Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain injury.However,whether bioactiv...Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain injury.However,whether bioactive materials can repair the damage caused by ischemic stroke by activating endogenous neurogenesis and angiogenesis is still unknown.In this study,we applied chitosan gel loaded with basic fibroblast growth factor to the stroke cavity 7 days after ischemic stroke in rats.The gel slowly released basic fibroblast growth factor,which improved the local microenvironment,activated endogenous neural stem/progenitor cells,and recruited these cells to migrate toward the penumbra and stroke cavity and subsequently differentiate into neurons,while enhancing angiogenesis in the penumbra and stroke cavity and ultimately leading to partial functional recovery.This study revealed the mechanism by which bioactive materials repair ischemic strokes,thus providing a new strategy for the clinical application of bioactive materials in the treatment of ischemic stroke.展开更多
The cathode-active materials, Li1＋yMxMn2-xO4 （M = Al, Co, Ni, Zn, y = 0.02, x = 0.02） powder, were synthesized by sol-gel method using LiOH, Mn（NO3）2 as the starting materials, citric acid as a carrier and Al（NO...The cathode-active materials, Li1＋yMxMn2-xO4 （M = Al, Co, Ni, Zn, y = 0.02, x = 0.02） powder, were synthesized by sol-gel method using LiOH, Mn（NO3）2 as the starting materials, citric acid as a carrier and Al（NO3）3·9H2O or Co（NO3）2·6H2O or Ni（NO3）2·6H2O or Zn（NO3）2·6H2O as dopants. The influence of different doping elements on the structural properties of the as-prepared samples was investigated by X-ray diffraction （XRD）, infrared （IR） spectroscopy and scanning electron microscopy （SEM）. X-ray diffraction patterns of the prepared samples were identified as the spinel structure with space group Fd3m. The grain size increases gradually as the sintering temperature rises and corresponding activation energies for the grain growth have been estimated using Arrhenius’ empirical relation.展开更多
In this work, TiO2 nanorods with uniform diameter of about 100 nm and a length of several micrometers were successfully prepared by the sol-gel template method. Also the influence of molar ratios of precursor on the m...In this work, TiO2 nanorods with uniform diameter of about 100 nm and a length of several micrometers were successfully prepared by the sol-gel template method. Also the influence of molar ratios of precursor on the morphology and structure of TiO2 nanorods has been investigated. The prepared samples were characterized by Fourier transform infrared spectroscopy （FTIR）, X-ray diffraction （XRD） and scanning electron microscopy （SEM）. The XRD results indicated that the TiO2 nanorods were crystallized in the anatase and rutile phases, after annealing to 400-700℃ up to 2 h.展开更多
We have experimentally studied the growth process of a water-absorbing polymer commonly known as hydro-gel. We took a number of spherical beads, immersed them in pure water, measured their diameters at regular interva...We have experimentally studied the growth process of a water-absorbing polymer commonly known as hydro-gel. We took a number of spherical beads, immersed them in pure water, measured their diameters at regular intervals of time and plotted graphs showing the change in volume with the time of immersion, to analyze their swelling properties. We have formulated a dynamical model on the basis of curve-fitting to our experimental data. Our mathematical modelling is devoted solely towards the explanation of the swelling of spherical hydro-gels and we have interpreted our observations on these basis. And finally evaluating the constants of the process, we have shown that the results obtained from our modelling and numerical simulation exactly match the experimental data. The justification of this new approach lies in its successful application for the complete explanation of our observations through numerical and analytical ways.展开更多
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are usually suitable candidates for the development of drug delivery devices. Sol-gel chemistry represents an easy method to obtain porous silica nanoparticles. Mesoporou...Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are usually suitable candidates for the development of drug delivery devices. Sol-gel chemistry represents an easy method to obtain porous silica nanoparticles. Mesoporous silica nanomaterials have been widely used for drug delivery purposes. In this work we synthesized silica based materials using two molar alkoxide:water ratios 1:4 and 1:8, incorporating paracetamol to develop a nano-sized matrix for controlled release purposes. The samples exhibited different values for surface area, porosity, particle size and distinct punctual defects. Infrared and UV-visible spectroscopic studies were carried out to demonstrate the effect of water concentration and the adequate incorporation of paracetamol molecules. Nitrogen adsorption characterization was realized and the estimated BET surface values were from 532 to 825 m<sup>2</sup>/g. Kinetic analysis of drug release profiles was performed using the hyperbola model. Transmission electron micrographs showed that all the materials formed aggregates of small particles with size between 10 - 60 nm. Mesoporous SiO<sub>2</sub> materials were proved to be a suitable system for controlled release of paracetamol.展开更多
基金supported by the National Natural Science Foundation of China,Nos.81941011(to XL),31771053(to HD),31730030(to XL),31971279(to ZY),31900749(to PH),31650001(to XL),31320103903(to XL),31670988(to ZY)the Natural Science Foundation of Beijing,Nos.7222004(to HD)+1 种基金a grant from Ministry of Science and Technology of China,Nos.2017YFC1104002(to ZY),2017YFC1104001(to XL)a grant from Beihang University,No.JKF-YG-22-B001(to FH)。
文摘Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain injury.However,whether bioactive materials can repair the damage caused by ischemic stroke by activating endogenous neurogenesis and angiogenesis is still unknown.In this study,we applied chitosan gel loaded with basic fibroblast growth factor to the stroke cavity 7 days after ischemic stroke in rats.The gel slowly released basic fibroblast growth factor,which improved the local microenvironment,activated endogenous neural stem/progenitor cells,and recruited these cells to migrate toward the penumbra and stroke cavity and subsequently differentiate into neurons,while enhancing angiogenesis in the penumbra and stroke cavity and ultimately leading to partial functional recovery.This study revealed the mechanism by which bioactive materials repair ischemic strokes,thus providing a new strategy for the clinical application of bioactive materials in the treatment of ischemic stroke.
基金This work was supported by the National Natural Science Foundation of China (60671010)Natural Science Foundation of Shandong Province (Y2006B29)
文摘The cathode-active materials, Li1＋yMxMn2-xO4 （M = Al, Co, Ni, Zn, y = 0.02, x = 0.02） powder, were synthesized by sol-gel method using LiOH, Mn（NO3）2 as the starting materials, citric acid as a carrier and Al（NO3）3·9H2O or Co（NO3）2·6H2O or Ni（NO3）2·6H2O or Zn（NO3）2·6H2O as dopants. The influence of different doping elements on the structural properties of the as-prepared samples was investigated by X-ray diffraction （XRD）, infrared （IR） spectroscopy and scanning electron microscopy （SEM）. X-ray diffraction patterns of the prepared samples were identified as the spinel structure with space group Fd3m. The grain size increases gradually as the sintering temperature rises and corresponding activation energies for the grain growth have been estimated using Arrhenius’ empirical relation.
文摘In this work, TiO2 nanorods with uniform diameter of about 100 nm and a length of several micrometers were successfully prepared by the sol-gel template method. Also the influence of molar ratios of precursor on the morphology and structure of TiO2 nanorods has been investigated. The prepared samples were characterized by Fourier transform infrared spectroscopy （FTIR）, X-ray diffraction （XRD） and scanning electron microscopy （SEM）. The XRD results indicated that the TiO2 nanorods were crystallized in the anatase and rutile phases, after annealing to 400-700℃ up to 2 h.
文摘We have experimentally studied the growth process of a water-absorbing polymer commonly known as hydro-gel. We took a number of spherical beads, immersed them in pure water, measured their diameters at regular intervals of time and plotted graphs showing the change in volume with the time of immersion, to analyze their swelling properties. We have formulated a dynamical model on the basis of curve-fitting to our experimental data. Our mathematical modelling is devoted solely towards the explanation of the swelling of spherical hydro-gels and we have interpreted our observations on these basis. And finally evaluating the constants of the process, we have shown that the results obtained from our modelling and numerical simulation exactly match the experimental data. The justification of this new approach lies in its successful application for the complete explanation of our observations through numerical and analytical ways.
文摘Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are usually suitable candidates for the development of drug delivery devices. Sol-gel chemistry represents an easy method to obtain porous silica nanoparticles. Mesoporous silica nanomaterials have been widely used for drug delivery purposes. In this work we synthesized silica based materials using two molar alkoxide:water ratios 1:4 and 1:8, incorporating paracetamol to develop a nano-sized matrix for controlled release purposes. The samples exhibited different values for surface area, porosity, particle size and distinct punctual defects. Infrared and UV-visible spectroscopic studies were carried out to demonstrate the effect of water concentration and the adequate incorporation of paracetamol molecules. Nitrogen adsorption characterization was realized and the estimated BET surface values were from 532 to 825 m<sup>2</sup>/g. Kinetic analysis of drug release profiles was performed using the hyperbola model. Transmission electron micrographs showed that all the materials formed aggregates of small particles with size between 10 - 60 nm. Mesoporous SiO<sub>2</sub> materials were proved to be a suitable system for controlled release of paracetamol.
