s from those searches were screened for relevance to our review topics.Publications were included if the subjects included glaucoma patients,and if ocular surface outcomes were described.Non-English papers were exclud...s from those searches were screened for relevance to our review topics.Publications were included if the subjects included glaucoma patients,and if ocular surface outcomes were described.Non-English papers were excluded.Key Content and Findings:Topical glaucoma medications frequently cause adverse effects on the ocular surface,both through direct action of the medications themselves as well as through toxicity from their associated preservatives.Optimization of the ocular surface may improve medication compliance rates.Traditional surgical treatments for glaucoma,such as trabeculectomy,can exacerbate OSD by disrupting the ocular surface but can also reduce the need for chronic medications.Optimization of ocular surface health is imperative in reducing trabeculectomy complication rates,while also potentially reducing the need for trabeculectomy in patients that are able to achieve intraocular pressure control through improved drop tolerability.The introduction of MIGS represents a promising alternative to existing therapies and has been shown to alleviate the overall medication burden.It would be reasonable to assume that decreasing the medication burden could reduce OSD prevalence and severity.However,more research is needed to directly assess the extent of improvement seen after MIGS.Conclusions:A comprehensive understanding of the importance of OSD in medical and surgical management of glaucoma is essential in optimizing patient care and improving outcomes.展开更多
目的探讨青光眼小梁切除手术对眼表结构及泪膜的影响。方法选择66例80只急性闭角型青光眼行小梁切除的患者,观察术前及术后6个月的角膜表面规则指数(SRI)、角膜表面非对称性指数(SAI)、角膜荧光素染色及虎红染色、基础泪液分泌试验(Schi...目的探讨青光眼小梁切除手术对眼表结构及泪膜的影响。方法选择66例80只急性闭角型青光眼行小梁切除的患者,观察术前及术后6个月的角膜表面规则指数(SRI)、角膜表面非对称性指数(SAI)、角膜荧光素染色及虎红染色、基础泪液分泌试验(Schirmer I test)、泪膜破裂时间(BUT),并对数据进行统计学分析。结果小梁切除术前,术后1周、1个月、3个月和6个月的SRI为(0.26±0.11)、(0.65±0.30)、(0.53±0.25)、(0.45±0.17)和(0.28±0.12),SAI为(0.42±0.22)、(0.78±0.23)、(0.68±0.26)、(0.60±0.22)、(0.46±0.21),术后3个月内的SRI及SAI明显增加,术后1周最明显,与术前相比差异有统计学意义(P<0.05),术后6个月SRI及SAI与术前相比差异无统计学意义(P>0.05);术后1周、1个月、3个月角膜荧光素染色及虎红染色点增多,泪液分泌量明显减少、BUT明显缩短,与术前相比差异有统计学意义(P<0.05),术后6个月角膜荧光素染色、虎红染色、SIt及BUT恢复至术前水平,与术前比差异无统计学意义(P>0.05)。结论青光眼小梁切除术对眼表结构和泪膜具有一定程度的影响,这可能与多种因素有关,应积极采取预防措施。展开更多
文摘s from those searches were screened for relevance to our review topics.Publications were included if the subjects included glaucoma patients,and if ocular surface outcomes were described.Non-English papers were excluded.Key Content and Findings:Topical glaucoma medications frequently cause adverse effects on the ocular surface,both through direct action of the medications themselves as well as through toxicity from their associated preservatives.Optimization of the ocular surface may improve medication compliance rates.Traditional surgical treatments for glaucoma,such as trabeculectomy,can exacerbate OSD by disrupting the ocular surface but can also reduce the need for chronic medications.Optimization of ocular surface health is imperative in reducing trabeculectomy complication rates,while also potentially reducing the need for trabeculectomy in patients that are able to achieve intraocular pressure control through improved drop tolerability.The introduction of MIGS represents a promising alternative to existing therapies and has been shown to alleviate the overall medication burden.It would be reasonable to assume that decreasing the medication burden could reduce OSD prevalence and severity.However,more research is needed to directly assess the extent of improvement seen after MIGS.Conclusions:A comprehensive understanding of the importance of OSD in medical and surgical management of glaucoma is essential in optimizing patient care and improving outcomes.
文摘目的探讨青光眼小梁切除手术对眼表结构及泪膜的影响。方法选择66例80只急性闭角型青光眼行小梁切除的患者,观察术前及术后6个月的角膜表面规则指数(SRI)、角膜表面非对称性指数(SAI)、角膜荧光素染色及虎红染色、基础泪液分泌试验(Schirmer I test)、泪膜破裂时间(BUT),并对数据进行统计学分析。结果小梁切除术前,术后1周、1个月、3个月和6个月的SRI为(0.26±0.11)、(0.65±0.30)、(0.53±0.25)、(0.45±0.17)和(0.28±0.12),SAI为(0.42±0.22)、(0.78±0.23)、(0.68±0.26)、(0.60±0.22)、(0.46±0.21),术后3个月内的SRI及SAI明显增加,术后1周最明显,与术前相比差异有统计学意义(P<0.05),术后6个月SRI及SAI与术前相比差异无统计学意义(P>0.05);术后1周、1个月、3个月角膜荧光素染色及虎红染色点增多,泪液分泌量明显减少、BUT明显缩短,与术前相比差异有统计学意义(P<0.05),术后6个月角膜荧光素染色、虎红染色、SIt及BUT恢复至术前水平,与术前比差异无统计学意义(P>0.05)。结论青光眼小梁切除术对眼表结构和泪膜具有一定程度的影响,这可能与多种因素有关,应积极采取预防措施。
