Huoxue Rongluo Tablet was made of tall gastrodis tuber, dahurian angelica root, honeysuckle stem, grassleaf sweetflag rhizome, common flowering quince fruit, figwort root, red peony root and peach seed at a ratio of 3...Huoxue Rongluo Tablet was made of tall gastrodis tuber, dahurian angelica root, honeysuckle stem, grassleaf sweetflag rhizome, common flowering quince fruit, figwort root, red peony root and peach seed at a ratio of 3：2：6：2：3：3：3：3. Huoxue Rongluo Tablet is a well-established and common pre- scription for the treatment of cerebral infarction. In this study, a rat model of cerebral ischemia was established and the animals were intragastrically administered Huoxue Rongluo Tablet. This treat- ment reduced infarct volume, decreased matrix metalloproteinase-9 expression, and improved neurological function. Moreover, the effects of Huoxue Rongluo Tablet were better than those of buflomedil pyridoxal phosphate. These results indicate that Huoxue Rongluo Tablet is effective in treating cerebral infarction by regulating matrix metalloproteinase-9 protein expression.展开更多
Objective：To observe the effect of warm needling plus oral administration of rosuvastatin calcium tablets on blood lipids in cerebral infarction patients. Methods：A total of 125 eligible cases were randomly allocate...Objective：To observe the effect of warm needling plus oral administration of rosuvastatin calcium tablets on blood lipids in cerebral infarction patients. Methods：A total of 125 eligible cases were randomly allocated into group A （n=42）, group B （n=40） and group C （n=43）. Cases in group A received warm needling plus oral administration of rosuvastatin calcium tablets, cases in group B received warm needling, whereas cases in group C received oral administration of rosuvastatin calcium tablets. Results：After treatment, the total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C） all dropped obviously in the three groups, with significant differences （allP〈0.05）, modified Barthel index （BI） scores all significantly rise （allP〈0.05）, and high-density lipoprotein cholesterol （HDL-C） remained unchanged （allP〉0.05）. After treatment, the changes of TC, TG and LDL-C in group A were significantly different from those in group B and group C （allP〈0.05）, while the changes showed no statistical significance between group B and group C （P〉0.05）. There were no between-group differences in HDL-C among the three groups （allP〉0.05）; the modified BI scores in groupA and groupB were significantly higher than that in group C （bothP〈0.05）, while there was no significant difference between group A and group B （P〉0.05）.After treatment, the total effective rate was significantly higher in group A than that in group B and group C （bothP〈0.05）, there was no significant difference between group B and group C （P〉0.05）. Conclusion：Warm needling and oral administration of rosuvastatin calcium tablets both can adjust blood lipids effectively in cerebral infarction patients with a similar therapeutic efficacy, while the effect gets better based upon combining both methods; acupuncture-moxibustion plays an important role in the recovery of nerve functions in cerebral infarction patients.展开更多
基金supported by the Scientific Research Project of Traditional Chinese Medicine of Hunan Province Chinese Medicine Research Administration Bureau in China,No.201136
文摘Huoxue Rongluo Tablet was made of tall gastrodis tuber, dahurian angelica root, honeysuckle stem, grassleaf sweetflag rhizome, common flowering quince fruit, figwort root, red peony root and peach seed at a ratio of 3：2：6：2：3：3：3：3. Huoxue Rongluo Tablet is a well-established and common pre- scription for the treatment of cerebral infarction. In this study, a rat model of cerebral ischemia was established and the animals were intragastrically administered Huoxue Rongluo Tablet. This treat- ment reduced infarct volume, decreased matrix metalloproteinase-9 expression, and improved neurological function. Moreover, the effects of Huoxue Rongluo Tablet were better than those of buflomedil pyridoxal phosphate. These results indicate that Huoxue Rongluo Tablet is effective in treating cerebral infarction by regulating matrix metalloproteinase-9 protein expression.
基金supported by Key Discipline Funded Project of Chongqing City No.2008-47~~
文摘Objective：To observe the effect of warm needling plus oral administration of rosuvastatin calcium tablets on blood lipids in cerebral infarction patients. Methods：A total of 125 eligible cases were randomly allocated into group A （n=42）, group B （n=40） and group C （n=43）. Cases in group A received warm needling plus oral administration of rosuvastatin calcium tablets, cases in group B received warm needling, whereas cases in group C received oral administration of rosuvastatin calcium tablets. Results：After treatment, the total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C） all dropped obviously in the three groups, with significant differences （allP〈0.05）, modified Barthel index （BI） scores all significantly rise （allP〈0.05）, and high-density lipoprotein cholesterol （HDL-C） remained unchanged （allP〉0.05）. After treatment, the changes of TC, TG and LDL-C in group A were significantly different from those in group B and group C （allP〈0.05）, while the changes showed no statistical significance between group B and group C （P〉0.05）. There were no between-group differences in HDL-C among the three groups （allP〉0.05）; the modified BI scores in groupA and groupB were significantly higher than that in group C （bothP〈0.05）, while there was no significant difference between group A and group B （P〉0.05）.After treatment, the total effective rate was significantly higher in group A than that in group B and group C （bothP〈0.05）, there was no significant difference between group B and group C （P〉0.05）. Conclusion：Warm needling and oral administration of rosuvastatin calcium tablets both can adjust blood lipids effectively in cerebral infarction patients with a similar therapeutic efficacy, while the effect gets better based upon combining both methods; acupuncture-moxibustion plays an important role in the recovery of nerve functions in cerebral infarction patients.
