Background:Diabetic nephropathy(DN)is the most common complication of type 2 diabetes mellitus and the main cause of end-stage renal disease worldwide.Diagnostic biomarkers may allow early diagnosis and treatment of D...Background:Diabetic nephropathy(DN)is the most common complication of type 2 diabetes mellitus and the main cause of end-stage renal disease worldwide.Diagnostic biomarkers may allow early diagnosis and treatment of DN to reduce the prevalence and delay the development of DN.Kidney biopsy is the gold standard for diagnosing DN;however,its invasive character is its primary limitation.The machine learning approach provides a non-invasive and specific criterion for diagnosing DN,although traditional machine learning algorithms need to be improved to enhance diagnostic performance.Methods:We applied high-throughput RNA sequencing to obtain the genes related to DN tubular tissues and normal tubular tissues of mice.Then machine learning algorithms,random forest,LASSO logistic regression,and principal component analysis were used to identify key genes(CES1G,CYP4A14,NDUFA4,ABCC4,ACE).Then,the genetic algorithm-optimized backpropagation neural network(GA-BPNN)was used to improve the DN diagnostic model.Results:The AUC value of the GA-BPNN model in the training dataset was 0.83,and the AUC value of the model in the validation dataset was 0.81,while the AUC values of the SVM model in the training dataset and external validation dataset were 0.756 and 0.650,respectively.Thus,this GA-BPNN gave better values than the traditional SVM model.This diagnosis model may aim for personalized diagnosis and treatment of patients with DN.Immunohistochemical staining further confirmed that the tissue and cell expression of NADH dehydrogenase(ubiquinone)1 alpha subcomplex,4-like 2(NDUFA4L2)in tubular tissue in DN mice were decreased.Conclusion:The GA-BPNN model has better accuracy than the traditional SVM model and may provide an effective tool for diagnosing DN.展开更多
For optimal design of mechanical clinching steel-aluminum joints, the back propagation (BP) neural network is used to research the mapping relationship between joining technique parameters including sheet thickness,...For optimal design of mechanical clinching steel-aluminum joints, the back propagation (BP) neural network is used to research the mapping relationship between joining technique parameters including sheet thickness, sheet hardness, joint bottom diameter etc., and mechanical properties of shearing and peeling in order to investigate joining technology between various material plates in the steel-aluminum hybrid structure car body. Genetic algorithm (GA) is adopted to optimize the back-propagation neural network connection weights. The training and validating samples are made by the BTM Tog-L-Loc system with different technologic parameters. The training samples' parameters and the corresponding joints' mechanical properties are supplied to the artificial neural network (ANN) for training. The validating samples' experimental data is used for checking up the prediction outputs. The calculation results show that GA can improve the model's prediction precision and generalization ability of BP neural network. The comparative analysis between the experimental data and the prediction outputs shows that ANN prediction models after training can effectively predict the mechanical properties of mechanical clinching joints and prove the feasibility and reliability of the intelligent neural networks system when used in the mechanical properties prediction of mechanical clinching joints. The prediction results can be used for a reference in the design of mechanical clinching steel-aluminum joints.展开更多
Although the Internet of Things has been widely applied,the problems of cloud computing in the application of digital smart medical Big Data collection,processing,analysis,and storage remain,especially the low efficie...Although the Internet of Things has been widely applied,the problems of cloud computing in the application of digital smart medical Big Data collection,processing,analysis,and storage remain,especially the low efficiency of medical diagnosis.And with the wide application of the Internet of Things and Big Data in the medical field,medical Big Data is increasing in geometric magnitude resulting in cloud service overload,insufficient storage,communication delay,and network congestion.In order to solve these medical and network problems,a medical big-data-oriented fog computing architec-ture and BP algorithm application are proposed,and its structural advantages and characteristics are studied.This architecture enables the medical Big Data generated by medical edge devices and the existing data in the cloud service center to calculate,compare and analyze the fog node through the Internet of Things.The diagnosis results are designed to reduce the business processing delay and improve the diagnosis effect.Considering the weak computing of each edge device,the artificial intelligence BP neural network algorithm is used in the core computing model of the medical diagnosis system to improve the system computing power,enhance the medical intelligence-aided decision-making,and improve the clinical diagnosis and treatment efficiency.In the application process,combined with the characteristics of medical Big Data technology,through fog architecture design and Big Data technology integration,we could research the processing and analysis of heterogeneous data of the medical diagnosis system in the context of the Internet of Things.The results are promising:The medical platform network is smooth,the data storage space is sufficient,the data processing and analysis speed is fast,the diagnosis effect is remarkable,and it is a good assistant to doctors’treatment effect.It not only effectively solves the problem of low clinical diagnosis,treatment efficiency and quality,but also reduces the waiting time of patients,effectively solves the contradiction between doctors and patients,and improves the medical service quality and management level.展开更多
Many biodynamic models have been derived using trial and error curve-fitting technique, such that the error between the computed and measured biodynamic response functions is minimum. This study developed a biomechani...Many biodynamic models have been derived using trial and error curve-fitting technique, such that the error between the computed and measured biodynamic response functions is minimum. This study developed a biomechanical model of the human body in a sitting posture without backrest for evaluating the vibration transmissibility and dynamic response to vertical vibration direction. In describing the human body motion, a three biomechanical models are discussed (two models are 4-DOF and one model 7-DOF). Optimization software based on stochastic techniques search methods, Genetic Algorithms (GAs), is employed to determine the human model parameters imposing some limit constraints on the model parameters. In addition, an objective function is formulated comprising the sum of errors between the computed and actual values (experimental data). The studied functions are the driving-point mechanical impedance, apparent mass and seat- to-head transmissibility functions. The optimization process increased the average goodness of fit and the results of studied functions became much closer to the target values (Experimental data). From the optimized model, the resonant frequencies of the driver parts computed on the basis of biodynamic response functions are found to be within close bounds to that expected for the human body.展开更多
Vortex induced vibration(VIV)is a challenge in ocean engineering.Several devices including fairings have been designed to suppress VIV.However,how to optimize the design of suppression devices is still a problem to be...Vortex induced vibration(VIV)is a challenge in ocean engineering.Several devices including fairings have been designed to suppress VIV.However,how to optimize the design of suppression devices is still a problem to be solved.In this paper,an optimization design methodology is presented based on data-driven models and genetic algorithm(GA).Data-driven models are introduced to substitute complex physics-based equations.GA is used to rapidly search for the optimal suppression device from all possible solutions.Taking fairings as example,VIV response database for different fairings is established based on parameterized models in which model sections of fairings are controlled by several control points and Bezier curves.Then a data-driven model,which can predict the VIV response of fairings with different sections accurately and efficiently,is trained through BP neural network.Finally,a comprehensive optimization method and process is proposed based on GA and the data-driven model.The proposed method is demonstrated by its application to a case.It turns out that the proposed method can perform the optimization design of fairings effectively.VIV can be reduced obviously through the optimization design.展开更多
基金the National Natural Science Foundation of China(Grant Number:81970631 to W.L.).
文摘Background:Diabetic nephropathy(DN)is the most common complication of type 2 diabetes mellitus and the main cause of end-stage renal disease worldwide.Diagnostic biomarkers may allow early diagnosis and treatment of DN to reduce the prevalence and delay the development of DN.Kidney biopsy is the gold standard for diagnosing DN;however,its invasive character is its primary limitation.The machine learning approach provides a non-invasive and specific criterion for diagnosing DN,although traditional machine learning algorithms need to be improved to enhance diagnostic performance.Methods:We applied high-throughput RNA sequencing to obtain the genes related to DN tubular tissues and normal tubular tissues of mice.Then machine learning algorithms,random forest,LASSO logistic regression,and principal component analysis were used to identify key genes(CES1G,CYP4A14,NDUFA4,ABCC4,ACE).Then,the genetic algorithm-optimized backpropagation neural network(GA-BPNN)was used to improve the DN diagnostic model.Results:The AUC value of the GA-BPNN model in the training dataset was 0.83,and the AUC value of the model in the validation dataset was 0.81,while the AUC values of the SVM model in the training dataset and external validation dataset were 0.756 and 0.650,respectively.Thus,this GA-BPNN gave better values than the traditional SVM model.This diagnosis model may aim for personalized diagnosis and treatment of patients with DN.Immunohistochemical staining further confirmed that the tissue and cell expression of NADH dehydrogenase(ubiquinone)1 alpha subcomplex,4-like 2(NDUFA4L2)in tubular tissue in DN mice were decreased.Conclusion:The GA-BPNN model has better accuracy than the traditional SVM model and may provide an effective tool for diagnosing DN.
基金supported by Guangdong Provincial Technology Planning of China (Grant No. 2007B010400052)State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body of China (Grant No. 30715006)Guangdong Provincial Key Laboratory of Automotive Engineering, China (Grant No. 2007A03012)
文摘For optimal design of mechanical clinching steel-aluminum joints, the back propagation (BP) neural network is used to research the mapping relationship between joining technique parameters including sheet thickness, sheet hardness, joint bottom diameter etc., and mechanical properties of shearing and peeling in order to investigate joining technology between various material plates in the steel-aluminum hybrid structure car body. Genetic algorithm (GA) is adopted to optimize the back-propagation neural network connection weights. The training and validating samples are made by the BTM Tog-L-Loc system with different technologic parameters. The training samples' parameters and the corresponding joints' mechanical properties are supplied to the artificial neural network (ANN) for training. The validating samples' experimental data is used for checking up the prediction outputs. The calculation results show that GA can improve the model's prediction precision and generalization ability of BP neural network. The comparative analysis between the experimental data and the prediction outputs shows that ANN prediction models after training can effectively predict the mechanical properties of mechanical clinching joints and prove the feasibility and reliability of the intelligent neural networks system when used in the mechanical properties prediction of mechanical clinching joints. The prediction results can be used for a reference in the design of mechanical clinching steel-aluminum joints.
基金supported by 2020 Foshan Science and Technology Project(Numbering:2020001005356),Baoling Qin received the grant.
文摘Although the Internet of Things has been widely applied,the problems of cloud computing in the application of digital smart medical Big Data collection,processing,analysis,and storage remain,especially the low efficiency of medical diagnosis.And with the wide application of the Internet of Things and Big Data in the medical field,medical Big Data is increasing in geometric magnitude resulting in cloud service overload,insufficient storage,communication delay,and network congestion.In order to solve these medical and network problems,a medical big-data-oriented fog computing architec-ture and BP algorithm application are proposed,and its structural advantages and characteristics are studied.This architecture enables the medical Big Data generated by medical edge devices and the existing data in the cloud service center to calculate,compare and analyze the fog node through the Internet of Things.The diagnosis results are designed to reduce the business processing delay and improve the diagnosis effect.Considering the weak computing of each edge device,the artificial intelligence BP neural network algorithm is used in the core computing model of the medical diagnosis system to improve the system computing power,enhance the medical intelligence-aided decision-making,and improve the clinical diagnosis and treatment efficiency.In the application process,combined with the characteristics of medical Big Data technology,through fog architecture design and Big Data technology integration,we could research the processing and analysis of heterogeneous data of the medical diagnosis system in the context of the Internet of Things.The results are promising:The medical platform network is smooth,the data storage space is sufficient,the data processing and analysis speed is fast,the diagnosis effect is remarkable,and it is a good assistant to doctors’treatment effect.It not only effectively solves the problem of low clinical diagnosis,treatment efficiency and quality,but also reduces the waiting time of patients,effectively solves the contradiction between doctors and patients,and improves the medical service quality and management level.
文摘Many biodynamic models have been derived using trial and error curve-fitting technique, such that the error between the computed and measured biodynamic response functions is minimum. This study developed a biomechanical model of the human body in a sitting posture without backrest for evaluating the vibration transmissibility and dynamic response to vertical vibration direction. In describing the human body motion, a three biomechanical models are discussed (two models are 4-DOF and one model 7-DOF). Optimization software based on stochastic techniques search methods, Genetic Algorithms (GAs), is employed to determine the human model parameters imposing some limit constraints on the model parameters. In addition, an objective function is formulated comprising the sum of errors between the computed and actual values (experimental data). The studied functions are the driving-point mechanical impedance, apparent mass and seat- to-head transmissibility functions. The optimization process increased the average goodness of fit and the results of studied functions became much closer to the target values (Experimental data). From the optimized model, the resonant frequencies of the driver parts computed on the basis of biodynamic response functions are found to be within close bounds to that expected for the human body.
基金supported by the National Natural Science Foundation of China(Grant No.51809279)the Major National Science and Technology Program(Grant No.2016ZX05028-001-05)+1 种基金Program for Changjiang Scholars and Innovative Research Team in University(Grant No.IRT14R58)the Fundamental Research Funds for the Central Universities,that is,the Opening Fund of National Engineering Laboratory of Offshore Geophysical and Exploration Equipment(Grant No.20CX02302A).
文摘Vortex induced vibration(VIV)is a challenge in ocean engineering.Several devices including fairings have been designed to suppress VIV.However,how to optimize the design of suppression devices is still a problem to be solved.In this paper,an optimization design methodology is presented based on data-driven models and genetic algorithm(GA).Data-driven models are introduced to substitute complex physics-based equations.GA is used to rapidly search for the optimal suppression device from all possible solutions.Taking fairings as example,VIV response database for different fairings is established based on parameterized models in which model sections of fairings are controlled by several control points and Bezier curves.Then a data-driven model,which can predict the VIV response of fairings with different sections accurately and efficiently,is trained through BP neural network.Finally,a comprehensive optimization method and process is proposed based on GA and the data-driven model.The proposed method is demonstrated by its application to a case.It turns out that the proposed method can perform the optimization design of fairings effectively.VIV can be reduced obviously through the optimization design.