Efficacy of 2LPAPI®, a Micro-Immunotherapy Drug, in Patients with High-Risk Papillomavirus Genital Infection

Human papillomaviruses (HPVs) are well known for being linked to the development of cervical cancers, most of them being caused by the high-risk (HR) oncogenic genotypes, mainly 16 and 18. The efficacy of 2LPAPI® (Labo’Life), a micro-immunotherapy homeopathic drug, has been evaluated in HR-HPV infected women (n = 18), in a private gynecology practice, by comparing them to an untreated control group (n = 18). Patients were 20 to 45 years old and had cytology with Atypical Squamous Cells of Undetermined Significance (ASCUS) or Low grade Superficial Intra Lesions/ Cervical Intraepithelial Neoplasia Grade I (LSIL/CINI). Patients freely chose to be treated with the drug or not. Those deciding not to take the drug remained untreated and were followed as a control group. The drug was taken at the regimen of one capsule per day during 6 months. HR-HPV and cytology were evaluated at 6 and 12 months. After 12 months, HR-HPV was cleared in 78% of the patients taking the drug versus 44% in those not taking it (p = 0.086). In patients over 25 years, HR-HPV clearance in the treated group was significantly higher (81.3%) than in the control group (20%) (p = 0.004). The difference in the regression of the lesion grades almost reached statistical significance (p = 0.053). This follow-up confirms that the micro-immunotherapy drug 2LPAPI® is a safe and effective therapeutic approach to treat HR-HPV cervical lesions in women over 25 years.

A case-control study of risk factors for male infertility in Nigeria

Aim： To evaluate the association between selected potential socio-demographic and behavioral risk factors and infertility in Nigerian men. Methods： There were two groups in this study. One group consisted of 150 men with proven male infertility, and the other consisted of 150 fertile men with normal semen parameters. Both were matched for age, place of residence and key socio-demographic variables. They were compared for sexual history, past medical and surgical history, past exposures to sexually transmitted infections and treatment, past and current use of drugs as well as smoking and alcohol intake history. Results： Infertile men were significantly more likely than fertile men to report having experienced penile discharge, painful micturition and genital ulcers, less likely to seek treatment for these symptoms and more likely to seek treatment with informal sector providers. Multivariate analysis showed that male infertility was significantly associated with bacteria in semen cultures, self-reporting of previous use of traditional medications and moderate to heavy alcohol intake, but not with smoking and occupational types. Conclusion： Infertility is associated with various proxies of sexually transmitted infections （STIs） and poor healthcare-seeking behavior for STIs in Nigerian men.

Epidemiology of Genital Chlamydial Infection in China in 2019

Objective:Genital chlamydial infection is a globally common sexually transmitted infection caused by Chlamydia trachomatis.This study aimed to describe the epidemiological characteristics of the disease reported in China in 2019.Methods:Genital chlamydial infection cases were identified in 105 national sexually transmitted disease surveillance sites from the National Notifiable Infectious Disease Reporting System,which covers 31 provinces,autonomous regions,and municipalities in Chinese mainland.Data were collected and used to calculate the overall incidence,and the incidences per surveillance site,province,sex,and age group.Results:In 2019,there were 50,874 new cases of genital chlamydial infection reported in China,corresponding to an incidence of 55.32 cases per 100,000 population,and comprising a 9.98%increase from 2018(50.30 cases per 100,000 population).The highest incidences of genital chlamydial infection occurred in Zhejiang,Guangdong province,Guangxi autonomous region,and Hainan province(average 137.49-233.37 cases per 100,000 population).The incidence of genital chlamydial infection was much higher in females than males,with a female-to-male ratio of 3.09(84.55 per 100,000 population vs 27.35 per 100,000 population).The highest incidence of genital chlamydial infection was reported in the 20-24-year age group(184.70 cases per 100,000 population),followed by the 25-29-year age group(180.79 cases per 100,000)and 30-34-year age group(151.53 cases per 100,000 population).The highest proportion(68.30%)of genital chlamydial infection was reported from general hospitals,followed by maternal and child health hospitals(25.59%).Conclusion:The incidence rate of genital chlamydial infection in 2019 has an increase trend from 2018 and be a common sexually transmitted infection in China.The incidence is much higher in females than in males.Sexually active young adults are the highest risk population.There is substantial geographic diversity in incidence,with the highest incidence occurring in the southeast coastal areas with a developed economy.Epidemic of genital chlamydial infection in China should be concerned,and its surveillance needs to be improved.