to the principle of tooth profile modification... Based on Newton ' s second law,the bend-torsion-shaft coupling nonlinear dynamic model and equations of power split gear transmission system are established.According to the principle of tooth profile modification,the tooth profile modification is considered as time-varying gear backlash function acting along the line of action.Then the dynamic functions are solved by using Runge-Kutta numerical method.After analyzing the effect of tooth profile modification quantity( TPMQ) and relative tooth profile modification length( TPML) to the nonlinear dynamic characteristics of power split gear transmission,the following conclusions are drawn:1 The TPMQ of a certain stage transmission affects the vibration of its own stage more significantly than the other stage,and the coupling effect between two stages can be ignored usually in the modification design;2 If the first stage TPMLs are less than 0.3,the influence of the first stage TPMLs to the first stage transmission vibration is much more greatly than the influence of the second stage TPMLs to the first stage transmission vibration,or else both the first and second stage TPMLs affect the first stage transmission vibration largely.The same is true for the second stage TPMLs,and the cutoff value is 0.2;3 The TPMQ affects the vibration of power split gear transmission system more principally than the TPML,and should be top-priority in the modification design. 展开更多
关键词 power SPLIT gear transmission system TOOTH profile modification nonlinear dynamic characteristics TIME-VARYING gear BACKLASH function
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Profile Modification for Increasing the Tooth Strength in Spur Gear Using CAD
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作者 Shanmugasundaram Sankar Maasanamuthu Sundar Raj Muthusamy Nataraj 《Engineering(科研)》 2010年第9期740-749,共10页
This paper examines the tooth failure in spur gears. Corrective measures are taken to avoid tooth damage by introducing profile modification in root fillet. In general, spur gear with less than 17 numbers of teeth had... This paper examines the tooth failure in spur gears. Corrective measures are taken to avoid tooth damage by introducing profile modification in root fillet. In general, spur gear with less than 17 numbers of teeth had the problem of undercutting during gear manufacturing process which minimizes the strength of gear at root. In this study, a novel design method, namely circular root fillet instead of the standard trochoidal root fillet is introduced in spur gear and analyzed using ANSYS version 11.0 software. The strength of these modified teeth is studied in comparison with the standard design. The analysis demonstrates that the novel design exhibit higher bending strength over the standard trochoidal root fillet gear. The result reveals that the circular root fillet design is particularly suitable for lesser number of teeth in pinion and where as the trochoidal root fillet gear is more opt for higher number of teeth. 展开更多
关键词 Bending Stress Circular ROOT FILLET DEFLECTION Profile modification SPUR gear Trochoidal ROOT FILLET
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High-Speed and Low-Noise Gear Finishing by Gear Grinding and Honing:A Review
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作者 Xiaoqing Tian Yukai Sun +2 位作者 Weihao Mu Lian Xia Jiang Han 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第5期19-39,共21页
Gears are important mechanical parts for transmitting power and play an increasingly important role in the machinery industry.The electric vehicle industry developed rapidly and became a vital development field of the... Gears are important mechanical parts for transmitting power and play an increasingly important role in the machinery industry.The electric vehicle industry developed rapidly and became a vital development field of the automotive industry over the past few years.The conversion of energy increases the requirements for electric vehicle transmissions,which promotes the development of high-speed and low-noise transmission gear.This paper elaborates on the research progress of high-speed and low-noise gear finishing methods.Firstly,this review analyses the machining requirements,finishing,and specific machining technologies of high-speed and low-noise gears.The importance of gear grinding and honing in high-speed and low-noise gear machining is highlighted.Secondly,the applications of gear grinding and honing in gear modification,error compensation,and texture control are analyzed.Furthermore,the role of precision machining technology in improving gear performance is clarified.Finally,the design and processing methods of the modified tooth flank for gear modification are summarized.In addition,the influence of tooth surface texture on noise is described,and the texture change methods are explored.The well-known open problems of gear finishing are finally identified,and some new research interests are also pointed out.This review will provide valuable references for further research on gear finishing. 展开更多
关键词 High-speed and low-noise gear gear machining technology gear finishing Tooth flank modification Tooth surface texture
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Reverse Design and Test of Non-circular Gear & Crank-Rocker & Gear Trains Weft Insertion Mechanism 被引量:2
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作者 陈建能 赵雄 +1 位作者 胡宇龙 任根勇 《Journal of Donghua University(English Edition)》 EI CAS 2011年第3期243-247,共5页
For the purpose of obtaining satisfactory performance of the non-circular gear & crank-rocker & gear trains (NCCRG) weft insertion mechanism which was proposed in this paper, the ideal kinematic curve of this ... For the purpose of obtaining satisfactory performance of the non-circular gear & crank-rocker & gear trains (NCCRG) weft insertion mechanism which was proposed in this paper, the ideal kinematic curve of this weft insertion mechanism was given, and the reverse solution models of this mechanism were established. A reverse design and simulation software was compiled based on Visual Basic 6.0 to obtain the mechanism parameters, including the pitch curves and tooth profiles of the non-circular gears. A test-bed of this mechanism was developed according to these parameters. The kinematic performance of this weft insertion mechanism was tested by high-speed video tape recorder with its corresponding video analytical software Blaster's MAS. And the test results were identical with the theoretical calculation. Compared with the conjugate cam weft insertion mechanism which is applied on TT96 rapier loom, under the condition of same weft insertion rate, the variation of acceleration of this mechanism is smaller. This novel weft insertion mechanism can meet the requirements of weft insertion on rapier looms with smooth and steady motion. 展开更多
关键词 non-circular gear weft insertion mechanism rapier loom reverse design test study
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Valuable Impulses and Successful Models of Gearbox Development from Practice
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作者 Tobias Schulze 《Journal of Mechanics Engineering and Automation》 2016年第8期408-418,共11页
Gears play an important role in mechanical engineering because of their moment and speed transmission possibilities. Design and optimization of a complete gearbox provide many requirements to the designer. The complex... Gears play an important role in mechanical engineering because of their moment and speed transmission possibilities. Design and optimization of a complete gearbox provide many requirements to the designer. The complex gearbox model consists of many machine elements (shafts, gears, bearings, housing, seals, and shaft-hub connections). The gearbox must be understood as a system with interactive parts. Next to the calculation of kinematics, load capacities and life times of single elements, aspects of load distribution and efficiency and noise excitation of gearboxes become important. The wide range of knowhow needed mostly cannot be covered by a small number of engineers. The development of automated calculation routines with understandable and comprehensive results is the goal for these research projects that lead to sottware-realizing solutions for engineers to efficiently design, calculate, optimize and verify gearboxes with minimal resources in terms of calculation experts and time. 展开更多
关键词 Tooth contact analysis gearbox design and verification finite element gearbox calculation gear modifications/optimization planetary gearboxes automated calculation process.
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Tooth surface geometry optimization of spiral bevel and hypoid gears generated by duplex helical method with circular profile blade 被引量:12
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作者 张宇 严宏志 +1 位作者 曾韬 曾亦愚 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第3期544-554,共11页
In order to effectively improve meshing performance of spiral bevel and hypoid gears generated by the duplex helical method, the effects of straight lined and circular cutting edges profile on meshing and contact of s... In order to effectively improve meshing performance of spiral bevel and hypoid gears generated by the duplex helical method, the effects of straight lined and circular cutting edges profile on meshing and contact of spiral bevel and hypoid gears were investigated analytically. Firstly, a mathematical model of spiral bevel and hypoid gears with circular blade profile was established according to the cutting characteristics of the duplex helical method. Based on a hypoid gear drive, the tooth bearings and the functions of transmission errors of four design cases were analyzed respectively by the use of the tooth contact analysis(TCA), and the contact stresses of the four design cases were analyzed and compared using simulation software. Finally, the curvature radius of the circular profile blade was optimized. The results show that the contact stresses are availably reduced, and the areas of edge contact and severe contact stresses can be avoided by selecting appropriate circular blade profile. In addition, the convex and concave sides are separately modified by the use of different curvature radii of inside and outside blades, which can increase the flexibility of the duplex helical method. 展开更多
关键词 circular blade profile duplex helical method spiral bevel and hypoid gears modification contact stress
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Analysis of lubrication performance for internal meshing gear pair considering vibration 被引量:3
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作者 JIAN Guang-xiao WANG You-qiang +2 位作者 ZHANG Ping LI Yun-kai LUO Heng 《Journal of Central South University》 SCIE EI CAS CSCD 2021年第1期126-139,共14页
The thermal elasto-hydrodynamic lubrication characteristics of the internal meshing gears in a planetary gear train under vibrations were examined considering the influence of the modification coefficient and time-var... The thermal elasto-hydrodynamic lubrication characteristics of the internal meshing gears in a planetary gear train under vibrations were examined considering the influence of the modification coefficient and time-varying meshing stiffness.Based on dynamic theory of the gear system,a dynamic model of the planetary gear train was established.The lubrication performances of modified gear systems under vibrations and static loads were analyzed.Compared with other transmission types,the best lubrication effect could be produced by the positive transmission.A thicker lubricating oil film could be formed,and the friction coefficient and oil film flash temperature are the smallest.Increasing modification coefficient improves the lubrication performance continuously but intensifies the engage-in and tooth-change impact.For the planetary and inner gears,the increase in the modification coefficient also leads a decrease in the oil film stiffness. 展开更多
关键词 internal meshing gears dynamic model modification coefficient lubrication performance oil film stiffness
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Thermal elastohydrodynamic lubrication of modified gear system considering vibration 被引量:2
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作者 JIAN Guang-xiao WANG You-qiang +2 位作者 ZHANG Ping LI Yun-kai LUO Heng 《Journal of Central South University》 SCIE EI CAS CSCD 2020年第11期3350-3363,共14页
The thermal elastohydrodynamic lubrication characteristics of a modified gear system under a dynamic load were investigated,including the influence of the modification coefficient and vibrations.Based on the dynamic t... The thermal elastohydrodynamic lubrication characteristics of a modified gear system under a dynamic load were investigated,including the influence of the modification coefficient and vibrations.Based on the dynamic theory of gear systems,a six-degree-of-freedom tribo-dynamics model was established.Thermal elastohydrodynamic lubrication characteristics of a modified gear system under vibrations and a static load were analyzed.The results showed that the positive transmission gear system exhibited the better lubrication effect compared with other transmission types.A thick lubricating oil film could be formed,and the friction coefficient between the teeth and the oil film flash temperature were the smallest.As the modification coefficient increased,the lubrication condition was continuously improved,and the scuffing load capacity was enhanced.The increment of the modification coefficient increased the meshing stiffness of the gear system but reduced the stiffness of the oil film. 展开更多
关键词 involute spur gear tribo-dynamics model oil film stiffness modification coefficient lubrication property
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DIRECT DIGITAL DESIGN AND SIMULATION OF MESHING IN WORM-GEAR DRIVE 被引量:10
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作者 XU Wujiao QIN Datong SHI Wankai 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2006年第3期428-433,共6页
A direct digital design method (DDDM) of worm-gear drive is proposed. It is directly based on the simulation of manufacturing process and completely different from the conventional modeling method. The loaded tooth ... A direct digital design method (DDDM) of worm-gear drive is proposed. It is directly based on the simulation of manufacturing process and completely different from the conventional modeling method. The loaded tooth contact analysis (LTCA) method is analyzed, in which the advanced surface to surface searching technique is included. The influence of misalignment errors and contact deformations on contact zone and transmission error (TE) is discussed. Combined modification approach on worm tooth surface is presented. By means of DDDM and LTCA, it is very conven- ient to verify the effect of worm-gear drive's modification approach. The analysis results show that, the modification in profile direction reduces the sensitivity of worm-gear drive to misalignment errors and the modification in longitudinal direction decreases the TE. Thus the optimization design of worm-gear drive can be achieved prior to the actual manufacturing process. 展开更多
关键词 Direct digital design Loaded tooth contact analysis Combined modification approach Worm-gear drive
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The Genetic Association between CDKN1A and Heart Failure:Genome-Wide Exploration of m6A-SNPs and Mendelian Randomization 被引量:1
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作者 Ziyi Yang Zhennan Lin +4 位作者 Xiaotong Ning Xingbo Mo Laiyuan Wang Xiangfeng Lu Shufeng Chen 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第12期1397-1408,共12页
Objective N6-methyladenosine(m^(6)A)is a common epigenetic modification in eukaryotes.In this study,we explore the potential impact of m^(6)A-associated single nucleotide polymorphisms(m^(6)A-SNPs)on heart failure(HF)... Objective N6-methyladenosine(m^(6)A)is a common epigenetic modification in eukaryotes.In this study,we explore the potential impact of m^(6)A-associated single nucleotide polymorphisms(m^(6)A-SNPs)on heart failure(HF).Methods Data from genome-wide association studies(GWAS)investigating HF in humans and from m^(6)A-SNPs datasets were used to identify HF-associated m^(6)A-SNPs.Their functions were explored using expression quantitative trait locus(eQTL),gene expression,and gene enrichment analyses.Mediation protein quantitative trait locus(pQTL)-Mendelian randomization(MR)was used to investigate the potential mechanism between critical protein levels and risk factors for HF.Results We screened 44 HF-associated m^(6)A-SNPs,including 10 m^(6)A-SNPs that showed eQTL signals and differential expressions in HF.The SNP rs1801270 in CDKN1A showed the strongest association with HF(P=7.75×10^(−6)).Additionally,MR verified the genetic association between the CDKN1A protein and HF,as well as the mediating effect of blood pressure(BP)in this pathway.Higher circulating level of CDKN1A was associated with a lower risk of HF(odds ratio[OR]=0.82,95%confidence interval[CI]:0.69 to 0.99).The proportions of hypertension,systolic BP,and diastolic BP were 48.10%,28.94%,and 18.02%,respectively.Associations of PDIA6(P=1.30×10^(−2))and SMAD3(P=4.80×10^(−2))with HF were also detected.Conclusion Multiple HF-related m^(6)A-SNPs were identified in this study.Genetic associations of CDKN1A and other proteins with HF and its risk factors were demonstrated,providing new ideas for further exploration of the molecular mechanisms of HF. 展开更多
关键词 Heart failure N6-methyladenosine modification Genome-wide association study Expression quantitative trait locus Mendelian randomization
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