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Mouse models in liver cancer research:A review of current literature 被引量:16
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作者 Martijn WH Leenders Maarten W Nijkamp Inne HM Borel Rinkes 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第45期6915-6923,共9页
Primary liver cancer remains one of the most lethal malignancies worldwide. Due to differences in prevalence of etiological factors the incidence of primary liver can-cer varies among the world, with a peak in East-As... Primary liver cancer remains one of the most lethal malignancies worldwide. Due to differences in prevalence of etiological factors the incidence of primary liver can-cer varies among the world, with a peak in East-Asia. As this disease is still lethal in most of the cases, research has to be done to improve our understanding of the disease, offering insights for possible treatment options. For this purpose, animal models are widely used, especially mouse models. In this review, we describe the different types of mouse models used in liver cancer research, with emphasis on genetically engineered mice used in this field. We focus on hepatocellular carcinoma (HCC), as this is by far the most common type of primary liver cancer, accounting for 70%-85% of cases. 展开更多
关键词 Primary liver cancer Hepatocellular carcinoma Mouse model genetically engineered mice
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