Inorganic Elemental Determinations of Marine Traditional Chinese Medicine Meretricis concha from Jiaozhou Bay:The construction of Inorganic Elemental Fingerprint Based on Chemometric Analysis

The goal of this paper is to explore the relationship between the inorganic elemental fingerprint and the geographical origin identification of Meretricis concha,which is a commonly used marine traditional Chinese medicine(TCM) for the treatment of asthma and scald burns.For that,the inorganic elemental contents of Meretricis concha from five sampling points in Jiaozhou Bay have been determined by means of inductively coupled plasma optical emission spectrometry,and the comparative investigations based on the contents of 14 inorganic elements(Al,As,Cd,Co,Cr,Cu,Fe,Hg,Mn,Mo,Ni,Pb,Se and Zn) of the samples from Jiaozhou Bay and the previous reported Rushan Bay were performed.It has been found that the samples from the two bays are approximately classified into two kinds using hierarchical cluster analysis,and a four-factor model based on principle component analysis could explain approximately 75% of the detection data,also linear discriminant analysis can be used to develop a prediction model to distinguish the samples from Jiaozhou Bay and Rushan Bay with accuracy of about 93%.The results of the present investigation suggested that the inorganic elemental fingerprint based on the combination of the measured elemental content and chemometric analysis is a promising approach for verifying the geographical origin of Meretricis concha,and this strategy should be valuable for the authenticity discrimination of some marine TCM.

Construction of Inorganic Elemental Fingerprint and Multivariate Statistical Analysis of Marine Traditional Chinese Medicine Meretricis concha from Rushan Bay

Meretricis concha is a kind of marine traditional Chinese medicine(TCM), and has been commonly used for the treatment of asthma and scald burns. In order to investigate the relationship between the inorganic elemental fingerprint and the geographical origin identification of Meretricis concha, the elemental contents of M. concha from five sampling points in Rushan Bay have been determined by means of inductively coupled plasma optical emission spectrometry(ICP-OES). Based on the contents of 14 inorganic elements(Al, As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Mo, Ni, Pb, Se, and Zn), the inorganic elemental fingerprint which well reflects the elemental characteristics was constructed. All the data from the five sampling points were discriminated with accuracy through hierarchical cluster analysis(HCA) and principle component analysis(PCA), indicating that a four-factor model which could explain approximately 80% of the detection data was established, and the elements Al, As, Cd, Cu, Ni and Pb could be viewed as the characteristic elements. This investigation suggests that the inorganic elemental fingerprint combined with multivariate statistical analysis is a promising method for verifying the geographical origin of M. concha, and this strategy should be valuable for the authenticity discrimination of some marine TCM.

Study on Elemental Fingerprint of Traditional Marine Chinese Medicine Oysters from Jiaozhou Bay,China

In order to investigate the relationship between the trace elements and the characteristics of the oysters, we analyzed the trace elements present in the germplasm of oysters from different producing areas in the Jiaozhou Bay. The element fingerprints were established to reflect the elemental characteristics of the oysters. Concentration patterns of the elements were deciphered by principle component analysis (PCA) and hierarchical cluster analysis (HCA). The six regions were discriminated with accuracy using HCA and PCA based on the concentration of 16 trace elements. The elements were viewed as characteristic elements of the oysters and the fingerprints of these elements could be used to distinguish the quality of the oysters.

Effects of Traditional Chinese Medicine Five-element Music Combined with Acupoint Application on Perioperative Sleep Quality in Patients Undergoing Joint Replacement Surgery

OBJECTIVE: To explore the effects of traditional Chinese medicine(TCM) five-element music combined with acupoint application on perioperative sleep quality in patients undergoing joint replacement surgery. METHODS: In this study, a total of 122 patients with joint replacement surgery in Beijing Jishuitan Hospital were targeted from 2015 to 2018. All patients were grouped by random number table method. Among them, 61 patients with routine nursing were included in the control group. On this basis, the other 61 patients with acupoint application and TCM five-element music therapy were included as the observation group. 2 weeks later, the Pittsburgh Sleep Quality Index(PSQI) was used to evaluate sleep quality in all patients. The sleep improvement of the 2 groups was evaluated, and the patient was assessed for anxiety and depression, and the curative efficacy was evaluated. RESULTS: After 2 weeks of nursing, the PSQI of the patients improved significantly. The PSQI of the observation group was only 6.6 ± 2.4, and the control group decreased to 9.9 ± 2.7. The observation group was better than the control group, and the difference was statistically significant(P < 0.05). Comparing the 2 groups, the anxiety score of the observation group decreased to 4.8 ± 1.6, which was significantly lower than that of 6.9 ± 2.2 in the control group. The depression score of the observation group decreased to 4.6 ± 1.3, which was significantly lower than that of 6.8 ± 2.3 in the control group. In the control group, the negative emotion scores after nursing were better than those before nursing, and the difference was statistically significant(P < 0.05). Comparing the 2 groups, the effective rate of sleep improvement in the observation group was 96.6%, and the cure rate was as high as 49.1%. The control group was 82.0%, and the cure rate was 18.0%. The observation group was better than the control group, and the difference was statistically significant(P < 0.05). CONCLUSION: The combination of TCM five-element music with acupoint application can improve the perioperative sleep quality of patients undergoing joint replacement surgery, and it can help patients to relieve negative emotions. It is worth promoting.

Effects of integrated traditional Chinese and western medicine on the vision recovery and serum trace elements of patients with herpes simplex keratitis

Objective:To explore the effects of integrated traditional Chinese and western Medicine on the vision recovery and serum trace elements in patients with herpes simplex keratitis.Methods:A total of 86 cases of HSK patients admitted in Baogang Hospital of Inner Mongolia from January 2015 to October 2016 were selected and divided randomly into the observation group(n=43)and the control group(n=43)according to the random number table.The control group was treated with ganciclovir eye drops and chondroitin sulfate eye drops,and the observation group was treated with Qinggan Mingmu Decoction on the basis of the control group.The 2 groups were treated for 4 weeks continuously.The clinical efficacy was compared between two groups.The vision recovery,serum trace elements and tear immune factor levels were also compared between two groups before and after treatment.Results:After treatment,the effective rate of treatment in the observation group was significantly higher than that in the control group(p<0.05);in the observation group of patients,visual analogue scale(VAS)score and visual acuity after treatment were obviously higher than those before treatment,and also remarkably higher than those in the control group of patients(p<0.05);after treatment,the levels of Fe,Ca and Cu ions in the observation group were significantly lower than those in the control group and before treatment(p<0.05);after treatment,the level of zinc ions in the serum in the observation group was significantly higher than that before treatment and in the control group(p<0.05);after treatment,the levels of tear IgA,IgG and C3 in the observation group were prominently higher than those before treatment and in the control group(p<0.05).Conclusions:In the treatment of HSK,integrated traditional Chinese and western medicine can promote effectively the vision recovery,regulate the level of trace elements in the serum and enhance the level of tear immune factors,with the clinical efficacy better than the treatment of western medicine alone.

A Review of Traditional Chinese Medicine for the Treatment of Depression

Depression is a common mental illness with symptoms such as loss of interest.At present,It is mainly treated with antidepressants,which are effective in a short time,but it is highly addictive and has a high probability of adverse reactions.Traditional Chinese medicine(TCM)treatment of depression has the advantages of high feasibility,good tolerance,obvious effect,and small side effects.In addition,TCM has great potential for the treatment of depression with the overall concept of the unity of nature and man as its guiding ideology and rich clinical experience.This review mainly expounds on the research progress of TCM treatment of depression from two aspects of TCM non-drug therapy and TCM drug therapy,to provide a reference for clinical treatment of depression.

方剂学课程思政研究概览

该文探讨方剂学课程思政的研究现状,为深入挖掘思政元素,广泛开辟实施途径集成更多的策略与方法。全面梳理方剂学教学中开展课程思政的相关文献,分析方剂学课程思政在全国各院校开展的实际情况,结合专业内容对可公知公用的思政元素融入策略、思政内涵等进行全面总结,同时探索课程思政的实施途径。共纳入源于全国28家单位的38篇文献,通过讲授式、案例式、讨论式、竞赛式和情景模拟式等教学方法,将精术尚德、传承守正、刻苦钻研、勇于创新和家国情怀等思政内涵悄然渗透到方剂学总论到各论的19个章节中。方剂学作为思政教育与专业课充分融合的主阵地,在以立德树人为根本任务的高校中医药人才培养过程中正发挥着巨大作用。

基于三要素之课程思政在中医外科学混合教学中的应用

“课程思政”是中国现代社会主义建设下教育发展的产物,符合中国社会主义新时代教育发展的规律。中医学具有融入思政教育的天然优势。中医外科学是中医学专业的主干课程,是重要的临床专业课。作者团队在中医外科学的教学中,除传统的课堂教学与临床实践教学外,还进行了基于在线开放课程的线上线下混合式教学,且围绕教师、教书育人、学生三要素,具体实施课程思政探索。

中医药预防大肠息肉术后复发证型证素分布及用药规律研究

目的:探讨近二十年各医家预防大肠息肉术后复发证型证素分布及用药规律,为中医药预防大肠息肉术后复发提供新的思路。方法:以各医家处方为切入点,提取处方涉及的证候类型、病位证素、病性证素及药物组成,基于中医传承辅助平台(V2.5)软件,运用关联规则、系统熵聚类等一系列高级的数据挖掘方法,总结处方的证型证素分布、用药频次、性味、归经、药物相关性以及聚类情况。结果:共收集到数据库相关文献所载预防大肠息肉复发的处方105首,涉及中医证型30种,中药186味。其中核心药物组合139对,潜在常用药对157对,新处方3首。结论:脾胃虚弱是大肠息肉的核心病机,治疗当以健脾益胃为基础,根据不同患者血瘀、湿阻、痰凝、热毒等的差异,佐以活血、祛湿、化痰、清热之法,标本兼治,方获良效。

中医妇科学教学融入思政元素探究

中医妇科学是一门临床学科,在掌握其基础理论之后的理论与实践相结合的教学过程中,要重视在教学大纲的认知中通过各种教学方法加入思政元素,同时深化以人为本的教学理念,加强教学队伍思政意识的建设,整体推动中医妇科学“思政元素”的挖掘,推崇“立德树人”的理念,并且围绕这一目标而开展卓有成效的教育体系改革。加强和扎实做好新时期医学院校中医妇科学思想政治路线教育和优秀人才培养相关工作,是在新的历史阶段提出的新政治任务、新发展方向和新战略要求。

创新创业人才培养视域下中医药院校无机化学双语教学的理念、价值和路径

随着经济全球化和国际交流的加深,培养具备跨文化交流和创新创业能力的中医药人才已成为中医药院校教育改革的核心任务之一。该文以创新创业人才培养视域为切入点,探讨了中医药院校在无机化学课程中引入双语教学的理念、价值和路径,并提出了相关策略和建议,以期为“高品质、国际化、创新型”中药专业人才的培养提供理论和实践参考。

慢性心力衰竭伴轻度认知障碍中医证素与认知功能的相关性研究

目的:探讨慢性心力衰竭(CHF)患者中医证候要素与认知功能的相关性。方法:选取2021年5月至2022年3月北京中医药大学东方医院收治的94例CHF伴轻度认知功能障碍(MCI)患者作为研究对象,进行中医证候要素辨证,记录患者的一般资料,采用蒙特利尔认知评估量表(MoCA)对患者的认知功能进行评估,最后对中医证候要素与各项认知功能进行比较。结果:气虚证患者的视空间与执行能力评分更低,血瘀证患者的MoCA总分、注意与计算能力评分更低,痰浊证患者的MoCA总分、延迟回忆力以及抽象思维评分更低。结论:气虚证患者更容易出现视空间与执行能力的下降,血瘀证患者更容易出现注意与计算能力的下降,痰浊证患者更容易出现延迟回忆力和抽象思维能力的下降。

基于美国国家健康和营养检查调查数据库的痛风病证素研究

目的:探讨痛风病高尿酸血症及尿酸盐沉积阶段的证素特点。方法:系统梳理美国国家健康和营养检查调查(NHANES)数据库中与中医症状/体征相对应的调查项目,采集NHANES数据库2007—2018年健康人群、高尿酸血症人群及尿酸盐沉积人群相关中医症状/体征数据进行频率分析,用χ^(2)检验确定不同人群中医症状/体征的变化,并以发生频率为权重,对证素诊断贡献度进行加权求和。结果:从NHANES数据库中确认与中医症状/体征相关的调查项目58个,证素分析结果表明痛风病高尿酸血症及尿酸盐沉积人群的病位证素均集中在肾、脾,病性证素均集中在气虚、湿、痰和阳虚;与健康人群比较,高尿酸血症人群病位证素变化主要为肾、脾、肝,病性证素变化主要为痰、湿、气虚;与高尿酸血症人群比较,尿酸盐沉积人群病位证素变化主要为肾,病性证素变化主要为痰。结论:痛风病高尿酸血症及尿酸盐沉积阶段的主要证素均为肾、脾、痰、湿、气虚,脾肾亏虚可能为高尿酸血症的发病基础,湿痰转化可能为尿酸盐沉积的发病过程。

从肺肾同调理论辨治多囊卵巢综合征

总结殷岫绮教授运用肺肾同调法辨治多囊卵巢综合征(PCOS)经验。殷教授立足阴阳五行及气血津液理论,认为肺肾协理气机、调节水液、输布精微之作用与女性生殖活动息息相关,肺肾二脏通调气液的功能异常是PCOS发病的重要病机;治疗PCOS可从宣通肺肾入手,上透肺郁不伤正气,下通经血不耗肾阴,以期气液宣通,精充血旺,化源得资。并附验案1则。

国家中医药综合改革示范区“十四五”中医药发展规划政策文本分析

目的剖析我国7个国家中医药综合改革示范区的“十四五”中医药发展规划政策的特征及政策工具使用情况,探讨政策缺陷,并提出优化策略,为推进国家中医药综合改革示范区建设提供参考。方法基于7省份“十四五”中医药发展规划,构建“政策工具—政策要素—政策清晰度”三维分析框架,进行多维度量化分析。结果7份中医药政策共提取564条编码,政策工具中命令规制型、激励型、能力建设型、系统变革型、象征劝诫型工具分别占比13.3%、7.1%、53.0%、22.9%、3.7%,政策要素中服务体系提及频率最高,占比33.9%,政策清晰度等级为“清晰”的编码条目占比9.4%。结论中医药政策激励机制不够完善,宣传力度不足,政策要素内部缺乏联动,政策工具与政策要素契合度不高,政策清晰度有待提升。建议丰富激励型与象征劝诫型政策工具的使用,建立中医药发展要素联动机制,优化政策工具内部结构,提升政策发展目标清晰度。

高等中医药院校无机化学课程思政建设的探索与实践

课程思政建设是新形势下高校课程教学改革的重要任务,也是落实立德树人根本任务的关键环节。无机化学是面向中医药院校中药学专业新生开设的专业基础课。该课程旨在通过理论知识学习和实验技能训练,培养学生的科学思维、探究精神和创新能力。开展课程思政建设是深化其育人作用的创新途径。立足于长春中医药大学无机化学课程思政建设现状,以无机化学课程思政建设目标的设置为出发点,从思政元素挖掘与提炼、创新教学方法、课程思政实施效果评价和教师思政能力提升等方面探索无机化学课程思政建设的有效路径和方法,以期为中医药院校化学课程教学质量提升,培养德才兼备、内外兼修的中医药人才提供有益的借鉴与参考。

幽门螺杆菌感染相关性疾病的证素分布规律研究

目的:探索幽门螺杆菌(Helicobacter pylori,Hp)感染相关性疾病的中医证候证素分布规律。方法:在中国知网、维普数据、万方数据库中检索相关文献,提取证候、证素信息并建立数据库。利用Microsoft Office Excel 2019进行描述性统计,借助IBM SPSS Modeler 18.0进行关联规则分析,探索证素的分布规律。结果:①纳入文献312篇,证候类型共28个,以脾胃湿热证、肝胃不和证和胃阴不足证较常见;提取病位证素6个、病性证素14个,病位证素集中分布于胃、脾和肝,高频病性证素依次为热、湿、阴虚、气虚、阳虚、血瘀,提示该类疾病顽固缠绵之性,常见虚实夹杂之证。②证素组合形式多样,二证素组合频次以“肝+胃”为最,三证素组合中“阳虚+脾+胃”最多,四证素组合中“湿+热+脾+胃”频次最高,组合形式一定程度揭示了肝和该疾病的密切关系,提示了久病伤阳和湿热胶着留恋的疾病趋势。③关联规则分析中显示“湿”“热”“脾”“胃”之间互相联系最强,恰符合Hp湿热毒邪的特性,提示湿热壅滞脾胃是该类疾病的核心病机。结论:Hp感染相关性疾病以胃热脾湿为基础,肝失疏泄为要点,虚实夹杂为后期主要转归,辨证应注意区分湿热轻重、虚实主次,再行清热化湿、疏肝行气、活血化瘀等法。

基于五行学说探讨从肝防治COVID-19

新型冠状病毒肺炎(COVID-19)肆虐至今,中医药对其的防控与治疗发挥了不可替代的作用。作者基于中医五行学说,从中西医不同角度出发,探讨肝与肺两脏之间的生理联系、病理影响。尤其强调COVID-19与肝脏的功能、机体免疫以及人体正气之间的关系,以期从中西医不同角度探讨从肝防治COVID-19的科学内涵,为中医药防治COVID-19提供理论依据与科研思路。

不同ApoE基因型急性冠脉综合征患者中医证素特征与GRACE评分相关性研究

目的 观察不同ApoE基因型急性冠状动脉综合征(ACS)患者中医证素特征和GRACE评分之间的关系,为ACS患者个体化诊疗提供新思路。方法 收集249例ACS患者的中医证素信息、ApoE基因型、GRACE评分等资料,分析不同ApoE基因型ACS患者中医证素特征与GRACE评分的相关性。结果 共纳入ApoE2基因型32例,ApoE3基因型175例,ApoE4基因型42例。其中具有统计学差异的结果(P<0.05):E4组寒凝证与GRACE-年龄评分相关系数r=0.325 0,气虚证与GRACE-年龄评分相关系数r=0.329 0,气虚证评分与GRACE-总分相关系数r=0.388 2,痰浊证和GRACE-Killip分级评分相关系数r=0.386 0;E3组寒凝证与GRACE-肌酐评分相关系数r=0.442 0,寒凝证评分与GRACE-危险因素评分相关系数r=0.888 5,痰浊证与GRACE-危险因素评分相关系数r=0.149 2,热蕴证评分与GRACE-收缩压评分相关系数r=0.601 9。结论 E4基因型寒凝证、气虚证、痰浊证的ACS患者GRACE评分危险程度更高;E3基因型寒凝证、痰浊证、热蕴证的ACS患者GRACE评分危险程度更高。

中医五行人之火行人与水行人认知功能差异比较研究

目的基于五行理论探究中医五行人中火行人与水行人的认知功能及加工过程差异性,为进一步丰富中医五行人理论内涵、推进我国本土化人格理论模型提供基础。方法在招募的受试者中根据前期制订的《中医五行(形)人面部表型分类量化规范》筛选出典型的火行人与水行人,采用成套重复性神经心理测查工具(Repeatable Battery for the Assessment of Neuropsychological Status,RBANS)和Top-down及Bottom-up认知心理测查范式对其认知功能进行测评。采用独立样本t检验对两组受试者的认知功能进行差异性分析。结果招募受试者火行人24人,水行人20人,与水行人组相比,火行人组在注意功能维度得分明显更高,在RBANS各部分得分上数字广度和编码测验任务得分更高;火行人组在Bottom-up认知心理测查范式的长时认知加工过程中的反应时更短、准确率更高,水行人在Bottom-up认知心理测查范式的短时加工准确率差值更低,差异均有统计学意义(P<0.05)。结论中医五行人中火行人更易高度集中注意力,更易被线索所吸引,但注意力的维持时间较短,同时水行人在注意力反应时间更长,更不易被线索所影响,且注意力稳定性更强。