André Gide is one of the most important writers in the history of French literature in the 20th century.His works are highly distinctive:on the one hand,there is strong coherence and beautiful language between hi...André Gide is one of the most important writers in the history of French literature in the 20th century.His works are highly distinctive:on the one hand,there is strong coherence and beautiful language between his works,which gives them a strong musicality.On the other hand,his works delve deeper into the struggle between the“soul”and the“body”under the oppression of“religious concepts”,which is most evident in one of his representative works:Pastoral Symphony.This article will analyze and explore the contradiction between“soul”and“body”reflected in the work of“Pastoral Symphony”from three aspects:“modernity”,“aesthetics”,and“characters’prototypes”.展开更多
目的评估Bio-Gide在引导种植体周围骨组织再生的临床疗效。方法选择2004年2月到2005年11月来我院就诊种植区存在骨缺损的患者56例,其中男性患者35例,女性21例;可通过GBR(Guided Bone Regeneration)技术同期植入种植体,共植入种植体81枚...目的评估Bio-Gide在引导种植体周围骨组织再生的临床疗效。方法选择2004年2月到2005年11月来我院就诊种植区存在骨缺损的患者56例,其中男性患者35例,女性21例;可通过GBR(Guided Bone Regeneration)技术同期植入种植体,共植入种植体81枚。生物膜均采用可吸收性的Bio-Gide生物膜,移植物采用自体骨与Bio-oss骨粉1∶1或2∶1的混合物。结果术后6个月,x线片观察到所有种植体骨结合良好,行二期修复术。结论Bio-Gide生物膜在引导骨再生中种植体骨结合成功率为100%。展开更多
Here, we report the identification of GIDE, a mitochondrially located E3 ubiquitin ligase. GIDE contains a C-terminal RING finger domain, which is mostly conserved with those of the lAP family members and is required ...Here, we report the identification of GIDE, a mitochondrially located E3 ubiquitin ligase. GIDE contains a C-terminal RING finger domain, which is mostly conserved with those of the lAP family members and is required for GIDE＇s E3 ligase activity. Overexpression of GIDE induces apoptosis via a pathway involving activation of caspases, since caspase inhibitors, XIAP and an inactive mutant of caspase-9 block GIDE-induced apoptosis. GIDE also activates JNK, and blockage of JNK activation inhibits GIDE-induced release of cytochrome c and Smac as well as apoptosis, suggesting that JNK activation precedes release of cytochrome c and Smac and is required for GIDE- induced apoptosis. These pro-apoptotic properties of GIDE require its E3 ligase activity. When somewhat over-or underexpressed, GIDE slows or accelerates cell growth, respectively. These pro-apoptotic or growth inhibition effects of GIDE may account for its absence in tumor cells.展开更多
基金This essay is supported by the China Scholarship Council Program(ID:202408440417).
文摘André Gide is one of the most important writers in the history of French literature in the 20th century.His works are highly distinctive:on the one hand,there is strong coherence and beautiful language between his works,which gives them a strong musicality.On the other hand,his works delve deeper into the struggle between the“soul”and the“body”under the oppression of“religious concepts”,which is most evident in one of his representative works:Pastoral Symphony.This article will analyze and explore the contradiction between“soul”and“body”reflected in the work of“Pastoral Symphony”from three aspects:“modernity”,“aesthetics”,and“characters’prototypes”.
文摘目的评估Bio-Gide在引导种植体周围骨组织再生的临床疗效。方法选择2004年2月到2005年11月来我院就诊种植区存在骨缺损的患者56例,其中男性患者35例,女性21例;可通过GBR(Guided Bone Regeneration)技术同期植入种植体,共植入种植体81枚。生物膜均采用可吸收性的Bio-Gide生物膜,移植物采用自体骨与Bio-oss骨粉1∶1或2∶1的混合物。结果术后6个月,x线片观察到所有种植体骨结合良好,行二期修复术。结论Bio-Gide生物膜在引导骨再生中种植体骨结合成功率为100%。
文摘Here, we report the identification of GIDE, a mitochondrially located E3 ubiquitin ligase. GIDE contains a C-terminal RING finger domain, which is mostly conserved with those of the lAP family members and is required for GIDE＇s E3 ligase activity. Overexpression of GIDE induces apoptosis via a pathway involving activation of caspases, since caspase inhibitors, XIAP and an inactive mutant of caspase-9 block GIDE-induced apoptosis. GIDE also activates JNK, and blockage of JNK activation inhibits GIDE-induced release of cytochrome c and Smac as well as apoptosis, suggesting that JNK activation precedes release of cytochrome c and Smac and is required for GIDE- induced apoptosis. These pro-apoptotic properties of GIDE require its E3 ligase activity. When somewhat over-or underexpressed, GIDE slows or accelerates cell growth, respectively. These pro-apoptotic or growth inhibition effects of GIDE may account for its absence in tumor cells.
