To discuss whether the capillary whole blood glucose （CBG） test can be used in glucose screening test （GST） for gestational diabetes mellitus （GDM） compared to the venous plasma glucose （ VPG） method, and to d...To discuss whether the capillary whole blood glucose （CBG） test can be used in glucose screening test （GST） for gestational diabetes mellitus （GDM） compared to the venous plasma glucose （ VPG） method, and to determine the cutoff value of CBG. Methods This was a self-control test. The 50-g oral GST was conducted among 1 557 pregnant women between 24-28 weeks. Every woman was measured CBG and VPG at the same time and same arm. Three hundred and forty women underwent 100-g 3-h oral glucose tolerance test （OGTT）. Receiver operation curve （ROC） was used to determine the potential cutoff level of CBG and VPG. Diagnose criteria of GDM was based on NDDG criteria. OGTT diagnosed GDM and VPG ≥ 7. 8 mmol/L were used as golden standard for ROC. Results There was good relationship between CBG and VPG （ P 〈0.01 ）. Correlation coefficient was O. 86. The value of CBG was lower than VPG. The statistical and high-sensitivity cutoff values were 7. 4 mmol/L in CBG and 7. 8 mmol/L in VPG when GDM was used as golden standard. Cutoff value of CBG was 7. 0 mmol/L when VPG≥7. 8 mmol/L was used as golden standard. The pregnant outcomes of positive cases of three thresholds had no significant differences. But it was better in case of the pregnant woman when the CBG value was more than 7. 4 mmol/L. Conclusion CBG can be used in GST, the threshold of CBG was suggested as 7. 4 mmol/L. CBG test was more convenience and effective than VPG test.展开更多
目的:探讨孕妇妊娠期糖尿病(GDM)的发生率,以及妊娠期有糖尿病相关高危因素者与无高危因素者葡萄糖耐量 试验异常的关系及对胎儿、新生儿的影响。方法:对孕中、晚期孕妇进行口服50 g葡萄糖筛查(50 g GCT),血糖≥7.8 mmol／L者做 正规糖...目的:探讨孕妇妊娠期糖尿病(GDM)的发生率,以及妊娠期有糖尿病相关高危因素者与无高危因素者葡萄糖耐量 试验异常的关系及对胎儿、新生儿的影响。方法:对孕中、晚期孕妇进行口服50 g葡萄糖筛查(50 g GCT),血糖≥7.8 mmol／L者做 正规糖耐量试验(OGTT)以明确诊断,并对诊断妊娠期糖耐量降低(GIGT)及GDM给予早期治疗,观察其妊娠结局。结果:50 g GCT阳性率为10.65％,GIGT及GDM发病率分别为3.80％及3.48％。经早诊断、早治疗的孕妇,妊娠并发症、巨大儿、围产儿窒息、 围产儿死亡率明显降低。结论:对所有孕妇进行早期50 g GCT筛查,并对GIGT、GDM进行早治疗,伴有高危因素的孕妇重点监测, 减少了母儿的病死率。展开更多
目的回顾性分析医院妊娠中期孕妇口服葡萄糖耐量试验(OGTT)检测结果,为广安市妊娠期糖尿病(GDM)的诊疗提供依据。方法选取2015年10月至2017年2月医院正常产检妊娠中期(孕24~28周)孕妇1 555例进行75 g OGTT,孕妇按年龄分为3组,即<25岁...目的回顾性分析医院妊娠中期孕妇口服葡萄糖耐量试验(OGTT)检测结果,为广安市妊娠期糖尿病(GDM)的诊疗提供依据。方法选取2015年10月至2017年2月医院正常产检妊娠中期(孕24~28周)孕妇1 555例进行75 g OGTT,孕妇按年龄分为3组,即<25岁组(A组,364例)、≥25~<35岁组(B组,997例)和≥35岁组(C组,194例),参照《妊娠合并糖尿病诊治指南(2014)》中的诊断标准统计GDM发病人数及检出率。结果该院GDM总检出率为11.57%,其中A,B,C组依次为5.22%,11.13%,25.77%,各组间比较,差异有统计学意义(P<0.05);餐后2 h血糖筛查阳性率最高(7.78%);孕妇随年龄增大,血糖水平呈上升趋势,GDM检出率升高。结论 GDM的发病率随年龄增大而增高,应加强孕期,尤其是高龄孕妇的血糖筛查。展开更多
目的探讨糖化血红蛋白(HbA1c)联合空腹血糖(FPG)在早期妊娠期糖尿病(GDM)筛查中的应用价值。方法选取2017年1月~2018年7月我院妇产科确诊的64例GDM患者作为GDM组,另选取同期来我院行常规产检的64例健康孕妇作为对照组。两组均行HbA1c及...目的探讨糖化血红蛋白(HbA1c)联合空腹血糖(FPG)在早期妊娠期糖尿病(GDM)筛查中的应用价值。方法选取2017年1月~2018年7月我院妇产科确诊的64例GDM患者作为GDM组,另选取同期来我院行常规产检的64例健康孕妇作为对照组。两组均行HbA1c及口服葡萄糖耐量试验(OGTT)检测。比较两组受试者FPG、HbA1c和服糖后不同时间的OGTT水平;比较不同指标检测的曲线下面积(AUC)、灵敏度、特异性及准确率。结果GDM组的FPG、HbA1c及服糖后1、2 h OGTT水平均高于对照组,差异有统计学意义(P<0.05);FPG与HbA1c联合检测诊断GDM的受试者工作特征(ROC)AUC高于二者单独检测,差异有统计学意义(P<0.05);FPG与HbA1c联合检测诊断GDM的灵敏度、特异性及准确率均高于二者单独检测,差异有统计学意义(P<0.05)。结论HbA1c与FPG两项指标联合应用于诊断GDM具有更高的诊断效能,对GDM患者的早期筛查具有指导意义。展开更多
基金Supported by grants from the Natrual Science Foundation of Shanghai, China (99ZB14071).
文摘To discuss whether the capillary whole blood glucose （CBG） test can be used in glucose screening test （GST） for gestational diabetes mellitus （GDM） compared to the venous plasma glucose （ VPG） method, and to determine the cutoff value of CBG. Methods This was a self-control test. The 50-g oral GST was conducted among 1 557 pregnant women between 24-28 weeks. Every woman was measured CBG and VPG at the same time and same arm. Three hundred and forty women underwent 100-g 3-h oral glucose tolerance test （OGTT）. Receiver operation curve （ROC） was used to determine the potential cutoff level of CBG and VPG. Diagnose criteria of GDM was based on NDDG criteria. OGTT diagnosed GDM and VPG ≥ 7. 8 mmol/L were used as golden standard for ROC. Results There was good relationship between CBG and VPG （ P 〈0.01 ）. Correlation coefficient was O. 86. The value of CBG was lower than VPG. The statistical and high-sensitivity cutoff values were 7. 4 mmol/L in CBG and 7. 8 mmol/L in VPG when GDM was used as golden standard. Cutoff value of CBG was 7. 0 mmol/L when VPG≥7. 8 mmol/L was used as golden standard. The pregnant outcomes of positive cases of three thresholds had no significant differences. But it was better in case of the pregnant woman when the CBG value was more than 7. 4 mmol/L. Conclusion CBG can be used in GST, the threshold of CBG was suggested as 7. 4 mmol/L. CBG test was more convenience and effective than VPG test.
文摘目的:探讨孕妇妊娠期糖尿病(GDM)的发生率,以及妊娠期有糖尿病相关高危因素者与无高危因素者葡萄糖耐量 试验异常的关系及对胎儿、新生儿的影响。方法:对孕中、晚期孕妇进行口服50 g葡萄糖筛查(50 g GCT),血糖≥7.8 mmol／L者做 正规糖耐量试验(OGTT)以明确诊断,并对诊断妊娠期糖耐量降低(GIGT)及GDM给予早期治疗,观察其妊娠结局。结果:50 g GCT阳性率为10.65％,GIGT及GDM发病率分别为3.80％及3.48％。经早诊断、早治疗的孕妇,妊娠并发症、巨大儿、围产儿窒息、 围产儿死亡率明显降低。结论:对所有孕妇进行早期50 g GCT筛查,并对GIGT、GDM进行早治疗,伴有高危因素的孕妇重点监测, 减少了母儿的病死率。
文摘目的探讨糖化血红蛋白(HbA1c)联合空腹血糖(FPG)在早期妊娠期糖尿病(GDM)筛查中的应用价值。方法选取2017年1月~2018年7月我院妇产科确诊的64例GDM患者作为GDM组,另选取同期来我院行常规产检的64例健康孕妇作为对照组。两组均行HbA1c及口服葡萄糖耐量试验(OGTT)检测。比较两组受试者FPG、HbA1c和服糖后不同时间的OGTT水平;比较不同指标检测的曲线下面积(AUC)、灵敏度、特异性及准确率。结果GDM组的FPG、HbA1c及服糖后1、2 h OGTT水平均高于对照组,差异有统计学意义(P<0.05);FPG与HbA1c联合检测诊断GDM的受试者工作特征(ROC)AUC高于二者单独检测,差异有统计学意义(P<0.05);FPG与HbA1c联合检测诊断GDM的灵敏度、特异性及准确率均高于二者单独检测,差异有统计学意义(P<0.05)。结论HbA1c与FPG两项指标联合应用于诊断GDM具有更高的诊断效能,对GDM患者的早期筛查具有指导意义。
