To improve the physiochemical properties of gellan gum（GG）, GG was modified with acrylamide and trimethylolpropane triglycidyl ether（TTE）. The structure and morphology of modified GG were characterized by Fourier ...To improve the physiochemical properties of gellan gum（GG）, GG was modified with acrylamide and trimethylolpropane triglycidyl ether（TTE）. The structure and morphology of modified GG were characterized by Fourier transform infrared（FT-IR） spectroscopy, X-ray diffraction（XRD）, differential scanning calorimetry（DSC） and scanning electron microscopy（SEM）. The characteristic peaks at 3448, 2788, 1654, 1411, 1117 and 1044 cm-1）in the FT-IR spectrum confirm the modification. The XRD and DSC data revealed that the modification enhanced the thermal stability of GG. SEM analysis suggested the modification introduced a porous microstructure, resulting in the adsorption of crystal violet. In addition, the adsorption capacity, thermal stability and swelling property of GGTTE3 were superior to GGTTE1, GGTTE2, GGTTE4 and GGTTE5.展开更多
The structure-function relationship of a gellan family of polysaccharides, S-198 gum produced by Alcaligenes ATCC31853 was investigated in terms of rheological aspects. The flow curves of S-198 gum showed plastic beha...The structure-function relationship of a gellan family of polysaccharides, S-198 gum produced by Alcaligenes ATCC31853 was investigated in terms of rheological aspects. The flow curves of S-198 gum showed plastic behavior above 0.3%. Gelation did not occur in S-198 gum solution at low temperature (0℃), even at 0.8%. Both the viscosity and the elastic modulus remained constant with increasing temperature up to 80?C. The elastic modulus decreased a little with the addition of CaCl2 (6.8 mM), but then once again remained constant up to 80℃. The highest elastic modulus was observed for deacylated gellan gum with the addition of CaCl2 and increased slightly with increasing temperature up to 80℃, which was considered to be a transition temperature, after which it decreased rapidly. The elastic modulus of S-198 gum in the presence of urea (4.0 M) was lower than that in aqueous solution at low temperature (0℃), but remained constant with increasing temperature up to 80℃. The intramolecular associations, (hydrogen bonding and van der Waals forces of attraction), of S-198 gum molecules in aqueous solutions were proposed. The gellan family of polysaccharides, S-198, S-88, S-657, rhamsan, welan and gellan gum, provided a good opportunity to investigate the structure-function relationship for polysaccharides.展开更多
本文设计并制备了口服布洛芬原位凝胶(in situgel systems for the oral delivery of ibuprofen,IBU-ISG),并对其在Beagle犬上药代动力学进行了研究。以去乙酰结冷胶和海藻酸钠为凝胶材料,分别对此两种凝胶材料进行了单因素考察,初步确...本文设计并制备了口服布洛芬原位凝胶(in situgel systems for the oral delivery of ibuprofen,IBU-ISG),并对其在Beagle犬上药代动力学进行了研究。以去乙酰结冷胶和海藻酸钠为凝胶材料,分别对此两种凝胶材料进行了单因素考察,初步确定了辅料的用量。以成胶前的复合黏度值、体外释放度等参数为评价指标,采用正交设计法进行处方优化。优化的制剂处方为:1.0%海藻酸钠、0.5%去乙酰结冷胶、0.21%枸橼酸钠和0.056%氯化钙。采用RP-HPLC法测定6只Beagle犬口服IBU-ISG和参比制剂(市售布洛芬混悬液)后不同时间血浆中布洛芬的浓度,所得药代动力学参数Tmax分别为(1.8±0.6)和(0.4±0.1)h,Cmax分别为(29.2±7.6)和(37.8±2.2)μg.mL-1,T1/2分别为(2.3±0.5)和(2.0±0.9)h,AUC0-t分别为(131.0±38.6)和(117.3±23.1)μg.mL-1.h。结果表明,采用去乙酰结冷胶和海藻酸钠二元骨架制备IBU-ISG可行。展开更多
基金financially supported by the International Science and Technology Cooperation and Exchange Program of Fujian Agriculture and Forestry University(KXGH17001)
文摘To improve the physiochemical properties of gellan gum（GG）, GG was modified with acrylamide and trimethylolpropane triglycidyl ether（TTE）. The structure and morphology of modified GG were characterized by Fourier transform infrared（FT-IR） spectroscopy, X-ray diffraction（XRD）, differential scanning calorimetry（DSC） and scanning electron microscopy（SEM）. The characteristic peaks at 3448, 2788, 1654, 1411, 1117 and 1044 cm-1）in the FT-IR spectrum confirm the modification. The XRD and DSC data revealed that the modification enhanced the thermal stability of GG. SEM analysis suggested the modification introduced a porous microstructure, resulting in the adsorption of crystal violet. In addition, the adsorption capacity, thermal stability and swelling property of GGTTE3 were superior to GGTTE1, GGTTE2, GGTTE4 and GGTTE5.
文摘The structure-function relationship of a gellan family of polysaccharides, S-198 gum produced by Alcaligenes ATCC31853 was investigated in terms of rheological aspects. The flow curves of S-198 gum showed plastic behavior above 0.3%. Gelation did not occur in S-198 gum solution at low temperature (0℃), even at 0.8%. Both the viscosity and the elastic modulus remained constant with increasing temperature up to 80?C. The elastic modulus decreased a little with the addition of CaCl2 (6.8 mM), but then once again remained constant up to 80℃. The highest elastic modulus was observed for deacylated gellan gum with the addition of CaCl2 and increased slightly with increasing temperature up to 80℃, which was considered to be a transition temperature, after which it decreased rapidly. The elastic modulus of S-198 gum in the presence of urea (4.0 M) was lower than that in aqueous solution at low temperature (0℃), but remained constant with increasing temperature up to 80℃. The intramolecular associations, (hydrogen bonding and van der Waals forces of attraction), of S-198 gum molecules in aqueous solutions were proposed. The gellan family of polysaccharides, S-198, S-88, S-657, rhamsan, welan and gellan gum, provided a good opportunity to investigate the structure-function relationship for polysaccharides.
文摘本文设计并制备了口服布洛芬原位凝胶(in situgel systems for the oral delivery of ibuprofen,IBU-ISG),并对其在Beagle犬上药代动力学进行了研究。以去乙酰结冷胶和海藻酸钠为凝胶材料,分别对此两种凝胶材料进行了单因素考察,初步确定了辅料的用量。以成胶前的复合黏度值、体外释放度等参数为评价指标,采用正交设计法进行处方优化。优化的制剂处方为:1.0%海藻酸钠、0.5%去乙酰结冷胶、0.21%枸橼酸钠和0.056%氯化钙。采用RP-HPLC法测定6只Beagle犬口服IBU-ISG和参比制剂(市售布洛芬混悬液)后不同时间血浆中布洛芬的浓度,所得药代动力学参数Tmax分别为(1.8±0.6)和(0.4±0.1)h,Cmax分别为(29.2±7.6)和(37.8±2.2)μg.mL-1,T1/2分别为(2.3±0.5)和(2.0±0.9)h,AUC0-t分别为(131.0±38.6)和(117.3±23.1)μg.mL-1.h。结果表明,采用去乙酰结冷胶和海藻酸钠二元骨架制备IBU-ISG可行。
