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Lou Gehrig’s病与SOD基因突变之间的联系使人们对神经营养因子产生了疑虑
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作者 陶冶 《生物技术通报》 CAS CSCD 1993年第8期17-18,共2页
由马萨诸塞综合医院(Charleston,MA)的 Daniel Rosen 领导的研究小组在国立老年研究所(NIA)(Bethesda,MD)的部分资助下,令人信服的揭示了家族性肌萎缩性侧索硬化(FALS 或 Lou Gehrig’s 病)与超氧化物歧化酶(SOD1)基因突变间的联系,在... 由马萨诸塞综合医院(Charleston,MA)的 Daniel Rosen 领导的研究小组在国立老年研究所(NIA)(Bethesda,MD)的部分资助下,令人信服的揭示了家族性肌萎缩性侧索硬化(FALS 或 Lou Gehrig’s 病)与超氧化物歧化酶(SOD1)基因突变间的联系,在研究的13个不同 FALS 家庭中,有11家的21号染色体长臂上的 SOD1基因发生了突变。 展开更多
关键词 神经营养因子 基因突变 Lou gehrig SOD基因 综合医院 马萨诸塞 族性 染色体长臂 再灌注损伤 氧化损伤
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Administering Anesthesia for Patients with ALS Having a Diaphragmatic Pacemaker Placed: Special Considerations
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作者 Molly Kraus Lopa Misra 《Open Journal of Anesthesiology》 2014年第9期223-226,共4页
Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s disease is a relentlessly progressive, fatal disease. Progression of the disease results 3 - 5 years after diagnosis, often from respiratory failure. The... Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s disease is a relentlessly progressive, fatal disease. Progression of the disease results 3 - 5 years after diagnosis, often from respiratory failure. The diaphragm pacing system (DPS) is a device that stimulates the diaphragm to maximally contract so patients can breathe more effectively. It has been used in patients with neurologic injuries such as spinal cord injury and ALS. From an anesthetic perspective, both the surgery and the patient population present several unique challenges. This case series describes three patients with ALS who had the diaphragmatic pacemaker placed and the anesthetic management during those surgeries. 展开更多
关键词 ALS Amyotrophic Lateral SCLEROSIS DIAPHRAGMATIC PACEMAKER DPS Lou gehrig’s Disease
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